was read the article
array:24 [ "pii" => "S000173102400262X" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.03.017" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3911" "copyright" => "AEDV" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2024;115:752-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0001731024005271" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.07.002" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3999" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2024;115:T752-T760" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Modelo computacional basado en la tomografía de coherencia óptica (TCO) para identificar y cuantificar la radiodermatitis aguda (RA): estudio observacional prospectivo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T752" "paginaFinal" => "T760" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Computational Model Based on Optical Coherence Tomography (OCT) Skin Scanning to Identify and Quantify Acute Radiation Dermatitis (ARD): A Prospective Diagnostic Study" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0025" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 886 "Ancho" => 1545 "Tamanyo" => 229260 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Gil-Lianes, G. Tena, M. Combalia, B. Alejo, G. Oses, A. Combalia, P. Iglesias, A. Huguet, S. Garrido, J. Sola, J. Malvehy, M. Mollà, C. Carrera" "autores" => array:13 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Gil-Lianes" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Tena" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Combalia" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Alejo" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Oses" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Combalia" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Iglesias" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "Huguet" ] 8 => array:2 [ "nombre" => "S." "apellidos" => "Garrido" ] 9 => array:2 [ "nombre" => "J." "apellidos" => "Sola" ] 10 => array:2 [ "nombre" => "J." "apellidos" => "Malvehy" ] 11 => array:2 [ "nombre" => "M." "apellidos" => "Mollà" ] 12 => array:2 [ "nombre" => "C." "apellidos" => "Carrera" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0025"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005271?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005271/v1_202409020432/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731024005829" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.07.009" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "4016" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2024;115:T747-T751" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo de opinión</span>" "titulo" => " Cutaneous squamous cell carcinoma that are difficult-to-manage with conventional local treatments" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T747" "paginaFinal" => "T751" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma escamoso cutáneo: escenarios de difícil manejo con tratamientos locales convencionales" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 550 "Ancho" => 1100 "Tamanyo" => 121930 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) 98-year-old male with a large cutaneous squamous cell carcinoma, affecting the entire scalp with bone invasion involving the entire cranial vault.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">b) Woman with cutaneous squamous cell carcinoma operated on the left forehead (see the scar) who developed satellite lesions in the form of a dermal tumor nodule on the left temple a few weeks after surgery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Marti-Marti, A. Toll" "autores" => array:2 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Marti-Marti" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Toll" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005829?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005829/v1_202409020432/en/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731024005271" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.07.002" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3999" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2024;115:T752-T760" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Modelo computacional basado en la tomografía de coherencia óptica (TCO) para identificar y cuantificar la radiodermatitis aguda (RA): estudio observacional prospectivo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T752" "paginaFinal" => "T760" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Computational Model Based on Optical Coherence Tomography (OCT) Skin Scanning to Identify and Quantify Acute Radiation Dermatitis (ARD): A Prospective Diagnostic Study" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0025" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 886 "Ancho" => 1545 "Tamanyo" => 229260 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Gil-Lianes, G. Tena, M. Combalia, B. Alejo, G. Oses, A. Combalia, P. Iglesias, A. Huguet, S. Garrido, J. Sola, J. Malvehy, M. Mollà, C. Carrera" "autores" => array:13 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Gil-Lianes" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Tena" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Combalia" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Alejo" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Oses" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Combalia" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Iglesias" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "Huguet" ] 8 => array:2 [ "nombre" => "S." "apellidos" => "Garrido" ] 9 => array:2 [ "nombre" => "J." "apellidos" => "Sola" ] 10 => array:2 [ "nombre" => "J." "apellidos" => "Malvehy" ] 11 => array:2 [ "nombre" => "M." "apellidos" => "Mollà" ] 12 => array:2 [ "nombre" => "C." "apellidos" => "Carrera" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0025"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005271?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005271/v1_202409020432/es/main.assets" ] ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Computational Model Based on Optical Coherence Tomography (OCT) Skin Scanning to Identify and Quantify Acute Radiation Dermatitis (ARD): A Prospective Diagnostic Study" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "752" "paginaFinal" => "760" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Gil-Lianes, G. Tena, M. Combalia, B. Alejo, G. Oses, A. Combalia, P. Iglesias, A. Huguet, S. Garrido, J. Sola, J. Malvehy, M. Mollà, C. Carrera" "autores" => array:13 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Gil-Lianes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Tena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Combalia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "B." "apellidos" => "Alejo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "G." "apellidos" => "Oses" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Combalia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "P." "apellidos" => "Iglesias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "A." "apellidos" => "Huguet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "S." "apellidos" => "Garrido" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "J." "apellidos" => "Sola" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 