Epidemiological and Clinical Features of 49 Hispanic Patients With Microcystic Adnexal Carcinoma

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Robles-Tenorio, V.M. Tarango Martínez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Robles-Tenorio" ] 1 => array:2 [ "nombre" => "V.M." "apellidos" => "Tarango Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022009292?idApp=UINPBA000044" "url" => "/00017310/0000011400000001/v1_202301060625/S0001731022009292/v1_202301060625/es/main.assets" ] ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Case and Research Letter" "titulo" => "Epidemiological and Clinical Features of 49 Hispanic Patients With Microcystic Adnexal Carcinoma" "tieneTextoCompleto" => true "saludo" => "To the Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "86" "paginaFinal" => "87" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Robles-Tenorio, V.M. Tarango Martínez" "autores" => array:2 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Robles-Tenorio" "email" => array:1 [ 0 => "arturo.rt@tec.mx" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "V.M." "apellidos" => "Tarango Martínez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Instituto Dermatologico de Jalisco “Dr. Jose Barba Rubio”, Zapopan, Jalisco, Mexico" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características epidemiológicas y clínicas de 49 pacientes hispanos con carcinoma anexial microquístico" ] ] "textoCompleto" => "Microcystic adnexal carcinoma (MAC) is a slow-growing, aggressive, cutaneous neoplasm with a tendency for perineural invasion and high recurrence rates.<a class="elsevierStyleCrossRef" href="#bib0050">1</a> There are less than 2000 reported cases worldwide, mostly in Caucasian individuals.<a class="elsevierStyleCrossRef" href="#bib0055">2</a> Although UV exposure, radiotherapy, and genetics may increase susceptibility, the exact pathogenesis remains uncertain. MAC presumably originates from pluripotent adnexal keratinocytes, as it shows elements of eccrine (keratinous cysts) and follicular (epithelial cords and ducts) differentiation.<a class="elsevierStyleCrossRef" href="#bib0050">1</a> It primarily affects the head and neck region; and may appear as an ill-defined, erythematous, skin-coloured, or yellowish plaque, nodule, or cyst. Due to the clinical and histopathological similarity with other skin or adnexal cancers, the disease may be particularly underappreciated in populations that have not been investigated. Therefore, our study aimed to describe the epidemiology and clinical presentation of MAC in Hispanic patients from a tertiary dermatology hospital in Mexico.We performed a retrospective analysis from 2010 to 2020 including complete patient records with a postoperative, histopathological diagnosis of MAC. A total of 49 cases were found, corresponding to 0.05% of the 83,364 samples reviewed in the dermatopathology department during the study period. The mean age was 67 years (median, 67 years; range, 24–101 years). Females (69.4%) were more commonly affected than males (30.6%). The average time-to-onset was 3 years (median, 2 years; range, 0.08–22 years). The head was involved in 91.8% of the cases, and the trunk in 8.2%. In the head region, most lesions occurred on the cheeks (40%), followed by the nose (28.9%), lips (11.11%), forehead (6.7%), eyelids (6.7%), scalp (4.4%), and ears (2.2%). The nodular aspect (71.4%) predominated over plaque (26.5%) and cyst (2%). Additional features such as a pearly border, ulceration, atrophy, and telangiectasias were described in 42.9%, 38.8%, 16.3% and 16.3% of the cases, respectively. The average lesion diameter was 1.6cm (median, 1cm; range, 0.3–10cm).Apart from the presence of a pearly border, our results are in line with the published literature. In a systematic review of 1968 patients, 92.8% of the subjects were Caucasian, and only 0.2% were Hispanics.<a class="elsevierStyleCrossRef" href="#bib0055">2</a> In total, mean age was 61.8 years, females represented 54.1% of the cases, and latency ranged from 1 to 11 years. Although the location and morphology were not quantitated, it includes other case series where head and neck involvement ranges from 60 to 100%.<a class="elsevierStyleCrossRefs" href="#bib0060">3–8</a> The mean diameter at diagnosis was 2.8cm.<a class="elsevierStyleCrossRef" href="#bib0055">2</a>Since MAC may be confused with other tumours, we also evaluated the clinical and histopathological diagnostic accuracy. Prior to the histopathology result, most were clinically diagnosed as basal cell carcinoma (BCC) (71.4%) and squamous cell carcinoma (SCC) (16.3%), followed by nevus (4.1%), lichen planus pilaris (2%), actinic keratosis (2%), trichodiscoma (2%), and adnexal tumour (2%). As expected, documentation of a pearly border was significantly associated with the presumptive clinical diagnosis (Fisher–Freeman–Halton p=0.041), from which BCC represented 90.5% of the cases (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The frequency of preoperative histopathological misdiagnosis was 20.4%, still below the 27–69% in other case series.<a class="elsevierStyleCrossRefs" href="#bib0060">3–5,9</a> In our sample, this included BCC (60%), basosquamous cancer (20%), and SCC (20%).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>The limitations of this study are inherent to its retrospective nature. We were not able to re-evaluate the clinical morphology of the lesions, since descriptions were obtained directly from the medical records. However, these were elaborated by qualified dermatologists from our institution. In the future, we hope to create a picture database to improve our descriptions, and also study various clinical–histopathological correlations with a focus on prognosis.In conclusion, this is the first study to characterise MAC in Hispanics, specifically of Mexican origin. Our data should complement previous epidemiological and clinical knowledge in a population that has been underrepresented in larger studies. Importantly, our results demonstrate that BCC was the main differential diagnosis of MAC, and that nearly half of our cases had a documented pearly border. Also, our analysis shows that MAC clinical suspicion remains low, with only 1 case (2%) being considered as an adnexal tumour. Moreover, the frequency of histopathological misdiagnosis suggests that initial sampling may be insufficient to establish the definitive diagnosis in more than a fifth of the cases. Therefore, increasing disease awareness is crucial to select an adequate biopsy technique that can improve the diagnostic accuracy of histopathology. Together, this may result in earlier, well-planned treatment strategies and better patient outcomes.Conflict of interestThe authors declare that they have no conflict of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Caption: A pearly border was documented in 42.86% of all MAC cases. Prior to the postoperative histopathology result, basal cell carcinoma was the most common presumptive clinical diagnosis. As expected, basal cell carcinoma was also the most frequent presumptive clinical diagnosis that had a documented pearly border (90.48%)." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="7" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Presumptive clinical diagnoses</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pearly border \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Basal cell carcinoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Squamous cell carcinoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lichen planus pilaris \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nevus \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Actinic keratoses \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Trichodiscoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adnexal tumour \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Totaln (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="9" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absent</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (57.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 (57.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="9" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="9" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Present</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (90.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (42.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Pearly border and presumptive clinical diagnoses." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma: a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Gordon" 1 => "C. Fischer" 2 => "A. Martin" 3 => "I. Rosman" 4 => "M. Council" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000001142" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2017" "volumen" => "43" "paginaInicial" => "1012" "paginaFinal" => "1016" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28654578" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0055" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence-based clinical practice guidelines for microcystic adnexal carcinoma: informed by a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Worley" 1 => "J.L. Owen" 2 => "C.A. Barker" 3 => "R. Behshad" 4 => "C. Bichakjian" 5 => "D. Bolotin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2019" "volumen" => "60611" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0060" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma: forty-eight cases, their treatment, and ther outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Chiller" 1 => "D. Passaro" 2 => "M. Scheuller" 3 => "M. Singer" 4 => "T. McCalmont" 5 => "R. Grekin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.136.11.1355" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2000" "volumen" => "136" "paginaInicial" => "1355" "paginaFinal" => "1359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11074698" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0065" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma: report of 13 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Snow" 1 => "D.D. Madjar" 2 => "S. Hardy" 3 => "M. Bentz" 4 => "M. Lucarelli" 5 => "R. Bechard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1524-4725.2001.00208.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2001" "volumen" => "27" "paginaInicial" => "401" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11298716" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0070" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma: review of 51 Japanese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Ohtsuka" 1 => "S. Nagamatsu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000057880" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2002" "volumen" => "204" "paginaInicial" => "190" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12037446" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0075" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surveillance, epidemiology, and end results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. Yu" 1 => "R.C. Blitzblau" 2 => "S.C. Patel" 3 => "R. Decker" 4 => "L. Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/COC.0b013e31819791eb" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Oncol" "fecha" => "2010" "volumen" => "33" "paginaInicial" => "125" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19675445" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0080" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcytic adnexal carcinoma: a population-based outcomes study involving 494 patients from the Surveillance. Epidemiology, and End Results (SEER) database (1973–2010)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Mahendraraj" 1 => "J. Sond" 2 => "R.S. Chamberlain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Am Coll Surg" "fecha" => "2014" "volumen" => "219" "paginaInicial" => "e93" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0085" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demographics and outcomes of microcystic adnexal carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.J. King" 1 => "S.N. Tolkachjov" 2 => "D.S. Winchester" 3 => "C. Baum" 4 => "J. Brewer" 5 => "C. Arpey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2018.03.010" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2018" "volumen" => "79" "paginaInicial" => "756" "paginaFinal" => "758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29559397" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0090" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Leibovitch" 1 => "S.C. Huilgol" 2 => "D. Selva" 3 => "K. Lun" 4 => "S. Richards" 5 => "R. 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Case and Research Letter

