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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Un tercio de los pacientes con psoriasis comienzan en la infancia<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a>&#44; con una edad media al diagn&#243;stico de 9 a&#241;os&#46; En la infancia y en la adolescencia&#44; la psoriasis suele tener un curso leve y habitualmente suele controlarse con tratamientos t&#243;picos y&#47;o fototerapia<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a>&#46; Sin embargo&#44; las formas moderadas o graves de la enfermedad pueden no responder a estos tratamientos y requerir tratamiento sist&#233;mico<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El comienzo de la enfermedad en la edad pedi&#225;trica supone un impacto psicosocial importante en el paciente y en su familia<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a>&#46; Adem&#225;s&#44; se relaciona con mayor comorbilidad cardiovascular y metab&#243;lica&#44; por lo que&#44; especialmente en casos graves&#44; es necesaria una intervenci&#243;n precoz que pudiera contribuir a cambiar el curso inflamatorio de la enfermedad&#44; y evitar complicaciones y secuelas posteriores<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; Al ser un grupo etario vulnerable&#44; es fundamental disponer de estudios que ofrezcan datos de seguridad a largo plazo e&#44; idealmente&#44; que avalen el ajuste de dosis por peso en estos pacientes<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es analizar la frecuencia relativa&#44; las caracter&#237;sticas de los pacientes y el tratamiento empleado en pacientes pedi&#225;tricos&#44; y conocer los efectos adversos &#40;EA&#41; de los tratamientos sist&#233;micos en psoriasis juvenil en la pr&#225;ctica real&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Material y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Los datos de este estudio se obtuvieron del registro BIOBADADERM&#46; Es un estudio impulsado por el Grupo de Psoriasis de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a &#40;AEDV&#41;&#44; cuyo objetivo es analizar la seguridad de los tratamientos sist&#233;micos en psoriasis&#46; La descripci&#243;n del estudio ha sido publicada previamente<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se recogieron las caracter&#237;sticas demogr&#225;ficas y cl&#237;nicas &#8212;incluyendo la forma cl&#237;nica&#44; as&#237; como la gravedad&#44; Psoriasis Area Severity Index &#40;PASI&#41;&#8212; las comorbilidades&#44; los tratamientos previos&#44; el n&#250;mero de tratamientos realizados&#44; los eventos adversos y la evoluci&#243;n de los pacientes incluidos en BIOBADADERM menores de 18 a&#241;os incluidos en el registro hasta noviembre 2020&#46; De forma an&#225;loga&#44; se describieron tambi&#233;n las caracter&#237;sticas de los pacientes con edades comprendidas entre los 19 y 21 a&#241;os&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">BIOBADADERM fue aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n Cl&#237;nica del Hospital Doce de Octubre &#40;216&#47;07&#44; Madrid&#41; y se realiz&#243; en conformidad con la Declaraci&#243;n de Helsinki&#46; Todos los pacientes incluidos dieron su consentimiento por escrito y&#44; en el caso de los menores de edad&#44; lo hicieron sus padres y&#47;o tutores legales&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis descriptivo&#46; Las variables continuas se mostraron como medias con desviaciones est&#225;ndar o medianas y rangos intercuart&#237;licos&#46; Las variables cualitativas se expresaron con porcentajes y valores absolutos&#46; El an&#225;lisis estad&#237;stico se realiz&#243; con Stata&#174; &#40;StataCorp&#46; 2019&#46; Stata Statistical Software&#58; Release 16&#46; College Station&#44; TX&#58; StataCorp LLC&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="par0040" class="elsevierStylePara elsevierViewall">Del total de 3&#46;946 pacientes incluidos en el registro&#44; 9 pacientes eran menores de 18 a&#241;os y 15 de edades entre 19 y 21 a&#241;os&#46; Globalmente&#44; presentaban una edad media al diagn&#243;stico de la enfermedad de 16 &#40;DE&#58; 3&#44;1&#41; a&#241;os y predominio del sexo masculino &#40;71&#37;&#41;&#46; La duraci&#243;n media de enfermedad desde el diagn&#243;stico hasta el inicio del tratamiento era de unos 5&#44;5 &#40;DE&#58; 4&#44;8&#41; a&#241;os y presentaban un PASI medio de 9&#44;4 &#40;DE&#58; 5&#44;7&#41; al inicio del registro&#46; A excepci&#243;n de dos pacientes en el grupo de 19-21 a&#241;os &#40;hipertensi&#243;n arterial e infecci&#243;n por VIH&#41;&#44; el resto de los pacientes no presentaba comorbilidades&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La forma cl&#237;nica de psoriasis y los tratamientos previos realizados por ambos grupos se recogen en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los pacientes incluidos en este estudio recibieron como primer tratamiento dentro del registro&#44; un f&#225;rmaco sist&#233;mico no biol&#243;gico &#40;67&#37;&#41;&#58; 5 recibieron tratamiento con acitretina&#44; 3 con ciclosporina y 8 con metotrexato &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; En el grupo de pacientes que comenzaron con tratamiento biol&#243;gico&#44; ustekinumab fue el m&#225;s frecuente&#44; seguido de adalimumab y guselkumab&#46; En el grupo de pacientes