Statistics

 array:24 [
  "pii" => "S0001731023009419"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2023.05.037"
  "estado" => "S300"
  "fechaPublicacion" => "2024-10-01"
  "aid" => "3750"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2023"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2024;115:917"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731024006458"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2024.08.003"
    "estado" => "S300"
    "fechaPublicacion" => "2024-10-01"
    "aid" => "4041"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2024;115:T917"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>"
      "titulo" => " Myeloid Sarcoma After &#171;Complete&#187; Remission of Acute Myeloid Leukemia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "T917"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Sarcoma mieloide tras remisi&#243;n &#171;completa&#187; de leucemia mieloide aguda"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 480
              "Ancho" => 650
              "Tamanyo" => 73944
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46;J&#46; Rodr&#237;guez-Cuadrado, G&#46; Silvestre-Egea, I&#46; Salg&#252;ero-Fern&#225;ndez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Rodr&#237;guez-Cuadrado"
            ]
            1 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Silvestre-Egea"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Salg&#252;ero-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024006458?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000009/v2_202410160548/S0001731024006458/v2_202410160548/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731024005222"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2023.02.043"
    "estado" => "S300"
    "fechaPublicacion" => "2024-10-01"
    "aid" => "3994"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:T915-T916"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "&#91;Art&#237;culo Traducido&#93; Masa cervical espont&#225;nea"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "T915"
          "paginaFinal" => "T916"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Spontaneous Cervical Mass"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 619
              "Ancho" => 900
              "Tamanyo" => 66235
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Morell&#243;-Vicente, A&#46; Espa&#241;a"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Morell&#243;-Vicente"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Espa&#241;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005222?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000009/v2_202410160548/S0001731024005222/v2_202410160548/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0001731024006458"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2024.08.003"
      "estado" => "S300"
      "fechaPublicacion" => "2024-10-01"
      "aid" => "4041"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2024;115:T917"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>"
        "titulo" => " Myeloid Sarcoma After &#171;Complete&#187; Remission of Acute Myeloid Leukemia"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "T917"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Sarcoma mieloide tras remisi&#243;n &#171;completa&#187; de leucemia mieloide aguda"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 480
                "Ancho" => 650
                "Tamanyo" => 73944
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46;J&#46; Rodr&#237;guez-Cuadrado, G&#46; Silvestre-Egea, I&#46; Salg&#252;ero-Fern&#225;ndez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Rodr&#237;guez-Cuadrado"
              ]
              1 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Silvestre-Egea"
              ]
              2 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Salg&#252;ero-Fern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024006458?idApp=UINPBA000044"
      "url" => "/00017310/0000011500000009/v2_202410160548/S0001731024006458/v2_202410160548/en/main.assets"
    ]
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Im&#225;genes en Dermatolog&#237;a</span>"
    "titulo" => "Sarcoma mieloide tras remisi&#243;n &#171;completa&#187; de leucemia mieloide aguda"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "917"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46;J&#46; Rodr&#237;guez-Cuadrado, G&#46; Silvestre-Egea, I&#46; Salg&#252;ero-Fern&#225;ndez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Rodr&#237;guez-Cuadrado"
            "email" => array:1 [
              0 => "franciscojose.rodriguezcuadrado@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Silvestre-Egea"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "Salg&#252;ero-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario Puerta de Hierro-Majadahonda&#44; Majadahonda&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario Puerta de Hierro-Majadahonda&#44; Majadahonda&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Myeloid Sarcoma After &#171;Complete&#187; Remission of Acute Myeloid Leukemia"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 480
            "Ancho" => 650
            "Tamanyo" => 73944
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Una mujer de 87 a&#241;os consult&#243; por una lesi&#243;n en la pierna izquierda de un a&#241;o de evoluci&#243;n&#46; La paciente ten&#237;a antecedentes de leucemia mieloide aguda con displasia trilineal y mutaci&#243;n BCR-ABL p1&#46;90&#44; que recibi&#243; quimioterapia hasta la remisi&#243;n completa 18 a&#241;os antes&#46; La exploraci&#243;n f&#237;sica revel&#243; una placa hiperquerat&#243;sica de un color marr&#243;n amarillento de 17<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>13<span class="elsevierStyleHsp" style=""></span>cm&#44; con unas proyecciones papilomatosas de aspecto velloso&#44; sobre una base eritemato-escamosa altamente infiltrada de 21<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>16&#44;5<span class="elsevierStyleHsp" style=""></span>cm de tama&#241;o &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">La biopsia de la lesi&#243;n mostr&#243; una infiltraci&#243;n d&#233;rmica de unas c&#233;lulas poligonales eosinof&#237;licas con un elevado n&#250;mero de mitosis&#44; n&#250;cleos pleom&#243;rficos y cariorrexis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2A y 2B</a>&#41;&#46; La inmunohistoqu&#237;mica fue positiva para el CD123 &#40;marcador de neoplasias hematol&#243;gicas malignas&#44; entre las que se incluyen neoplasia de c&#233;lulas dendr&#237;ticas plasmocitoides o leucemia mieloide aguda&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2C</a>&#41;&#44; as&#237; como para CD43&#44; CD45&#44; CD99&#44; CD117 y Bcl-2&#46; El estudio molecular mostr&#243; una relaci&#243;n FLT3 mutado&#47;no mutado de 0&#44;78&#59; una mutaci&#243;n patog&#233;nica en el ex&#243;n 12 de NPM1 y una expresi&#243;n del gen <span class="elsevierStyleItalic">WT1</span>&#44; sin identificarse mutaci&#243;n en BCR-ABL&#46; Con estos hallazgos se diagnostic&#243; de sarcoma mieloide relacionado con el proceso mieloproliferativo previo&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Se le administr&#243; radioterapia &#40;primera fase de 4<span class="elsevierStyleHsp" style=""></span>Gy fraccionados en 2 sesiones y segunda fase de 20<span class="elsevierStyleHsp" style=""></span>Gy fraccionados en 10 sesiones&#41; y quimioterapia &#40;8 ciclos de&#58; azacitidina 100<span class="elsevierStyleHsp" style=""></span>mg&#47;cada 24<span class="elsevierStyleHsp" style=""></span>h&#47;durante 7 d&#237;as por cada ciclo y midostaurina 50<span class="elsevierStyleHsp" style=""></span>mg&#47;cada 12<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Dos a&#241;os despu&#233;s del diagn&#243;stico permanec&#237;a con muy buena respuesta&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:2 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 480
            "Ancho" => 650
            "Tamanyo" => 73944
          ]
        ]
      ]
      1 => array:6 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 371
            "Ancho" => 1000
            "Tamanyo" => 181605
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00017310/0000011500000009/v2_202410160548/S0001731023009419/v2_202410160548/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "41021"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Im&#225;genes en Dermatolog&#237;a"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000009/v2_202410160548/S0001731023009419/v2_202410160548/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023009419?idApp=UINPBA000044"
]