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en las poblaciones europeas<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">5&#44;6</span></a>&#44; y afecta principalmente a adultos j&#243;venes&#46; En general&#44; la HS es un problema de salud infravalorado que tiene un impacto significativo en la calidad de vida &#40;CdV&#41; de los pacientes<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">7&#8211;9</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Actualmente&#44; se dispone de una amplia gama de opciones terap&#233;uticas para tratar la HS<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">10</span></a>&#46; La mayor&#237;a de los estudios se centran en el perfil de eficacia y seguridad en las formas moderadas y graves de HS&#46; Sin embargo&#44; las pruebas cient&#237;ficas que respaldan el uso de terapias t&#243;picas e intralesionales &#40;IL&#41; son escasas&#46; En la pr&#225;ctica cl&#237;nica habitual&#44; las terapias t&#243;picas e IL suelen ser de primera l&#237;nea para tratar los estadios iniciales de la HS&#46; Tambi&#233;n pueden ser &#250;tiles para brotes limitados en pacientes que ya reciben un tratamiento sist&#233;mico<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">10&#8211;12</span></a>&#46; Aunque una revisi&#243;n bibliogr&#225;fica sistem&#225;tica Cochrane &#40;SLR&#41; previa<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">10</span></a> resumi&#243; las pruebas de ensayos cl&#237;nicos aleatorizados &#40;ECA&#41;&#44; hasta donde sabemos&#44; a la fecha&#44; no se ha publicado ninguna SLR sobre tratamientos t&#243;picos e IL para la HS&#46; Por lo tanto&#44; el objetivo de nuestra revisi&#243;n fue evaluar la eficacia y el perfil de seguridad de los tratamientos t&#243;picos e IL en pacientes con HS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Se dise&#241;&#243; una SLR para evaluar la eficacia y el perfil de seguridad de los tratamientos t&#243;picos e IL para tratar a los pacientes con HS&#46; Siguiendo el enfoque PICOT&#44; se defini&#243; la poblaci&#243;n &#40;P&#41;&#44; la intervenci&#243;n &#40;I&#41;&#44; el comparador &#40;C&#41;&#44; los resultados &#40;O&#41; y el tipo de estudios &#40;T&#41; como parte de esta SLR realizada de acuerdo con las gu&#237;as de pr&#225;ctica cl&#237;nica proporcionadas por la declaraci&#243;n de elementos de informaci&#243;n preferidos para revisiones sistem&#225;ticas y metan&#225;lisis &#40;PRISMA&#41;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">13</span></a>&#46; PROSPERO &#40;ID n&#250;m&#46; CRD42022361114&#41;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se incluyeron estudios sobre individuos con HS de cualquier sexo&#44; edad y etnia</p><p id="par0025" class="elsevierStylePara elsevierViewall">&#40;P&#41;&#46; El diagn&#243;stico de HS pod&#237;a ser definido por el m&#233;dico tratante&#44; o cumplir los criterios diagn&#243;sticos disponibles<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">15</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Se incluy&#243; cualquier tipo de tratamiento t&#243;pico o IL para la HS &#40;I&#41;&#46; Por lo tanto&#44; se pod&#237;an tomar en cuenta tanto intervenciones farmacol&#243;gicas como f&#237;sicas&#46; Las terapias destructivas como el l&#225;ser o la cirug&#237;a se consideraron fuera del &#225;mbito de esta revisi&#243;n&#46; Tambi&#233;n se excluyeron los estudios que evaluaban una combinaci&#243;n de intervenciones t&#243;picas y sist&#233;micas&#46; Para facilitar la interpretaci&#243;n&#44; se predefinieron un total de cinco grupos de intervenci&#243;n&#58; terapia fotodin&#225;mica &#40;TFD&#41;&#44; corticosteroides IL&#44; resorcinol t&#243;pico&#44; antibi&#243;ticos y otras intervenciones&#46; No se impusieron restricciones a los comparadores &#40;C&#41;&#59; se incluyeron placebo&#44; ausencia de intervenci&#243;n o cualquier otra intervenci&#243;n m&#233;dica &#40;t&#243;pica o sist&#233;mica&#41;&#46; Tambi&#233;n se consideraron estudios sin comparador&#44; as&#237; como aquellos comparativos entre diferentes terapias t&#243;picas o IL&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La selecci&#243;n de los resultados se bas&#243; en el documento de consenso <span class="elsevierStyleItalic">&#171;International Dermatology Outcome Measures&#187;</span> &#40;IDEOM&#41; para el desarrollo de los hallazgos de la HS en mediciones sanitarias<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">16</span></a>&#46; Se definieron dos resultados coprimarios &#40;O&#41;&#44; uno relativo a la eficacia &#40;la CdV autopercibida&#41; y otro relativo a la seguridad &#40;n&#250;mero de pacientes con&#44; al menos&#44; un evento adverso &#91;EA&#93;&#41;&#46; Para evaluar la CdV&#44; se incluyeron escalas gen&#233;ricas &#40;SF-36 o EQ-5D&#41;&#44; espec&#237;ficas de dermatolog&#237;a &#40;<span class="elsevierStyleItalic">Dermatology Life Quality Index</span> &#91;DLQI&#93;&#44; Skindex 29&#41; y de la HS &#40;<span class="elsevierStyleItalic">Hidradenitis Suppurativa Quality of Life 24</span> &#91;HSQoL-24&#93;&#41;&#46; Los resultados secundarios de eficacia predefinidos incluyeron la evaluaci&#243;n global del paciente&#44; el dolor&#44; el prurito&#44; la actividad de la enfermedad&#44; la evaluaci&#243;n global del m&#233;dico y la satisfacci&#243;n con el tratamiento&#46; Los resultados pod&#237;an evaluarse en cualquier escala&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se incluyeron todos los tipos de estudios &#40;T&#41;&#58; aleatorizados&#44; de casos y controles&#44; de cohortes y series de casos&#46; Para ser tomadas en cuenta&#44; estas &#250;ltimas deb&#237;an informar sobre m&#225;s de cinco pacientes&#46; Se excluyeron las revisiones narrativas&#59; las revisiones sistem&#225;ticas previas de la literatura solo se utilizaron para la identificaci&#243;n secundaria de referencias&#46; Tambi&#233;n se omitieron los estudios cuyo documento completo no estaba disponible o si estaba escrito en un idioma distinto del ingl&#233;s&#44; el espa&#241;ol o el franc&#233;s&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La b&#250;squeda se realiz&#243; en tres bases de datos cient&#237;ficas principales &#40;Cochrane Library&#44; MEDLINE y Embase&#41; el 29 de septiembre de 2022 sin limitaciones de tiempo&#46; Debido a la dificultad de definir con precisi&#243;n las m&#250;ltiples intervenciones&#44; la b&#250;squeda se centr&#243; en recuperar art&#237;culos con la poblaci&#243;n de estudio &#40;pacientes con HS&#41;&#46; Para ello&#44; se utiliz&#243; una combinaci&#243;n de t&#233;rminos estandarizados &#40;<span class="elsevierStyleItalic">Medical Subject Headings</span> &#91;MeSH&#93;&#41; y libres&#46; Los detalles de la b&#250;squeda se muestran en el Ap&#233;ndice B informaci&#243;n complementaria &#40;<a class="elsevierStyleCrossRef" href="#sec0055">Anexo&#44; tabla 1</a>&#41;&#46; Se realiz&#243; una b&#250;squeda en ClinicalTrials&#46;gov utilizando los t&#233;rminos &#171;<span class="elsevierStyleItalic">hidradenitis suppurativa</span>&#187; y el filtro <span class="elsevierStyleItalic">&#171;complete&#187;</span>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Los resultados obtenidos de la b&#250;squeda se a&#241;adieron a un gestor de citas &#40;EndNote&#174; X7&#41;&#46; Los t&#237;tulos y res&#250;menes recuperados fueron revisados de forma independiente por dos autores &#40;JCP y RHQ&#41;&#46; Tras el cribado de t&#237;tulos y res&#250;menes&#44; se realiz&#243; una revisi&#243;n del texto completo de los estudios seleccionados&#46; Los desacuerdos entre los autores fueron resueltos por un &#225;rbitro &#40;FS&#41;&#46; Los criterios de inclusi&#243;n siguieron la estructura PICOT descrita anteriormente&#46; A continuaci&#243;n&#44; se comprob&#243; la lista de referencias de los estudios incluidos en la SLR para identificar los art&#237;culos omitidos&#46; No se efectuaron b&#250;squedas adicionales en las reuniones internacionales ni en las revistas clave&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">La curaci&#243;n de los datos fue realizada de forma independiente por JCP y RHQ mediante una hoja de extracci&#243;n de datos dise&#241;ada <span class="elsevierStyleItalic">ad hoc</span>&#44; basada en la <span class="elsevierStyleItalic">&#171;Checklist of items to consider in data collection or data extraction&#187;</span> disponible en el <span class="elsevierStyleItalic">&#171;Cochrane Handbook for Systematic Reviews of Interventions&#187;</span>&#46; Las discrepancias se resolvieron por consenso&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Tambi&#233;n se evalu&#243; el riesgo de sesgo y la calidad metodol&#243;gica de los estudios incluidos&#46; Debido a la heterogeneidad de estos &#40;desde series de casos hasta ECA&#41;&#44; se establecieron diferentes herramientas para su correcta evaluaci&#243;n&#58; la de &#171;riesgo de sesgo&#187; de la Cochrane versi&#243;n 2 &#40;RoB 2&#41;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">17</span></a> para los ensayos cl&#237;nicos&#44; y la <span class="elsevierStyleItalic">&#171;Newcastle-Ottawa Quality Assessment Scale&#187;</span> &#40;NOS&#41;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">17</span></a> para los estudios observacionales<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">18</span></a>&#46; Todas las series de casos se consideraron de alto riesgo de sesgo&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Si la heterogeneidad era baja&#44; se planific&#243; un metan&#225;lisis&#46; Los resultados de las variables dicot&#243;micas se expresaron como frecuencias relativas&#44; mientras que los de las variables continuas como medias y desviaciones est&#225;ndar&#46; Se planificaron los an&#225;lisis del sesgo de publicaci&#243;n y se expresaron mediante un gr&#225;fico en embudo &#40;<span class="elsevierStyleItalic">funnel plot</span>&#41;&#46; Sin embargo&#44; debido a la insuficiencia de material&#44; estos an&#225;lisis no pudieron realizarse&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0070" class="elsevierStylePara elsevierViewall">La b&#250;squeda recuper&#243; un total de 11&#46;363 referencias&#44; 4&#46;184 de las cuales se obtuvieron de MEDLINE&#44; 6&#46;807 de Embase&#44; 312 de Cochrane Library y 60 de Clinicaltrials&#46;gov&#46; Tras la eliminaci&#243;n de duplicados y el cribado por t&#237;tulo y resumen&#44; se seleccion&#243; un total de 43 estudios para la revisi&#243;n del texto completo&#46; De ellos&#44; 31 cumpl&#237;an todos los criterios de inclusi&#243;n &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1-5</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19&#8211;49</span></a> y 12 fueron excluidos <a class="elsevierStyleCrossRef" href="#sec0055">&#40;Anexo&#44; tabla 2&#41;</a><a class="elsevierStyleCrossRefs" href="#bib0620"><span class="elsevierStyleSup">50&#8211;61</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Los 31 estudios seleccionados informaron sobre un total de 1&#46;143 pacientes con HS&#44; 62&#37; de los cuales eran mujeres&#46; La edad media de los participantes era de 34&#44;1 a&#241;os&#46; El n&#250;mero medio de sujetos por estudio fue de 36&#44;2&#44; oscilando entre cinco<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">20&#44;21</span></a> y 131<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">37</span></a>&#44; y el seguimiento medio fue de 113&#44;2 d&#237;as&#46; La mayor&#237;a de los pacientes ten&#237;an HS cr&#243;nica con una evoluci&#243;n media de la enfermedad de 11&#44;7 a&#241;os&#44; y gravedad moderada &#40;21&#44;4&#37; eran Hurley I y 62&#44;9&#37; Hurley II&#41; <a class="elsevierStyleCrossRef" href="#sec0055">&#40;Anexo&#44; tablas 3 y 4&#41;</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los trabajos informaron sobre series de casos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#41;&#44; con solo cinco ECA y un &#250;nico estudio de cohortes&#46; Los ECA exploraron una variedad de intervenciones&#58; TFD t&#243;pica&#44; comparando una formulaci&#243;n de azul de metileno niosomal al 1&#37; &#40;AMN&#41; con azul de metileno libre &#40;AML&#41;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">24</span></a>&#44; corticosteroides IL&#44; contrastando acet&#243;nido de triamcinolona &#40;ACT&#41; con soluci&#243;n salina normal<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">29</span></a>&#44; clindamicina t&#243;pica&#44; comparada con tetraciclina oral<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">44</span></a> o placebo<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">43</span></a>&#44; y toxina botul&#237;nica tipo B &#40;BTX&#41; vs&#46; placebo<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">45</span></a>&#46; El estudio de cohortes contrast&#243; la clindamicina t&#243;pica con el resorcinol t&#243;pico<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">42</span></a>&#46; Las 25 series de casos restantes evaluaron las intervenciones y otras como la combinaci&#243;n de corticosteroides IL y lincomicina<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">46</span></a>&#44; ictiamol t&#243;pico<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">47</span></a>&#44; citrato de trietilo t&#243;pico<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">48</span></a> o soluci&#243;n salina hipert&#243;nica IL<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Considerando los resultados primarios&#44; 14 estudios proporcionaron datos sobre la CdV&#44; 12 de los cuales utilizaron el DLQI<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19&#44;22&#44;25&#8211;27&#44;33&#44;34&#44;39&#44;40&#44;42&#44;45&#8211;47&#44;49</span></a>&#46; Mientras tanto&#44; 23 informaron de la frecuencia de pacientes con&#44; al menos&#44; un EA<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19-21&#44;23&#44;25-28&#44;30-32&#44;35&#44;37-46&#44;49</span></a>&#46; Los resultados restantes se evaluaron en un n&#250;mero menor de estudios&#58; evaluaci&#243;n global por el paciente del estado de la enfermedad &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41;<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">24&#44;30&#44;33&#44;43-45&#44;49</span></a>&#44; dolor &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;<a class="elsevierStyleCrossRefs" href="#bib0480"><span class="elsevierStyleSup">22&#44;23&#44;25&#44;26&#44;29-34&#44;36&#44;38-42&#44;44&#44;45&#44;49</span></a>&#44; prurito<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">31</span></a> &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; actividad de la enfermedad &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">20&#44;22-27&#44;30&#44;34&#44;36&#44;39&#44;40&#44;42&#44;44&#44;45&#44;48&#44;49</span></a> evaluaci&#243;n