menores de 18 a&#241;os&#44; el tratamiento sist&#233;mico m&#225;s frecuentemente prescrito a lo largo del seguimiento fue acitretina&#44; a diferencia de los pacientes de 19-21 a&#241;os&#44; en los que fue metotrexato&#46; El tiempo global de seguimiento para todos los pacientes fue de 38 personas&#47;a&#241;o&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">De los 46 ciclos de tratamiento administrados&#44; 28 &#40;61&#37;&#41; fueron suspendidos&#44; 14 &#40;28&#37;&#41; de los cuales fueron por p&#233;rdida o falta de eficacia o por EA&#44; perteneciendo cuatro de estos pacientes al grupo de menores de 18 a&#241;os&#46; Los EA que motivaron la suspensi&#243;n fueron diarrea y n&#225;useas asociadas a cefalea&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Del total de los 27 EA registrados&#44; 5 fueron en menores de 18 a&#241;os &#40;ninguno de ellos considerado como grave&#41; y 22 en pacientes de 19-21 a&#241;os&#46; En este grupo&#44; se registraron dos EA infecciosos en pacientes diferentes que no condicionaron la suspensi&#243;n del tratamiento&#58; una otitis media aguda&#44; en un paciente en tratamiento con acitretina y una apendicitis aguda&#44; en otro paciente con risankizumab&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">En este estudio se recogieron los datos de los 24 pacientes menores de 21 a&#241;os con diagn&#243;stico de psoriasis incluidos en el registro BIOBADADERM&#44; los cuales representaban solo el 0&#44;6&#37; del total de participantes&#46; La edad media al inicio del tratamiento sist&#233;mico cl&#225;sico o biol&#243;gico entre los menores de 18 a&#241;os fue de 14&#44;5 a&#241;os&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Estos datos podr&#237;an ser reflejo de la menor carga de enfermedad en la edad pedi&#225;trica&#44; en la que la mayor&#237;a de los casos se controlar&#237;a con tratamiento t&#243;pico<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;2</span></a> o de infratratamiento&#44; en los que el inicio de un tratamiento sist&#233;mico ser&#237;a retrasado hasta la edad adulta<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;7</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La mayor&#237;a de la evidencia disponible en el tratamiento de la psoriasis moderada-grave en la edad pedi&#225;trica con tratamientos sist&#233;micos cl&#225;sicos y biol&#243;gicos est&#225; basada en la experiencia descrita en adultos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a>&#46; Aun as&#237;&#44; los datos en seguridad y eficacia de los diferentes biol&#243;gicos en la edad pedi&#225;trica est&#225; aumentando de forma considerable en los &#250;ltimos a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">8&#8211;17</span></a>&#46; A d&#237;a de hoy&#44; existen 5 f&#225;rmacos sist&#233;micos biol&#243;gicos aprobados por la European Medicines Agency &#40;EMA&#41; para el tratamiento de la psoriasis pedi&#225;trica&#58; etanercept&#44; ustekinumab&#44; secukinumab&#44; ixekizumab y adalimumab&#46; Los 4 primeros tienen indicaci&#243;n para el tratamiento de psoriasis moderada-grave en placas en pacientes pedi&#225;tricos mayores de 6 a&#241;os&#44; tras fallo o contraindicaci&#243;n a tratamientos sist&#233;micos cl&#225;sicos y&#47;o fototerapia y&#44; en el caso de adalimumab&#44; en pacientes mayores de 4 a&#241;os y como primera l&#237;nea de tratamiento en psoriasis grave<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Existen varios estudios retrospectivos que analizan las caracter&#237;sticas y el tratamiento de pacientes menores de 18 a&#241;os&#44; con diagn&#243;stico de psoriasis moderada-severa&#46; Charbit et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a> realizaron un estudio retrospectivo multic&#233;ntrico en el que se recogieron 154 pacientes&#46; Presentaban una edad media al diagn&#243;stico de 7&#44;7 a&#241;os y una edad media de inicio de tratamiento sist&#233;mico de 10&#44;3 a&#241;os&#46; Acitretina fue el tratamiento m&#225;s usado &#40;55&#44;2&#37;&#41; y prescrito como primera l&#237;nea de tratamiento &#40;76&#44;6&#37;&#41;&#59; 34 pacientes de la serie precisaron tratamiento biol&#243;gico&#46; De los 261 ciclos de tratamiento&#44; 15 tuvieron que ser suspendidos por EA&#46; Ciclosporina fue el f&#225;rmaco que m&#225;s se asoci&#243; a EA graves&#44; condicionando la suspensi&#243;n del tratamiento &#40;mialgias&#44; trastornos gastrointestinales&#44; hipertricosis&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Otro estudio<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> recogi&#243; las caracter&#237;sticas de 51 pacientes&#46; Analizan los pacientes que reciben tratamiento sist&#233;mico cl&#225;sico y biol&#243;gico en monoterapia y&#47;o en combinaci&#243;n&#46; Metotrexato es el tratamiento no biol&#243;gico m&#225;s utilizado &#40;27&#44;5&#37;&#41; en monoterapia y combinado con f&#225;rmaco biol&#243;gico&#59; solo un paciente recibi&#243; tratamiento con acitretina&#46; El tratamiento biol&#243;gico m&#225;s usado fue etanercept &#40;23 pacientes&#41;&#44; seguido de adalimumab y ustekinumab&#46; Se reportaron 29 EA del total de 80 ciclos de tratamiento&#46; Los esquemas de tratamiento combinado no presentaron mayor n&#250;mero de EA&#44; aunque el poder estad&#237;stico para detectar diferencias es bajo&#46; El EA m&#225;s frecuente en los pacientes