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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La hidradenitis supurativa &#40;HS&#41; suele iniciarse entre la segunda y la tercera d&#233;cadas de la vida y se mantiene activa&#44; con fluctuaciones&#44; de forma cr&#243;nica&#46; Aunque no hay estudios prospectivos que lo avalen&#44; se ha descrito una mejor&#237;a tras la menopausia<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Existe una amplia variabilidad en las estimaciones de la prevalencia de HS en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Un estudio reciente&#44; en el que se buscaban diagn&#243;sticos afines y se contactaba con los pacientes para confirmar el diagn&#243;stico&#44; obtuvo una estimaci&#243;n de prevalencia global del 0&#44;77&#37;&#44; y del 0&#44;4&#37; en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; En cambio&#44; los estudios que se basan en la presencia de los diagn&#243;sticos codificados en las bases de datos de grandes aseguradoras apuntan a una frecuencia menor del 0&#44;05&#37; en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La posibilidad de encontrarnos con una enfermedad avanzada en pacientes mayores&#44; como corresponde a una enfermedad que es progresiva&#44; y la dificultad en el manejo que pueden representar algunos tratamientos m&#233;dicos y la cirug&#237;a en este grupo de edad son razones de peso para aumentar la evidencia disponible&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Describimos los casos de HS en pacientes mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os en la primera visita&#44; atendidos en la consulta monogr&#225;fica de HS entre octubre de 2021 y mayo de 2023&#46; Todos los pacientes firmaron el consentimiento informado para la inclusi&#243;n en el Registro de HS de nuestro centro&#44; que cuenta con la aprobaci&#243;n del comit&#233; de &#233;tica de las Islas Baleares&#46; Se registraron las comorbilidades relevantes&#44; el tiempo de evoluci&#243;n hasta la primera visita&#44; las caracter&#237;sticas cl&#237;nicas&#44; el fenotipo seg&#250;n Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#44; el recuento de lesiones para calcular el <span class="elsevierStyleItalic">International</span><span class="elsevierStyleItalic">Hidradenitis Suppurativa Severity Score System</span> &#40;IHS4&#41;&#44; la cuantificaci&#243;n de dolor&#44; prurito y Dermatology Life Quality Index &#40;DLQI&#41;&#46; El recuento de lesiones se llev&#243; a cabo con la ayuda de ecograf&#237;a&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se recogieron 14 pacientes&#44; que son el 4&#44;8&#37; del total de pacientes incluidos en el Registro de HS en este tiempo &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La mediana de tiempo de seguimiento fue de 77<span class="elsevierStyleHsp" style=""></span>d&#237;as &#40;rango 0-466<span class="elsevierStyleHsp" style=""></span>d&#237;as&#41;&#46; Se pautaron antibi&#243;ticos en dos pacientes&#44; metformina en uno&#44; biol&#243;gicos en dos &#40;uno adalimumab y uno secukinumab&#41;&#44; retinoides en un paciente&#44; se realiz&#243; cirug&#237;a en tres pacientes y terapia fotodin&#225;mica en dos &#40;en uno con irradiaci&#243;n externa y en otro con irradiaci&#243;n intralesional&#41;&#46; Un paciente con una neoplasia de pulm&#243;n activa se benefici&#243; de la inserci&#243;n de un set&#243;n laxo en una f&#237;stula perianal sin que fuera necesario m&#225;s tratamiento para controlar la sintomatolog&#237;a&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Existen pocas publicaciones que se refieran a la HS en mayores de 65 a&#241;os&#46; En una publicaci&#243;n reciente&#44; Blum et al&#46; describen una cohorte de 26 pacientes mayores de 65 a&#241;os&#44; que representan tan solo el 2&#44;3&#37; del total de pacientes atendidos por una HS<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Como en nuestra serie&#44; destaca la alta prevalencia de enfermedades en la esfera metab&#243;lica y cardiovascular&#44; y tambi&#233;n c&#225;ncer&#44; que condicionan de forma muy importante el manejo y la morbimortalidad&#46; Comparado con el grupo de menores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; existe una mayor proporci&#243;n de varones y una mayor presencia de obesidad y de tabaquismo<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46; Estas