global del m&#233;dico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19&#44;21-23&#44;28-32&#44;34&#44;35&#44;41&#44;44&#44;46&#44;47&#44;49</span></a> y satisfacci&#243;n con el tratamiento &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">29&#44;33&#44;37&#44;46</span></a> &#40;<a class="elsevierStyleCrossRef" href="#sec0055">Anexo&#44; tabla 5&#41;</a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">El RoB de los ensayos cl&#237;nicos incluidos se consider&#243; bajo para tres y alto para dos<a class="elsevierStyleCrossRefs" href="#bib0590"><span class="elsevierStyleSup">44&#44;45</span></a> estudios&#58; el primero con un riesgo elevado de sesgo de desgaste debido a retiradas no equilibradas y a un an&#225;lisis por protocolo<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">44</span></a>&#44; el segundo con un alto riesgo de sesgo de rendimiento y detecci&#243;n debido a su dise&#241;o abierto<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">45</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; El RoB del &#250;nico estudio de cohortes tambi&#233;n se consider&#243; bajo<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">42</span></a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Terapia fotodin&#225;mica</span><p id="par0090" class="elsevierStylePara elsevierViewall">Un total de 10 estudios investigaron el uso de la TFD&#44; incluyendo 194 pacientes<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19-28</span></a>&#46; Estos estudios incluyeron cinco series de casos retrospectivas<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19-21&#44;28</span></a>&#44; cinco series de casos prospectivos<a class="elsevierStyleCrossRefs" href="#bib0480"><span class="elsevierStyleSup">22&#44;23&#44;25-27</span></a> y un ECA intraindividual de cuerpo dividido<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">24</span></a>&#46; El tipo de lesiones abarcadas fue heterog&#233;neo&#44; ya que se consideraron n&#243;dulos&#44; abscesos y f&#237;stulas&#46; La mayor&#237;a de los informes sobre TFD-IL se centran en el tratamiento de las f&#237;stulas&#46; Se han evaluado tres fotosensibilizadores diferentes&#58; azul de metileno &#40;AM&#41;&#44; &#225;cido 5-aminolevul&#237;nico &#40;ALA&#41; y aminolevulinato de metilo &#40;MAL&#41;&#46; Tambi&#233;n se han estudiado diferentes fuentes y longitudes de onda&#46; Tanto la DLP t&#243;pica como la TFD-IL proporcionan datos similares sobre eficacia&#44; aunque la aplicaci&#243;n t&#243;pica se asocia a menos EA&#46; El EA notificado con m&#225;s frecuencia fue el dolor durante el tratamiento&#44; con hasta 100&#37; de los pacientes que notificaron dolor en algunos estudios&#46; La ecograf&#237;a &#40;ECO&#41; se utiliz&#243; para medir la respuesta en tres series de casos<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19&#44;20&#44;23</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Un &#250;nico ECA con bajo riesgo de sesgo evalu&#243; el perfil de eficacia de la TFD t&#243;pica con AMN en comparaci&#243;n con el AML<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">24</span></a>&#46; Este estudio mostr&#243; una mayor mejor&#237;a de la actividad de la HS cuando se utiliz&#243; el AMN &#40;AMN&#44; 75&#44;9&#37; vs&#46; AML&#44; 46&#44;3&#37; de mejor&#237;a&#41;&#46; Adem&#225;s&#44; tambi&#233;n revel&#243; una mayor reducci&#243;n del tama&#241;o de la f&#237;stula&#46; Sin embargo&#44; no se aportaron datos de CdV ni de seguridad&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Corticosteroides intralesionales</span><p id="par0100" class="elsevierStylePara elsevierViewall">Han evaluado el tratamiento con corticosteroides para la HS ocho estudios&#44; incluyendo un total de 394 pacientes&#46; Todas las publicaciones se han centrado en el uso de corticosteroides IL<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">29-36</span></a>&#59; en nuestra SLR no se consideraron publicaciones sobre corticosteroides t&#243;picos&#46; Se incluyeron un ECA<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">29</span></a>&#44; cuatro prospectivos<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">30&#44;31&#44;34&#44;36</span></a> y tres series de casos retrospectivas<a class="elsevierStyleCrossRefs" href="#bib0530"><span class="elsevierStyleSup">32&#44;33&#44;35</span></a>&#46; Los estudios engloban lesiones agudas&#44; n&#243;dulos o abscesos&#44; lesiones cr&#243;nicas m&#225;s persistentes y f&#237;stulas&#46; El ACT fue el corticosteroide estudiado con mayor frecuencia&#44; con dosis que oscilaban entre 10<span class="elsevierStyleHsp" style=""></span>mg&#47;mL y 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#46; Los EA oscilaron entre 2 y 56&#37; de los casos en cada estudio&#44; siendo la atrofia cut&#225;nea y la hipopigmentaci&#243;n los m&#225;s frecuentes&#46; La ECO se utiliz&#243; para la liberaci&#243;n del tratamiento o para determinar la respuesta en cinco estudios<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">30-32&#44;34&#44;35</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Un ECA reciente evalu&#243; dos dosis IL de ATC &#40;40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL &#91;ATC40&#93; y 10<span class="elsevierStyleHsp" style=""></span>mg&#47;mL &#91;ATC10&#93;&#41; frente a placebo &#40;soluci&#243;n salina normal&#41;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">29</span></a>&#46; Este ECA no encontr&#243; diferencias significativas entre ninguno de los brazos de tratamiento activo y el placebo&#46; La reducci&#243;n del dolor cinco d&#237;as despu&#233;s del tratamiento&#44; evaluada con una escala visual anal&#243;gica &#40;EVA&#41; de 0-10&#44; fue similar en todos los brazos &#40;TCA40 2&#44;3 vs&#46; TCA10 2&#44;0 vs&#46; placebo 2&#44;6&#41;&#46; Otros resultados&#44; como la duraci&#243;n media de las lesiones hasta su resoluci&#243;n y la satisfacci&#243;n con el tratamiento&#44; tambi&#233;n fueron similares entre los grupos&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resorcinol t&#243;pico</span><p id="par0110" class="elsevierStylePara elsevierViewall">Seis publicaciones han evaluado el perfil de eficacia y seguridad del resorcinol t&#243;pico al 15&#37; para la HS&#44; incluyendo un total de 359 pacientes<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">37-42</span></a>&#46; Tres estudios fueron series de casos prospectivas<a class="elsevierStyleCrossRefs" href="#bib0565"><span class="elsevierStyleSup">39-41</span></a>&#44; dos fueron series de casos retrospectivas<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">37&#44;38</span></a>&#44; y un estudio de cohortes retrospectivo evalu&#243; el perfil de eficacia del resorcinol al 15&#37; frente a la clindamicina t&#243;pica al 1&#37;&#46; El resorcinol fue superior a la clindamicina en la mejor&#237;a del <span class="elsevierStyleItalic">International Hidradenitis Suppurativa Severity Score System</span> &#40;IHS4&#41;&#44; <span class="elsevierStyleItalic">hidradenitis suppurativa clinical response</span> &#40;HiSCR&#41;&#44; dolor y DLQI<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">42</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Ning&#250;n ECA ha evaluado la eficacia o el perfil de seguridad del resorcinol t&#243;pico&#46; Los pacientes incluidos presentaban un estado de la enfermedad m&#225;s leve &#40;Hurley I y II&#41;&#44; y las lesiones tratadas eran principalmente n&#243;dulos y abscesos&#46; Un total de 15&#37; de resorcinol se asoci&#243; a una mejor&#237;a del DLQI&#44; el dolor y la actividad de la HS&#44; determinada por el IHS4 o el HiSCR&#44; y a una elevada satisfacci&#243;n con el tratamiento&#46; Se produjeron EA en 29-100&#37; de los pacientes&#44; siendo la descamaci&#243;n y la pigmentaci&#243;n marr&#243;n reversible los signos m&#225;s frecuentes&#46; En tres publicaciones se utiliz&#243; la ECO para evaluar la eficacia<a class="elsevierStyleCrossRefs" href="#bib0565"><span class="elsevierStyleSup">39-41</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Antibi&#243;ticos</span><p id="par0120" class="elsevierStylePara elsevierViewall">Dos ECA exploraron el uso de antibi&#243;ticos t&#243;picos para la HS incluyendo a 73 pacientes<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">43&#44;44</span></a>&#46; El primero&#44; evalu&#243; la eficacia y el perfil de seguridad de la clindamicina t&#243;pica 1&#37; vs&#46; placebo<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">43</span></a>&#46; La evaluaci&#243;n de los s&#237;ntomas por parte de los pacientes se realiz&#243; mediante un diario de s&#237;ntomas&#44; en el que con cada entrada se sumaban hasta dos puntos si estos notaban mejor&#237;a cl&#237;nica&#44; y se restaban hasta dos puntos en caso de empeoramiento&#46; Se registr&#243; una diferencia estad&#237;sticamente significativa entre el grupo de clindamicina t&#243;pica y el grupo placebo &#40;media&#44; &#43;311 y &#8722;91&#44; respectivamente&#41;&#46; El n&#250;mero de n&#243;dulos inflamatorios&#44; abscesos y p&#250;stulas mostr&#243; una reducci&#243;n significativa en los pacientes en tratamiento activo&#46; En cuanto a los EA&#44; solo se notific&#243; un episodio de irritaci&#243;n local &#40;3&#44;7&#37;&#41;&#46; El segundo ECA compar&#243; la clindamicina t&#243;pica al 1&#37; con las tetraciclinas orales<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">44</span></a>&#46; Al realizar esta comparaci&#243;n&#44; no se encontraron diferencias significativas entre ambos tratamientos&#46; En cuanto a la seguridad&#44; se describieron tres EA en el grupo de tetraciclina oral frente a cinco en el grupo de clindamicina t&#243;pica&#44; aunque no se proporcion&#243; ninguna descripci&#243;n adicional&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Otras intervenciones</span><p id="par0125" class="elsevierStylePara elsevierViewall">En cuanto a otras intervenciones t&#243;picas o IL&#44; un &#250;nico ECA evalu&#243; el perfil de eficacia de un ciclo de tres meses de inyecciones de BTX vs&#46; placebo&#44; seguido de tres meses de BTX en ambos grupos<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">45</span></a>&#46; A los tres meses&#44; la CdV mejor&#243; 6&#44;6&#37; en el grupo de BTX &#40;DLQI basal BTX&#58; 16 vs&#46; DLQI tres meses BTX&#58; 9&#44;9&#41;&#44; y 0&#44;9&#37; en el grupo placebo&#46; Por &#250;ltimo&#44; cuatro series de casos informaron sobre la combinaci&#243;n IL de TCA40 y lincomicina<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">46</span></a>&#44; ictiamol t&#243;pico al 10&#37;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">47</span></a>&#44; citrato de trietilo t&#243;pico al 1&#37; y linoleato de etilo p&#233;ptido G<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">48</span></a>&#44; o soluci&#243;n salina hipert&#243;nica IL<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a>&#46; Esta &#250;ltima publicaci&#243;n inform&#243; de una mejora significativa en el DLQI y el n&#250;mero de lesiones&#46; Todas las publicaciones sobre lavados antis&#233;pticos cumpl&#237;an los criterios para ser incluidas en esta SLR&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Hasta donde sabemos&#44; esta es la primera SLR realizada sobre tratamientos t&#243;picos e IL para la HS&#46; Varias revisiones sistem&#225;ticas en los &#250;ltimos cinco a&#241;os han evaluado la eficacia o el perfil de seguridad de los tratamientos para la HS&#58; Robert et al&#46;<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">62</span></a>&#44; Gracia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">63</span></a> y Cuenca-Barrales et al&#46;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">64</span></a>&#46; La primera se centra en terapias sist&#233;micas y l&#225;ser &#40;incluyendo TFD&#41;&#44; la segunda en tratamientos lum&#237;nicos&#44; y por tanto incluye datos sobre TFD&#44; mientras que la &#250;ltima se enfoca exclusivamente en terapias IL&#46; Desde esta &#250;ltima SLR&#44; se han publicado tres nuevos estudios sobre tratamientos IL que se han recogido en nuestra SLR<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">34&#44;35&#44;49</span></a>&#46; Una revisi&#243;n Cochrane previa publicada por Ingram et al&#46;&#44; hace ocho a&#241;os evalu&#243; todas las intervenciones disponibles para la HS<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">10</span></a>&#59; siguiendo las recomendaciones Cochrane&#44; los autores incluyeron exclusivamente ECA&#44; el mejor dise&#241;o para aportar datos sobre opciones terap&#233;uticas&#46; Sin embargo&#44; los resultados muestran escasa evidencia sobre terapias poco estudiadas&#44; como las t&#243;picas y las IL&#44; incluy&#233;ndose solo tres publicaciones<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">43&#44;44&#44;65</span></a>&#46; No se consideraron los datos de los 29 estudios restantes tomados en cuenta en nuestra SLR&#44; incluidos dos ECA publicados recientemente&#46; Por &#250;ltimo&#44; debemos mencionar que ninguna de estas revisiones abord&#243; estudios sobre resorcinol t&#243;pico ni BTX&#46; Los estudios incluidos en nuestra SLR presentaban un alto grado de heterogeneidad en cuanto a las caracter&#237;sticas de los pacientes&#44; el tipo de lesiones&#44; los resultados evaluados y el periodo de seguimiento&#46; Esto subraya la necesidad de llegar a un consenso sobre los dominios centrales de resultados que deben evaluarse en los estudios de pacientes con HS<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">66</span></a>&#46; Este ha demostrado ser un camino exitoso en otras enfermedades&#44; como la artritis reumatoide&#44; estableciendo un conjunto de dominios centrales de resultados a trav&#233;s de OMERACT&#44; que se han aplicado universalmente en los estudios realizados desde entonces<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">67</span></a>&#46; Adem&#225;s&#44; la ECO se utiliz&#243; en 12 de los 31 estudios incluidos en esta revisi&#243;n&#44; tanto como ayuda para la administraci&#243;n del tratamiento como para evaluar el perfil de eficacia<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">19&#44;20&#44;23&#44;30-32&#44;34&#44;39-41&#44;49</span></a>&#46; Este hallazgo refuerza la utilidad de la ECO en el manejo de los pacientes con HS&#46; Por otro lado&#44; la historia natural de la HS complica la evaluaci&#243;n del perfil de eficacia de los tratamientos t&#243;picos para n&#243;dulos y abscesos&#46; Von der Werth et al&#46; describieron que los n&#243;dulos y abscesos suelen resolverse en siete a 10 d&#237;as incluso sin tratamiento<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">68</span></a>&#44; lo que pone de relieve la