Epidemiological and Clinical Features of 49 Hispanic Patients With Microcystic Adnexal Carcinoma

Características epidemiológicas y clínicas de 49 pacientes hispanos con carcinoma anexial microquístico

A. Robles-Tenorio

Corresponding author

arturo.rt@tec.mx

Corresponding author.

, V.M. Tarango Martínez

Instituto Dermatologico de Jalisco “Dr. Jose Barba Rubio”, Zapopan, Jalisco, Mexico

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    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Epidemiological and Clinical Features of 49 Hispanic Patients With Microcystic Adnexal Carcinoma"
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    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#44;</span>"
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    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Robles-Tenorio, V&#46;M&#46; Tarango Mart&#237;nez"
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          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Robles-Tenorio"
            "email" => array:1 [
              0 => "arturo.rt@tec.mx"
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            "nombre" => "V&#46;M&#46;"
            "apellidos" => "Tarango Mart&#237;nez"
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        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Instituto Dermatologico de Jalisco &#8220;Dr&#46; Jose Barba Rubio&#8221;&#44; Zapopan&#44; Jalisco&#44; Mexico"
            "identificador" => "aff0005"
          ]
        ]
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            "identificador" => "cor0005"
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            "correspondencia" => "Corresponding author&#46;"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Caracter&#237;sticas epidemiol&#243;gicas y cl&#237;nicas de 49 pacientes hispanos con carcinoma anexial microqu&#237;stico"
      ]
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Microcystic adnexal carcinoma &#40;MAC&#41; is a slow-growing&#44; aggressive&#44; cutaneous neoplasm with a tendency for perineural invasion and high recurrence rates&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> There are less than 2000 reported cases worldwide&#44; mostly in Caucasian individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Although UV exposure&#44; radiotherapy&#44; and genetics may increase susceptibility&#44; the exact pathogenesis remains uncertain&#46; MAC presumably originates from pluripotent adnexal keratinocytes&#44; as it shows elements of eccrine &#40;keratinous cysts&#41; and follicular &#40;epithelial cords and ducts&#41; differentiation&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> It primarily affects the head and neck region&#59; and may appear as an ill-defined&#44; erythematous&#44; skin-coloured&#44; or yellowish plaque&#44; nodule&#44; or cyst&#46; Due to the clinical and histopathological similarity with other skin or adnexal cancers&#44; the disease may be particularly underappreciated in populations that have not been investigated&#46; Therefore&#44; our study aimed to describe the epidemiology and clinical presentation of MAC in Hispanic patients from a tertiary dermatology hospital in Mexico&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We performed a retrospective analysis from 2010 to 2020 including complete patient records with a postoperative&#44; histopathological diagnosis of MAC&#46; A total of 49 cases were found&#44; corresponding to 0&#46;05&#37; of the 83&#44;364 samples reviewed in the dermatopathology department during the study period&#46; The mean age was 67 years &#40;median&#44; 67 years&#59; range&#44; 24&#8211;101 years&#41;&#46; Females &#40;69&#46;4&#37;&#41; were more commonly affected than males &#40;30&#46;6&#37;&#41;&#46; The average time-to-onset was 3 years &#40;median&#44; 2 years&#59; range&#44; 0&#46;08&#8211;22 years&#41;&#46; The head was involved in 91&#46;8&#37; of the cases&#44; and the trunk in 8&#46;2&#37;&#46; In the head region&#44; most lesions occurred on the cheeks &#40;40&#37;&#41;&#44; followed by the nose &#40;28&#46;9&#37;&#41;&#44; lips &#40;11&#46;11&#37;&#41;&#44; forehead &#40;6&#46;7&#37;&#41;&#44; eyelids &#40;6&#46;7&#37;&#41;&#44; scalp &#40;4&#46;4&#37;&#41;&#44; and ears &#40;2&#46;2&#37;&#41;&#46; The nodular aspect &#40;71&#46;4&#37;&#41; predominated over plaque &#40;26&#46;5&#37;&#41; and cyst &#40;2&#37;&#41;&#46; Additional features such as a pearly border&#44; ulceration&#44; atrophy&#44; and telangiectasias were described in 42&#46;9&#37;&#44; 38&#46;8&#37;&#44; 16&#46;3&#37; and 16&#46;3&#37; of the cases&#44; respectively&#46; The average lesion diameter was 1&#46;6<span class="elsevierStyleHsp" style=""></span>cm &#40;median&#44; 1<span class="elsevierStyleHsp" style=""></span>cm&#59; range&#44; 0&#46;3&#8211;10<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Apart from the presence of a pearly border&#44; our results are in line with the published literature&#46; In a systematic review of 1968 patients&#44; 92&#46;8&#37; of the subjects were Caucasian&#44; and only 0&#46;2&#37; were Hispanics&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> In total&#44; mean age was 61&#46;8 years&#44; females represented 54&#46;1&#37; of the cases&#44; and latency ranged from 1 to 11 years&#46; Although the location and morphology were not quantitated&#44; it includes other