comorbilidades se han descrito como predictores de la persistencia de la enfermedad en estudios retrospectivos<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a>&#44; lo que refuerza la importancia de su abordaje en la consulta&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La proporci&#243;n de pacientes con estadios 2 y 3 de Hurley en nuestra serie alcanza los dos tercios&#46; A pesar de ello&#44; solo dos pacientes &#40;14&#44;2&#37;&#41; hab&#237;an iniciado el tratamiento con un biol&#243;gico&#46; Ello se podr&#237;a deber a varios factores&#44; como la mayor presencia de comorbilidades o la relativa baja carga inflamatoria&#44; como muestra la existencia de un nivel bajo de dolor y un IHS4 relativamente bajo en comparaci&#243;n con el estadio de Hurley&#46; La presencia de m&#225;s f&#237;stulas drenantes &#40;mediana<span class="elsevierStyleHsp" style=""></span>1&#44; rango<span class="elsevierStyleHsp" style=""></span>0-6&#41; y un bajo recuento en el n&#250;mero de lesiones inflamatorias de tipo n&#243;dulo y absceso &#40;mediana<span class="elsevierStyleHsp" style=""></span>0&#44; rango<span class="elsevierStyleHsp" style=""></span>0-3&#41; deber&#237;an favorecer el uso de tratamientos dirigidos a la lesi&#243;n&#44; como la cirug&#237;a o la terapia fotodin&#225;mica&#46; Esta &#250;ltima&#44; en diferentes modalidades&#44; ha demostrado su utilidad en el control local de la HS<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46; Otra t&#233;cnica dirigida a la lesi&#243;n&#44; interesante por su sencillez y su efectividad&#44; es el uso de setones&#44; que se ha descrito en la HS con un buen control de los s&#237;ntomas<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los pacientes de m&#225;s de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os vistos por primera vez con un diagn&#243;stico de HS representan una proporci&#243;n baja del total &#40;2&#44;3-5&#37; del total&#41;&#46; Tienen una frecuenta alta de grados<span class="elsevierStyleHsp" style=""></span>2 y<span class="elsevierStyleHsp" style=""></span>3 de Hurley&#44; lo que plantea la necesidad de contar con todas las opciones terap&#233;uticas&#44; aunque algunas comorbilidades limitan el acceso a los tratamientos biol&#243;gicos o a la cirug&#237;a amplia&#46; Las terapias dirigidas a la lesi&#243;n pueden ser una alternativa adecuada y suficiente para el control de los s&#237;ntomas&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicto de intereses</span><p id="par0045" class="elsevierStylePara elsevierViewall">J Garcias-Ladaria declara haber participado como investigador principal en ensayos cl&#237;nicos para Acelyrin y ha recibido apoyo financiero para atender congresos de Alfasigma&#44; Isdin&#44; Cantabria Labs&#44; Janssen&#44; Almirall&#44; Novartis y UCB&#44; as&#237; como haber recibido honorarios de Novartis como asesor y Novartis y Leo-Pharma como ponente invitado&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ines Gracia-Darder declara haber realizado conferencias en eventos de UCB&#44; Novartis&#44; Sanofi&#44; Almirall&#44; Janssen&#44; Isdin&#44; Loreal&#44; Pierre Fabre&#46; Haber participado como investigador de ensayos de Almirall&#44; Leo-Pharma&#44; Acelyrin y Pierre Fabre&#46; Haber recibido colaboraci&#243;n para la asistencia a congresos de Almirall&#44; Janssen&#44; Leo-Pharma&#44; Lilly&#44; Novartis&#44; Pierre Fabre&#44; Sanofi&#44; UCB&#44; Amgen&#44; Isdin&#44; Cantabria Labs&#44; Rilastil y Loreal&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Juan Jer&#243;nimo Gonz&#225;lez Malmierca declara no tener conflicto de intereses&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ana Mart&#237;n-Santiago declara haber colaborado como consultora para Abbvie&#44; Amryt&#44; Leo-Pharma&#44; Pfizer y Sanofi&#46; Haber realizado conferencias en eventos de Abbvie&#44; Amgen&#44; Leo&#44; Leti&#44; Novartis&#44; Pfizer&#44; Sanofi&#46; Haber firmado acuerdos de investigaci&#243;n con Almirall&#44; Amgen&#44; Lilly&#44; Leo-Pharma&#44; 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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas epidemiol&#243;gicas de los pacientes</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antecedentes familiares de HS &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Edad