array:24 [
  "pii" => "S0001731022001442"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.02.018"
  "estado" => "S300"
  "fechaPublicacion" => "2022-03-01"
  "aid" => "2933"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2022;113:T219-T221"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731021003768"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "2789"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2022;113:222-35"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "Evaluaci&#243;n de la calidad de gu&#237;as de pr&#225;ctica cl&#237;nica para el tratamiento de psoriasis mediante la herramienta AGREE II"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "222"
          "paginaFinal" => "235"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Quality Assessment of Clinical Practice Guidelines on the Treatment of Psoriasis Using the AGREE&#160;II Tool"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2914
              "Ancho" => 2083
              "Tamanyo" => 332420
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Metodolog&#237;a empleada para la evaluaci&#243;n de la calidad de GPCs&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Montesinos-Guevara, A&#46; Andrade Miranda, E&#46; Bedoya-Hurtado, C&#46;M&#46; Escobar Liquitay, J&#46;V&#46;A&#46; Franco, D&#46; Simancas-Racines, Y&#46; Sami Amer, R&#46;W&#46;M&#46; Vernooij, A&#46; Viteri-Garc&#237;a"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Montesinos-Guevara"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Andrade Miranda"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Bedoya-Hurtado"
            ]
            3 => array:2 [
              "nombre" => "C&#46;M&#46;"
              "apellidos" => "Escobar Liquitay"
            ]
            4 => array:2 [
              "nombre" => "J&#46;V&#46;A&#46;"
              "apellidos" => "Franco"
            ]
            5 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Simancas-Racines"
            ]
            6 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Sami Amer"
            ]
            7 => array:2 [
              "nombre" => "R&#46;W&#46;M&#46;"
              "apellidos" => "Vernooij"
            ]
            8 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Viteri-Garc&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003768?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021003768/v2_202212210529/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021004087"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.06.010"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "2799"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2022;113:219-21"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ART&#205;CULO DE OPINI&#211;N</span>"
      "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "219"
          "paginaFinal" => "221"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 454
              "Ancho" => 805
              "Tamanyo" => 85144
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatitis pitiriasiforme de novo en cuero cabelludo en paciente tratado con dupilumab a los 2 meses de iniciar el tratamiento&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Navarro-Trivi&#241;o"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004087?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021004087/v2_202212210529/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021004087"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2021.06.010"
      "estado" => "S300"
      "fechaPublicacion" => "2022-03-01"
      "aid" => "2799"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2022;113:219-21"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">ART&#205;CULO DE OPINI&#211;N</span>"
        "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "219"
            "paginaFinal" => "221"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 454
                "Ancho" => 805
                "Tamanyo" => 85144
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatitis pitiriasiforme de novo en cuero cabelludo en paciente tratado con dupilumab a los 2 meses de iniciar el tratamiento&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Navarro-Trivi&#241;o"
              ]
              1 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ruiz-Villaverde"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004087?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021004087/v2_202212210529/es/main.assets"
    ]
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>"
    "titulo" => " Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T219"
        "paginaFinal" => "T221"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
        "autores" => array:2 [
          0 => array:2 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Navarro-Trivi&#241;o"
          ]
          1 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Ruiz-Villaverde"
            "email" => array:1 [
              0 => "fntmed@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Eczema de Contacto e Inmunoalergia&#44; Dermatolog&#237;a&#44; Hospital Universitario San Cecilio&#44; Granada&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con Dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 454
            "Ancho" => 805
            "Tamanyo" => 85144
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">De novo pityriasiform dermatitis that appeared on the scalp of a dupilumab-treated patient 2 months after starting treatment&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic dermatitis is a chronic inflammatory skin disease that is very common in childhood&#46; Among adults it is an increasingly common reason for consultation and is diagnosed with increasing frequency&#46; Dupilumab is a monoclonal antibody that blocks the interleukin 4 &#40;IL-4&#41; receptor subunit &#945;&#44; decreasing activation of cells that express this receptor &#40;mainly Th2 lymphocytes&#41;&#46; The decreased polarization of na&#239;ve Th to Th2 lymphocytes results in a decrease in the secretion and function of the cytokines IL-4&#44; IL-13&#44; and IL-5&#46; Naive Th lymphocytes are instead polarized to Th1 and Th17 lymphocytes&#44; increasing the secretion of the corresponding