10 => array:3 [ "nombre" => "J." "apellidos" => "Malvehy" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 11 => array:3 [ "nombre" => "M." "apellidos" => "Mollà" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 12 => array:4 [ "nombre" => "C." "apellidos" => "Carrera" "email" => array:1 [ 0 => "ccarrera@clinic.cat" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Dermatology Department, Hospital Clínic, University of Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Radiation Oncology Department, Hospital Clínic Barcelona, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "IDIBAPS, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Modelo computacional basado en la tomografía de coherencia óptica (TCO) para identificar y cuantificar la radiodermatitis aguda (RA): estudio observacional prospectivo" ] ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig1020" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 886 "Ancho" => 1565 "Tamanyo" => 209013 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Breast cancer is the most prevalent malignancy worldwide with 1 out of every 4 malignancies reported in women.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> For women with early-stage breast cancer, adjuvant breast radiation therapy is an essential component of breast-conserving therapy and has been shown to decrease local recurrences and improve the overall survival.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">2–4</span></a> Whole breast irradiation (WBI) was previously performed using a standard 5-week fractionated schedule with a total dose of 50<span class="elsevierStyleHsp" style=""></span>Gy. However, 3 large randomized clinical trials have shown that hypofractionated WBI, with a total dose of 40.05–42<span class="elsevierStyleHsp" style=""></span>Gy, achieves equivalent local disease control and cosmetic outcomes vs standard fractionation. Therefore, a 3-week hypofractionated WBI regimen is now considered the standard of care for women with early-stage, node negative, operable breast cancer.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">4,5</span></a> Furthermore, the addition of a radiation boost to the tumor bed is an important component of adjuvant therapy, improving local control over WBI alone.<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">6,7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite these new developments, acute or chronic skin toxicity is still a common finding (80–90% of the patients), with unpredictable severity and progression.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">8–10</span></a> This has prompted several attempts to find the best therapeutic and prophylactic topical therapy for acute radiation dermatitis (ARD). However, the management of ARD is not firmly based on scientific evidence, since there is no standardization of treatment and multiple agents have been proposed (aloe-vera, sucralfate, steroids, trolamine, hyaluronic acid, biaffine, calendula, chamomile, almond oil, vitamin C, etc.).<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">8,10–17</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Different grading scales for ARD have been developed (RTOG, NCI CTCAE, LENT/SOMA).<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">18–20</span></a> However, all of them are somewhat subjective and difficult to replicate.<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">21–24</span></a> The optical coherence tomography (OCT) is a non-invasive imaging modality based on low coherence interferometry that provides in vivo imaging and detailed pictures of subsurface tissue micro-structures down to a depth of 2<span class="elsevierStyleHsp" style=""></span>mm with a real-time resolution of 4–10<span class="elsevierStyleHsp" style=""></span>μm. The OCT can be used to acquire images from the derman and epidermal layers of the skin, skin appendages, and blood vessels. In addition, dynamic-OCT (D-OCT) allows for the detection of blood flow in vivo and visualization of skin microvasculature.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">25</span></a> Therefore, the OCT allows for the study of a continuous process such as wound healing and vascularization,<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> and could be a promising tool in the management and research of several skin conditions.<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">27,28</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The primary endpoint of the study was to demonstrate the usefulness of OCT scanning in measuring radiotherapy-induced skin changes. Secondary endpoints were to compare the degree of ARD between different radiotherapy regimes, and to assess the tolerability of a standardized topical therapy.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study design</span><p id="par0025" class="elsevierStylePara elsevierViewall">This was a prospective and observational study to evaluate the skin changes observed by clinical examination and dermoscopy and OCT imaging by dynamic skin scanning in consecutive patients diagnosed with breast cancer from a tertiary referral center and on standard radiotherapy in 3 different schemes (15, 20, or 25 fractions).</p><p id="par0030" class="elsevierStylePara elsevierViewall">In addition to the general recommendations, to standardize the cohort, a hypoallergenic restorative cream, containing copper and zinc sulfate and a postbiotic repairing ingredient C+ Restore® was used on the target areas on a daily basis until 1 month after finishing radiotherapy.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> All adverse events, including ARD, were recorded during and 3 months after radiotherapy.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study population</span><p id="par0035" class="elsevierStylePara elsevierViewall">Volunteer patients aged 18 and over who were breast cancer candidates for radiotherapy according to the radio-oncologist regular scheme from a tertiary referral center. Inclusion date: from January 2020 to July 2021, until, at least, 10 patients from each fractionation group were included. Data collection was concluded in November 2021. All patients signed an informed consent form, and the study was approved by Hospital Clínic de Barcelona research ethics committee (registration HCB/2019/0796).</p><p id="par0040" class="elsevierStylePara elsevierViewall">The 3 breast radiotherapy schemes used were a hypofractionated scheme with a total dose of 40.05<span class="elsevierStyleHsp" style=""></span>Gy in 15 fractions (2.67<span class="elsevierStyleHsp" style=""></span>Gy/fraction) (scheme-15), the same hypofractionated scheme plus a sequential boost on the surgical bed for a total dose of 13.35<span class="elsevierStyleHsp" style=""></span>Gy in 5 fractions (2.67<span class="elsevierStyleHsp" style=""></span>Gy/fraction) (scheme-20), and breast and regional lymph nodes radiotherapy in a normo-fractionated scheme plus concomitant boost for a total dose of 57.5<span class="elsevierStyleHsp" style=""></span>Gy in 25 fractions (2.30<span class="elsevierStyleHsp" style=""></span>Gy/fraction) (scheme-25).