en tratamiento con metotrexato fue la intolerancia gastrointestinal&#59; solo un paciente recib&#237;a el tratamiento de forma subcut&#225;nea&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">En nuestro medio&#44; un estudio<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a> recogi&#243; un grupo de 40 pacientes menores de edad que presentaban una edad media al diagn&#243;stico de psoriasis de 10&#44;2 a&#241;os y de inicio de tratamiento sist&#233;mico de 13&#44;4 a&#241;os&#46; De los 63 ciclos de tratamiento y excluyendo 36 de los mismos &#40;tratamiento con fototerapia&#41;&#44; el tratamiento m&#225;s usado en primera l&#237;nea fue acitretina&#44; pero&#44; globalmente&#44; fue metotrexato&#46; Etanercept y acitretina fueron los tratamientos m&#225;s prolongados&#46; Describen un 11&#37; de EA&#44; ninguno de los cuales condicion&#243; la suspensi&#243;n del f&#225;rmaco&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Con respecto al uso de tratamientos biol&#243;gicos&#44; Bronckers et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> realizaron un estudio retrospectivo de 390 pacientes&#44; con una edad media de 11 a&#241;os y 482 ciclos de tratamiento incluidos&#46; El tratamiento biol&#243;gico m&#225;s usado fue etanercept&#44; seguido de adalimumab&#44; ustekinumab e infliximab&#46; De los 270 pacientes que fueron tratados con metotrexato&#44; el 48&#44;1&#37; experiment&#243; alg&#250;n EA&#44; siendo 3 de ellos considerados como graves y condicionando la suspensi&#243;n del tratamiento&#46; Tres pacientes en tratamiento con fumaratos y 2 con adalimumab tuvieron que suspender el tratamiento por EA grave&#46; No se observ&#243; ning&#250;n EA en los 2 pacientes tratados con infliximab&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Ollech et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> recogieron una serie de 10 pacientes con psoriasis grave&#59; etanercept tambi&#233;n fue el tratamiento biol&#243;gico m&#225;s prescrito&#46; La edad media de inicio de tratamiento biol&#243;gico fue de 12&#44;6 a&#241;os&#46; Fue preciso el uso de una segunda l&#237;nea en 6 casos y de una tercera&#44; en 3&#46; En cuanto a los EA&#44; los dos casos que hab&#237;an recibido tratamiento con infliximab tuvieron que ser suspendidos por reacci&#243;n de hipersensibilidad al f&#225;rmaco&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los datos del registro BIOBADADERM muestran que los menores representan un grupo muy peque&#241;o dentro de los pacientes con psoriasis que reciben tratamiento sist&#233;mico y son manejados m&#225;s frecuentemente con tratamientos cl&#225;sicos&#44; sin poder establecer si el motivo es por la menor gravedad o un posible infratratamiento&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Financiaci&#243;n</span><p id="par0110" class="elsevierStylePara elsevierViewall">El proyecto BIOBADADERM est&#225; promovido por la Fundaci&#243;n Piel Sana&#44; Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a&#44; que cuenta con el apoyo econ&#243;mico de la Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios y de empresas farmac&#233;uticas &#40;Abbott&#47;AbbVie&#44; Amgen&#44; Almirall&#44; Janssen&#44; Novartis y UCB&#41;&#46; Las siguientes empresas tambi&#233;n han colaborado en el pasado &#40;Leo Pharma&#44; Lilly&#44; MSD y Pfizer&#41;&#46; Las empresas farmac&#233;uticas colaboradoras no han participado en el dise&#241;o y la realizaci&#243;n del estudio&#59; recopilaci&#243;n&#44; gesti&#243;n&#44; an&#225;lisis e interpretaci&#243;n de datos&#59; preparaci&#243;n&#44; revisi&#243;n o aprobaci&#243;n del manuscrito&#59; decisi&#243;n de enviar el manuscrito para su publicaci&#243;n&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">La Dra&#46; Baniandr&#233;s-Rodr&#237;guez ha actuado como consultora y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Celgene&#44; Leo Pharma y Almirall&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">El Dr&#46; Carretero ha sido reembolsado por Janssen&#44; AbbVie&#44; Novartis&#44; Pfizer&#44; MSD y Celgene por servicios de asesoramiento y conferencias&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">El Dr&#46; Vilar-Alejo particip&#243; como AB de Janssen&#44; Novartis&#44; AbbVie&#44; Almirall y Celgene&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">La Dra&#46; Rivera actu&#243; como consultora y&#47;o ponente y&#47;o particip&#243; en ensayos cl&#237;nicos como IP para AbbVie&#44; Almirall&#44; Celgene&#44; Janssen&#44; Leo Pharma&#44; Lilly&#44; Novartis&#44; MSD y Pfizer-Wyeth&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El Dr&#46; Carrascosa ha participado como ponente y&#47;o asesor de Celgene&#44; Janssen&#44; Lilly&#44; Novartis&#44; Leo Pharma&#44; Pfizer&#44; MSD&#44; AbbVie&#44; Biogen Amgen&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">El Dr&#46; Dauden actu&#243; como consultor para Abbott&#44; Amgen&#44; Astellas&#44; Centocor Ortho Biotech Inc&#44; Galderma&#44; Glaxo&#44; Jansenn-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD y Celgene&#44; recibi&#243; honorarios de Abbott&#44; Amgen&#44; Janssen-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD&#44; Celgene&#44; particip&#243; en <span class="elsevierStyleItalic">speakers bureau</span> para Abbott&#44; Pfizer&#44; MSD y Janssen y recibi&#243; subvenciones de