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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Los nevus melanoc&#237;ticos adquiridos &#40;NMA&#41; son unas tumoraciones benignas de los melanocitos&#44; consideradas como las neoplasias benignas m&#225;s frecuentes de la poblaci&#243;n blanca<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#46; Es bien conocido que el n&#250;mero de NMA es uno de los factores de riesgo m&#225;s importantes para desarrollar un melanoma<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Aunque la mayor&#237;a de NMA suelen localizarse en las zonas expuestas a la radiaci&#243;n solar &#40;RS&#41;&#44; tambi&#233;n aparecen en otras zonas que lo son menos&#44; como las palmas o las plantas&#44; y se conocen como NMA acrales<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a>&#46; Las publicaciones de recuentos de estos NMA son m&#225;s bien escasas<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#8211;13</span></a>&#46; Su patogenia es desconocida y presentan un perfil mutacional diferente respecto a los nevus no acrales y al melanoma lentiginoso acral &#40;ALM&#41;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a>&#46; Por otra parte&#44; la posible asociaci&#243;n entre el ALM y los NMA acrales es controvertida<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#44;15&#44;16</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">No existen&#44; sin embargo&#44; estudios que caractericen los NMA en los espacios interdigitales&#44; una zona especialmente oculta a la RS&#46; Esta localizaci&#243;n es una zona de transici&#243;n entre el dorso y la planta de los pies&#44; por lo que se desconoce si la presencia de NMA en las zonas interdigitales se puede equiparar con los localizados en alguna de estas dos &#225;reas&#44; o si existe relaci&#243;n con el n&#250;mero de nevus del resto del cuerpo&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El objetivo del presente estudio fue observar si el recuento de los nevus interdigitales de los pies &#40;NIDp&#41; se asociaba con el n&#250;mero total de NMA del pie&#44; y con otros factores de riesgo de desarrollar melanoma&#44; como el n&#250;mero de NMA totales del cuerpo &#40;NMA-C&#41;&#44; las caracter&#237;sticas fenot&#237;picas raciales y los antecedentes de exposici&#243;n a la radiaci&#243;n ultravioleta &#40;RUV&#41;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a>&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todo</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se dise&#241;&#243; un estudio observacional transversal de todos los pacientes adultos &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&#41; que acudieron a la consulta de lesiones pigmentadas de Dermatolog&#237;a del Hospital General Universitario de Alicante &#40;HGUA&#41; durante el periodo comprendido entre septiembre de 2020 y febrero de 2021&#46; Se seleccionaron los pacientes que tuvieran un fototipo seg&#250;n la escala de Fitzpatrick de I al IV<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a>&#44; y que no presentaran alguno de los siguientes <span class="elsevierStyleItalic">criterios de exclusi&#243;n</span>&#58; presencia de nevus cong&#233;nitos gigantes&#44; enfermedades mentales graves y&#47;o malas condiciones higi&#233;nicas que impidieran la exploraci&#243;n de los pies&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">El protocolo del estudio fue realizado de acuerdo con los principios de la Declaraci&#243;n de Helsinki y fue aprobado por el CEIm del HGUA &#40;Acta 2021-03&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables del estudio</span><p id="par0035" class="elsevierStylePara elsevierViewall">La <span class="elsevierStyleItalic">variable de resultado</span> fue el n&#250;mero de NMA &#8805;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm interdigitales en los pies&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se consideraron las siguientes <span class="elsevierStyleItalic">variables explicativas</span>&#58; sexo&#44; edad&#44; color de ojos &#40;claros &#91;azules o verdes&#93; y oscuros &#91;marrones o negros&#93;&#41;&#59; color de pelo a los 20 a&#241;os de edad &#40;claro &#91;pelirrojo&#44; rubio o casta&#241;o claro&#93;&#44; oscuro &#91;casta&#241;o oscuro o negro&#93;&#41;&#59; fototipo &#40;claro &#91;I y II&#93; u oscuro &#91;III y IV&#93;&#41;&#44; presencia de ef&#233;lides&#44; antecedentes personales de quemaduras solares graves &#40;definidas como presencia de ampollas tras exposici&#243;n solar&#41;&#44; antecedentes personales de melanoma&#44; de c&#225;ncer cut&#225;neo no melanoma &#40;CCNM&#41; y de c&#225;ncer no cut&#225;neo&#44; uso de l&#225;mpara UVA&#44; n&#250;mero de NMA-C &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm &#40;&#8804;<span class="elsevierStyleHsp" style=""></span>50 y &#62;<span class="elsevierStyleHsp" style=""></span>50&#41;&#44; n&#250;mero