</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Interventions and assessments</span><p id="par0045" class="elsevierStylePara elsevierViewall">Patients were closely monitored by the dermatology and radiation oncologist to ensure early detection of skin toxicity in the irradiated field. All previous dermatological skin condition were ruled out. Participants were evaluated clinically, through dermoscopy and OCT-scanning at 3 different points in time: before (t0), at the end (maximum dose received, tF) and 3 months after the end of radiotherapy (t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m). A window margin of ±3 days in tF and ±7 days in t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m was permitted. Both breasts (treated and non-treated) were systematically examined and registered by clinical and dermoscopy images of 25<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>25<span class="elsevierStyleHsp" style=""></span>mm areas, and OCT mosaics (6<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm) to cover the 4 quadrants of both breasts. The non-irradiated breast was systematically used as an internal control. <a class="elsevierStyleCrossRef" href="#sec0090">Supplementary figures (Fig. S1)</a> show an example of the dynamic information obtained by OCT.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The grade of ARD was categorized based on the Common Terminology Criteria for Adverse Events (CTCAE) scale (grade 0: absence of perceptive lesions, grade I: presence of mild erythema, dry peeling; grade II: presence of moderate-to-mild erythema, irregular wet peeling, confined mainly to skin folds and wrinkles, moderate edema; grade III: presence of wet peeling in areas other than skin folds or wrinkles; bleeding induced by minor trauma or abrasion; and grade IV: presence of skin necrosis or ulcers).</p><p id="par0055" class="elsevierStylePara elsevierViewall">Prior to radiotherapy, the patients’ baseline functional condition, symptoms, and overall performance status were evaluated through a quality-of-life questionnaire (EORTC QLQ-C30).<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">25</span></a> At the end of the study, patients’ skin tolerance was measured using a standardized test (dermatological-level quality of life; DLQI).</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">SPSS with python and statistical and image processing libraries (statsmodel, opencv, skimage, and numpy) were used to perform the statistical analyses. ANOVA and the Chi-square test were used to assess inter-group differences between quantitative and qualitative variables. To compare OCT determinations, we first normalized the intra-patient measurements using the 1st acquisition of each breast (non-irradiated). Then, we computed the differences in the vascularization biomarker at the 2 posterior points in time and computed the statistical differences between acquisitions using the <span class="elsevierStyleItalic">t</span>-test.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Study population and baseline features</span><p id="par0065" class="elsevierStylePara elsevierViewall">Eleven out of the 59 patients invited to participate refused to do so, 9 were lost to the follow-up due to the COVID-19 lockdown, and 39 were included and completed the <span class="elsevierStyleItalic">per protocol</span> analysis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). <a class="elsevierStyleCrossRef" href="#sec0085">Table 1 (see supplementary material)</a> shows the demographic data of the participants included.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Overall, the patients’ mean age was 58.5 years, they had a predominantly light phototype (I–III, 76.92%) and were non-smokers (79.49%). Regarding radiotherapy schemes, 38.46% of the patients received scheme-15; 35.89%, scheme-20; and 24.64%, scheme-25. Statistically significant differences were reported among the different radiotherapy groups in terms of age (older in scheme-25; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.0078) and body mass index (BMI) (higher in scheme-25; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.0392). No significant differences were seen based on the skin phototype, smoking status, or functional baseline performance status.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Radiotherapy-induced dermatological changes</span><p id="par0075" class="elsevierStylePara elsevierViewall">Clinical examination and dermoscopy allowed for the detection of ARD in 69.2% of the patients. At the end of the therapy (tF), 12 patients (30.8%) did not show ARD, 25 patients (64.1%) had grade 1 ARD, and 2 patients (5.1%) presented with grade 2 ARD. No patient presented grade 3–4 toxicity. At t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m, patients did not show any clinical or dermoscopically measurable changes (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">OCT scanning evaluation</span><p id="par0080" class="elsevierStylePara elsevierViewall">A novel computational model was designed to process OCT volumes and detect the amount of blood on the OCT image from the sample. OCT imaging could detect differences in terms of skin vascularity and quantify the amount of blood in every volume. Through a series of computer vision techniques, we drew the vascularized regions. Briefly, we first used a color-based separation to draw blood circulation from the volume and skin's structures. Then, a series of morphological techniques based on dilating and eroding operators were used to eliminate any acquired noise at the frame level. Finally, the volumetric information was added and filtered to eliminate any noise triggered by the patient's unintentional movements. The sum of the red pixels in the image was then used as the quantifiable biomarker for erythema (and vascularization) in an OCT Volume.</p><p id="par0085" class="elsevierStylePara elsevierViewall">First, a comparative approach was made by studying the skin changes of each patient on the irradiated vs non-irradiated breast at the end of radiotherapy (tF). Quantitative analyses showed a statistically significant increase of erythema after (tF) (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.05) irradiating fields (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A). Second, the process was repeated 3 months after treatment completion (t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m). The results showed a statistically relevant decrease of erythema (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.032) in irradiated fields (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Each breast was also compared to itself at baseline (t0) at different time points; at tF the irradiated breast showed a significant increase in the erythema index (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.024) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>B) and a decrease in the erythema index at t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.07) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>B). In this regard, the OCT imaging revealed statistically significant differences in terms of vascularization of treated breasts.