necesidad de un comparador para establecer la eficacia&#46; Por ejemplo&#44; todas las lesiones en las que se utiliz&#243; resorcinol fueron n&#243;dulos y abscesos&#46; No obstante&#44; algunos resultados&#44; como la satisfacci&#243;n del paciente&#44; pueden respaldar indirectamente la eficacia<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">37</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">En la &#250;ltima d&#233;cada se ha producido un aumento de las opciones de tratamiento de la HS moderada y grave&#44; con la aprobaci&#243;n del adalimumab por la Agencia Europea del Medicamento &#40;EMA&#41; y varios f&#225;rmacos nuevos en busca de aprobaci&#243;n&#46; Este mayor esfuerzo de la industria farmac&#233;utica se ha centrado en las formas moderadas o graves de la HS&#44; lo que ha dado lugar a un mayor n&#250;mero de estudios cient&#237;ficos de alta calidad &#40;ECA&#41; en estos subtipos de pacientes<a class="elsevierStyleCrossRefs" href="#bib0715"><span class="elsevierStyleSup">69-72</span></a>&#46; Sin embargo&#44; la evidencia que respalda el tratamiento de las formas leves de la enfermedad sigue siendo escasa&#46; La HS leve suele ser el escal&#243;n que conduce a las formas moderadas o graves&#46; Adem&#225;s&#44; incluso las formas leves de la enfermedad tienen un impacto en la CdV<a class="elsevierStyleCrossRef" href="#bib0735"><span class="elsevierStyleSup">73</span></a>&#46; El uso de f&#225;rmacos t&#243;picos e IL&#44; utilizados habitualmente en la pr&#225;ctica cl&#237;nica en las formas leves&#44; no est&#225; en general respaldado por ECA&#46; Este hecho se pone de manifiesto en la presente SLR y exige el desarrollo de un ECA para determinar el perfil de eficacia y seguridad de dichos tratamientos&#44; independientemente de los intereses farmac&#233;uticos&#46; Aunque los EA parecen estar asociados al uso de terapias t&#243;picas e IL&#44; estos son&#44; en general&#44; leves y no requieren la interrupci&#243;n del tratamiento&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Los resultados relativos a la TFD sugieren que podr&#237;a ser un procedimiento eficaz y bien tolerado&#44; siendo el principal EA&#44; el dolor&#46; En cuanto a los corticoides IL&#44; aunque el estudio realizado por Fajgenbaum et al&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">29</span></a> est&#225; metodol&#243;gicamente bien dise&#241;ado&#44; dos limitaciones dificultan su validez externa&#44; el peque&#241;o volumen de corticoides utilizado &#40;0&#44;1<span class="elsevierStyleHsp" style=""></span>mL&#41; y el tama&#241;o reducido de la muestra&#46; Las publicaciones sobre el resorcinol podr&#237;an sugerir un buen perfil de eficacia y seguridad&#44; pero carecen de un grupo de control&#46; Un &#250;nico estudio de cohortes confirm&#243; la superioridad del resorcinol sobre la clindamicina t&#243;pica&#44; destacando una alternativa terap&#233;utica que podr&#237;a evitar la aparici&#243;n de la resistencia a los antibi&#243;ticos&#46; Por &#250;ltimo&#44; un &#250;nico ECA con BTX sugiere eficacia&#59; un posible mecanismo de acci&#243;n podr&#237;a ser su efecto anhidr&#243;tico que podr&#237;a cambiar la microbiota cut&#225;nea&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">La gu&#237;a de la Asociaci&#243;n Brit&#225;nica de Dermat&#243;logos sobre el manejo de pacientes con HS solo incluye dos tratamientos t&#243;picos o IL en sus recomendaciones&#58; clindamicina t&#243;pica y corticoides IL&#44; este &#250;ltimo&#44; exclusivamente para lesiones agudas&#46; Ambos tratamientos se clasifican como recomendaciones fuertes&#44; ya que los beneficios superan a los riesgos&#46; Las directrices europeas sobre el tratamiento de la HS sugieren<a class="elsevierStyleCrossRef" href="#bib0740"><span class="elsevierStyleSup">74</span></a> el uso de resorcinol t&#243;pico&#44; adapaleno y &#225;cido azelaico&#46; Tambi&#233;n se menciona el uso de corticosteroides IL y&#44; como tratamientos experimentales&#44; BTX y TFD&#46; Sin embargo&#44; en su algoritmo final solo se incluye la clindamicina t&#243;pica para las formas leves<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">8</span></a>&#46; Las gu&#237;as norteamericanas sobre el manejo de la HS recomiendan limpiadores cut&#225;neos y queratol&#237;ticos&#44; clindamicina t&#243;pica y corticosteroides IL<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">11</span></a>&#46; Como vemos&#44; las gu&#237;as son heterog&#233;neas en su recomendaci&#243;n de terapias t&#243;picas e IL&#44; muchas veces basadas en preferencias de expertos y no en el soporte de la evidencia&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Esta SLR adolece de algunas limitaciones&#46; Se tomaron todas las precauciones para recopilar toda la informaci&#243;n disponible&#44; con una amplia b&#250;squeda en tres bases de datos&#46; Los estudios incluidos muestran un amplio grado de heterogeneidad con respecto a la intervenci&#243;n&#44; la poblaci&#243;n&#44; el dise&#241;o del estudio&#44; los resultados y las escalas&#44; y el an&#225;lisis de los datos&#46; De hecho&#44; la heterogeneidad de las intervenciones&#44; junto con la falta de un comparador en la mayor&#237;a de los estudios&#44; ha impedido el desarrollo del metaan&#225;lisis previsto&#46; Adem&#225;s&#44; los periodos de seguimiento en muchos de estos estudios son cortos&#44; sin que se pueda profundizar en la administraci&#243;n prolongada de estas terapias&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; aunque cada vez hay m&#225;s inter&#233;s y m&#225;s estudios sobre la HS&#44; la calidad de las pruebas que respaldan el uso de tratamientos t&#243;picos individuales o IL en esta enfermedad es muy baja&#44; con un apoyo condicional hacia la clindamicina t&#243;pica&#44; la TFD con AMN y BTX&#46; Se agradecer&#237;a la realizaci&#243;n de m&#225;s ECA adecuadamente dise&#241;ados&#44; con resultados estandarizados y poblaciones de pacientes y lesiones homog&#233;neas para respaldar las decisiones de la pr&#225;ctica cl&#237;nica&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Financiaci&#243;n</span><p id="par0170" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ninguna financiaci&#243;n&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicto de intereses</span><p id="par0160" class="elsevierStylePara elsevierViewall">J&#46;C&#46; Pascual declara ser consultor de Abbvie&#44; Novartis y UCB en el campo de la HS&#46; R&#46; Hern&#225;ndez-Quiles&#44; V&#46; S&#225;nchez-Garc&#237;a A&#46; Viudez-Mart&#237;nez&#44; I&#46; Belinch&#243;n y F&#46; Siver declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los tratamientos t&#243;picos e intralesionales &#40;IL&#41; pueden ser considerados como de primera l&#237;nea en pacientes con hidradenitis supurativa &#40;HS&#41;&#44; sin embargo&#44; la evidencia que apoya su uso es limitada&#46; El objetivo de nuestra revisi&#243;n es evaluar la eficacia y la seguridad de los tratamientos t&#243;picos e IL en pacientes con HS&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dise&#241;amos una revisi&#243;n sistem&#225;tica de la literatura siguiendo el m&#233;todo <span class="elsevierStyleItalic">poblaci&#243;n&#44; intervenci&#243;n&#44; comparaci&#243;n&#44; resultado &#40;outcome&#41; y tipo</span> &#40;PICOT&#41;&#46; Incluimos todo tipo de estudios &#40;tipo &#91;T&#93;&#41; que integraran individuos con HS de cualquier sexo&#44; edad y etnicidad &#40;poblaci&#243;n &#91;P&#93;&#41;&#44; que recibieran cualquier tratamiento t&#243;pico o IL para la HS &#40;intervenci&#243;n &#91;I&#93;&#41; que compararan con placebo&#44; otros tratamientos o no tratamiento &#40;comparador &#91;C&#93;&#41; y reportaran resultados de eficacia y&#47;o seguridad &#40;<span class="elsevierStyleItalic">outcomes</span> &#91;O&#93;&#41;&#46; Dos resultados fueron definidos&#58; calidad de vida &#40;CdV&#41; y n&#250;mero de pacientes con al menos un efecto adverso&#46; La b&#250;squeda se llev&#243; a cabo en las bases de datos Cochrane Library&#44; MEDLINE y Embase&#59; la selecci&#243;n de estudios se realiz&#243; de acuerdo con los criterios predefinidos&#46; El riesgo de sesgo se determin&#243; en cada estudio&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se obtuvieron 11&#46;363 referencias de las cuales 31 cumplieron los criterios de inclusi&#243;n&#46; Estos estudios incluyeron 1&#46;143 pacientes con HS&#44; 62&#37; fueron mujeres&#46; Evaluaron la terapia fotodin&#225;mica &#40;TFD&#41; 10 estudios&#44; ocho los glucocorticoides&#44; seis el resorcinol&#44; dos los antibi&#243;ticos t&#243;picos y cinco otras intervenciones&#46; La mayor&#237;a de los art&#237;culos fueron series de casos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#41;&#44; con solo cinco ensayos cl&#237;nicos aleatorizados &#40;ECA&#41; y un estudio de cohortes&#46; Los ECA demostraron mejor&#237;a de la actividad de la enfermedad con clindamicina t&#243;pica y con toxina botul&#237;nica tipo B &#40;BTX&#41; frente a placebo y TFD con azul de metileno &#40;AM&#41; niosomal &#40;AMN&#41; frente a AM libre &#40;AML&#41;&#59; sin embargo&#44; el acet&#243;nido de triamcinolona &#40;ACT&#41; IL no fue superior al placebo&#46; El riesgo de sesgo fue bajo en tres y alto en dos ECA&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La calidad de la evidencia que apoya el uso de tratamientos t&#243;picos o IL es baja&#44; pero respalda el empleo de clindamicina t&#243;pica&#44; TFD y BTX&#46; Se requieren ECA adecuadamente dise&#241;ados con resultados estandarizados y poblaciones homog&#233;neas de pacientes y lesiones para apoyar la toma de decisiones en la pr&#225;ctica cl&#237;nica&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Topical and intralesional &#40;IL&#41; treatments may be considered the first-line therapy in patients with hidradenitis suppurativa &#40;HS&#41;&#59; however&#44; the evidence supporting their use is limited&#46; The aim of our review is to evaluate the efficacy and safety profile of topical and IL treatments in patients with HS&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We designed a systematic review of the current medical literature available following the PICO&#40;T&#41; method&#46; And including all types of studies &#40;Study type &#91;T&#93;&#41; of individuals with HS of any sex&#44; age&#44; and ethnicity &#40;Population &#91;P&#93;&#41; who received any topical or IL treatment for HS &#40;Intervention &#91;I&#93;&#41; compared to placebo&#44; other treatments&#44; or no treatment at all &#40;Comparator &#91;C&#93;&#41;&#44; and reported efficacy and&#47;or safety outcomes &#40;Outcomes &#91;O&#93;&#41;&#46; Two outcomes were defined&#58; quality of life and the no&#46; of patients with&#44; at least&#44; one adverse event&#46; The search was conducted in the Cochrane Library&#44; MEDLINE&#44; and Embase databases&#59; study selection was performed based on pre-defined criteria&#46; The risk of bias was determined in each study&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We obtained a total of 11&#44;363 references&#44; 31 of which met the inclusion criteria&#46; These studies included 1143 patients with HS&#44; 62&#37; of whom were women&#46; A total of 10&#44; 8&#44; 6&#44; 2&#44; and 5 studies&#44; respectively&#44; evaluated the use of photodynamic therapy &#40;PDT&#41;&#44; glucocorticoids&#44; resorcinol&#44; topical antibiotics&#44; and other interventions&#46; Most articles were case series &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>25&#41;&#44; with only five randomized clinical trials &#40;RCTs&#41; and one cohort study&#46; RCTs showed improvement in disease activity with topical clindamycin and botulinum toxin &#40;BTX&#41; vs placebo&#44; and PDT with methylene blue &#40;MB&#41; niosomal vs free MB&#59; however&#44; intralesional triamcinolone acetonide was not superior to placebo&#46; The risk of bias was low in three RCTs and high in two RCTs&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The quality of evidence supporting the use of topical&#44; or IL treatments is low&#46; However&#44; it supports the use of topical clindamycin&#44; PDT&#44; and BTX&#46; Well-designed RCTs with standardized outcomes and homogeneous populations of patients and lesions are needed to support decision-making in the routine clinical practice&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Materials and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusion"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0175" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Material adicional"
            "identificador" => "sec0060"
          ]
        ]
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1805
            "Ancho" => 2508
            "Tamanyo" => 182981
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Flujograma PRISMA&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">PRISMA&#58; declaraci&#243;n de elementos de informaci&#243;n preferidos para revisiones sistem&#225;ticas y metan&#225;lisis&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr2.jpeg"
            "Alto" => 1079
            "Ancho" => 2933
            "Tamanyo" => 329592
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        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Riesgo de sesgos 2 &#40;RoB 2&#41;&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ALA&#58; &#225;cido aminolevul&#237;nico&#59; AML&#58; azul de metileno libre&#59; AMN&#58; azul de metileno niosomal&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; DLQI&#58; <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#59; EVA&#58; escala visual anal&#243;gica&#59; HS-LASI&#58; <span class="elsevierStyleItalic">HS lesion&#44; area and severity index</span>&#59; IL&#58; intralesional&#59; IPL&#58; <span class="elsevierStyleItalic">intense pulsed light</span>&#59; MAL&#58; aminolevulinato de metilo&#59; nm&#58; nan&#243;metro&#59; NP&#58; no proporcionado&#59; PGA&#58; <span class="elsevierStyleItalic">physician global assessment</span>&#59; TFD&#58; terapia fotodin&#225;mica&#46;</p>"