de NMA &#8805;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm en la planta &#40;NMA-P&#41; y en el dorso de los pies &#40;NMA-D&#41;&#44; tomando como punto de referencia aquellos que se encontraran por debajo de los mal&#233;olos&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Respecto al punto de corte para considerar NMA acrales&#44; incluidos los NIDp&#44; elegimos los &#8805;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm por ser el tama&#241;o m&#237;nimo para no confundirlas con otras lesiones&#44; especialmente lentigos solares en el dorso&#46; Respecto al punto de corte en los NMA-C&#44; escogimos los &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm&#44; ya que est&#225; ampliamente establecido<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">16&#44;17</span></a> y nuestro grupo ten&#237;a experiencia de un estudio anterior<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a>&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">M&#233;todo de recogida de datos y variables de estudio</span><p id="par0050" class="elsevierStylePara elsevierViewall">La recogida de datos se realiz&#243; en dos fases&#46; La primera fue de entrevista&#44; donde se revisaron los criterios de inclusi&#243;n y de exclusi&#243;n&#46; En la segunda se les examin&#243; en ropa interior para contabilizar los NMA-C y de los pies&#44; incluyendo los espacios interdigitales y excluyendo las &#225;reas cubiertas por la ropa interior y el cuero cabelludo&#46; A todos los pacientes se les asign&#243; un n&#250;mero de identificaci&#243;n para asegurar la anonimizaci&#243;n&#46; Se realiz&#243; un examen dermatosc&#243;pico de todas las lesiones dudosas&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Todos los datos fueron recogidos por una residente de dermatolog&#237;a entrenada previamente &#40;V&#46;S&#46;G&#46;&#41;&#44; supervisada por un dermat&#243;logo experto en lesiones pigmentadas &#40;J&#46;B&#46;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">An&#225;lisis estad&#237;stico</span><p id="par0060" class="elsevierStylePara elsevierViewall">Se estudi&#243; la normalidad de las variables cuantitativas &#40;edad y n&#250;mero de NMA&#41; mediante la prueba de Kolmogorov-Smirnov&#46; Dado que el n&#250;mero de NMA-D y NMA-P no segu&#237;an una distribuci&#243;n normal&#44; se utilizaron la mediana y el rango intercuart&#237;lico &#91;RI&#93;&#46; Para estudiar la relaci&#243;n entre variables cualitativas y cuantitativas se utiliz&#243; la prueba U de Mann-Whitney&#46; Por &#250;ltimo&#44; para estudiar la relaci&#243;n entre las variables cuantitativas se realiz&#243; la prueba de correlaci&#243;n de Spearman&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Las variables categ&#243;ricas se expresaron como frecuencias absolutas y relativas&#46; Las variables continuas se categorizaron para el posterior an&#225;lisis estad&#237;stico&#58; la edad se categoriz&#243; en terciles y los NMA de los pies &#40;dorso&#44; planta e interdigitales&#41; en presencia y ausencia de los mismos&#46; En el estudio bivariante se utiliz&#243; la regresi&#243;n log&#237;stica binaria&#46; Para cuantificar la magnitud de asociaci&#243;n&#44; se utiliz&#243; la <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; con un intervalo de confianza al 95&#37; &#40;IC 95&#37;&#41;&#46; Las asociaciones estad&#237;sticamente significativas se analizaron posteriormente en un an&#225;lisis multivariante&#44; calculando la OR ajustada &#40;aOR&#41;&#44; con un IC 95&#37;&#46; Adicionalmente se realiz&#243; un an&#225;lisis del n&#250;mero crudo de los NIDp y el n&#250;mero de NMA-D y NMA-P&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">El nivel de significaci&#243;n utilizado para el contraste de hip&#243;tesis fue de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Para analizar los datos del estudio se utiliz&#243; el programa estad&#237;stico SPSS &#40;versi&#243;n 25&#46;0&#44; IBM Corp&#44; Armonk&#44; NY&#44; EE&#46;UU&#46;&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Resultados</span><p id="par0075" class="elsevierStylePara elsevierViewall">De los 257 sujetos a los que se propuso el estudio&#44; 2 de ellos &#40;0&#44;8&#37;&#41; fueron excluidos por una higiene deficiente de los pies&#46; Finalmente&#44; se incluyeron 255 pacientes que cumpl&#237;an los criterios de selecci&#243;n&#44; siendo el 51&#44;4&#37; mujeres&#44; con una mediana de 53 a&#241;os &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se presentan las diferencias de las variables explicativas seg&#250;n la presencia o ausencia de NIDp y los resultados del an&#225;lisis bivariante&#46; El an&#225;lisis crudo mostr&#243; que solo los pacientes &#60;<span class="elsevierStyleHsp" style=""></span>45 a&#241;os se asociaban significativamente con la presencia de NIDp&#46; Por otra parte&#44; no se observaron diferencias significativas respecto al sexo&#44; el