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Overall, at the end of radiotherapy (tF), almost all patients (33 out of 39) showed a significant increase in their erythema index according to the OCT (<a class="elsevierStyleCrossRefs" href="#fig0015">Figs. 3B and 4</a>), while, at t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m, irradiated breasts showed a significant decrease of the erythema index (<a class="elsevierStyleCrossRef" href="#fig0015">Figs. 3B and 4</a>). As for the not-irradiated breasts evaluated at the 3 different points in time, no significant differences were found (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>C).</p><p id="par0100" class="elsevierStylePara elsevierViewall">Vascularization changes by OCT through radiotherapy treatment (t0, tF and t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m) were also compared across the 3 different radiotherapy scheme protocols (15, 20 and 25 fraction regimes) (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The OCT clearly showed quantitative differences between regimes in terms of mean change to the erythema index (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>B). Scheme-25 triggered the highest intensity changes to the erythema index, with a significant increase at tF. At t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m, the shortest regime (15 fractions) reached the most prominent decrease of the erythema index vs the longest treatment (25 fractions) which showed the lowest decrease of the erythema index (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>B).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Quality of life and tolerance of adjuvant therapy</span><p id="par0105" class="elsevierStylePara elsevierViewall">No adverse events associated with the OCT imaging tests or topical adjuvant therapy were ever reported. All patients showed an excellent tolerance to the adjuvant repairing cream. None of them abandoned the daily routine of using the adjuvant therapy on the irradiated areas.</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">ARD is the most common adverse event associated with breast radiotherapy. Despite being usually of mild-to-moderate intensity, it can impact the patients’ quality of life tremendously putting the completion of the radiotherapy protocol at risk.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">22</span></a> Currently, the most widely used categorizations of ARD are subjective clinical scales based on skin changes perceived by the naked eye, which are difficult to replicate and quantify.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">21</span></a> The lack of an objectively quantifiable assessment of ARD poses significant challenges such as accurately predicting the grade of skin toxicity, the development of chronic radiation dermatitis, and measuring the effect of adjuvant topical therapies. The present study demonstrates that non-invasive OCT skin scanning detects statistically significant changes to irradiated skin after radiotherapy through a new objective quantitative computational erythema index.</p><p id="par0115" class="elsevierStylePara elsevierViewall">As shown in this study, clinical examination could barely classify ARD as grade 0, 1 or 2 with very subtle differences between each group. In addition, dermoscopy was not sensitive enough to identify changes to the skin and almost one third of the patients did not present any changes. Conversely, through a specifically designed algorithm of OCT dynamic images, we could detect and quantify the changes induced in various irradiated areas even when the clinical examination could not perceive such differences. Comparative analysis with the non-irradiated breast proved that these changes are solely observed in the treated areas. These results support the view that the differences seen on the OCT in the irradiate breast are real and not due to measurement artifacts or physiological changes. Therefore, OCT skin scanning allows for the quantitative measurement of erythema associated with radiotherapy-induced skin changes.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Secondly, the OCT images were able to demonstrate that vascularization changes reach their maximum level of intensity toward the end of radiotherapy with the highest increase in the erythema index vs baseline and 3 months after radiotherapy. At this point, the skin has received the total radiation dose, and the healing process is still at the beginning. The most prominent changes were seen in scheme-25: patients with a higher risk of locoregional recurrence who, consequently, receive breast and regional lymph node radiotherapy.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Additionally, 3 months after finishing radiotherapy, the OCT images revealed a significant decrease in the erythema index of the target areas in all groups, even vs baseline non-treated skin. Therefore, observed changes seem to be mostly reversible and only focused on irradiated areas. Interestingly, the shortest radiotherapy scheme (scheme-15) showed a more prominent decrease of the erythema index at the end of therapy.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Previous studies have explored the development and implementation of objective methods for assessing vascularization, inflammation, and radiotherapy-induced fibrotic changes to the skin (hyperspectral imaging, thermal imaging, laser Doppler flowmetry, reflection spectrophotometry, tissue oxygenation). Unfortunately, such techniques have had limited success and have not been implemented in the everyday practice.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">29</span></a> Recently, a prospective study evaluating ARD with reflectance confocal microscopy (RCM) showed that exocytosis, spongiosis, disarrayed epidermis and abnormal dermal papillae were frequently present in ARD and correlated with the degree of severity of ARD.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">30</span></a> Among the non-invasive imaging modalities used to evaluate the skin, the OCT may provide an ideal balance between resolution and depth, along with the dynamic mode to measure vascularization changes. One of the main OCT applications in dermatology has been the study of fibrotic disorders<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> since orientation, organization, and the reflective properties of skin collagen render the tissue birefringent and detectable to the OCT. Regarding ARD, Photiou et al. showed that weekly imaging with OCT of irradiated skin could detect early ARD with accuracy rates of up to 88.3%.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">31</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Multiple former studies have tried to demonstrate the benefits of using a specific adjuvant therapy; however, the lack of objective measurements of the effects is a main limitation of such studies.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">8,21</span></a> In an attempt to standardize ARD prevention and treatment in our cohort, we used a hypoallergenic restorative protective cream containing copper and zinc sulfate and a postbiotic repairing ingredient C+ Restore® which was well tolerated.