Pfizer&#44; Abbott&#44; Janssen y MSD&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">El Dr&#46; Herrera-Acosta ha desempe&#241;ado como consultor y&#47;o ponente en Leo Pharma&#44; Novartis&#44; Janssen&#44; Lilly&#44; Celgene y AbbVie&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El Dr&#46; Sahuquillo ha desempe&#241;ado como consultor y&#47;o orador pagado y&#47;o participado en ensayos cl&#237;nicos patrocinados por compa&#241;&#237;as que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">El Dr&#46; de la Cueva actu&#243; como consultor y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; UCB&#44; Biogen&#44; Celgene&#44; Amgen&#44; Sandoz&#44; Sanofi y Leo-Pharma&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">El Dr&#46; L&#243;pez-Estebaranz particip&#243; como AB y recibi&#243; becas de Janssen&#44; AbbVie&#44; MSD&#44; Lilly&#44; Novartis&#44; Leo Pharma&#44; Pfizer&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">La Dra&#46; Belinch&#243;n actu&#243; como consultora y&#47;o ponente para y&#47;o particip&#243; en ensayos cl&#237;nicos patrocinados por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas Janssen Pharmaceuticals Inc&#44; Almirall SA&#44; Lilly&#44; AbbVie&#44; Novartis&#44; Celgene&#44; Biogen Amgen&#44; Leo-Pharma&#44; UCB&#44; Pfizer-Wyeth y MSD&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La Dra&#46; Ferran-Farr&#233;s ha participado como ponente o asesor de Janssen&#44; Lilly&#44; Novartis&#44; Pfizer&#44; MSD&#44; Abbvie Celgene y Almirall&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La Dra&#46; Rodr&#237;guez Fern&#225;ndez-Freire actu&#243; como consultor y ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; Celgene y Leo-Pharma&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">La Dra&#46; Garc&#237;a-Donoso particip&#243; como AB de AbbVie&#44; Almirall y ponente de Janssen&#44; Lilly y Celgene&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">La Dra&#46; Llamas-Velasco actu&#243; como consultor y ponente y particip&#243; en ensayos cl&#237;nicos para Janssen-Cilag&#44; AbbVie&#44; Celgene&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall y Leo-Pharma&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">La Dra&#46; Herrera-Ceballos se ha desempe&#241;ado como consultora y&#47;o ponente para y&#47;o participado en ensayos cl&#237;nicos como IP y patrocinada por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">El Dr&#46; Botella-Estrada se ha desempe&#241;ado como consultor y&#47;o orador pagado y&#47;o participado en ensayos cl&#237;nicos patrocinados por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">La Dra&#46; Ruiz-Genao ha sido reembolsada por Pfizer&#44; Janssen&#44; Celgene&#44; AbbVie&#44; Novartis y LEO Pharma por servicios de asesoramiento y conferencias&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">El Dr&#46; Riera-Monroig recibi&#243; becas de viaje para congresos de AbbVie&#44; Almirall&#44; Janssen&#44; LEO-Pharma y Novartis&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">El Dr&#46; Garc&#237;a-Doval recibi&#243; becas de viaje para congresos de AbbVie&#44; MSD y Pfizer&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Ninguno de los otros autores tiene intereses en conflicto que declarar&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El comienzo de la psoriasis en la edad pedi&#225;trica&#44; aunque generalmente leve&#44; puede requerir tratamiento sist&#233;mico en las formas moderadas o graves de la enfermedad&#46; El objetivo de este trabajo es analizar la frecuencia relativa&#44; las caracter&#237;sticas de los pacientes&#44; el tratamiento empleado y los eventos adversos &#40;EA&#41; observados a partir del registro BIOBADADERM en ni&#241;os y j&#243;venes con psoriasis moderada-grave&#46; Del total de 3&#46;946 pacientes del registro&#44; se incluyen 24 pacientes menores de 21 a&#241;os&#44; con una edad media al inicio del tratamiento en BIOBADADERM de 16&#44;1 a&#241;os y un PASI medio de 9&#44;4&#46; El 67&#37; de los pacientes estaba en tratamiento sist&#233;mico cl&#225;sico al inicio del registro&#46; Catorce pacientes &#40;58&#37;&#41; suspendieron el tratamiento por p&#233;rdida o falta de eficacia o por EA&#46; En conclusi&#243;n&#44; los datos del registro BIOBADADERM muestran que los menores representan un grupo muy peque&#241;o dentro de los pacientes con psoriasis que reciben tratamiento sist&#233;mico y son manejados m&#225;s frecuentemente con tratamientos cl&#225;sicos&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment&#46; The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe psoriasis in the BIOBADADERM registry and to analyze the characteristics of these patients&#44; treatments used&#44; and adverse events&#46; Of the 3946 patients in the registry&#44; 24 were aged 21 years or younger&#46; They had mean age of 16&#46;1 years on starting treatment&#46; When the registry was started&#44; they had a Psoriasis Area and Severity Index of 9&#46;4 and 67&#37; were being treated with a conventional systemic drug&#46; Treatment was discontinued in 14 patients &#40;58&#37;&#41; due to adverse events or a loss or lack of effectiveness&#46; In conclusion&#44; the BIOBADADERM registry shows that young people account for a small proportion of psoriasis patients receiving systemic treatment&#44; and they are more likely to be treated using conventional systemic drugs&#46;</p></span>"