color de los ojos&#44; de pelo&#44; fototipo&#44; presencia de ef&#233;lides&#44; antecedentes de quemaduras solares&#44; exposici&#243;n a RUV&#44; antecedentes personales de melanoma&#44; ni con los de c&#225;ncer no cut&#225;neo&#46; Sin embargo&#44; los antecedentes personales de CCNM presentaron una asociaci&#243;n negativa o &#171;protectora&#187; respecto a la presencia de NIDp&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La relaci&#243;n de presencia de NIDp respecto a las variables que se refer&#237;an al n&#250;mero de nevus fue la siguiente&#58; se observ&#243; una asociaci&#243;n con la presencia y n&#250;mero de NMA-P&#46; Por el contrario&#44; no se observ&#243; una asociaci&#243;n con la presencia ni el n&#250;mero de NMA-D&#46; Asimismo&#44; el n&#250;mero elevado de NMA-C &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>50 NMA&#41; se asoci&#243; con la presencia de NIDp&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Por otra parte&#44; observamos que el recuento de NMA-P aumentaba de manera significativa con el recuento de NIDp&#44; con un coeficiente de correlaci&#243;n de 0&#44;248 &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;v&#233;ase <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Por el contrario&#44; no exist&#237;a una correlaci&#243;n significativa entre los recuentos de NMA-D y NIDp&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Tras el an&#225;lisis multivariante&#44; las variables que se asociaron de forma independiente con NIDp fueron las siguientes&#58; la presencia de NMA-P &#40;ORa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44;4&#59; IC 95&#37; 1&#44;2-5&#44;1&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;020&#41; y la presencia de &#62;<span class="elsevierStyleHsp" style=""></span>50 NMA-C &#40;ORa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44;5&#59; IC 95&#37; 1&#44;5-7&#44;9&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">Este estudio ha demostrado que la presencia de NIDp se relaciona con el n&#250;mero de NMA-P&#44; y tambi&#233;n con los NMA-C&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El n&#250;mero de NMA de la piel es un factor de riesgo conocido de melanoma cut&#225;neo<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a> y se ha asociado con rasgos fenot&#237;picos raciales y con la RS<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">19&#8211;21</span></a>&#46; Los recuentos de NMA acrales&#44; zonas m&#237;nimamente expuestas a la RUV&#44; han sido poco referidos en la literatura y&#44; en esos casos&#44; casi exclusivamente a las plantas y palmas&#44; no estudi&#225;ndose el dorso<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3&#8211;13</span></a>&#46; Por otra parte&#44; los espacios interdigitales son todav&#237;a m&#225;s ocultos&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Finalmente se incluyeron 255 pacientes&#44; de los cuales el 17&#44;3&#37; presentaron NIDp&#46; Respecto a la edad&#44; observamos que los pacientes con &#60;<span class="elsevierStyleHsp" style=""></span>45 a&#241;os presentaban un mayor riesgo de tener NIDp&#46; No existen estudios respecto a recuentos de NIDp&#44; por lo que la informaci&#243;n que tenemos es indirecta de los NMA-C&#46; Se ha observado que los NMA acrales aumentan con la adolescencia hasta la edad media y disminuyen en la edad avanzada<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;22</span></a>&#46; Palicka y Rhodes<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> y Kogushi-Nishi et al<span class="elsevierStyleItalic">&#46;</span><a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> encuentran prevalencias superiores de NMA acrales en menores de 50 a&#241;os &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; En el mismo sentido&#44; el n&#250;mero de NMA-C sigue una evoluci&#243;n parecida<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#46; Si bien no hay estudios espec&#237;ficos en relaci&#243;n con recuentos de NIDp&#44; en nuestro estudio el mayor riesgo de tener NIDp se observaba en pacientes con menos de 45 a&#241;os&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">No hemos encontrado diferencias significativas entre en la presencia de NIDp y el sexo&#46; En relaci&#243;n con los nevus acrales&#44; Palicka y Rhodes<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> encuentran que las prevalencias de NMA acrales en sujetos de raza blanca es mayor en mujeres que en hombres&#44; mientras que otros autores no encuentran diferencias<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;23</span></a>&#46; Respecto al n&#250;mero de NMA-C&#44; los resultados son dispares&#44; observ&#225;ndose recuentos mayores en hombres<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a>&#44; en mujeres<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a>&#44; y sin diferencias entre sexos<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">No