mediana de inicio&#44; a&#241;os &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;15-70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Duraci&#243;n mediana enfermedad&#44; a&#241;os &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;0&#44;3-64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidades</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador o exfumador &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;85&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador activo &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesidad &#40;IMC <span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica y&#47;o enfermedad cerebrovascular &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>C&#225;ncer &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Insuficiencia renal &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Depresi&#243;n&#47;ansiedad &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro cognitivo con dependencia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad inflamatoria intestinal &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artropat&#237;a inflamatoria &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas de la enfermedad en la primera visita</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fenotipo folicular &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;28&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fenotipo mixto &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fenotipo inflamatorio &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 1 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 3 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de recuento de n&#243;dulos &#43;<span class="elsevierStyleHsp" style=""></span>abscesos &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de recuento medio de f&#237;stulas drenantes &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de IHS4 inicial &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0-24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de DLQI inicial &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0-29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de puntuaci&#243;n en escala de dolor &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-9&#41;&nbsp;\t\t\t\t\t\t\n
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Hidradenitis supurativa en mayores de 65años: estudio retrospectivo de 14 pacientes
Hidradenitis Suppurativa in Individuals Older than 65Years: A 14-Patient Retrospective Trial
J. Garcias-Ladaria
Corresponding author
jgarcila@gmail.com

Autor para correspondencia.
, I. Gracia-Darder, J.J. González Malmierca, A. Martín-Santiago
Servicio de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La hidradenitis supurativa &#40;HS&#41; suele iniciarse entre la segunda y la tercera d&#233;cadas de la vida y se mantiene activa&#44; con fluctuaciones&#44; de forma cr&#243;nica&#46; Aunque no hay estudios prospectivos que lo avalen&#44; se ha descrito una mejor&#237;a tras la menopausia<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>&#46; Existe una amplia variabilidad en las estimaciones de la prevalencia de HS en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Un estudio reciente&#44; en el que se buscaban diagn&#243;sticos afines y se contactaba con los pacientes para confirmar el diagn&#243;stico&#44; obtuvo una estimaci&#243;n de prevalencia global del 0&#44;77&#37;&#44; y del 0&#44;4&#37; en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; En cambio&#44; los estudios que se basan en la presencia de los diagn&#243;sticos codificados en las bases de datos de grandes aseguradoras apuntan a una frecuencia menor del 0&#44;05&#37; en mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La posibilidad de encontrarnos con una enfermedad avanzada en pacientes mayores&#44; como corresponde a una enfermedad que es progresiva&#44; y la dificultad en el manejo que pueden representar algunos tratamientos m&#233;dicos y la cirug&#237;a en este grupo de edad son razones de peso para aumentar la evidencia disponible&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Describimos los casos de HS en pacientes mayores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os en la primera visita&#44; atendidos en la consulta monogr&#225;fica de HS entre octubre de 2021 y mayo de 2023&#46; Todos