</p><p id="par0140" class="elsevierStylePara elsevierViewall">As for the limitations of this study, it is a single-center study with a short follow-up. On the other hand, since the OCT is a novel non-invasive imaging modality, it is not widely available in all hospitals. Therefore, the use of OCT in the routine clinical practice is, currently, limited. Regarding the therapeutic effect of the applied cream, this study was of a small sample and no randomized arm was ever included. Therefore, we could not properly explore any treatment effects or draw any conclusions. Finally, age and body mass index (BMI) were not homogeneously distributed amongs the different radiotherapy groups, which could have impacted our results. This was an expected bias though since younger patients (< 60 years) almost always receive a boost scheme, whereas in older patients (>60 years), usually of a higher BMI, the boost scheme is usually indicated only in cases of high-risk tumors.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conclusions</span><p id="par0145" class="elsevierStylePara elsevierViewall">This study is the first prospective study ever conducted on a new computational algorithm of noninvasive OCT skin imaging to detect and quantify the effects of radiotherapy-induced microvasculature. The OCT revealed vascularization changes even in the absence of other clinical signs. More intense and longer radiotherapy schemes showed more prominent vascular changes, though mostly reversible after 3 months on radiotherapy. Future studies should explore if late-onset adverse events associated with radiotherapy in terms of scarring and fibrosis could be detected early on with the OCT be associated with persistent increased vascularization. This study could be a preliminary step for the standardization of the determination, graduation, and classification of ARD. Importantly, this method could also take into consideration the existing diverse ethnicity, especially that in which redness is not visible and could objectively assess the impact of different preventive measures.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Funding/support</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was partially funded by <span class="elsevierStyleGrantSponsor" id="gs1">Pierre Fabre Intl</span>. Pierre Fabre laboratories funded part of the computational analysis and provided free samples of topical cream to the patients. No analysis or result has been manipulated or controlled by the company.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Research at the Melanoma Unit of Hospital Clinic Barcelona was partially financed by <span class="elsevierStyleGrantSponsor" id="gs2">Instituto de Salud Carlos III (ISCIII)</span>, Madrid, Spain through projects <span class="elsevierStyleGrantNumber" refid="gs2">PI18/01077</span>, <span class="elsevierStyleGrantNumber" refid="gs2">PI18/00419</span>, <span class="elsevierStyleGrantNumber" refid="gs2">PI18/0959</span> and <span class="elsevierStyleGrantNumber" refid="gs2">PI22/01457</span>, and co-funded by the <span class="elsevierStyleGrantSponsor" id="gs3">European Union, CIBER de Enfermedades Raras of Instituto de Salud Carlos III</span>, Spain, co-funded by <span class="elsevierStyleGrantSponsor" id="gs4">ISCIII-Subdirección General de Evaluación</span>, and the <span class="elsevierStyleGrantSponsor" id="gs5">European Regional Development Fund (ERDF)</span>, “a way to make Europe”; <span class="elsevierStyleGrantSponsor" id="gs6">AGAUR 2017_SGR_1134 and CERCA Programme by Generalitat de Catalunya</span>, Spain; <span class="elsevierStyleGrantSponsor" id="gs7">European Commission under the 6th Framework Programme</span>, Contract No. LSHC-CT-2006-018702 (GenoMEL), by the European Commission under the <span class="elsevierStyleGrantSponsor" id="gs8">7th Framework Programme, Diagnoptics, and the European Union's Horizon 2020 research and innovation programme</span> under grant agreements <span class="elsevierStyleGrantNumber" refid="gs8">875171</span> Qualitop (Horizon 2020), <span class="elsevierStyleGrantNumber" refid="gs8">965221</span> iTOBOS (Horizon 2020) and <span class="elsevierStyleGrantNumber" refid="gs8">101096667</span> MELCAYA (HORIZON-RIA-Call: HORIZON-MISS-2021-CANCER-02) within the framework of the Horizon Europe research and innovation programme; the <span class="elsevierStyleGrantSponsor" id="gs9">National Cancer Institute (NCI) of the U.S. National Institute of Health (NIH)</span> (<span class="elsevierStyleGrantNumber" refid="gs9">CA83115</span>); a grant from <span class="elsevierStyleGrantSponsor" id="gs10">“Fundació La Marató de TV3”</span><span class="elsevierStyleGrantNumber" refid="gs10">201331-30</span>, Catalonia, Spain; and a grant from <span class="elsevierStyleGrantSponsor" id="gs11">“Fundación Científica de la Asociación Española Contra el Cáncer”</span><span class="elsevierStyleGrantNumber" refid="gs11">GCB15152978SOEN</span>, Spain and <span class="elsevierStyleGrantSponsor" id="gs12">“Fundación Leo Messi”</span>.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflict of interests</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres2231398" "titulo" => "Graphical abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst1005" ] ] ] 1 => array:3 [ "identificador" => "xres2231396" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1868483" "titulo" => "Keywords" ] 3 => array:3 [ "identificador" => "xres2231397" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] 4 => array:2 [ "identificador" => "xpalclavsec1868482" "titulo" => "Palabras clave" ] 5 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 6 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and methods" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study design" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Study population" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Interventions and assessments" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistical analysis" ] ] ] 7 => array:3 [ "identificador" => "sec0035" "titulo" => "Results" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Study population and baseline features" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Radiotherapy-induced dermatological changes" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "OCT scanning evaluation" ] 3 => array:2 [ "identificador" => "sec0055" "titulo" => "Quality of life and tolerance of adjuvant therapy" ] ] ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0065" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0070" "titulo" => "Funding/support" ] 11 => array:2 [ "identificador" => "sec0075" "titulo" => "Conflict of interests" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-07-23" "fechaAceptado" => "2024-03-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1868483" "palabras" => array:5 [ 0 => "Acute radiation dermatitis" 1 => "Optical coherence tomography" 2 => "OCT" 3 => "Radiotherapy" 4 => "Breast cancer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1868482" "palabras" => array:5 [ 0 => "Radiodermatitis aguda" 1 => "Tomografía de coherencia óptica" 2 => "TCO" 3 => "Radioterapia" 4 => "Cáncer de mama" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acute radiation dermatitis (ARD) is the most widely reported radiotherapy-induced adverse event. Currently, there is no objective or reliable method to measure ARD.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Our main objective was to identify and quantify the effects of radiotherapy with a computational model using optical coherence tomography (OCT) skin scanning. Secondary objectives included determining the ARD impact of different radiotherapeutic schemes and adjuvant topical therapies.