hemos observado en nuestro estudio relaci&#243;n de los recuentos de NIDp con el color de ojos ni de pelo&#46; No hemos encontrado publicaciones que relacionen el n&#250;mero de NMA acrales con estas caracter&#237;sticas&#46; Respecto al n&#250;mero de NMA-C&#44; los resultados son dispares&#44; as&#237; algunos autores no encuentran relaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a>&#44; mientras que otros concluyen que los sujetos con ojos y pelo claro presentan m&#225;s NMA<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Tampoco hemos encontrado diferencias con relaci&#243;n a la presencia de NIDp y el fototipo y la presencia de ef&#233;lides&#46; Respecto a los recuentos de nevus acrales y el color de la piel&#44; algunos autores observan que los sujetos de color tienen m&#225;s nevus palmares que los blancos&#44; sin diferencias en los NMA-P<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;11</span></a>&#44; mientras que otros autores encuentran que&#44; tanto la prevalencia de nevus palmares como plantares&#44; aumenta con el grado de pigmentaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a>&#46; En cuanto a los recuentos de NMA-C&#44; si bien hay estudios que encuentran mayor n&#250;mero de NMA en sujetos con fototipos claros que en oscuros<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">17&#44;19&#44;20&#44;23</span></a>&#44; otros no hallan relaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;24&#44;25</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">No hemos observado asociaci&#243;n de NIDp con la exposici&#243;n a RUV&#46; Dado que los espacios interdigitales son zonas especialmente cubiertas a la RS&#44; y que los NMA suelen aparecer en zonas fotoexpuestas<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#44; parece l&#243;gica esta falta de asociaci&#243;n&#46; Aunque se han descrito diferentes patrones de ALM seg&#250;n la localizaci&#243;n y la exposici&#243;n relativa al sol<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a>&#44; no se ha publicado nada sobre los NMA acrales en este sentido&#46; En general&#44; los NMA-C se ha descrito que aumentan tras la RS<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">21&#44;23&#44;24</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La presencia de NIDp se asoci&#243; significativamente con un mayor riesgo de recuento elevado de NMA-C&#46; Los recuentos de NMA acrales se han asociado con un mayor recuento de NMA-C<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#44;24</span></a>&#44; aunque en otros estudios esta asociaci&#243;n no se ha encontrado<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46; Respecto a la relaci&#243;n con el recuento de NMA acrales&#44; los resultados del estudio bivariante muestran como la presencia de NIDp se asocia con un riesgo mayor de tener un NMA-P&#44; sin embargo&#44; los NIDp no se relacionaron con los NMA-D&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La presencia de NIDp se asoci&#243; con un riesgo negativo de tener CCNM&#46; Este papel protector podr&#237;a explicarse debido a que los NIDp&#44; al estar en zonas cubiertas&#44; a diferencia de la mayor&#237;a de los CCNM&#44; presentan factores patog&#233;nicos diferentes&#46; Por otra parte&#44; no hemos encontrado en la literatura relaci&#243;n entre recuentos de nevus acrales y CCNM&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Otro hallazgo destacable es que la presencia de NIDp no se asoci&#243; con los antecedentes personales de melanoma&#46; La relaci&#243;n del n&#250;mero de NMA-P y la historia de melanoma es variable en la literatura&#46; Algunos estudios no observan diferencias en la prevalencia de NMA-P entre el grupo de melanoma plantar y el control<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a>&#59; otros autores han asociado el ALM con recuentos elevados de NMA-P<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a>&#44; y otros concluyen que el recuento de NMA es un factor de riesgo importante para el melanoma no acral&#44; pero no para el ALM<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a>&#46; En general&#44; se ha demostrado que los altos recuentos de NMA-C se han asociado con un alto riesgo de melanoma<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">27&#44;28</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Finalmente&#44; en el estudio multivariante&#44; observamos que las dos &#250;nicas variables que explicaron de manera independiente la presencia de NIDp fueron la presencia de NMA-P y la presencia de &#62;<span class="elsevierStyleHsp" style=""></span>50 NMA en el cuerpo&#46; Esta asociaci&#243;n de los NIDp y la presencia de los nevus de la planta hipotetizamos que podr&#237;a deberse a la similitud anat&#243;mica de los espacios interdigitales con las plantas de los pies&#44; de forma que estos ser&#237;an una expansi&#243;n de la planta&#46; La no