cytokines&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Therapeutic blockade of certain cytokines or their receptors causes certain immunological modifications&#46; Beneficial effects have been described for several such therapies&#44; mainly in patients with psoriasis&#44; although paradoxical reactions occur in some patients&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The persistence or de novo appearance of head and neck dermatitis&#44; which is observed in up to 10&#37; of the cases in clinical practice&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> was not reported in the phase 3 clinical trial of dupilumab&#46; Zhu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> reported the appearance or persistence of facial dermatitis in 14 patients treated with dupilumab&#46; In their study of 1000 patients with atopic dermatitis who were treated with dupilumab&#44; Soria et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> found that this biological treatment resulted in the appearance of de novo head and neck dermatitis in 10 patients&#44; and aggravation of the same presentation in 32&#44; requiring discontinuation of dupilumab treatment in some cases&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given these findings&#44; it is important to consider the possibility of dermatosis of the head and neck in dupilumab-treated patients&#46; This requires knowledge of the peculiarities of the corresponding lesions in affected patients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Malassezia</span> hypersensitivity<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> is proposed as the main reason for the de novo appearance or exacerbation of facial dermatitis&#46; Pityriasiform lesions on the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; whether associated or not with localized facial lesions in seborrheic areas&#44; are indicative of seborrheic dermatitis&#46; Detection of specific immunoglobulin &#40;Ig&#41; E against <span class="elsevierStyleItalic">Malassezia</span> species and a culture positive for this fungus can help orient the diagnosis&#46; The underlying etiology is not well defined&#46; Studies&#44; including that of Adalsteinsson et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> have proposed that Th2 lymphocytes are the main adaptive immune system cells responsible for regulating interactions with this commensal fungus&#46; An adequate therapeutic response to oral or topical antifungals has been described in these cases&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Rosacea is another dermatosis that appears to play a key role in head and neck dermatitis in dupilumab-treated patients&#46; Of 94 patients treated with dupilumab&#44; 6&#46;4&#37; showed histologically confirmed inflammatory rosacea with an increase in colonization by the parasite <span class="elsevierStyleItalic">Demodex</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> The proliferation of <span class="elsevierStyleItalic">Demodex</span> after polarization to Th1 and Th17 is proposed as trigger for rosacea&#46; Although flushing episodes were observed in these patients&#44; the main clinical manifestation appears to be basal erythema with inflammatory papules located mainly in the malar area&#46; Histology reveals the abundant presence of <span class="elsevierStyleItalic">Demodex folliculorum</span>&#44; although an adhesive tape test can demonstrate the presence of this parasite less invasively&#46; It is important to remember the utility of the dermoscopy for the detection of <span class="elsevierStyleItalic">Demodex</span> species&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Topical ivermectin or oral tetracyclines are the treatments of choice in these cases&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The persistence or de novo appearance of eyelid dermatitis may pose the greatest diagnostic and therapeutic challenge in clinical practice&#46; In such cases&#44; it will be necessary to rule out the presence of allergic contact dermatitis &#40;ACD&#41;&#46; The main culprits are fragrances and preservatives&#44; although others&#44; such as surfactants &#40;e&#46;g&#46; cocamidopropyl betaine&#44; derived from coconut&#41;&#44; are common components of hair cosmetics&#46; Both Raffi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> and Zhu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> reported no interference of continuous dupilumab treatment with patch testing&#46; Another potential cause is ACD resulting from contact between the hands and face&#46; In such cases&#44; acrylates are one of the main allergens responsible&#44; especially in women&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sensitization to pneumoallergens is another potential cause in patients who show a seasonal worsening of head and neck dermatitis&#46; Detection of specific IgE and collaboration with an allergologist is essential to confirm this etiology&#46; Despite antihistamine treatment&#44; skin lesions in these patients do not usually improve&#44; necessitating specific recommendations on environmental exposure and the use of topical calcineurin inhibitors for the period during which the individual is exposed to pneumoallergens&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Obviously&#44; there will be complex cases in which the cause of head and neck dermatitis in a given patient will not be clear&#46; A growing body of evidence on this topic will help further our knowledge&#46; However&#44; the persistence or de novo appearance of head and neck dermatitis in patients taking dupilumab should not be a reason for treatment discontinuation&#46; Clinical peculiarities may aid the dermatologist in selecting the most appropriate adjuvant treatment for each patient&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the clinical characteristics&#44; corresponding additional tests&#44; and recommended treatments in dupilumab-treated patients with head and neck dermatitis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 454
            "Ancho" => 805
            "Tamanyo" => 85144