los pacientes firmaron el consentimiento informado para la inclusi&#243;n en el Registro de HS de nuestro centro&#44; que cuenta con la aprobaci&#243;n del comit&#233; de &#233;tica de las Islas Baleares&#46; Se registraron las comorbilidades relevantes&#44; el tiempo de evoluci&#243;n hasta la primera visita&#44; las caracter&#237;sticas cl&#237;nicas&#44; el fenotipo seg&#250;n Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#44; el recuento de lesiones para calcular el <span class="elsevierStyleItalic">International</span><span class="elsevierStyleItalic">Hidradenitis Suppurativa Severity Score System</span> &#40;IHS4&#41;&#44; la cuantificaci&#243;n de dolor&#44; prurito y Dermatology Life Quality Index &#40;DLQI&#41;&#46; El recuento de lesiones se llev&#243; a cabo con la ayuda de ecograf&#237;a&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se recogieron 14 pacientes&#44; que son el 4&#44;8&#37; del total de pacientes incluidos en el Registro de HS en este tiempo &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La mediana de tiempo de seguimiento fue de 77<span class="elsevierStyleHsp" style=""></span>d&#237;as &#40;rango 0-466<span class="elsevierStyleHsp" style=""></span>d&#237;as&#41;&#46; Se pautaron antibi&#243;ticos en dos pacientes&#44; metformina en uno&#44; biol&#243;gicos en dos &#40;uno adalimumab y uno secukinumab&#41;&#44; retinoides en un paciente&#44; se realiz&#243; cirug&#237;a en tres pacientes y terapia fotodin&#225;mica en dos &#40;en uno con irradiaci&#243;n externa y en otro con irradiaci&#243;n intralesional&#41;&#46; Un paciente con una neoplasia de pulm&#243;n activa se benefici&#243; de la inserci&#243;n de un set&#243;n laxo en una f&#237;stula perianal sin que fuera necesario m&#225;s tratamiento para controlar la sintomatolog&#237;a&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Existen pocas publicaciones que se refieran a la HS en mayores de 65 a&#241;os&#46; En una publicaci&#243;n reciente&#44; Blum et al&#46; describen una cohorte de 26 pacientes mayores de 65 a&#241;os&#44; que representan tan solo el 2&#44;3&#37; del total de pacientes atendidos por una HS<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Como en nuestra serie&#44; destaca la alta prevalencia de enfermedades en la esfera metab&#243;lica y cardiovascular&#44; y tambi&#233;n c&#225;ncer&#44; que condicionan de forma muy importante el manejo y la morbimortalidad&#46; Comparado con el grupo de menores de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; existe una mayor proporci&#243;n de varones y una mayor presencia de obesidad y de tabaquismo<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#46; Estas comorbilidades se han descrito como predictores de la persistencia de la enfermedad en estudios retrospectivos<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a>&#44; lo que refuerza la importancia de su abordaje en la consulta&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La proporci&#243;n de pacientes con estadios 2 y 3 de Hurley en nuestra serie alcanza los dos tercios&#46; A pesar de ello&#44; solo dos pacientes &#40;14&#44;2&#37;&#41; hab&#237;an iniciado el tratamiento con un biol&#243;gico&#46; Ello se podr&#237;a deber a varios factores&#44; como la mayor presencia de comorbilidades o la relativa baja carga inflamatoria&#44; como muestra la existencia de un nivel bajo de dolor y un IHS4 relativamente bajo en comparaci&#243;n con el estadio de Hurley&#46; La presencia de m&#225;s f&#237;stulas drenantes &#40;mediana<span class="elsevierStyleHsp" style=""></span>1&#44; rango<span class="elsevierStyleHsp" style=""></span>0-6&#41; y un bajo recuento en el n&#250;mero de lesiones inflamatorias de tipo n&#243;dulo y absceso &#40;mediana<span class="elsevierStyleHsp" style=""></span>0&#44; rango<span class="elsevierStyleHsp" style=""></span>0-3&#41; deber&#237;an favorecer el uso de tratamientos dirigidos a la lesi&#243;n&#44; como la cirug&#237;a o la terapia fotodin&#225;mica&#46; Esta &#250;ltima&#44; en diferentes modalidades&#44; ha demostrado su utilidad en el control local de la HS<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>&#46; Otra t&#233;cnica dirigida a la lesi&#243;n&#44; interesante por su sencillez y su efectividad&#44; es el uso de setones&#44; que se ha descrito en la HS con un buen control de los