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Duraci&#243;n del tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Agut-Busquet et al&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">19</span></a> 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD IL AML 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;media&#41; 9&#44;43 &#8211; DLQI &#40;media&#41; 1&#44;9PGA&#58; Buena respuesta 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EVA&#41;<span class="elsevierStyleHsp" style=""></span>Bajo &#40;1&#8211;3&#41;&#58; 14&#37;<span class="elsevierStyleHsp" style=""></span>Moderado &#40;4&#8211;6&#41;&#58; 86&#37;Eritema&#47;edema&#58; 86&#37;Celulitis&#58; 14&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Andino-Navarrete et al&#46; <a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">25</span></a> 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD t&#243;pica ALA 20&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>635<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 28&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7&#8211;7&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;8Dolor &#40;EAS 0&#8211;10&#41;&#58; 3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#8211;0&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;5Puntuaci&#243;n de Sartorius&#58; 35&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;0&#8211;18&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor leve&#58; 40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Calzavara-Pinton et al&#46; <a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">28</span></a> 2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD t&#243;pica MAL 16&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>635<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;6 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PGA<span class="elsevierStyleHsp" style=""></span>Respuesta completa&#58; 33&#44;3&#37;<span class="elsevierStyleHsp" style=""></span>Respuesta parcial&#58; 50&#37;<span class="elsevierStyleHsp" style=""></span>Sin respuesta&#58; 166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eritema y edema&#58; 83&#44;3&#37;Dolor leve o moderado&#58; 100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fadel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">24</span></a> 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD t&#243;pica AMN 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AML 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensayo cl&#237;nico aleatorizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HS-LASI<span class="elsevierStyleHsp" style=""></span>AMN 14&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;6&#8211;3&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;4<span class="elsevierStyleHsp" style=""></span>AML 14&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;2&#8211;7&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6&#8211;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01Reducci&#243;n de tama&#241;o &#40;&#37;&#41;<span class="elsevierStyleHsp" style=""></span>AMN 77&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;9<span class="elsevierStyleHsp" style=""></span>AML 44&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;2&#8211;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gamissans et al&#46; <a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">20</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD - IL AML 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>635<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reducci&#243;n del di&#225;metro del tunel &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>75&#37;&#8211;58&#44;5&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#41;&#8211;8&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;0&#8211;2&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;7<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>50&#8211;75&#37;&#8211;22&#44;0&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&#8211;8&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8&#8211;3&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;2<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#60; 50&#37;&#8211;19&#44;5&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&#8211;9&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9&#8211;7&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;4<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor y eritema &#40;&#37; NP&#41;Celulitis&#58; 2&#44;4&#37;Retirada debido a&#58; 2&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Garcias-Ladaria et al&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">21</span></a> 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD - IL ALA 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PGA<span class="elsevierStyleHsp" style=""></span>Respuesta completa&#58; 22&#44;2&#37;<span class="elsevierStyleHsp" style=""></span>Mejor&#237;a&#58; 62&#44;4&#37;<span class="elsevierStyleHsp" style=""></span>Sin cambios&#58; 15&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor&#58; 45&#44;3&#37;Abscesos&#58; 6&#44;8&#37;Fiebre&#58; 7&#44;2&#37;Parestesia&#58; 2&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Schweiger et al&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">27</span></a> 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD t&#243;pica ALA 20&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>IPL&#47;luz azul&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI&#58; 17&#44;3&#8211;14&#44;0Puntuaci&#243;n de gravedad &#40;0&#8211;3&#41;&#58; 2&#44;2&#8211;1&#44;5N&#250;mero de lesiones&#58; 11&#44;2&#8211;7&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eritema local &#40;&#37; NP&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sotiriou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">26</span></a> 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD T&#243;pica ALA 20&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>635<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI 6&#44;4&#37; reducci&#243;n tras tratamientoDolor &#40;EAS 0&#8211;5&#41;&#58; 2&#44;4&#8211;2&#44;1Puntuaci&#243;n de Sartorius&#58; 18&#44;8&#8211;17&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor&#58; 100&#37;Eritema y edema&#58; 40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suarez-Valladares et al&#46; <a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">22</span></a> 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD - IL ALA 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;5 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI&#58; 10 &#40;7&#8211;17&#41;&#8211;1 &#40;0&#8211;2&#44;25&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;Dolor &#40;EAS 0&#8211;10&#41;&#58; 3 &#40;2&#8211;5&#44;25&#41;&#8211;NPPuntuaci&#243;n de Sartorius modificada&#58; 28&#44;5 &#40;11&#44;75&#8211;38&#44;5&#41;&#8211;0 &#40;0&#8211;45&#41;PGA<span class="elsevierStyleHsp" style=""></span>Respuesta completa response&#58; 76&#44;3&#37;<span class="elsevierStyleHsp" style=""></span>Respuesta parcial&#58; 21&#37;<span class="elsevierStyleHsp" style=""></span>Recurrencia&#58; 2&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valladares-Narganes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">23</span></a> 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TFD - IL ALA 1&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>630<span class="elsevierStyleHsp" style=""></span>nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Puntuaci&#243;n de Sartorius &#40;media&#41; 20&#44;7&#8211;8&#44;8PGA<span class="elsevierStyleHsp" style=""></span>Resoluci&#243;n completa&#58; 37&#44;0&#37;<span class="elsevierStyleHsp" style=""></span>Buena respuesta&#58; 40&#44;7&#37;<span class="elsevierStyleHsp" style=""></span>Respuesta parcial&#58; 18&#44;6&#37;<span class="elsevierStyleHsp" style=""></span>Sin respuesta&#58; 3&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor grave&#58; 3&#44;7&#37;Dolor moderado&#58; 14&#44;8&#37;Fiebre&#58; 3&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Resumen de los estudios incluidos que eval&#250;an la terapia fotodin&#225;mica</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">ACT&#58; acet&#243;nido de triamcinolona&#59; BMS&#58; betametasona&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; EVA&#58; escala visual anal&#243;gica&#59; ECO&#58; ecograf&#237;a&#59; HSSI&#58; <span class="elsevierStyleItalic">hidradenitis suppurativa severity index</span> IHS4&#58; <span class="elsevierStyleItalic">International Hidradenitis Suppurativa Severity Score System</span>&#59; IL&#58; intralesional&#59; NP&#58; no proporcionado&#59; PGA&#58; <span class="elsevierStyleItalic">physician global assessment</span>&#59; QoL&#58; <span class="elsevierStyleItalic">quality of life</span>&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Duraci&#243;n del tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alvarez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">31</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EVA 0&#8211;10&#41;&#58; 3&#44;1&#8211;0&#44;7Prurito &#40;EVA 0&#8211;10&#41;&#58; 2&#44;0&#8211;0&#44;4Respuesta cl&#237;nica completa&#58; 71&#44;7&#37;Respuesta ECO completa&#58; 43&#44;5&#37;Eritema &#40;0&#8211;4&#41;&#58; 2&#44;0&#8211;0&#44;4Edema &#40;0&#8211;4&#41;&#58; 2&#44;1&#8211;0&#44;5Supuraci&#243;n &#40;0&#8211;4&#41;&#58; 1&#44;6&#8211;0&#44;4Di&#225;metro de las f&#237;stulas &#40;mm&#41;&#58; 2&#44;7&#8211;1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atrofia cut&#225;nea ECO&#58; 37&#44;0&#37;Cambios de pigmentaci&#243;n&#58; 54&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fajgenbaum et al&#46; <a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">29</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL o 10<span class="elsevierStyleHsp" style=""></span>mg&#47;mL IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Placebo &#40;suero salino&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensayo cl&#237;nico aleatorizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reducci&#243;n del dolor &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;<span class="elsevierStyleHsp" style=""></span>Suero salino&#59; 2&#44;6 &#40;2&#44;4&#8211;3&#44;9&#41;<span class="elsevierStyleHsp" style=""></span>ACT 10&#58; 2&#44;0 &#40;0&#44;7&#8211;3&#44;4&#41;<span class="elsevierStyleHsp" style=""></span>ACT 40&#58; 2&#44;3 &#40;1&#44;1&#8211;3&#44;4&#41;PGA &#40;d&#237;as hasta la resoluci&#243;n&#44; media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;<span class="elsevierStyleHsp" style=""></span>Suero salino&#58; 9&#44;4 &#40;6&#44;9&#8211;11&#44;8&#41;<span class="elsevierStyleHsp" style=""></span>ACT 10&#58; 10&#44;8 &#40;8&#44;2&#8211;13&#44;4&#41;<span class="elsevierStyleHsp" style=""></span>ACT 40&#58; 10&#44;9 &#40;9&#8211;3-12&#44;4&#41;Satisfacci&#243;n del tratamiento &#40;0&#8211;4&#41; &#40;media&#41;<span class="elsevierStyleHsp" style=""></span>Suero salino&#58; 2&#44;4<span class="elsevierStyleHsp" style=""></span>ACT 10&#58; 2&#44;6<span class="elsevierStyleHsp" style=""></span>ACT 40&#58; 2&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Garcia-Martinez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">32</span></a> 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL o BMS 3<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EAS 0&#8211;10&#41; &#40;media&#41;&#58; 4&#44;6&#8211;0&#44;6PGA&#58;<span class="elsevierStyleHsp" style=""></span>Respuesta completa&#58; 70&#44;4&#37;<span class="elsevierStyleHsp" style=""></span>Respuesta parcial&#58; 25&#44;2&#37;<span class="elsevierStyleHsp" style=""></span>No respuesta&#58; 4&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atrofia cut&#225;nea ECO&#58; 1&#44;0&#37;Hipopigmentaci&#243;n&#58; 1&#44;0&#37;Empeoramiento&#58; 2&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Garelik et al&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">33</span></a> 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL or ACT 20<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mejor&#237;a del QoL &#40;0<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;4&#41;<span class="elsevierStyleHsp" style=""></span>Significativo&#58; 40&#44;7&#37;<span class="elsevierStyleHsp" style=""></span>Moderado&#58; 16&#44;7&#37;<span class="elsevierStyleHsp" style=""></span>M&#237;nimo&#58; 18&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>No mejor&#237;a&#58; 22&#44;2&#37;<span class="elsevierStyleHsp" style=""></span>Empeoramiento&#58; 1&#44;9&#37;Evaluaci&#243;n de la mejor&#237;a global del paciente &#40;0&#8211;4&#41;<span class="elsevierStyleHsp" style=""></span>Significativo&#58; 42&#44;6&#37;<span class="elsevierStyleHsp" style=""></span>Moderado&#58; 31&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>M&#237;nimo&#58; 18&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>Sin mejor&#237;a&#58; 7&#44;4&#37;<span class="elsevierStyleHsp" style=""></span>Satisfacci&#243;n del tratamiento &#40;0&#8211;3&#41;Muy satisfecho&#58; 36&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>Satisfecho&#58; 40&#44;0&#37;<span class="elsevierStyleHsp" style=""></span>Neutro&#58; 15&#44;4&#37;<span class="elsevierStyleHsp" style=""></span>Insatisfecho&#58; 7&#44;7&#37;Disminuci&#243;n del dolor &#40;0&#8211;4&#41; &#40;&#37; de los pacientes&#41;<span class="elsevierStyleHsp" style=""></span>Significativa&#58; 20<span class="elsevierStyleHsp" style=""></span>Moderada&#58; 20<span class="elsevierStyleHsp" style=""></span>M&#237;nima&#58; 7<span class="elsevierStyleHsp" style=""></span>Ninguna&#58; 6<span class="elsevierStyleHsp" style=""></span>Peor&#58; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Iannone et al&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">34</span></a> 2021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 20<span class="elsevierStyleHsp" style=""></span>mg&#47;mL o ACT 10<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 mes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI<span class="elsevierStyleHsp" style=""></span>ACT 10 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 8&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;0&#8211;7&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;2 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004<span class="elsevierStyleHsp" style=""></span>ACT 20 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 9&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;8&#8211;6&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;2 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007Dolor &#40;EVA 0&#8211;10&#41;<span class="elsevierStyleHsp" style=""></span>ACT 10 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 4&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;2&#8211;2&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;6 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04<span class="elsevierStyleHsp" style=""></span>ACT 20 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 4&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9&#8211;3&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;114HSSI<span class="elsevierStyleHsp" style=""></span>ACT 10 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 2&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;0&#8211;1&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;0 