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">De novo pityriasiform dermatitis that appeared on the scalp of a dupilumab-treated patient 2 months after starting treatment&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bacterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical manifestations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Complementary test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Seborrheic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pityriasiform lesions &#40;dry whitish scales&#41; over orange erythema in seborrheic areas and on the scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Microbiological cultureMalassezia IgE<span class="elsevierStyleItalic">Malassezia</span> spp&#46; prick testSkin biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral antifungalsFluconazole 150<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#44; 2 dosesItraconazole 50&#8211;100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; 7&#8211;14 daysTopical antifungalsClotrimazoleFenticonazoleKetoconazole&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Flushing &#40;less frequent&#41;Malar erythemaErythematous papulesPustules&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Punch biopsyIn vivo study with adhesive test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Topical ivermectin 1&#37;Oral doxycyclineOral isotretinoin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Allergic contact dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localized eczema on the eyelids and hairline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patch testsStandard seriesFragrance seriesCosmetic seriesOwn cosmetics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Avoid allergenHigh-potency topical corticosteroidsTopical calcineurin inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Airborne dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Facial eczema with involvement of skinfolds such as the eyelids and the retroauricular area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Specific IgE against pneumoallergensSpecific prick tests&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral antihistaminesHigh-potency topical corticosteroidsTopical calcineurin inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Possible etiologies of head and neck dermatitis in dupilumab-treated patients&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterizing dupilumab facial redness&#58; a multi-institution retrospective medical record review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Waldman"
                            1 => "M&#46;E&#46; DeWane"
                            2 => "B&#46; Sloan"
                            3 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.06.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "230"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31228530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of the development of new regional dermatoses in patients treated for atopic dermatitis with dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;A&#46; Zhu"
                            1 => "J&#46;K&#46; Chen"
                            2 => "A&#46; Chiou"
                            3 => "J&#46; Ko"
                            4 => "G&#46; Honari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2019.0109"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2019"
                        "volumen" => "155"
                        "paginaInicial" => "850"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31042259"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GREAT research group development or exacerbation of head and neck dermatitis in patients treated for atopic dermatitis with dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Soria"
                            1 => "A&#46; Du-Thanh"
                            2 => "J&#46; Seneschal"
                            3 => "M&#46; Jachiet"
                            4 => "D&#46; Staumont-Sall&#233;"
                            5 => "S&#46; Barbarot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2019.2613"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2019"
                        "volumen" => "155"
                        "paginaInicial" => "1312"
                        "paginaFinal" => "1315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31483439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of Malassezia in atopic dermatitis affecting the head and neck of adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Darabi"
                            1 => "S&#46;G&#46; Hostetler"
                            2 => "M&#46;A&#46; Bechtel"
                            3 => "M&#46; Zirwas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2008.07.058"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2009"
                        "volumen" => "60"
                        "paginaInicial" => "125"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18834647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An update on the microbiology&#44; immunology and genetics of seborrheic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;A&#46; Adalsteinsson"
                            1 => "S&#46; Kaushik"
                            2 => "S&#46; Muzumdar"
                            3 => "E&#46; Guttman-Yassky"
                            4 => "J&#46; Ungar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.14091"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2020"
                        "volumen" => "29"
                        "paginaInicial" => "481"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32125725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dupilumab for the treatment of atopic dermatitis in an Austrian cohort-real-life data shows rosacea-like folliculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Quint"
                            1 => "P&#46;M&#46; Brunner"
                            2 => "C&#46; Sinz"
                            3 => "I&#46; Steiner"
                            4 => "R&#46; Ristl"
                            5 => "K&#46; Vigl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/jcm9041241"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Med"
                        "fecha" => "2020"
                        "volumen" => "9"