relaci&#243;n con la presencia de NMA-D indicar&#237;a que probablemente otros factores anat&#243;micos&#44; gen&#233;ticos&#44; e incluso de fotoexposici&#243;n&#44; influir&#237;an en la aparici&#243;n de NMA-D&#44; y no en los NMA-P ni NIDp&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">El recuento de nevus lugar espec&#237;fico y su relaci&#243;n con los NMA-C se ha descrito en diversas ocasiones<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#46; Las mejores correlaciones han sido encontradas en el n&#250;mero de nevus del antebrazo y del muslo&#46; No hemos hallado trabajos que estudien espec&#237;ficamente los NIDp&#46; Sin embargo&#44; Papageorgiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> detectaron una relaci&#243;n entre la presencia de nevus acrales y elevados recuentos de NMA-C&#44; lo que concuerda con los resultados de nuestro estudio entre la presencia de NIDp y los NMA-C&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Por otro lado&#44; los NMA acrales y el ALM parecen no presentar una relaci&#243;n directa<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a>&#46; Ambas entidades presentan caracter&#237;sticas cl&#237;nicas e histopatol&#243;gicas independientes&#44; as&#237; como un perfil mutacional diferente&#44; lo que sugiere que los ALM surgen en su mayor&#237;a <span class="elsevierStyleItalic">de novo</span>&#44; no a partir de NMA&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Respecto a la exploraci&#243;n de los espacios interdigitales&#44; pensamos que no se realiza en la pr&#225;ctica habitual de manera rutinaria&#44; lo que retrasar&#237;a el diagn&#243;stico de una patolog&#237;a maligna&#46; De hecho&#44; en nuestro estudio detectamos un ALM <span class="elsevierStyleItalic">in situ</span> interdigital que el paciente no refer&#237;a<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Respecto a las limitaciones del estudio&#44; se trata de un estudio unic&#233;ntrico&#44; con un peque&#241;o tama&#241;o muestral&#44; lo cual limita su validez externa&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la presencia de NIDp se relaciona con un mayor n&#250;mero de NMA-P y de NMA-C&#46; Hasta donde sabemos&#44; este es el primer estudio publicado sobre NIDp&#44; lo que ofrece una nueva perspectiva de los nevus acrales desde el punto de vista epidemiol&#243;gico de una zona corporal sin RS&#44; como son los espacios interdigitales&#46; Por otra parte&#44; la relaci&#243;n que hemos observado entre la presencia de NIDp y el n&#250;mero de NMA-C posiblemente se deba a que factores gen&#233;ticos y no solo ambientales&#44; como la RS&#44; influyen en el n&#250;mero de NMA&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Financiaci&#243;n</span><p id="par0185" class="elsevierStylePara elsevierViewall">El estudio no ha recibido financiaci&#243;n externa&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicto de intereses</span><p id="par0180" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        ]
        11 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2024-03-06"
    "fechaAceptado" => "2024-04-14"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1847789"
          "palabras" => array:5 [
            0 => "Nevus melanoc&#237;ticos"
            1 => "Nevus interdigitales"
            2 => "Nevus plantares"
            3 => "Nevus acral"
            4 => "Recuento de nevus"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1847788"
          "palabras" => array:5 [
            0 => "Melanocytic nevi"
            1 => "Interdigital nevi"
            2 => "Plantar nevi"
            3 => "Acral nevi"
            4 => "Nevi count"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Antecedentes y objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Existe una ausencia de estudios centrados en el recuento de nevus melanoc&#237;ticos adquiridos &#40;NMA&#41; interdigitales de los pies &#40;NIDp&#41;&#46; Nuestro objetivo fue estudiar la relaci&#243;n de la presencia de NIDp con el n&#250;mero total de NMA de los pies y del resto del cuerpo&#44; las caracter&#237;sticas fenot&#237;picas raciales y otros factores de riesgo de melanoma&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio observacional transversal que incluy&#243; a 255 pacientes&#44; &#8805;<span class="elsevierStyleHsp" style=""></span>18 a&#241;os&#44; que acudieron a nuestro servicio de Dermatolog&#237;a desde septiembre de 2020 a febrero de 2021&#46; Se registraron todos los NMA &#8805;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm de los pies y &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm del resto del cuerpo&#46; Se estudi&#243; la asociaci&#243;n entre las variables mediante un modelo de regresi&#243;n log&#237;stica uni- y multivariante&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La presencia de NIDp se asoci&#243; de manera estad&#237;sticamente significativa e independiente