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;014<span class="elsevierStyleHsp" style=""></span>ACT 20 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 2&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;8&#8211;1&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;7 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002ECO Sartorio<span class="elsevierStyleHsp" style=""></span>ACT 10 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 29&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;6&#8211;23&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;8 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;038<span class="elsevierStyleHsp" style=""></span>ACT 20 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 26&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;8&#8211;23&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#44;4 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001PGA<span class="elsevierStyleHsp" style=""></span>ACT 10 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1&#8211;1&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;3 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;021<span class="elsevierStyleHsp" style=""></span>ACT 20 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 2&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9&#8211;0&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;7 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Riis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">36</span></a> 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 10<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EVA 0&#8211;10&#41; &#40;media&#41;&#58; 5&#44;5&#8211;1&#44;1Eritema &#40;0&#8211;4&#41;&#58; 2&#8211;1Edema &#40;0&#8211;4&#41;&#58; 2&#8211;1Supuraci&#243;n &#40;0&#8211;4&#41;&#58; 2&#8211;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Salvador-Rodr&#237;guez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">30</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluaci&#243;n global del paciente &#40;PRS&#41; &#40;&#37; de reducci&#243;n&#41;&#58; 1&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;4Dolor &#40;EVA 0&#8211;10&#41;&#58; 1&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1IHS4 &#40;&#37; de reducci&#243;n&#41;&#58; 2&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;6 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001Respuesta completa PGA<span class="elsevierStyleHsp" style=""></span>N&#243;dulos&#58; 81&#37;<span class="elsevierStyleHsp" style=""></span>Abscesos&#58; 72&#37;<span class="elsevierStyleHsp" style=""></span>F&#237;stulas de drenaje&#58; 53&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descompensaci&#243;n gluc&#233;mica 1&#47;77Agresividad 1&#47;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sechi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">35</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT 20<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#8211;34 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PGA<span class="elsevierStyleHsp" style=""></span>Respuesta&#58; 69&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atrofia cut&#225;nea ECO&#58; 30&#44;8Hipopigmentaci&#243;n&#58; 7&#44;7&#37;Ambos&#58; 15&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; DLQI&#58; <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#59; EVA&#58; escala visual anal&#243;gica&#59; ECO&#58; ecograf&#237;a&#59; HiSCR&#58; <span class="elsevierStyleItalic">hidradenitis suppurativa clinical response</span>&#59; IHS4&#58; <span class="elsevierStyleItalic">International Hidradenitis Suppurativa Severity Score System</span>&#59; PGA&#58; <span class="elsevierStyleItalic">physician global assessment</span>&#59; TSQM&#58; <span class="elsevierStyleItalic">treatment questionnaire for medication</span>&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Duraci&#243;n del tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados princiaples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Boer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">38</span></a> 2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EVA 0&#8211;10&#41; &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 7&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5&#8211;2&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descamaci&#243;n&#58; 100&#37;Decoloraci&#243;n marr&#243;n&#58; 33&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cordero-Ramos et al&#46; <a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">39</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI&#58; 16&#44;5 &#40;14&#44;0&#8211;19&#44;0&#41; &#8211; 4&#44;0 &#40;2&#44;4&#8211;5&#44;7&#41; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001Dolor &#40;EVA 0&#8211;10&#41;&#58; 4&#44;7 &#40;3&#44;5&#8211;5&#44;8&#41;&#8211;1&#44;5 &#40;1&#44;0&#8211;2&#44;0&#41; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001IHS4&#58; 4&#44;5 &#40;3&#44;0&#8211;6&#44;1&#41; &#8211; 2&#44;0 &#40;0&#44;9&#8211;1&#44;2&#41; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descamaci&#243;n&#58; 32&#44;1&#37;Prurito&#58; 21&#44;4&#37;Escozor&#58; 14&#44;3&#37;Eritema&#58; 10&#44;7&#37;Hiperpigmentaci&#243;n&#58; 3&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Docampo-Sim&#243;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">37</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TSQM v1&#44;4&#58; 317&#44;5&#47;400 puntos<span class="elsevierStyleHsp" style=""></span>Efectividad&#58; 71&#44;0&#47;100 puntos<span class="elsevierStyleHsp" style=""></span>Efectos secundarios&#58; 93&#44;6&#47;100 puntos<span class="elsevierStyleHsp" style=""></span>Inconvenientes&#58; 79&#44;3&#47;100 puntos<span class="elsevierStyleHsp" style=""></span>Satisfacci&#243;n global&#58; 73&#44;2&#47;100 puntos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cualquier EA&#58; 29&#44;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molinelli 2020<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">40</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&#58; 16&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;8&#8211;1&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1Dolor &#40;EVA 0&#8211;10&#41; &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 6&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8&#8211;0&#44;4&#8211;0&#44;7HiSCR&#58; 85&#44;2&#37; &#40;52&#47;61 pacientes&#41;IHS4 &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 3&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;4&#8211;3&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Irritaci&#243;n&#58; 34&#44;4&#37;Descamaci&#243;n&#58; 63&#44;9&#37;Decoloraci&#243;n marr&#243;n&#58; 41&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molinelli et al&#46; <a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">42</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clindamicina t&#243;pica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Estudio de cohortes retrospectivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;<span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 17&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;4&#8211;11&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01<span class="elsevierStyleHsp" style=""></span>Resorcinol&#58; 16&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;8&#8211;1&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001Dolor &#40;EVA&#58; 0&#8211;10&#41; &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;<span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 7&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9&#8211;5&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;3 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05<span class="elsevierStyleHsp" style=""></span>Resorcinol&#58; 6&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8&#8211;0&#44;4&#8211;0&#44;7 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001HiSCR<span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 52&#44;1&#37; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01<span class="elsevierStyleHsp" style=""></span>Resorcinol&#58; 85&#44;2&#37; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clindamicina<span class="elsevierStyleHsp" style=""></span>Irritaci&#243;n leve 15&#37;Resorcinol<span class="elsevierStyleHsp" style=""></span>Irritaci&#243;n leve&#47;moderada&#58; 43&#37;<span class="elsevierStyleHsp" style=""></span>Descamaci&#243;n&#58; 57&#37;<span class="elsevierStyleHsp" style=""></span>Decoloraci&#243;n marr&#243;n&#58; 41&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pascual et al&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">41</span></a> 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resorcinol 15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor &#40;EVA&#58; 0&#8211;10&#41; &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;2&#8211;0&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;4 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001PGA<span class="elsevierStyleHsp" style=""></span>Resoluci&#243;n clinica&#58; 84&#44;4&#37;<span class="elsevierStyleHsp" style=""></span>Resoluci&#243;n ECO&#58; 65&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descamaci&#243;n&#58; 50&#37;Decoloraci&#243;n marr&#243;n&#58; 15&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; DLQI&#58; <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#59; EVA&#58; escala visual anal&#243;gica&#59; HiSCR&#58; <span class="elsevierStyleItalic">hidradenitis suppurativa clinical response</span>&#59; PGA&#58; <span class="elsevierStyleItalic">physician global assessment</span>&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Durac&#243;n del tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clemmensen<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">43</span></a> 1983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clindamicina t&#243;pica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensayo cl&#237;nico aleatorizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluaci&#243;n global del paciente &#40;&#8722;2 a 2&#41;<span class="elsevierStyleHsp" style=""></span>Gran mejor&#237;a o mejor&#237;a&#58;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 8&#47;13 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placebo&#58; 4&#47;14<span class="elsevierStyleHsp" style=""></span>N&#250;mero de abscesos<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 1&#44;15&#8211;0&#44;46 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placebo&#58; 1&#44;14&#8211;1&#44;50<span class="elsevierStyleHsp" style=""></span>N&#250;mero de n&#243;dulos<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 1&#44;43&#8211;0&#44;14 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;02<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placebo&#58; 1&#44;46&#8211;0&#44;77<span class="elsevierStyleHsp" style=""></span>N&#250;mero de p&#250;stulas<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Clindamicina&#58; 8&#44;9&#8211;0&#44;38 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Placebo&#58; 9&#44;9&#8211;18&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Irritaci&#243;n local por clindamicina3&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jemec et al&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">44</span></a> 1998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clindamicina t&#243;pica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tetraciclina oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensayo cl&#237;nico aleatorizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluaci&#243;n global del paciente &#40;EVA 0&#8211;100&#41;&#58;<span class="elsevierStyleHsp" style=""></span>Tetraciclina oral&#58; 35&#44;9&#8211;12&#44;0<span class="elsevierStyleHsp" style=""></span>Clindamicina t&#243;pica&#58; 48&#44;0&#8211;40&#44;0Dolor &#40;EVA 0&#8211;100&#41;<span class="elsevierStyleHsp" style=""></span>Tetraciclina oral&#58; 52&#44;0&#8211;38&#44;0<span class="elsevierStyleHsp" style=""></span>Clindamicina t&#243;pica&#58; 51&#44;0&#8211;37&#44;0N&#250;mero de lesiones &#40;n&#243;dulos&#41;<span class="elsevierStyleHsp" style=""></span>Tetraciclina oral&#58; 2&#44;5&#8211;1&#44;8<span class="elsevierStyleHsp" style=""></span>Clindamicina t&#243;pica&#58; 2&#44;9&#8211;1&#44;5N&#250;mero de lesiones &#40;abscesos&#41;&#58;<span class="elsevierStyleHsp" style=""></span>Tetraciclina oral&#58; 1&#44;9&#8211;1&#44;0<span class="elsevierStyleHsp" style=""></span>Clindamicina t&#243;pica&#58; 0&#44;8&#8211;0&#44;3PGA &#40;EVA 0&#8211;100&#41;&#58;<span class="elsevierStyleHsp" style=""></span>Tetraciclina oral&#58; 31&#44;6&#8211;18&#44;0<span class="elsevierStyleHsp" style=""></span>Clindamicina t&#243;pica&#58; 25&#44;7&#8211;10&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clindamicina t&#243;pica 13&#44;6&#37;No especificadoTetraciclina oral 20&#44;8&#37;No especificado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">ACT&#58; acet&#243;nido de triamcinolona&#59; BTX&#58; toxina botul&#237;nica&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; DLQI&#58; <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#59; EVA&#58; escala visual anal&#243;gica&#59; IL&#58; intralesional&#59; NP&#58; no proporcionado&#59; ns&#58; no significativo&#58; PGA&#58; <span class="elsevierStyleItalic">physician global assessment</span>&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Duraci&#243;n del tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fania et al&#46; <a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">46</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACT - IL 40<span class="elsevierStyleHsp" style=""></span>mg&#47;mL<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>lincomicina IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Skindex-17 &#40;s&#237;ntomas&#41;&#58; 60&#44;3&#8211;49&#44;6 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;035Skindex-17 &#40;psicosocial&#41;&#58; 50&#44;9&#8211;43&#44;7 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;137Evaluaci&#243;n global del paciente &#40;mejor&#237;a reportada por el paciente&#41;<span class="elsevierStyleHsp" style=""></span>Marcada 40&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>Moderada 40&#44;5&#37;<span class="elsevierStyleHsp" style=""></span>Leve 10&#44;8&#37;<span class="elsevierStyleHsp" style=""></span>Sin cambios 2&#44;7&#37;<span class="elsevierStyleHsp" style=""></span>Leve empeoramiento 5&#44;4&#37;Dolor &#40;EVA 0&#8211;10&#41;<span class="elsevierStyleHsp" style=""></span>4&#44;6 &#40;3&#44;2&#8211;5&#44;9&#41; &#8211; 1&#44;5 &#40;0&#44;5&#8211;7&#44;6&#41; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;027PGA &#40;0&#8211;20&#41;&#58; 12&#44;2 &#40;11&#44;6&#8211;12&#44;9&#41;&#8211;6&#44;8 &#40;6&#44;0&#8211;7&#44;6&#41; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Empeoramineto de la acantosis <span class="elsevierStyleItalic">nigricans</span> &#40;1 paciente&#41;Retraso menstrual &#40;1 paciente&#41;Fiebre &#40;1 paciente&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fisher et al&#46; <a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">47</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ichthammol t&#243;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 d&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI&#58; 19&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;4 &#8211;NPPGA&#44; n &#40;&#37;&#41;&#58;<span class="elsevierStyleHsp" style=""></span>Respuesta completa&#58; 45&#37;<span class="elsevierStyleHsp" style=""></span>Respuesta parcial&#58; 45&#37;<span class="elsevierStyleHsp" style=""></span>Sin respuesta&#58; 10&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grimstad et al&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">45</span></a> 2020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Toxina botul&#237;nica B IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensayo cl&#237;nico aleatorizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI<span class="elsevierStyleHsp" style=""></span>Placebo<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 10&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;2&#8211;6&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;4 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07<span class="elsevierStyleHsp" style=""></span>BTX<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 16&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;4&#8211;11&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01Evaluaci&#243;n global de los pacientes &#40;EVA 0&#8211;10&#41;<span class="elsevierStyleHsp" style=""></span>Placebo<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 5&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7&#8211;4&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5 p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;11<span class="elsevierStyleHsp" style=""></span>BTX<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 7&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;4&#8211;5&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;2 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05Dolor &#40;EVA 0&#8211;10&#41;<span class="elsevierStyleHsp" style=""></span>Placebo<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 6&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;3&#8211;6&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;0 ns&#44;<span class="elsevierStyleHsp" style=""></span>BTX<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 8&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;1&#8211;5&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;3 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05N&#250;mero de lesiones<span class="elsevierStyleHsp" style=""></span>Placebo<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 8&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;5&#8211;3&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>&#44;56 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05<span class="elsevierStyleHsp" style=""></span>BTX<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>BTX&#58; 8&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;6&#8211;2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9 p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Un paciente del grupo placebo requiri&#243; una incisi&#243;n y drenaje de un n&#243;dulo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Porter et al&#46; <a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> 2022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suero salino hipert&#243;nico IL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 9&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;8&#8211;6&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6Evaluaci&#243;n global de los pacientes&#58; mejor&#237;a p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001Dolor&#58; mejor&#237;a p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hematoma &#40;1 paciente&#41; requiri&#243; drenaje&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Skroza et al&#46; <a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">48</span></a> 2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trietilcitrato t&#243;pico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sartorius &#40;media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&#41;&#58; 30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;0&#8211;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                      "doi" => "10.1111/j.1468-3083.2009.03356.x"
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                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
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                        "volumen" => "23"
                        "paginaInicial" => "985"
                        "paginaFinal" => "998"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19682181"
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              "etiqueta" => "3"
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                    0 => array:2 [
                      "titulo" => "Prevalence and factors associated with hidradenitis suppurativa&#58; results from two case&#8211;control studies"
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                            3 => "C&#46; Viallette"
                            4 => "G&#46; Gabison"
                            5 => "F&#46; Pouget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "596"
                        "paginaFinal" => "601"
                      ]
                    ]
                  ]
                ]
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                  "contribucion" => array:1 [
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                            2 => "S&#46; Esmann"
                            3 => "J&#46; Boer"
                            4 => "E&#46;P&#46; Prens"
                            5 => "G&#46;B&#46; Jemec"
                          ]
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                        "fecha" => "2014"
                        "volumen" => "171"
                        "paginaInicial" => "819"
                        "paginaFinal" => "824"
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                ]
              ]
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                      "titulo" => "Hidradenitis suppurativa and inflammatory bowel disease&#58; are they associated&#63; Results of a pilot study"
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                          "autores" => array:4 [
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                            2 => "E&#46;F&#46; Florencia"
                            3 => "E&#46;P&#46; Prens"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "The prevalence of hidradenitis suppurativa and its potential precursor lesions"
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                    ]
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "numero" => "Pt 1"
                        "paginaInicial" => "191"
                        "paginaFinal" => "194"
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                            0 => "A&#46; Kurek"
                            1 => "E&#46;M&#46; Peters"
                            2 => "A&#46; Chanwangpong"
                            3 => "R&#46; Sabat"
                            4 => "W&#46; Sterry"
                            5 => "S&#46; Schneider-Burrus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
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                        "paginaInicial" => "422"
                        "paginaFinal" => "428"
                      ]
                    ]
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                ]
              ]
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                      "titulo" => "European S1 guideline for the treatment of hidradenitis suppurativa&#47;acne inversa"
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                          "etal" => true
                          "autores" => array:6 [
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                            2 => "L&#46; Emtestam"
                            3 => "R&#46;E&#46; Hunger"
                            4 => "D&#46; Ioannides"
                            5 => "I&#46; Juh&#225;sz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.12966"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "619"
                        "paginaFinal" => "644"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25640693"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0415"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Shavit"
                            1 => "J&#46; Dreiher"
                            2 => "T&#46; Freud"
                            3 => "S&#46; Halevy"
                            4 => "S&#46; Vinker"
                            5 => "A&#46;D&#46; Cohen"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.12567"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "371"
                        "paginaFinal" => "376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24909646"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0420"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interventions for hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Ingram"
                            1 => "P&#46;N&#46; Woo"
                            2 => "S&#46;L&#46; Chua"
                            3 => "A&#46;D&#46; Ormerod"
                            4 => "N&#46; Desai"
                            5 => "A&#46;C&#46; Kai"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/14651858.CD010081.pub2"
                      "Revista" => array:5 [
                        "tituloSerie" => "Cochrane Database Syst Rev&#46;"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "CD010081"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26443004"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0425"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "North American clinical management guidelines for hidradenitis suppurativa&#58; a publication from the United States and Canadian Hidradenitis Suppurativa Foundations&#46; Part II&#46; Topical&#44; intralesional&#44; and systemic medical management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "C&#46; Sayed"
                            2 => "A&#46; Alavi"
                            3 => "R&#46; Alhusayen"
                            4 => "A&#46; Brassard"
                            5 => "C&#46; Burkhart"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.02.068"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2019"
                        "volumen" => "81"
                        "paginaInicial" => "91"
                        "paginaFinal" => "101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30872149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0430"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa&#47;acne inversa&#58; a practical framework for treatment optimization &#8211; systematic review and recommendations from the HS ALLIANCE working group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Zouboulis"
                            1 => "F&#46;G&#46; Bechara"
                            2 => "J&#46;L&#46; Dickinson-Blok"
                            3 => "W&#46; Gulliver"
                            4 => "B&#46; Horv&#225;th"
                            5 => "R&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Eur Acad Dermatol&#46;"
                        "fecha" => "2019"
                        "volumen" => "33"
                        "paginaInicial" => "19"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0435"
              "etiqueta" => "13"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PRISMA 2020 explanation and elaboration&#58; updated guidance and exemplars for reporting systematic reviews"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Page"
                            1 => "D&#46; Moher"
                            2 => "P&#46;M&#46; Bossuyt"
                            3 => "I&#46; Boutron"
                            4 => "T&#46;C&#46; Hoffmann"
                            5 => "C&#46;D&#46; Mulrow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMJ&#46;"
                        "fecha" => "2021"
                        "volumen" => "29"
                        "paginaInicial" => "n160"
                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "14"
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                0 => array:1 [
                  "referenciaCompleta" => "&#91;consultado 02 May 2023&#93; Disponible en&#58; <a target="_blank" href="https://www.crd.york.ac.uk/PROSPEROFILES/361114%20PROTOCOL20220918.pdf">https&#58;&#47;&#47;www&#46;crd&#46;york&#46;ac&#46;uk&#47;PROSPEROFILES&#47;361114 PROTOCOL20220918&#46;pdf</a>"
                ]
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              "identificador" => "bib0445"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa&#47;acne inversa&#58; criteria for diagnosis&#44; severity assessment&#44; classification and disease evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "V&#46; Del Marmol"
                            2 => "U&#46; Mrowietz"
                            3 => "E&#46;P&#46; Prens"
                            4 => "T&#46; Tzellos"
                            5 => "G&#46;B&#46; Jemec"
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                    0 => array:2 [
                      "doi" => "10.1159/000431175"
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                        "tituloSerie" => "Dermatology&#46;"
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                        "paginaInicial" => "184"
                        "paginaFinal" => "190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26139027"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "identificador" => "bib0450"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A core domain set for hidradenitis suppurativa trial outcomes&#58; an international Delphi process"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Thorlacius"
                            1 => "J&#46;R&#46; Ingram"
                            2 => "B&#46; Villumsen"
                            3 => "S&#46; Esmann"
                            4 => "J&#46;S&#46; Kirby"