                        "paginaInicial" => "1241"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32344789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scale and pustule on dermoscopy of rosacea&#58; a diagnostic clue for demodex species"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Serarslan"
                            1 => "&#214;&#46; Makbule Kaya"
                            2 => "E&#46; Dirican"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5826/dpc.1101a139"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Pract Concept"
                        "fecha" => "2021"
                        "volumen" => "11"
                        "paginaInicial" => "e2021139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33614217"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis&#58; a retrospective chart review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Raffi"
                            1 => "R&#46; Suresh"
                            2 => "N&#46; Botto"
                            3 => "J&#46;E&#46; Murase"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.09.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "132"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31562940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;A&#46; Zhu"
                            1 => "J&#46;K&#46; Chen"
                            2 => "A&#46; Chiou"
                            3 => "J&#46; Ko"
                            4 => "G&#46; Honari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2019.01.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAAD Case Rep"
                        "fecha" => "2019"
                        "volumen" => "5"
                        "paginaInicial" => "336"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30989102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000003/v2_202212210529/S0001731022001442/v2_202212210529/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93542"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Art&#237;culo de opini&#243;n &#47; Opinion Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000003/v2_202212210529/S0001731022001442/v2_202212210529/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022001442?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Opinion article
Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab: Differential Diagnosis and Treatment
Patrón de dermatitis de cabeza y cuello en pacientes tratados con Dupilumab: diagnóstico diferencial y tratamiento
F.J. Navarro-Triviño, R. Ruiz-Villaverde
Corresponding author
fntmed@gmail.com

Corresponding author.
Departamento de Eczema de Contacto e Inmunoalergia, Dermatología, Hospital Universitario San Cecilio, Granada, Spain
Read
5144
Times
was read the article
1705
Total PDF
3439
Total HTML
Share statistics
 array:24 [
  "pii" => "S0001731022001442"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.02.018"
  "estado" => "S300"
  "fechaPublicacion" => "2022-03-01"
  "aid" => "2933"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2022;113:T219-T221"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731021003768"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "2789"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2022;113:222-35"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "Evaluaci&#243;n de la calidad de gu&#237;as de pr&#225;ctica cl&#237;nica para el tratamiento de psoriasis mediante la herramienta AGREE II"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "222"
          "paginaFinal" => "235"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Quality Assessment of Clinical Practice Guidelines on the Treatment of Psoriasis Using the AGREE&#160;II Tool"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2914
              "Ancho" => 2083
              "Tamanyo" => 332420
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Metodolog&#237;a empleada para la evaluaci&#243;n de la calidad de GPCs&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Montesinos-Guevara, A&#46; Andrade Miranda, E&#46; Bedoya-Hurtado, C&#46;M&#46; Escobar Liquitay, J&#46;V&#46;A&#46; Franco, D&#46; Simancas-Racines, Y&#46; Sami Amer, R&#46;W&#46;M&#46; Vernooij, A&#46; Viteri-Garc&#237;a"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Montesinos-Guevara"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Andrade Miranda"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Bedoya-Hurtado"
            ]
            3 => array:2 [
              "nombre" => "C&#46;M&#46;"
              "apellidos" => "Escobar Liquitay"
            ]
            4 => array:2 [
              "nombre" => "J&#46;V&#46;A&#46;"
              "apellidos" => "Franco"
            ]
            5 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Simancas-Racines"
            ]
            6 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Sami Amer"
            ]
            7 => array:2 [
              "nombre" => "R&#46;W&#46;M&#46;"
              "apellidos" => "Vernooij"
            ]
            8 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Viteri-Garc&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003768?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021003768/v2_202212210529/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021004087"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.06.010"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "2799"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2022;113:219-21"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ART&#205;CULO DE OPINI&#211;N</span>"
      "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "219"
          "paginaFinal" => "221"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 454
              "Ancho" => 805
              "Tamanyo" => 85144
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatitis pitiriasiforme de novo en cuero cabelludo en paciente tratado con dupilumab a los 2 meses de iniciar el tratamiento&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Navarro-Trivi&#241;o"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004087?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021004087/v2_202212210529/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021004087"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2021.06.010"