case series where head and neck involvement ranges from 60 to 100&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;8</span></a> The mean diameter at diagnosis was 2&#46;8<span class="elsevierStyleHsp" style=""></span>cm&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Since MAC may be confused with other tumours&#44; we also evaluated the clinical and histopathological diagnostic accuracy&#46; Prior to the histopathology result&#44; most were clinically diagnosed as basal cell carcinoma &#40;BCC&#41; &#40;71&#46;4&#37;&#41; and squamous cell carcinoma &#40;SCC&#41; &#40;16&#46;3&#37;&#41;&#44; followed by nevus &#40;4&#46;1&#37;&#41;&#44; lichen planus pilaris &#40;2&#37;&#41;&#44; actinic keratosis &#40;2&#37;&#41;&#44; trichodiscoma &#40;2&#37;&#41;&#44; and adnexal tumour &#40;2&#37;&#41;&#46; As expected&#44; documentation of a pearly border was significantly associated with the presumptive clinical diagnosis &#40;Fisher&#8211;Freeman&#8211;Halton <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;041&#41;&#44; from which BCC represented 90&#46;5&#37; of the cases &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The frequency of preoperative histopathological misdiagnosis was 20&#46;4&#37;&#44; still below the 27&#8211;69&#37; in other case series&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5&#44;9</span></a> In our sample&#44; this included BCC &#40;60&#37;&#41;&#44; basosquamous cancer &#40;20&#37;&#41;&#44; and SCC &#40;20&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The limitations of this study are inherent to its retrospective nature&#46; We were not able to re-evaluate the clinical morphology of the lesions&#44; since descriptions were obtained directly from the medical records&#46; However&#44; these were elaborated by qualified dermatologists from our institution&#46; In the future&#44; we hope to create a picture database to improve our descriptions&#44; and also study various clinical&#8211;histopathological correlations with a focus on prognosis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; this is the first study to characterise MAC in Hispanics&#44; specifically of Mexican origin&#46; Our data should complement previous epidemiological and clinical knowledge in a population that has been underrepresented in larger studies&#46; Importantly&#44; our results demonstrate that BCC was the main differential diagnosis of MAC&#44; and that nearly half of our cases had a documented pearly border&#46; Also&#44; our analysis shows that MAC clinical suspicion remains low&#44; with only 1 case &#40;2&#37;&#41; being considered as an adnexal tumour&#46; Moreover&#44; the frequency of histopathological misdiagnosis suggests that initial sampling may be insufficient to establish the definitive diagnosis in more than a fifth of the cases&#46; Therefore&#44; increasing disease awareness is crucial to select an adequate biopsy technique that can improve the diagnostic accuracy of histopathology&#46; Together&#44; this may result in earlier&#44; well-planned treatment strategies and better patient outcomes&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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          "identificador" => "sec0005"
          "titulo" => "Conflict of interest"
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        1 => array:1 [
          "titulo" => "References"
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      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Caption&#58; A pearly border was documented in 42&#46;86&#37; of all MAC cases&#46; Prior to the postoperative histopathology result&#44; basal cell carcinoma was the most common presumptive clinical diagnosis&#46; As expected&#44; basal cell carcinoma was also the most frequent presumptive clinical diagnosis that had a documented pearly border &#40;90&#46;48&#37;&#41;&#46;</p>"
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pearly border&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pearly border and presumptive clinical diagnoses&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcystic adnexal carcinoma&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Gordon"
                            1 => "C&#46; Fischer"
                            2 => "A&#46; Martin"
                            3 => "I&#46; Rosman"
                            4 => "M&#46; Council"
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                      "doi" => "10.1097/DSS.0000000000001142"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2017"
                        "volumen" => "43"
                        "paginaInicial" => "1012"
                        "paginaFinal" => "1016"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28654578"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence-based clinical practice guidelines for microcystic adnexal carcinoma&#58; informed by a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Worley"
                            1 => "J&#46;L&#46; Owen"
                            2 => "C&#46;A&#46; Barker"
                            3 => "R&#46; Behshad"
                            4 => "C&#46; Bichakjian"
                            5 => "D&#46; Bolotin"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2019"
                        "volumen" => "60611"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcystic adnexal carcinoma&#58; forty-eight cases&#44; their treatment&#44; and ther outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Chiller"
