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2</a>&#41;&#46; Although these episodes were not associated with prolonged sun exposure&#44; 2 of the occurrences were consistent with car trips&#46; The patient did not use topical sunscreen&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">The histological study of the biopsy was consistent with a picture of phototoxicity&#44; highlighting an epidermis with ballooned keratinocytes and numerous necrotic and apoptotic keratinocytes&#46; The dermal-epidermal junction showed vacuolation changes&#46; The superficial dermis revealed the presence of edema and a sparse perivascular lymphocytic infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Immunofluorescence testing was negative&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Other supplementary tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">The analytical study conducted included a complete blood count&#44; biochemistry&#44; PCR&#44; ESR&#44; autoimmunity study&#44; and porphyria tests&#44; which all tested negative&#46; One genetic test was conducted too&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">The genetic study diagnosed xeroderma pigmentosum &#40;XP&#41; type D in compound heterozygosity&#44; after detecting the pathogenic c&#46;2046&#43;1G&#62;C variant and the R683W variant as well&#46; The patient had left congenital torticollis&#44; which caused continuous exposure of the same hemiface&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Treatment and course of the disease</span><p id="par0035" class="elsevierStylePara elsevierViewall">After following guidelines related to solar damage prevention&#44; the patient has not experienced any similar episodes&#46; Currently&#44; he remains asymptomatic with vitamin D supplementation and sunscreen&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">XP is characterized by photosensitivity&#44; pigmentation changes&#44; premature skin aging&#44; photophobia&#44; and neoplasms&#46; The prevalence in Europe is 2&#46;3 cases per million inhabitants&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-3</span></a> XP is an autosomal recessive genetic disorder due to mutations in some of the 8 genes involved in nucleotide excision repair &#40;NER&#41; pathways&#44; which protect us from UV-induced damage&#46; Eight types of XP have been described&#44; all showing a marked increase in the risk of developing melanoma and non-melanoma skin cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> The mean age of tumor growth is 9 years for non-melanoma skin carcinoma and 20 years for melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-3</span></a> Up to 25&#37; of patients have neurological symptoms&#44; which are more common in types A and D1&#44; including sensorineural hearing loss&#44; microcephaly&#44; or cognitive impairment1&#44; which are crucial for disease prognosis&#46; Additionally&#44; ocular signs appear in up to 80&#37; of patients and can cause corneal opacifications&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Differential diagnosis should include diseases induced or aggravated by light&#46; Rheumatological diseases&#44; such as systemic lupus erythematosus&#44; metabolic diseases&#44; such as porphyrias&#44; or drug-induced photosensitivity reactions could explain the process&#46; A different group of diseases that could justify the presentation includes hereditary conditions with solar hypersensitivity&#44; such as Cockayne syndrome&#44; Bloom syndrome&#44; Rothmund-Thomson syndrome&#44; and progeria syndromes&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-4</span></a> On the other hand&#44; 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Cases for diagnosis
Recurrent Rash on the Left Side of the Face: A Diagnostic Challenge
Un reto diagnóstico: erupción recidivante en la hemicara izquierda
I. Pérez-Lópeza,
Corresponding author
ipl_elmadrono@hotmail.com

Corresponding author.
, C. Garrido-Colmenerob, R. Ruiz-Villaverdea
a Servicio de Dermatología Médico Quirúrgica y Venerología, Hospital Universitario San Cecilio, Granada, Spain
b Servicio de Dermatología, Complejo Hospitalario de Jaén, Jaén, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical history</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 4-month-old infant&#44; with no significant personal or family history&#44; was referred due to the presence of a rash on his left hemiface for which they had been admitted 3 times to his local hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Upon examination&#44; an erythematous-edematous rash with a few adhered crusts was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; On this occasion&#44; the patient exhibited similar lesions&#44; including blisters&#44; on the pretibial area and forearms &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Although these episodes were not associated with prolonged sun exposure&#44; 2 of the occurrences were consistent with car trips&#46; The patient did not use topical sunscreen&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">The histological study of the biopsy was consistent with a picture of phototoxicity&#44; highlighting an epidermis with ballooned keratinocytes and numerous necrotic and apoptotic keratinocytes&#46; The dermal-epidermal junction showed vacuolation changes&#46; The superficial dermis revealed the presence of edema and a sparse perivascular lymphocytic infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Immunofluorescence testing was negative&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Other supplementary tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">The analytical study conducted included a complete blood count&#44; biochemistry&#44; PCR&#44; ESR&#44; autoimmunity study&#44; and porphyria tests&#44; which all tested negative&#46; One genetic test was conducted too&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">The genetic study diagnosed xeroderma pigmentosum &#40;XP&#41; type D in compound heterozygosity&#44; after detecting the pathogenic c&#46;2046&#43;1G&#62;C variant and the R683W variant as well&#46; The patient had left congenital torticollis&#44; which caused continuous exposure of the same hemiface&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Treatment and course of the disease</span><p id="par0035" class="elsevierStylePara elsevierViewall">After following guidelines related to solar damage prevention&#44; the patient has not experienced any similar episodes&#46; Currently&#44; he remains asymptomatic with vitamin D supplementation and sunscreen&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">XP is characterized by photosensitivity&#44; pigmentation changes&#44; premature skin aging&#44; photophobia&#44; and neoplasms&#46; The prevalence in Europe is 2&#46;3 cases per million inhabitants&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-3</span></a> XP is an autosomal recessive genetic disorder due to mutations in some of the 8 genes involved in nucleotide excision repair &#40;NER&#41; pathways&#44; which protect us from UV-induced damage&#46; Eight types of XP have been described&#44; all showing a marked increase in the risk of developing melanoma and non-melanoma skin cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> The mean age of tumor growth is 9 years for non-melanoma skin carcinoma and 20 years for melanoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-3</span></a> Up to 25&#37; of patients have neurological symptoms&#44; which are more common in types A and D1&#44; including sensorineural hearing loss&#44; microcephaly&#44; or cognitive impairment1&#44; which are crucial for disease prognosis&#46; Additionally&#44; ocular signs appear in up to 80&#37; of patients and can cause corneal opacifications&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Differential diagnosis should include diseases induced or aggravated by light&#46; Rheumatological diseases&#44; such as systemic lupus erythematosus&#44; metabolic diseases&#44; such as porphyrias&#44; or drug-induced photosensitivity reactions could explain the process&#46; A different group of diseases that could justify the presentation includes hereditary conditions with solar hypersensitivity&#44; such as Cockayne syndrome&#44; Bloom syndrome&#44; Rothmund-Thomson syndrome&#44; and progeria syndromes&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1-4</span></a> On the other hand&#44; certain disorders unrelated to solar exposure could also have a similar onset to that of the patient in question&#44; such as bacterial infections &#40;<span class="elsevierStyleItalic">Staphylococcus aureus-</span>induced bullous impetigo&#41;&#44; or viral infections &#40;herpes zoster&#41;&#46; The Meyerson phenomenon with capillary malformation could also start with a similar lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In this disease&#44; early diagnosis and strict UV radiation protection are essential&#46; Indeed&#44; solar damage prevention is the cornerstone of treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">5&#44;6</span></a> Although there is no curative treatment&#44; various chemopreventives have been developed in the last decade&#44; including systemic retinoids&#44; 5-fluorouracil&#44; endonuclease VT4&#44; and topical imiquimod&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Early recognition of photosensitivity in pediatric patients is crucial to minimize long-term complications associated with inadequate photoprotection&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflicto de intereses</span><p id="par0065" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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