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujeres&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Varones&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;71&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Edad media &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Edad media al inicio del tratamiento &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;DE&#58; 3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Gravedad de la enfermedad al inicio del registro &#40;PASI&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#44;7 &#40;DE&#58; 6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#44;3 &#40;DE&#58; 4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&#44;4 &#40;DE&#58; 5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Forma cl&#237;nica de psoriasis &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Psoriasis en placas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Psoriasis en gotas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Eritrodermia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artritis psori&#225;sica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamientos previos realizados &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PUVA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UVBbe&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Metotrexato&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ciclosporina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acitretina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de tratamientos previos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2917523.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de las caracter&#237;sticas epidemiol&#243;gicas&#44; cl&#237;nicas y tratamientos previos realizados por los pacientes incluidos en el estudio</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">COVID-19&#58; coronavirus disease-19&#59; N&#58; n&#250;mero&#59; &#37;&#58; porcentaje&#46;</p>"
          "tablatextoimagen" => array:3 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes &#8804; 18 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes 19-21 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tratamiento al inicio del registro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acitretina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adalimumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guselkumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2917525.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ciclos de tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acitretina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fumarato de dimetilo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adalimumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guselkumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risankizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secukinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2917526.png"
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            2 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Motivos de suspensi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ineficacia o p&#233;rdida de eficacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acontecimiento adverso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remisi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspensi&#243;n preventiva por COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Tratamientos realizados y efectos adversos notificados durante el registro BIOBADADERM</p>"
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    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "1"
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                  "contribucion" => array:1 [
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                      "titulo" => "Psoriasis&#58; Which therapy for which patient Focus on special populations and chronic infections"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;B&#46; Kaushik"
                            1 => "M&#46;G&#46; Lebwohl"
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2018.06.056"
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                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2019"
                        "volumen" => "80"
                        "paginaInicial" => "43"
                        "paginaFinal" => "53"
                        "link" => array:1 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint American Academy of Dermatology &#8211; National Psoriasis Foundation guidelines of care for the manegement and treatment of psoriasis in pediatric patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Menter"
                            1 => "K&#46;M&#46; Cordoro"
                            2 => "D&#46;M&#46; Davis"
                            3 => "D&#46; Kroshinsky"
                            4 => "A&#46;M&#46; Paller"
                            5 => "A&#46;W&#46; Armsrong"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "161"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31703821"
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              "identificador" => "bib0115"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint AAD-NPF Guidelines for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;A&#46; Elmets"