                            5 => "A&#46;B&#46; Gottlieb"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.16672"
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                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "179"
                        "paginaInicial" => "642"
                        "paginaFinal" => "650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29654696"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0455"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "RoB 2&#58; a revised tool for assessing risk of bias in randomised trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46;C&#46; Sterne"
                            1 => "J&#46; Savovic"
                            2 => "M&#46;J&#46; Page"
                            3 => "R&#46;G&#46; Elbers"
                            4 => "N&#46;S&#46; Blencowe"
                            5 => "I&#46; Boutron"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.l4898"
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                        "tituloSerie" => "BMJ&#46;"
                        "fecha" => "2019"
                        "volumen" => "366"
                        "paginaInicial" => "l4898"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31462531"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            17 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Newcastle-Ottawa Scale &#40;NOS&#41; for assessing the quality of non-randomised studies in meta-analyses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Wells"
                            1 => "B&#46;J&#46; Shea"
                            2 => "D&#46; O&#8217;Connell"
                            3 => "J&#46; Peterson"
                            4 => "V&#46; Welch"
                            5 => "M&#46; Losos"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
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              "identificador" => "bib0465"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy with intralesional methylene blue and a 635<span class="elsevierStyleHsp" style=""></span>nm light-emitting diode lamp in hidradenitis suppurativa&#58; a retrospective follow-up study in 7 patients and a review of the literature"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "J&#46; Roman&#237;"
                            2 => "Y&#46; Gilaberte"
                            3 => "A&#46; Garc&#237;a-Malinis"
                            4 => "M&#46; Ribera-Pibernat"
                            5 => "J&#46; Luelmo"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1039/c6pp00082g"
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                        "tituloSerie" => "Photochem Photobiol Sci&#46;"
                        "fecha" => "2016"
                        "volumen" => "15"
                        "paginaInicial" => "1020"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27417568"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            19 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasound-guided photodynamic therapy with intralesional methylene blue and a 635<span class="elsevierStyleHsp" style=""></span>nm light-emitting diode lamp in hidradenitis suppurativa&#58; a retrospective study of 41 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Gamissans"
                            1 => "N&#46; Riera-Mart&#237;"
                            2 => "J&#46; Roman&#237;"
                            3 => "Y&#46; Gilaberte"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Photodermatol Photoimmunol Photomed&#46;"
                        "fecha" => "2022"
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                        "paginaInicial" => "12"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34157160"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0475"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional photodynamic therapy in hidradenitis suppurativa&#58; getting closer to the target"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Garcias-Ladaria"
                            1 => "O&#46; Corral-Maga&#241;a"
                            2 => "L&#46;J&#46; Del Pozo"
                            3 => "A&#46; Mart&#237;n-Santiago"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pdpdt.2021.102339"
                      "Revista" => array:5 [
                        "tituloSerie" => "Photodiagnosis Photodyn Ther&#46;"
                        "fecha" => "2021"
                        "volumen" => "34"
                        "paginaInicial" => "102339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33992813"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            21 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of hidradenitis suppurativa with intralesional photodynamic therapy with 5-aminolevulinic acid and 630<span class="elsevierStyleHsp" style=""></span>nm laser beam"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "N&#46; Eiris-Salvado"
                            2 => "M&#46;A&#46; Rodr&#237;guez-Prieto"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2016.12.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci&#46;"
                        "fecha" => "2017"
                        "volumen" => "85"
                        "paginaInicial" => "241"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28034606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0485"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of hidradenitis suppurativa with intralesional photodynamic therapy using a laser diode attached to an optical cable&#58; a promising new approach"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "M&#46;D&#46; Blanco-Su&#225;rez"
                            3 => "C&#46; Rodriguez-Lage"
                            4 => "I&#46; Garc&#237;a-Doval"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.13385"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "172"
                        "paginaInicial" => "1136"
                        "paginaFinal" => "1139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25196140"
                            "web" => "Medline"
                          ]
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                ]
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            23 => array:3 [
              "identificador" => "bib0490"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel&#58; a single-blind&#44; randomized&#44; comparative study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                            1 => "A&#46;A&#46; Tawfik"
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                  "host" => array:1 [
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                        "tituloSerie" => "Clin Exp Dermatol&#46;"
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                        "volumen" => "40"
                        "paginaInicial" => "116"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25262788"
                            "web" => "Medline"
                          ]
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                  ]
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              "identificador" => "bib0495"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness of 5-aminolevulinic acid photodynamic therapy in the treatment of hidradenitis suppurativa&#58; a report of 5 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Andino-Navarrete"
                            1 => "A&#46; Hasson-Nisis"
                            2 => "J&#46; Parra Cares"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2013.10.016"
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                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
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                        "volumen" => "105"
                        "paginaInicial" => "614"
                        "paginaFinal" => "617"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24472519"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
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              "identificador" => "bib0500"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of recalcitrant hidradenitis suppurativa with photodynamic therapy&#58; report of five cases"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "F&#46; Maliamani"
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                        ]
                      ]
                    ]
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                        "tituloSerie" => "Clin Exp Dermatol&#46;"
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                        "paginaInicial" => "e235"
                        "paginaFinal" => "e236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19508581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of hidradenitis suppurativa by photodynamic therapy with aminolevulinic acid&#58; preliminary results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;S&#46; Schweiger"
                            1 => "C&#46;C&#46; Riddle"
                            2 => "D&#46;J&#46; Aires"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "10"
                        "paginaInicial" => "381"
                        "paginaFinal" => "386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21455548"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            27 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate &#40;MAL-PDT&#41; in 20 Italian dermatology departments&#46; Part 1&#46; Inflammatory and aesthetic indications"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Italian Group For Photodynamic Therapy"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;G&#46; Calzavara-Pinton"
                            1 => "M&#46;T&#46; Rossi"
                            2 => "E&#46; Aronson"
                            3 => "R&#46; Sala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1039/c2pp25124h"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photochem Photobiol Sci&#46;"
                        "fecha" => "2013"
                        "volumen" => "12"
                        "paginaInicial" => "148"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22949035"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            28 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional triamcinolone may not be beneficial for treating acute hidradenitis suppurativa lesions&#58; a double-blind&#44; randomized&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Fajgenbaum"
                            1 => "L&#46; Crouse"
                            2 => "L&#46; Dong"
                            3 => "D&#46; Zeng"
                            4 => "C&#46; Sayed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DSS.0000000000002112"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2020"
                        "volumen" => "46"
                        "paginaInicial" => "685"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31490300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasound-assisted intralesional corticosteroid infiltrations for patients with hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Salvador-Rodr&#237;guez"
                            1 => "S&#46; Arias-Santiago"
                            2 => "A&#46; Molina-Leyva"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41598-020-70176-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "Sci Rep&#46;"
                        "fecha" => "2020"
                        "volumen" => "10"
                        "paginaInicial" => "13363"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32770058"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional triamcinolone for fistulous tracts in hidradenitis suppurativa&#58; an uncontrolled prospective trial with clinical and ultrasonographic follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Alvarez"
                            1 => "F&#46;J&#46; Garc&#237;a-Mart&#237;nez"
                            2 => "I&#46; Poveda"
                            3 => "J&#46;C&#46; Pascual"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000499934"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2020"
                        "volumen" => "236"
                        "paginaInicial" => "46"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31141811"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional corticosteroid injection for the treatment of hidradenitis suppurativa&#58; a multicenter retrospective clinical study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Garcia-Martinez"
                            1 => "E&#46; Vilarrasa Rull"
                            2 => "L&#46; Salgado-Boquete"
                            3 => "A&#46; Martorell"
                            4 => "J&#46;C&#46; Pascual"
                            5 => "&#193;&#46; Hern&#225;ndez-Mart&#237;n"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
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                        "volumen" => "32"
                        "paginaInicial" => "286"
                        "paginaFinal" => "290"
                      ]
                    ]
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            32 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of high-dose intralesional triamcinolone for hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Garelik"
                            1 => "K&#46; Babbush"
                            2 => "M&#46; Ghias"
                            3 => "S&#46;R&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.15124"
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                        "tituloSerie" => "Int J Dermatol&#46;"
                        "fecha" => "2021"
                        "volumen" => "60"
                        "paginaInicial" => "217"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32808305"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            33 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasound-guided injection of intralesional steroids in acute hidradenitis suppurativa lesions&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Iannone"
                            1 => "A&#46; Janowska"
                            2 => "T&#46; Oranges"
                            3 => "L&#46; Balderi"
                            4 => "B&#46;B&#46; Benincasa"
                            5 => "S&#46; Vitali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.15068"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2021"
                        "volumen" => "34"