con la presencia de NMA plantares y con recuentos de &#8805;<span class="elsevierStyleHsp" style=""></span>50 NMA en el cuerpo&#46; Sin embargo&#44; no se observaron diferencias significativas respecto al sexo&#44; la edad&#44; los antecedentes personales de melanoma&#44; la presencia de nevus en el dorso de los pies&#44; antecedentes de quemaduras solares o rayos UVA&#44; ni con caracter&#237;sticas fenot&#237;picas raciales&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La presencia de NIDp se relaciona con un mayor recuento de nevus plantares y NMA totales del cuerpo&#44; lo que puede significar que los espacios interdigitales son una expansi&#243;n anat&#243;mica de la planta del pie y que otras causas&#44; posiblemente gen&#233;ticas&#44; ser&#237;an responsables del n&#250;mero de NMA en esta localizaci&#243;n&#44; al ser zonas nada fotoexpuestas&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background and objectives</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">No studies focused on counting the interdigital acquired melanocytic nevi &#40;AMN&#41; of the foot &#40;IDNf&#41; have ever been conducted&#46; Therefore&#44; our objective was to study the relationship between the presence of IDNf and the total number of AMN in the feet and the rest of the body&#44; the racial phenotypic characteristics&#44; and other risk factors for melanoma&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We conducted a cross-sectional observational study with 255 patients &#8805;<span class="elsevierStyleHsp" style=""></span>18 years old who attended our Dermatology Unit from September 2020 through February 2021&#44; and included all AMN &#8805;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm from the feet and &#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm from the rest of the bod&#46; The association between the variables was studied using univariate and multivariate logistic regression models&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The presence of IDNf was significantly and independently associated with the presence of plantar AMN and body counts &#8805;<span class="elsevierStyleHsp" style=""></span>50 AMN&#46; However&#44; no significant differences were observed regarding sex&#44; age&#44; personal history of melanoma&#44; presence of nevi on the dorsum of the foot&#44; history of sunburn or UV rays&#44; or racial phenotypic characteristics&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The presence of IDNf is associated with a higher count of plantar nevi and total AMN in the body&#44; meaning that interdigital spaces of the foot&#8212;anatomical expansions of the sole and other possibly genetic causes&#8212;could be responsible for the number of AMN found in this location&#44; as these regions are not photoexposed&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:4 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Resaltados en negrita los resultados estad&#237;sticamente significativos&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CCNM&#58; c&#225;ncer cut&#225;neo no melanoma&#59; IC&#58; intervalo de confianza&#59; NMA&#58; nevus melanoc&#237;ticos adquiridos&#59; MM&#58; melanoma&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio</span> cruda&#59; ORa&#58; <span class="elsevierStyleItalic">odds ratio</span> ajustada&#59; UVA&#58; ultravioleta A&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable de resultado</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">An&#225;lisis bivariante</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">An&#225;lisis multivariante</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables explicativas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>255&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NMA interdigitales &#40;s&#237;&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NMA interdigitales &#40;no&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>211&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-valor<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ORa &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-valor&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Edad&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>45 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;35&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25 &#40;56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;31&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;002</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;8 &#40;0&#44;3-2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>45-63 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">79 &#40;31&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;27&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">67 &#40;32&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;0 &#40;0&#44;7-5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;179&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8 &#40;0&#44;6-5&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>63 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84 &#40;33&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;15&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77 &#40;36&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de nevus interdigitales</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables explicativas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de NMA plantares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;248</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#250;mero de NMA dorsales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;095&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estudio de correlaci&#243;n entre el n&#250;mero de nevus interdigitales &#40;variable de resultado&#41; y el n&#250;mero de nevus de la planta y del dorso de los pies &#40;variables explicativas&#41;</p>"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Resaltados en negrita los resultados estad&#237;sticamente significativos&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">CCNM&#58; c&#225;ncer cut&#225;neo no melanoma&#59; IC&#58; intervalo de confianza&#59; NMA&#58; nevus melanoc&#237;ticos adquiridos&#59; NMA-C&#58; nevus melanoc&#237;ticos adquiridos del cuerpo&#59; MM&#58; melanoma&#59; RS&#58; radiaci&#243;n solar&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio</span> cruda&#59; ORa&#58; <span class="elsevierStyleItalic">odds ratio</span> ajustada&#59; UVA&#58; ultravioleta A&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">An&#225;lisis bivariante de nuestro estudio</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados de la literatura</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables explicativas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-valor<a class="elsevierStyleCrossRef" href="#tblfn0015">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados de la literatura en NMA acrales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados de la literatura en NMA-C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>45 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">4&#44;2 &#40;1&#44;7-10&#44;4&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;002</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recuentos mayores de NMA acrales en &#60;<span class="elsevierStyleHsp" style=""></span>50 a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;9&#44;13&#44;22</span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recuentos mayores de NMA-C en &#60;<span class="elsevierStyleHsp" style=""></span>50 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>45-63 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0 &#40;0&#44;7-5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;179&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>63 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo &#40;hombre&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;3 &#40;0&#44;7-2&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#44;10&#44;23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;24&#44;25</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Color de ojos &#40;claros&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#44;5-1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sin datos al respecto</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">23&#44;26</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Color de pelo &#40;claro&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1 &#40;0&#44;6-2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Fototipo &#40;claro&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0 &#40;0&#44;4-2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recuentos mayores de NMA acrales en fototipos altos<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">5&#44;9&#44;11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;17&#44;19&#44;20&#44;23&#8211;25</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ef&#233;lides &#40;presencia&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5 &#40;0&#44;8-3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sin datos al respecto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sin datos al respecto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes de quemadura solar &#40;s&#237;&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0 &#40;0&#44;5-2&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sin datos al respecto</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recuentos mayores de NMA-C tras RS<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">21&#44;23&#44;24</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Rayos UVA&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1 &#40;0&#44;4-3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">3&#44;6 &#40;1&#44;7-7&#44;6&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;001</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#44;10&#44;24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes personales CCNM &#40;s&#237;&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sin datos al respecto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes personales de MM &#40;s&#237;&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resultados contradictorios<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#44;19&#44;22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Recuentos mayores de NMA-C en pacientes con MM<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">27&#44;28</span></a>&nbsp;\t\t\t\t\t\t\n