                            1 => "N&#46;J&#46; Korman"
                            2 => "E&#46;F&#46; Prater"
                            3 => "E&#46;B&#46; Wong"
                            4 => "R&#46;N&#46; Rupani"
                            5 => "D&#46; Kivelevitch"
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.07.087"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "432"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32738429"
                            "web" => "Medline"
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            3 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biologic treatment of recalcitrant pediatric psoriasis&#58; A case series from a terciary medical center"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Ollech"
                            1 => "A&#46; Zvulunov"
                            2 => "L&#46; Pavlovsky"
                            3 => "E&#46; Hodak"
                            4 => "D&#46; Ben-Amitai"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546634.2018.1476655"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat"
                        "fecha" => "2019"
                        "volumen" => "30"
                        "paginaInicial" => "152"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29757046"
                            "web" => "Medline"
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            4 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "BIOBADADERM&#58; registro espa&#241;ol de acontecimientos adversos de terapias biol&#243;gicas en Dermatolog&#237;a&#46; Primer informe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Rivera"
                            1 => "I&#46; Garc&#237;a-Doval"
                            2 => "G&#46; Carretero"
                            3 => "E&#46; Daud&#233;n"
                            4 => "J&#46; S&#225;nchez-Carazo"
                            5 => "C&#46; Ferr&#225;ndiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2010.10.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "132"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21377137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cambios en las tendencias de la prescripci&#243;n y causas de la interrupci&#243;n en los tratamientos biol&#243;gicos indicados en la psoriasis durante los primeros 10 a&#241;os Datos obtenidos del registro espa&#241;ol Biobadaderm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;P&#46; Ruiz-Genao"
                            1 => "G&#46; Carretero"
                            2 => "R&#46; Rivera"
                            3 => "C&#46; Ferr&#225;ndiz"
                            4 => "E&#46; Daud&#233;n"
                            5 => "P&#46; de la Cueva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2020.05.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2020"
                        "volumen" => "111"
                        "paginaInicial" => "752"
                        "paginaFinal" => "760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33058793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Translating the 2019 AAD-NPF guidelines of care for the management of psoriasis in pediatric patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;J&#46; Pithadia"
                            1 => "K&#46;A&#46; Reynolds"
                            2 => "E&#46;V&#46; Lee"
                            3 => "J&#46;J&#46; Wu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.12788/cutis.0115"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2020"
                        "volumen" => "106"
                        "paginaInicial" => "257"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33465190"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of systemic agents for the treatment of pediatric psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Bronckers"
                            1 => "M&#46;M&#46;B&#46; Seyger"
                            2 => "D&#46;P&#46; West"
                            3 => "I&#46; Lara-Corrales"
                            4 => "M&#46;M&#46; Tollefson"
                            5 => "W&#46;L&#46; Tom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2017.3029"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2017"
                        "volumen" => "153"
                        "paginaInicial" => "1147"
                        "paginaFinal" => "1157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28903160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and safety of cyclosporine in pediatric plaque psoriasis&#58; A multicentric retrospective analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Di Lernia"
                            1 => "L&#46; Stingeni"
                            2 => "V&#46; Boccaletti"
                            3 => "P&#46;G&#46; Calzavara Pinton"
                            4 => "C&#46; Guarneri"
                            5 => "A&#46; Belloni Fortina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatol Treat"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "395"
                        "paginaFinal" => "398"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacokinetics and safety of apremilast in pediatric patients with moderate to severe plaque psoriasis&#58; Results form a phase 2 open-label study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "Y&#46; Hong"