                        "paginaInicial" => "e15068"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34297465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            34 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional steroid injections to target sinus tract fibrosis in hidradenitis suppurativa&#58; results from an ultrasound-based retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Sechi"
                            1 => "A&#46; Patrizi"
                            2 => "B&#46; Raone"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.15710"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2022"
                        "volumen" => "35"
                        "paginaInicial" => "e15710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35811390"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional triamcinolone for flares of hidradenitis suppurativa &#40;HS&#41;&#58; a case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;T&#46; Riis"
                            1 => "J&#46; Boer"
                            2 => "E&#46;P&#46; Prens"
                            3 => "D&#46;M&#46; Saunte"
                            4 => "I&#46;E&#46; Deckers"
                            5 => "L&#46; Emtestam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2016.06.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "75"
                        "paginaInicial" => "1151"
                        "paginaFinal" => "1155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27692735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical 15&#37; resorcinol is associated with high treatment satisfaction in patients with mild to moderate hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Docampo-Sim&#243;n"
                            1 => "I&#46; Beltra-Pico"
                            2 => "M&#46;J&#46; S&#225;nchez-Pujol"
                            3 => "R&#46; Fuster-Ruiz-de-Apodaca"
                            4 => "J&#46; Selva-Otaolaurruchi"
                            5 => "I&#46; Betlloch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000515450"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2022"
                        "volumen" => "238"
                        "paginaInicial" => "82"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33887735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resorcinol peels as a possible self-treatment of painful nodules in hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Boer"
                            1 => "G&#46;B&#46;E&#46; Jemec"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2009.03377.x"
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                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2010"
                        "volumen" => "35"
                        "paginaInicial" => "36"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and safety of topical 15&#37; resorcinol in the management of mild-to-moderate hidradenitis suppurativa&#58; a cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1346-8138.16275"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol&#46;"
                        "fecha" => "2022"
                        "volumen" => "49"
                        "paginaInicial" => "459"
                        "paginaFinal" => "462"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            39 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of topical resorcinol 15&#37; as long-term treatment of mild-to-moderate hidradenitis suppurativa&#58; a valid alternative to clindamycin in the panorama of antibiotic resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.19337"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2020"
                        "volumen" => "183"
                        "paginaInicial" => "1117"
                        "paginaFinal" => "1119"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical 15&#37; resorcinol for hidradenitis suppurativa&#58; an uncontrolled prospective trial with clinical and ultrasonographic follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2017.07.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "77"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            41 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of topical resorcinol 15&#37; versus topical clindamycin 1&#37; in the management of mild-to-moderate hidradenitis suppurativa&#58; a retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.15439"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2022"
                        "volumen" => "35"
                        "paginaInicial" => "e15439"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical treatment of hidradenitis suppurativa with clindamycin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4362.1983.tb02150.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol&#46;"
                        "fecha" => "1983"
                        "volumen" => "22"
                        "paginaInicial" => "325"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical clindamycin versus systemic tetracycline in the treatment of hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(98)70272-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "1998"
                        "volumen" => "39"
                        "paginaInicial" => "971"
                        "paginaFinal" => "974"
                        "link" => array:1 [
                          0 => array:2 [ …2]
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                      ]
                    ]
                  ]
                ]
              ]
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            44 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Botulinum toxin type B for hidradenitis suppurativa&#58; a randomised&#44; double-blind&#44; placebo-controlled pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Clin Dermatol&#46;"
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                        "volumen" => "21"
                        "paginaInicial" => "741"
                        "paginaFinal" => "748"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional ultrasound-guided combined treatment with triamcinolone plus lincomycin in hidradenitis suppurativa&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.13901"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e13901"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            46 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of topical ichthammol 10&#37; for hidradenitis suppurativa&#58; case series and systematic review of its use in dermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.13868"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e13868"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and tolerability of a lotion containing triethyl citrate&#44; ethyl linoleate&#44; and GT peptide-10 in the adjuvant treatment of hidradenitis suppurativa&#58; real-life data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.12599"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2018"
                        "volumen" => "31"
                        "paginaInicial" => "e12599"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An open-label&#44; prospective&#44; pilot study of hypertonic saline for hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DSS.0000000000003510"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2022"
                        "volumen" => "48"
                        "paginaInicial" => "954"
                        "paginaFinal" => "960"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two cases of hidradenitis suppurativa and botulinum toxin type a therapy&#58; a novel approach for a pathology that is still difficult to manage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.12841"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2019"
                        "volumen" => "32"
                        "paginaInicial" => "e12841"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulsed dye laser-mediated photodynamic therapy for acne inversa is not successful&#58; a pilot study on four cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "297"
                        "paginaFinal" => "298"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of intralesional photodynamic therapy for the treatment of hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2012.11.030"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2013"
                        "volumen" => "68"
                        "paginaInicial" => "873"
                        "paginaFinal" => "875"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ALA-iPDT for follicular occlusion tetrad concomitant with pachyonychia congenital type II and ankylosing spondylitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Photodiagnosis Photodyn Ther&#46;"
                        "fecha" => "2022"
                        "volumen" => "39"
                        "paginaInicial" => "102891"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bath psoralen plus ultraviolet A for hidradenitis suppurativa&#58; a review of 13 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2010.10193.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "164"
                        "paginaInicial" => "895"
                        "paginaFinal" => "896"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2005.06475.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2005"
                        "volumen" => "152"
                        "paginaInicial" => "803"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Innov Opt Health Sci&#46;"
                        "fecha" => "2016"
                        "volumen" => "9"
                        "paginaInicial" => "1640002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of scarring HS fistulas with intralesional steroids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.15708"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2022"
                        "volumen" => "35"
                        "paginaInicial" => "e15708"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional corticosteroid injections are less painful without local anesthetic&#58; a double-blind&#44; randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546634.2021.1906842"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2022"
                        "volumen" => "33"
                        "paginaInicial" => "2034"
                        "paginaFinal" => "2037"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New magistral formulation for the topical treatment of suppurative hidradenitis with clindamycin-containing solution according to the S1-guideline recommendation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Dtsch Dermatol Ges&#46;"
                        "fecha" => "2016"
                        "volumen" => "14"
                        "paginaInicial" => "650"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Crystallized phenol for sacral hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546634.2019.1638878"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2021"
                        "volumen" => "32"
                        "paginaInicial" => "193"
                        "paginaFinal" => "196"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combination of oral zinc gluconate and topical triclosan&#58; an anti-inflammatory treatment modality for initial hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdermsci.2016.08.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Sci&#46;"
                        "fecha" => "2016"
                        "volumen" => "84"
                        "paginaInicial" => "197"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-surgical treatments for hidradenitis suppurativa&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Chir Plast Esthet&#46;"
                        "fecha" => "2017"
                        "volumen" => "62"
                        "paginaInicial" => "274"
                        "paginaFinal" => "294"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic review of light-based treatments for hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2020"
                        "volumen" => "111"
                        "paginaInicial" => "89"
                        "paginaFinal" => "106"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional treatments in hidradenitis suppurativa&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000524121"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2022"
                        "volumen" => "238"
                        "paginaInicial" => "1084"
                        "paginaFinal" => "1091"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical treatment of hidradenitis suppurativa with gentamicin sulfate&#58; a prospective randomized study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2007.34041.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "224"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Towards global consensus on core outcomes for hidradenitis suppurativa research&#58; an update from the HISTORIC consensus meetings I and II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "178"
                        "paginaInicial" => "715"
                        "paginaFinal" => "721"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A method for achieving consensus on rheumatoid arthritis outcome measures&#58; the OMERACT conference process"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol&#46;"
                        "fecha" => "1993"
                        "volumen" => "20"
                        "paginaInicial" => "548"
                        "paginaFinal" => "551"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The natural history of hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1468-3083.2000.00087.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2000"
                        "volumen" => "14"
                        "paginaInicial" => "389"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two phase 3 trials of adalimumab for hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1504370"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2016"
                        "volumen" => "375"
                        "paginaInicial" => "422"
                        "paginaFinal" => "434"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Apremilast for moderate hidradenitis suppurativa&#58; results of a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2018.06.046"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2019"
                        "volumen" => "80"
                        "paginaInicial" => "80"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0725"
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