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                      "doi" => "10.1111/J.1610-0387.2011.07741.X"
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                            3 => "T&#46; Buhl"
                            4 => "S&#46; Emmert"
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                      "doi" => "10.1111/1523-1747.EP13075564"
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                      "titulo" => "Prevalence&#44; histological types&#44; and significance of palmar and plantar nevi"
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                      "titulo" => "A dissenting view on the prophylactic removal of plantar and palmar nevi"
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                            0 => "F&#46;C&#46; Wilson"
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                      "titulo" => "Incidence of nevi Report of survey of the palms&#44; soles&#44; and genitalia of 10&#44;000 young men"
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                          "etal" => false
                          "autores" => array:1 [
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                        "tituloSerie" => "Arch Dermatol&#46;"
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                        "volumen" => "86"
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                        "paginaFinal" => "43"
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                      "titulo" => "Incidence of pigmented nevi"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Allyn"
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                            2 => "M&#46; Kahn"
                            3 => "V&#46;H&#46; Witten"
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                      "doi" => "10.1001/JAMA.1963.03710100028006"
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                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "1963"
                        "volumen" => "186"
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                        "paginaFinal" => "893"
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                      "titulo" => "Acral melanocytic nevi&#58; prevalence and distribution of gross morphologic features in white and black adults"
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                          "autores" => array:2 [
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                      "titulo" => "Acral Melanocytic Nevi in a High-Risk Population&#58; Prevalence Clinical Characteristics and Dermatoscopic Patterns"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46; Kyrgidis"
                            2 => "P&#46;A&#46; Ilut"
                            3 => "Gkentsidi T&#46;"
                            4 => "Manoli S&#46;M&#46;"
                            5 => "Camela E&#46;"
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                        "tituloSerie" => "Dermatology&#46;"
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                      "titulo" => "Acral melanocytic lesions in the United States&#58; Prevalence&#44; awareness&#44; and dermoscopic patterns in skin-of-color and non-Hispanic white patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "P&#46;V&#46; Gumaste"
                            2 => "K&#46; Martires"
                            3 => "P&#46;R&#46; Schaffer"
                            4 => "S&#46; Choudhary"
                            5 => "L&#46; Falto-Aizpurua"
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                    0 => array:2 [
                      "doi" => "10.1016/J.JAAD.2015.11.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "74"
                        "paginaInicial" => "724"
                        "paginaFinal" => "730"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26803347"
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                      "titulo" => "Acral melanocytic nevi in the Polish population&#58; prevalence&#44; clinical characteristics and dermoscopic patterns"
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