                            2 => "E&#46;M&#46; Becker"
                            3 => "R&#46; de Lucas"
                            4 => "M&#46; Paris"
                            5 => "W&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "389"
                        "paginaFinal" => "397"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31408686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term safety and efficacy of etanercept in children and adolescents with plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "E&#46;C&#46; Siegfried"
                            2 => "D&#46;M&#46; Pariser"
                            3 => "K&#46;C&#46; Rice"
                            4 => "M&#46; Trivedi"
                            5 => "J&#46; Iles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.09.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2016"
                        "volumen" => "74"
                        "paginaInicial" => "280"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26775775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis&#58; A randomised&#44; double-blind&#44; phase 3 trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Papp"
                            1 => "D&#46; Tha&#231;i"
                            2 => "D&#46; Marcoux"
                            3 => "L&#46; Weibel"
                            4 => "S&#46; Philipp"
                            5 => "P&#46;D&#46; Ghislain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(17)31189-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2017"
                        "volumen" => "390"
                        "paginaInicial" => "40"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28478975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ustekinumab for the treatment of moderate to severe plaque psoriasis in paediatric patients &#40;&#8805; 6 to &#8804; 12 years of age&#41;&#58; Efficacy&#44; safety&#44; pharmakokinetic and biomarker results from the open-label CADMUS Jr study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Philipp"
                            1 => "A&#46; Menter"
                            2 => "A&#46;F&#46; Nikkels"
                            3 => "K&#46; Barber"
                            4 => "I&#46; Landells"
                            5 => "L&#46;F&#46; Eichenfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "fecha" => "2020"
                        "volumen" => "183"
                        "paginaInicial" => "664"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32173852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secukinumab demonstrates high efficacy and a favourable safety profile in paediatric patients with severe chronic plaque psoriasis&#58; 52-week results from a Phase 3 double-blind randomised&#44; controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            1 => "A&#46; Kaszuba"
                            2 => "K&#46; Kingo"
                            3 => "A&#46; Tsianakas"
                            4 => "A&#46; Morita"
                            5 => "E&#46; Rivas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17002"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2021"
                        "volumen" => "35"
                        "paginaInicial" => "938"
                        "paginaFinal" => "947"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33068444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of ixekizumab in a phase III&#44; randomized&#44; doubl&#233;-blind&#44; placenbo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis &#40;IXORA-PEDS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "M&#46;M&#46;B&#46; Seyger"
                            2 => "G&#46; Alejandro Magari&#241;os"
                            3 => "J&#46; Bagel"
                            4 => "A&#46; Pinter"
                            5 => "J&#46; Cather"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2020"
                        "volumen" => "183"
                        "paginaInicial" => "231"
                        "paginaFinal" => "241"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "European Medicines Agency&#46; &#91;consultado 7 Feb 2021&#93; Disponible en&#58; https&#58;&#47;&#47;www&#46;ema&#46;europa&#46;eu&#47;en&#47;medicines&#46;2021"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic treatment of recalcitrant pediatric psoriasis&#58; a case series and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;A&#46; Garber"
                            1 => "B&#46;A&#46; Creighton-Smith"
                            2 => "E&#46;P&#46;B&#46;S&#46; Sorensen"
                            3 => "N&#46; Dumont"
                            4 => "A&#46;B&#46; Gottlieb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "14"
                        "paginaInicial" => "881"
                        "paginaFinal" => "886"
                        "itemHostRev" => array:3 [
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                          "estado" => "S300"
                          "issn" => "10647481"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic treatments in childhood psoriasis&#58; A French multicentre study on 154 children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Charbit"