      "estado" => "S300"
      "fechaPublicacion" => "2022-03-01"
      "aid" => "2799"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2022;113:219-21"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">ART&#205;CULO DE OPINI&#211;N</span>"
        "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "219"
            "paginaFinal" => "221"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 454
                "Ancho" => 805
                "Tamanyo" => 85144
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatitis pitiriasiforme de novo en cuero cabelludo en paciente tratado con dupilumab a los 2 meses de iniciar el tratamiento&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Navarro-Trivi&#241;o"
              ]
              1 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ruiz-Villaverde"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004087?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000003/v2_202212210529/S0001731021004087/v2_202212210529/es/main.assets"
    ]
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Opinion article</span>"
    "titulo" => " Patterns of Head and Neck Dermatitis in Patients Treated With Dupilumab&#58; Differential Diagnosis and Treatment"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T219"
        "paginaFinal" => "T221"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46;J&#46; Navarro-Trivi&#241;o, R&#46; Ruiz-Villaverde"
        "autores" => array:2 [
          0 => array:2 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Navarro-Trivi&#241;o"
          ]
          1 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Ruiz-Villaverde"
            "email" => array:1 [
              0 => "fntmed@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Eczema de Contacto e Inmunoalergia&#44; Dermatolog&#237;a&#44; Hospital Universitario San Cecilio&#44; Granada&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Patr&#243;n de dermatitis de cabeza y cuello en pacientes tratados con Dupilumab&#58; diagn&#243;stico diferencial y tratamiento"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 454
            "Ancho" => 805
            "Tamanyo" => 85144
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">De novo pityriasiform dermatitis that appeared on the scalp of a dupilumab-treated patient 2 months after starting treatment&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic dermatitis is a chronic inflammatory skin disease that is very common in childhood&#46; Among adults it is an increasingly common reason for consultation and is diagnosed with increasing frequency&#46; Dupilumab is a monoclonal antibody that blocks the interleukin 4 &#40;IL-4&#41; receptor subunit &#945;&#44; decreasing activation of cells that express this receptor &#40;mainly Th2 lymphocytes&#41;&#46; The decreased polarization of na&#239;ve Th to Th2 lymphocytes results in a decrease in the secretion and function of the cytokines IL-4&#44; IL-13&#44; and IL-5&#46; Naive Th lymphocytes are instead polarized to Th1 and Th17 lymphocytes&#44; increasing the secretion of the corresponding cytokines&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Therapeutic blockade of certain cytokines or their receptors causes certain immunological modifications&#46; Beneficial effects have been described for several such therapies&#44; mainly in patients with psoriasis&#44; although paradoxical reactions occur in some patients&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The persistence or de novo appearance of head and neck dermatitis&#44; which is observed in up to 10&#37; of the cases in clinical practice&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> was not reported in the phase 3 clinical trial of dupilumab&#46; Zhu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> reported the appearance or persistence of facial dermatitis in 14 patients treated with dupilumab&#46; In their study of 1000 patients with atopic dermatitis who were treated with dupilumab&#44; Soria et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> found that this biological treatment resulted in the appearance of de novo head and neck dermatitis in 10 patients&#44; and aggravation of the same presentation in 32&#44; requiring discontinuation of dupilumab treatment in some cases&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given these findings&#44; it is important to consider the possibility of dermatosis of the head and neck in dupilumab-treated patients&#46; This requires knowledge of the peculiarities of the corresponding lesions in affected patients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Malassezia</span> hypersensitivity<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> is proposed as the main reason for the de novo appearance or exacerbation of facial dermatitis&#46; Pityriasiform lesions on the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; whether associated or not with localized facial lesions in seborrheic areas&#44; are indicative of seborrheic dermatitis&#46; Detection of specific immunoglobulin &#40;Ig&#41; E against <span class="elsevierStyleItalic">Malassezia</span> species and a culture positive for this fungus can help orient the diagnosis&#46; The underlying etiology is not well defined&#46; Studies&#44; including that of Adalsteinsson et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> have proposed that Th2 lymphocytes are the main adaptive immune system cells responsible for regulating interactions with this commensal fungus&#46; An adequate therapeutic response to oral or topical antifungals has been described in these cases&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Rosacea is another dermatosis that appears to play a key role in head and neck dermatitis in dupilumab-treated patients&#46; Of 94 patients treated with dupilumab&#44; 6&#46;4&#37; showed histologically confirmed inflammatory rosacea with an increase in colonization by the parasite <span class="elsevierStyleItalic">Demodex</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> The proliferation of <span class="elsevierStyleItalic">Demodex</span> after polarization to Th1 and Th17 is proposed as trigger for rosacea&#46; Although flushing episodes were observed in these patients&#44; the main clinical