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We conducted a prospective, single-center case series study in a tertiary referral center of patients with breast cancer who were eligible for whole breast radiotherapy (WBRT).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 39 women were included and distributed according to the radiotherapeutic schemes (15, 20, and 25 fractions). A computational model was designed to quantitatively analyze OCT findings. After radiotherapy, OCT scanning was more sensitive revealing vascularization changes in 84.6% of the patients (vs 69.2% of the patients with ARD by clinical examination). OCT quantified an increased vascularization at the end of WBRT (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.05) and a decrease after 3 months (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.032). Erythematous skin changes by OCT were more pronounced in the 25-fraction regime.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">An OCT computational model allowed for the identification and quantification of vascularization changes on irradiated skin, even in the absence of clinical ARD. This may allow the design of standardized protocols for ARD beyond the skin color of the patients involved.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La radiodermatitis aguda (RA) es el efecto adverso más común de la radioterapia. Actualmente, no existe un método objetivo y reproducible para medir RA.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El objetivo principal es identificar y cuantificar los efectos de la radioterapia en la piel mediante tomografía de coherencia óptica (TCO) usando un modelo computacional. Los objetivos secundarios son determinar el grado de RA según diferentes esquemas de radioterapia y el efecto del tratamiento tópico adyuvante.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio de serie de casos prospectivo unicéntrico de pacientes con cáncer de mama candidatas a radioterapia.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Treinta y nueve mujeres fueron incluidas y distribuidas según el esquema de radioterapia de 15, 20 y 25 fracciones. Se diseñó un modelo computacional para analizar cuantitativamente los hallazgos de la TCO. Después de la radioterapia, la exploración TCO fue más sensible y mostró cambios en la vascularización en el 84,6% de los pacientes (frente al 69,2% de los pacientes con signos clínico-dermatoscópicos de RA). La TCO cuantificó un aumento en la vascularización al final de la radioterapia (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05) y una disminución después de 3 meses (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,032). Los cambios en el eritema por TCO fueron más pronunciados en el régimen de 25 fracciones.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusión</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Un modelo computacional basado en TCO permite la identificación y cuantificación de los cambios de vascularización en la piel irradiada, incluso en ausencia de RA clínica. Esto puede permitir el diseño de protocolos estandarizados para RA más allá del color de la piel de los pacientes.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0175" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0090" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3148 "Ancho" => 2925 "Tamanyo" => 476108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Study flowchart. <span class="elsevierStyleItalic">Abbreviations</span>: Td, total dose; f, fractions.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1172 "Ancho" => 2340 "Tamanyo" => 317634 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Clinical and dermoscopic images of a patient with breast cancer on radiotherapy with grade 2 ARD before (a, b), at the end of (c, d), and 3 months into (e, f) radiotherapy.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2158 "Ancho" => 2925 "Tamanyo" => 282361 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Quantitative results of OCT imaging vascularization of the entire cohort. Positive numbers reflect a higher blood volume than the comparative sample. Negative numbers are indicative of a decreased flow. Treated and not-treated breasts reflect the comparison between the breast which received radiation, and the contralateral one which did not at that time. A: Comparison between treated and non-treated contralateral breasts at the tF (blue: end of therapy) and t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m points in time (orange: 3 months after end of therapy). B: Comparison of the treated breasts at the tF (blue) and t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m points in time (orange) vs t0 (baseline). C: Comparison of non-treated breasts at tF (blue) and t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m points in time (orange), compared to t0.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1008 "Ancho" => 2341 "Tamanyo" => 208979 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Evolution of vascularization with radiotherapy measured quantitatively with OCT imaging across different radiotherapy fractionation schemes. A: Vascularization changes of all cohort samples at the beginning of RT (t0), at the end (tF), and 3 months later (t<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>3m). B: Vascularization mean changes comparing the 3 radiotherapy scheme regimes: 15- (light pink), 20- (dark pink) and 25-fraction (black) schemes.</p>" ] ] 4 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 287964 ] ] 5 => array:5 [ "identificador" => "fig1020" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 886 "Ancho" => 1565 "Tamanyo" => 209013 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib0165" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Sung" 1 => "J. Ferlay" 2 => "R.L. Siegel" 3 => "M. Laversanne" 4 => "I. Soerjomataram" 5 => "A. Jemal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3322/caac.21660" "Revista" => array:6 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2021" "volumen" => "71" "paginaInicial" => "209" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33538338" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0170" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)" "etal" => true "autores" => array:2 [ 0 => "S. Darby" 1 => "P. McGale" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(11)61629-2" "Revista" => array:5 [ "tituloSerie" => "Lancet Lond Engl" "fecha" => "2011" "volumen" => "378" "paginaInicial" => "1707" "paginaFinal" => "1716" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0175" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Haviland" 1 => "J.R. Owen" 2 => "J.A. Dewar" 3 => "R.K. Agrawal" 4 => "J. Barrett" 5 => "P.J. Barrett-Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(13)70386-3" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "1086" "paginaFinal" => "1094" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24055415" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0180" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.J. Whelan" 1 => "J.A. Julian" 2 => "T.S. Berrang" 3 => "D.