s&#237;ntomas<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los pacientes de m&#225;s de 65<span class="elsevierStyleHsp" style=""></span>a&#241;os vistos por primera vez con un diagn&#243;stico de HS representan una proporci&#243;n baja del total &#40;2&#44;3-5&#37; del total&#41;&#46; Tienen una frecuenta alta de grados<span class="elsevierStyleHsp" style=""></span>2 y<span class="elsevierStyleHsp" style=""></span>3 de Hurley&#44; lo que plantea la necesidad de contar con todas las opciones terap&#233;uticas&#44; aunque algunas comorbilidades limitan el acceso a los tratamientos biol&#243;gicos o a la cirug&#237;a amplia&#46; Las terapias dirigidas a la lesi&#243;n pueden ser una alternativa adecuada y suficiente para el control de los s&#237;ntomas&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicto de intereses</span><p id="par0045" class="elsevierStylePara elsevierViewall">J Garcias-Ladaria declara haber participado como investigador principal en ensayos cl&#237;nicos para Acelyrin y ha recibido apoyo financiero para atender congresos de Alfasigma&#44; Isdin&#44; Cantabria Labs&#44; Janssen&#44; Almirall&#44; Novartis y UCB&#44; as&#237; como haber recibido honorarios de Novartis como asesor y Novartis y Leo-Pharma como ponente invitado&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ines Gracia-Darder declara haber realizado conferencias en eventos de UCB&#44; Novartis&#44; Sanofi&#44; Almirall&#44; Janssen&#44; Isdin&#44; Loreal&#44; Pierre Fabre&#46; Haber participado como investigador de ensayos de Almirall&#44; Leo-Pharma&#44; Acelyrin y Pierre Fabre&#46; Haber recibido colaboraci&#243;n para la asistencia a congresos de Almirall&#44; Janssen&#44; Leo-Pharma&#44; Lilly&#44; Novartis&#44; Pierre Fabre&#44; Sanofi&#44; UCB&#44; Amgen&#44; Isdin&#44; Cantabria Labs&#44; Rilastil y Loreal&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Juan Jer&#243;nimo Gonz&#225;lez Malmierca declara no tener conflicto de intereses&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ana Mart&#237;n-Santiago declara haber colaborado como consultora para Abbvie&#44; Amryt&#44; Leo-Pharma&#44; Pfizer y Sanofi&#46; Haber realizado conferencias en eventos de Abbvie&#44; Amgen&#44; Leo&#44; Leti&#44; Novartis&#44; Pfizer&#44; Sanofi&#46; Haber firmado acuerdos de investigaci&#243;n con Almirall&#44; Amgen&#44; Lilly&#44; Leo-Pharma&#44; 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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a isqu&#233;mica y&#47;o enfermedad cerebrovascular &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>C&#225;ncer &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Depresi&#243;n&#47;ansiedad &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Deterioro cognitivo con dependencia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artropat&#237;a inflamatoria &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fenotipo folicular &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;28&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fenotipo mixto &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;21&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 1 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;35&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hurley 3 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de recuento de n&#243;dulos &#43;<span class="elsevierStyleHsp" style=""></span>abscesos &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de recuento medio de f&#237;stulas drenantes &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de IHS4 inicial &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0-24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de DLQI inicial &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0-29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de puntuaci&#243;n en escala de dolor &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediana de puntuaci&#243;n en escala de prurito &#40;rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas cl&#237;nicas de los pacientes &#62;<span class="elsevierStyleHsp" style=""></span>65 a&#241;os atendidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#41;</p>"
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Article information
ISSN: 00017310
Original language: Spanish
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