                            1 => "D&#46; Passaro"
                            2 => "M&#46; Scheuller"
                            3 => "M&#46; Singer"
                            4 => "T&#46; McCalmont"
                            5 => "R&#46; Grekin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.136.11.1355"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2000"
                        "volumen" => "136"
                        "paginaInicial" => "1355"
                        "paginaFinal" => "1359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11074698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcystic adnexal carcinoma&#58; report of 13 cases and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Snow"
                            1 => "D&#46;D&#46; Madjar"
                            2 => "S&#46; Hardy"
                            3 => "M&#46; Bentz"
                            4 => "M&#46; Lucarelli"
                            5 => "R&#46; Bechard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1524-4725.2001.00208.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2001"
                        "volumen" => "27"
                        "paginaInicial" => "401"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11298716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcystic adnexal carcinoma&#58; review of 51 Japanese patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; Ohtsuka"
                            1 => "S&#46; Nagamatsu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000057880"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2002"
                        "volumen" => "204"
                        "paginaInicial" => "190"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12037446"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surveillance&#44; epidemiology&#44; and end results &#40;SEER&#41; database analysis of microcystic adnexal carcinoma &#40;sclerosing sweat duct carcinoma&#41; of the skin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;B&#46; Yu"
                            1 => "R&#46;C&#46; Blitzblau"
                            2 => "S&#46;C&#46; Patel"
                            3 => "R&#46; Decker"
                            4 => "L&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/COC.0b013e31819791eb"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Oncol"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "125"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19675445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcytic adnexal carcinoma&#58; a population-based outcomes study involving 494 patients from the Surveillance&#46; Epidemiology&#44; and End Results &#40;SEER&#41; database &#40;1973&#8211;2010&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Mahendraraj"
                            1 => "J&#46; Sond"
                            2 => "R&#46;S&#46; Chamberlain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Am Coll Surg"
                        "fecha" => "2014"
                        "volumen" => "219"
                        "paginaInicial" => "e93"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Demographics and outcomes of microcystic adnexal carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;J&#46; King"
                            1 => "S&#46;N&#46; Tolkachjov"
                            2 => "D&#46;S&#46; Winchester"
                            3 => "C&#46; Baum"
                            4 => "J&#46; Brewer"
                            5 => "C&#46; Arpey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2018.03.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2018"
                        "volumen" => "79"
                        "paginaInicial" => "756"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29559397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microcystic adnexal carcinoma&#58; treatment with Mohs micrographic surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Leibovitch"
                            1 => "S&#46;C&#46; Huilgol"
                            2 => "D&#46; Selva"
                            3 => "K&#46; Lun"
                            4 => "S&#46; Richards"
                            5 => "R&#46; Paver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "295"
                        "paginaFinal" => "300"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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Article information

ISSN: 00017310
Original language: English

DOI:10.1016/j.ad.2021.03.005

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Year/Month	Html	Pdf	Total

2024 November	7	12	19
2024 October	74	49	123
2024 September	57	29	86
2024 August	85	81	166
2024 July	69	52	121
2024 June	81	40	121
2024 May	72	44	116
2024 April	56	40	96
2024 March	54	41	95
2024 February	48	41	89
2024 January	81	24	105
2023 December	103	18	121
2023 November	53	39	92
2023 October	84	33	117
2023 September	49	26	75
2023 August	57	14	71
2023 July	69	38	107
2023 June	54	23	77
2023 May	55	28	83
2023 April	42	21	63
2023 March	43	48	91
2023 February	44	37	81
2023 January	118	48	166
2022 December	54	42	96
2022 November	32	37	69
2022 October	31	28	59
2022 September	32	39	71
2022 August	48	68	116
2022 July	146	112	258
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