-H. Kim" 4 => "I. Germain" 5 => "A.M. Nichol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(19)32515-2" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2019" "volumen" => "394" "paginaInicial" => "2165" "paginaFinal" => "2172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31813635" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0190" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.A. Jones" 1 => "N. Antonini" 2 => "A.A.M. Hart" 3 => "J.L. Peterse" 4 => "J.-C. Horiot" 5 => "F. Collin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.200821.5764" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "4939" "paginaFinal" => "4947" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19720914" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0325" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Bentzen" 1 => "R.K. Agrawal" 2 => "E.G.A. Aird" 3 => "J.M. Barrett" 4 => "P.J. Barrett-Lee" 5 => "J.M. Bliss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2008" "volumen" => "9" "paginaInicial" => "331" "paginaFinal" => "341" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0195" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Bartelink" 1 => "P. Maingon" 2 => "P. Poortmans" 3 => "C. Weltens" 4 => "A. Fourquet" 5 => "J. Jager" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(14)71156-8" "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "47" "paginaFinal" => "56" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0200" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.J. Chan" 1 => "J. Webster" 2 => "B. Chung" 3 => "L. Marquart" 4 => "M. Ahmed" 5 => "S. Garantziotis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2407-14-53" "Revista" => array:5 [ "tituloSerie" => "BMC Cancer" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24484999" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0205" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modifiable risk factors for acute skin toxicity in adjuvant breast radiotherapy: dosimetric analysis and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.G. Keenan" 1 => "N. Lavan" 2 => "M. Dunne" 3 => "O. McArdle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.meddos.2018.01.004" "Revista" => array:7 [ "tituloSerie" => "Med Dosim" "fecha" => "2019" "volumen" => "44" "paginaInicial" => "51" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29576443" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022347618302178" "estado" => "S300" "issn" => "00223476" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0210" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation-induced skin injury: pathogenesis, treatment, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "X. Yang" 1 => "H. Ren" 2 => "X. Guo" 3 => "C. Hu" 4 => "J. Fu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.18632/aging.103932" "Revista" => array:7 [ "tituloSerie" => "Aging" "fecha" => "2020" "volumen" => "12" "paginaInicial" => "23379" "paginaFinal" => "23393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33202382" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022347608008780" "estado" => "S300" "issn" => "00223476" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0215" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical cream containing nanoparticles with vitamin E to prevent radiodermatitis in women with breast cancer: a clinical trial protocol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.M.Q. Schmidt" 1 => "C.V.S. González" 2 => "R.C. Mattar" 3 => "L.B. Lopes" 4 => "M.F. dos Santos" 5 => "V.L.C. de Gouveia Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.12968/jowc.2020.29.LatAm_sup_1.18.eng" "Revista" => array:7 [ "tituloSerie" => "J Wound Care" "fecha" => "2020" "volumen" => "29" "numero" => "LatAm Suppl. 1" "paginaInicial" => "18" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33249985" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0220" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical use of a silymarin-based preparation to prevent radiodermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Becker-Schiebe" 1 => "U. Mengs" 2 => "M. Schaefer" 3 => "M. Bulitta" 4 => "W. Hoffmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00066-011-2204-z" "Revista" => array:5 [ "tituloSerie" => "Strahlenther Onkol" "fecha" => "2011" "volumen" => "187" "paginaInicial" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21786113" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0225" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical use of recombinant human epidermal growth factor (EGF)-based cream to prevent radiation dermatitis in breast cancer patients: a single-blind randomized preliminary study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kong" 1 => "S.E. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7314/APJCP.2013148.4859" "Revista" => array:6 [ "tituloSerie" => "Asian Pac J Cancer Prev" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "4859" "paginaFinal" => "4864" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24083759" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0230" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solución CM-95 tratada magnéticamente como profilaxis y terapia de la radiodermitis en pacientes con cáncer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.G. Fernández" 1 => "A. Montoya" 2 => "C.R. de la" 3 => "C.M. Manrique" 4 => "M.B. Bonne" 5 => "I.F. Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "MEDISAN" "fecha" => "2016" "volumen" => "20" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0235" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Herbal medicines for treatment of radiodermatitis: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Heydarirad" 1 => "B. Ahadi" 2 => "H. Molavi Vardanjani" 3 => "H. Cramer" 4 => "H.R. Mirzaei" 5 => "M. Pasalar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/acm.2021.0166" "Revista" => array:6 [ "tituloSerie" => "J Altern Complement Med" "fecha" => "2021" "volumen" => "27" "paginaInicial" => "1098" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34449259" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0240" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Ryan Wolf" 1 => "J.S. Gewandter" 2 => "J. Bautista" 3 => "C.E. Heckler" 4 => "J. Strasser" 5 => "P. Dyk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00520-019-05166-5" "Revista" => array:6 [ "tituloSerie" => "Support Care Cancer" "fecha" => "2020" "volumen" => "28" "paginaInicial" => "3303" "paginaFinal" => "3311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31758326" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0245" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efetividade de protetores cutâneos e calendula officinalis para prevenção e tratamento de radiodermatites: revisão integrativa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.V. Simões" 1 => "V.O. Santos" 2 => "R.N. da Silva" 3 => "R.C. da Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/0034-7167-2019-0815" "Revista" => array:3 [ "tituloSerie" => "Rev Bras Enferm" "fecha" => "2020" "paginaInicial" => "73" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0250" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.D. Cox" 1 => "J. Stetz" 2 => "T.F. Pajak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0360-3016(95)00060-C" "Revista" => array:5 [ "tituloSerie" => "Int J Radiat Oncol" "fecha" => "1995" "volumen" => "31" "paginaInicial" => "1341" "paginaFinal" => "1346" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0255" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Using