manifestation appears to be basal erythema with inflammatory papules located mainly in the malar area&#46; Histology reveals the abundant presence of <span class="elsevierStyleItalic">Demodex folliculorum</span>&#44; although an adhesive tape test can demonstrate the presence of this parasite less invasively&#46; It is important to remember the utility of the dermoscopy for the detection of <span class="elsevierStyleItalic">Demodex</span> species&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Topical ivermectin or oral tetracyclines are the treatments of choice in these cases&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The persistence or de novo appearance of eyelid dermatitis may pose the greatest diagnostic and therapeutic challenge in clinical practice&#46; In such cases&#44; it will be necessary to rule out the presence of allergic contact dermatitis &#40;ACD&#41;&#46; The main culprits are fragrances and preservatives&#44; although others&#44; such as surfactants &#40;e&#46;g&#46; cocamidopropyl betaine&#44; derived from coconut&#41;&#44; are common components of hair cosmetics&#46; Both Raffi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> and Zhu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> reported no interference of continuous dupilumab treatment with patch testing&#46; Another potential cause is ACD resulting from contact between the hands and face&#46; In such cases&#44; acrylates are one of the main allergens responsible&#44; especially in women&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sensitization to pneumoallergens is another potential cause in patients who show a seasonal worsening of head and neck dermatitis&#46; Detection of specific IgE and collaboration with an allergologist is essential to confirm this etiology&#46; Despite antihistamine treatment&#44; skin lesions in these patients do not usually improve&#44; necessitating specific recommendations on environmental exposure and the use of topical calcineurin inhibitors for the period during which the individual is exposed to pneumoallergens&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Obviously&#44; there will be complex cases in which the cause of head and neck dermatitis in a given patient will not be clear&#46; A growing body of evidence on this topic will help further our knowledge&#46; However&#44; the persistence or de novo appearance of head and neck dermatitis in patients taking dupilumab should not be a reason for treatment discontinuation&#46; Clinical peculiarities may aid the dermatologist in selecting the most appropriate adjuvant treatment for each patient&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the clinical characteristics&#44; corresponding additional tests&#44; and recommended treatments in dupilumab-treated patients with head and neck dermatitis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 454
            "Ancho" => 805
            "Tamanyo" => 85144
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">De novo pityriasiform dermatitis that appeared on the scalp of a dupilumab-treated patient 2 months after starting treatment&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bacterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical manifestations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Complementary test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Seborrheic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pityriasiform lesions &#40;dry whitish scales&#41; over orange erythema in seborrheic areas and on the scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Microbiological cultureMalassezia IgE<span class="elsevierStyleItalic">Malassezia</span> spp&#46; prick testSkin biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral antifungalsFluconazole 150<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#44; 2 dosesItraconazole 50&#8211;100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; 7&#8211;14 daysTopical antifungalsClotrimazoleFenticonazoleKetoconazole&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rosacea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Flushing &#40;less frequent&#41;Malar erythemaErythematous papulesPustules&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Punch biopsyIn vivo study with adhesive test&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Topical ivermectin 1&#37;Oral doxycyclineOral isotretinoin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Allergic contact dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localized eczema on the eyelids and hairline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patch testsStandard seriesFragrance seriesCosmetic seriesOwn cosmetics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Avoid allergenHigh-potency topical corticosteroidsTopical calcineurin inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Airborne dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Facial eczema with involvement of skinfolds such as the eyelids and the retroauricular area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Specific IgE against pneumoallergensSpecific prick tests&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral antihistaminesHigh-potency topical corticosteroidsTopical calcineurin inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Possible etiologies of head and neck dermatitis in dupilumab-treated patients&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterizing dupilumab facial redness&#58; a multi-institution retrospective medical record review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Waldman"
                            1 => "M&#46;E&#46; DeWane"
                            2 => "B&#46; Sloan"
                            3 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.06.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "230"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31228530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of the development of new regional dermatoses in patients treated for atopic dermatitis with dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;A&#46; Zhu"
                            1 => "J&#46;K&#46; Chen"
                            2 => "A&#46; Chiou"
                            3 => "J&#46; Ko"