the common terminology criteria for adverse events (CTCAE – version 5.0) to evaluate the severity of adverse events of anticancer therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Freites-Martinez" 1 => "N. Santana" 2 => "S. Arias-Santiago" 3 => "A. Viera" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2019.05.009" "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2021" "volumen" => "112" "paginaInicial" => "90" "paginaFinal" => "92" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0260" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "LENT SOMA scales for all anatomic sites" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0360-3016(95)90159-0" "Revista" => array:5 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "1995" "volumen" => "31" "paginaInicial" => "1049" "paginaFinal" => "1091" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0265" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of acute radiation dermatitis: a review of the literature and proposal for treatment algorithm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rosenthal" 1 => "R. Israilevich" 2 => "R. Moy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.02.047" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" "volumen" => "81" "paginaInicial" => "558" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30802561" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0270" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention and treatment of acute and chronic radiodermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Seité" 1 => "R.J. Bensadoun" 2 => "J.M. Mazer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/BCTT.S149752" "Revista" => array:5 [ "tituloSerie" => "Breast Cancer Targets Ther" "fecha" => "2017" "volumen" => "9" "paginaInicial" => "551" "paginaFinal" => "557" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0275" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optical coherence tomography imaging of normal, chronologically aged photoaged and photodamaged skin: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Mamalis" 1 => "D. Ho" 2 => "J. Jagdeo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000000457" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2015" "volumen" => "41" "paginaInicial" => "993" "paginaFinal" => "1005" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26322560" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0280" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. De Langhe" 1 => "T. Mulliez" 2 => "L. Veldeman" 3 => "V. Remouchamps" 4 => "A. van Greveling" 5 => "M. Gilsoul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2407-14-711" "Revista" => array:4 [ "tituloSerie" => "BMC Cancer" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "711" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0285" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "OCT imaging of skin cancer and other dermatological diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Mogensen" 1 => "L. Thrane" 2 => "T.M. Jørgensen" 3 => "P.E. Andersen" 4 => "G.B.E. Jemec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jbio.200910020" "Revista" => array:6 [ "tituloSerie" => "J Biophotonics" "fecha" => "2009" "volumen" => "2" "paginaInicial" => "442" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19557752" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0290" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of optical coherence tomography (OCT) in aesthetic skin assessment—a short review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Kislevitz" 1 => "Y. Akgul" 2 => "C. Wamsley" 3 => "J. Hoopman" 4 => "J. Kenkel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.23219" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med" "fecha" => "2020" "volumen" => "52" "paginaInicial" => "699" "paginaFinal" => "704" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31957060" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0295" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kuck" 1 => "H. Strese" 2 => "S.A. Alawi" 3 => "M.C. Meinke" 4 => "J.W. Fluhr" 5 => "G.J. Burbach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/srt.12077" "Revista" => array:6 [ "tituloSerie" => "Skin Res Technol" "fecha" => "2014" "volumen" => "20" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23782399" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0300" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of OCT-derived attenuation coefficient in acute burn-damaged skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Lu" 1 => "A.J. Deegan" 2 => "Y. Cheng" 3 => "T. Liu" 4 => "Y. Zheng" 5 => "S.P. Mandell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.23415" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med" "fecha" => "2021" "volumen" => "53" "paginaInicial" => "1192" "paginaFinal" => "1200" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33998012" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0310" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Potential use of novel image and signal processing methods to develop a quantitative assessment of the severity of acute radiation dermatitis in breast cancer radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Kondziołka" 1 => "S. Wilczyński" 2 => "Ł. Michalecki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/CCID.S354320" "Revista" => array:6 [ "tituloSerie" => "Clin Cosmet Investig Dermatol" "fecha" => "2022" "volumen" => "15" "paginaInicial" => "725" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35497689" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0315" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute radiation dermatitis evaluation with reflectance confocal microscopy: a prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Kišonas" 1 => "J. Venius" 2 => "M. Grybauskas" 3 => "D. Dabkevičienė" 4 => "A. Burneckis" 5 => "R. Rotomskis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/diagnostics11091670" "Revista" => array:5 [ "tituloSerie" => "Diagnostics" "fecha" => "2021" "volumen" => "11" "paginaInicial" => "1670" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34574012" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0320" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo early detection of acute radiation dermatitis using optical coherence tomography (OCT) images" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Photiou" 1 => "I. Strouthos" 2 => "C. Cloconi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1117/12.2608095" "Libro" => array:4 [ "fecha" => "2022" "paginaInicial" => "32" "paginaFinal" => "35" "editorial" => "SPIE" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011500000008/v1_202409020432/S000173102400262X/v1_202409020432/en/main.assets" "Apartado" => array:4 [ "identificador" => "6163" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000008/v1_202409020432/S000173102400262X/v1_202409020432/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102400262X?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 3 | 9 |
2024 October | 187 | 109 | 296 |
2024 September | 453 | 81 | 534 |
2024 August | 189 | 98 | 287 |
2024 July | 182 | 46 | 228 |
2024 June | 152 | 58 | 210 |
2024 May | 152 | 67 | 219 |
2024 April | 128 | 54 | 182 |
2024 March | 21 | 26 | 47 |