                            4 => "G&#46; Honari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2019.0109"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2019"
                        "volumen" => "155"
                        "paginaInicial" => "850"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31042259"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GREAT research group development or exacerbation of head and neck dermatitis in patients treated for atopic dermatitis with dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Soria"
                            1 => "A&#46; Du-Thanh"
                            2 => "J&#46; Seneschal"
                            3 => "M&#46; Jachiet"
                            4 => "D&#46; Staumont-Sall&#233;"
                            5 => "S&#46; Barbarot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2019.2613"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2019"
                        "volumen" => "155"
                        "paginaInicial" => "1312"
                        "paginaFinal" => "1315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31483439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of Malassezia in atopic dermatitis affecting the head and neck of adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Darabi"
                            1 => "S&#46;G&#46; Hostetler"
                            2 => "M&#46;A&#46; Bechtel"
                            3 => "M&#46; Zirwas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2008.07.058"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2009"
                        "volumen" => "60"
                        "paginaInicial" => "125"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18834647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An update on the microbiology&#44; immunology and genetics of seborrheic dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;A&#46; Adalsteinsson"
                            1 => "S&#46; Kaushik"
                            2 => "S&#46; Muzumdar"
                            3 => "E&#46; Guttman-Yassky"
                            4 => "J&#46; Ungar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.14091"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2020"
                        "volumen" => "29"
                        "paginaInicial" => "481"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32125725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dupilumab for the treatment of atopic dermatitis in an Austrian cohort-real-life data shows rosacea-like folliculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Quint"
                            1 => "P&#46;M&#46; Brunner"
                            2 => "C&#46; Sinz"
                            3 => "I&#46; Steiner"
                            4 => "R&#46; Ristl"
                            5 => "K&#46; Vigl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/jcm9041241"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Med"
                        "fecha" => "2020"
                        "volumen" => "9"
                        "paginaInicial" => "1241"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32344789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scale and pustule on dermoscopy of rosacea&#58; a diagnostic clue for demodex species"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Serarslan"
                            1 => "&#214;&#46; Makbule Kaya"
                            2 => "E&#46; Dirican"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5826/dpc.1101a139"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Pract Concept"
                        "fecha" => "2021"
                        "volumen" => "11"
                        "paginaInicial" => "e2021139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33614217"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis&#58; a retrospective chart review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Raffi"
                            1 => "R&#46; Suresh"
                            2 => "N&#46; Botto"
                            3 => "J&#46;E&#46; Murase"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.09.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "132"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31562940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;A&#46; Zhu"
                            1 => "J&#46;K&#46; Chen"
                            2 => "A&#46; Chiou"
                            3 => "J&#46; Ko"
                            4 => "G&#46; Honari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2019.01.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAAD Case Rep"
                        "fecha" => "2019"
                        "volumen" => "5"
                        "paginaInicial" => "336"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30989102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000003/v2_202212210529/S0001731022001442/v2_202212210529/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93542"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Art&#237;culo de opini&#243;n &#47; Opinion Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000003/v2_202212210529/S0001731022001442/v2_202212210529/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022001442?idApp=UINPBA000044"
]
Article information
ISSN: 00017310
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 22 14 36
2024 October 143 64 207
2024 September 165 48 213
2024 August 206 80 286
2024 July 131 50 181
2024 June 155 53 208
2024 May 126 56 182
2024 April 105 47 152
2024 March 123 45 168
2024 February 130 76 206
2024 January 104 48 152
2023 December 98 24 122
2023 November 95 36 131
2023 October 100 38 138
2023 September 90 33 123
2023 August 81 32 113
2023 July 96 53 149
2023 June 69 37 106
2023 May 67 44 111
2023 April 50 21 71
2023 March 82 45 127
2023 February 72 33 105
2023 January 75 53 128
2022 December 73 54 127
2022 November 72 53 125
2022 October 105 57 162
2022 September 77 45 122
2022 August 86 56 142
2022 July 74 52 126
2022 June 90 46 136
2022 May 218 104 322
2022 April 78 50 128
2022 March 115 72 187
2022 February 66 86 152
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?