                            1 => "E&#46; Mah&#233;"
                            2 => "A&#46; Pahn"
                            3 => "C&#46; Chiaverini"
                            4 => "F&#46; Boralevi"
                            5 => "E&#46; Bourrat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2015"
                        "volumen" => "174"
                        "paginaInicial" => "1118"
                        "paginaFinal" => "1121"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0195"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of moderate to severe pediatric psoriasis&#58; A retrospective case series"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2016"
                        "volumen" => "33"
                        "paginaInicial" => "142"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tratamiento sist&#233;mico de la psoriasis moderada-grave en edad pedi&#225;trica en Galicia&#58; estudio descriptivo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Batalla"
                            1 => "R&#46; Fern&#225;ndez-Torres"
                            2 => "L&#46; Rodr&#237;guez-Pazos"
                            3 => "B&#46; Monteagudo"
                            4 => "R&#46; Pardavila-Riveiro"
                            5 => "R&#46; Rodr&#237;guez-Lojo"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2018.05.003"
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                        "fecha" => "2018"
                        "volumen" => "109"
                        "paginaInicial" => "722"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30293554"
                            "web" => "Medline"
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                    ]
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                ]
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Comunicación breve
Psoriasis moderada-grave en pacientes pediátricos y jóvenes: experiencia en el registro BIOBADADERM
Moderate to Severe Psoriasis in Pediatric and Young Patients: The BIOBADADERM Registry Experience
L.M. Nieto Benitoa,
Corresponding author
lula.m.nieto@gmail.com

Autor para correspondencia.
, G. Carreterob, R. Rivera-Díazc, J.M. Carrascosad, E. Daudéne, P. de la Cuevaf, A. Sahuquillo-Torralbag, E. Herrera-Acostah, O. Baniandrés-Rodrígueza, J.L. Lopez-Estebaranzi, I. Belinchónj, J. Riera-Monroigk, M. Ferránl, F.J. Gómez-Garcíam, A. Mateun, L. Rodríguezo, J. Vilar-Alejob, C. García-Donosoc, F. Ballescád, Llamas-M. Velascoe..., R. Botella-Estradag, E. Herrera-Ceballosh, D.P. Ruiz-Genaoi, M.A. Descalzop, I. García-Dovalp,q, el grupo de estudio BIOBADADERM Ver más
a Departamento de Dermatología, CEIMI, Hospital General Universitario Gregorio Marañón, Madrid, España
b Departamento de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Islas Canarias, España
c Departamento de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España
d Departamento de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Universidad Autónoma de Barcelona, Barcelona, España
e Departamento de Dermatología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa (IIS-IP), Madrid, España
f Departamento de Dermatología, Hospital Universitario Infanta Leonor, Madrid, España
g Departamento de Dermatología, Hospital Universitario y Politécnico La Fe, Instituto de investigación Sanitaria La Fe (IIS La Fe), Facultad de Medicina, Universidad de Valencia, Valencia, España
h Departamento de Dermatología, Hospital Universitario Virgen de la Victoria, Málaga, España
i Departamento de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
j Departamento de Dermatología, Hospital General Universitario de Alicante-ISABIAL-UMH, Alicante, España
k Departamento de Dermatología, Hospital Clinic de Barcelona, UB, Barcelona, España
l Departamento de Dermatología, Hospital del Mar, Parc de Salut Mar, Barcelona, España
m Departamento de Dermatología, Hospital Universitario Reina Sofía, Córdoba, España
n Departamento de Dermatología, Hospital Universitario Doctor Peset, Valencia, España
o Departamento de Dermatología, Hospital Virgen del Rocío, Sevilla, España
p Unidad de Investigación, Fundación Piel Sana, AEDV, Madrid, España
q Departamento de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España
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Adem&#225;s&#44; se relaciona con mayor comorbilidad cardiovascular y metab&#243;lica&#44; por lo que&#44; especialmente en casos graves&#44; es necesaria una intervenci&#243;n precoz que pudiera contribuir a cambiar el curso inflamatorio de la enfermedad&#44; y evitar complicaciones y secuelas posteriores<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; Al ser un grupo etario vulnerable&#44; es fundamental disponer de estudios que ofrezcan datos de seguridad a largo plazo e&#44; idealmente&#44; que avalen el ajuste de dosis por peso en estos pacientes<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es analizar la frecuencia relativa&#44; las caracter&#237;sticas de los pacientes y el tratamiento empleado en pacientes pedi&#225;tricos&#44; y conocer los efectos adversos &#40;EA&#41; de los tratamientos sist&#233;micos en psoriasis juvenil en la pr&#225;ctica real&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Material y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Los datos de este estudio se obtuvieron del registro BIOBADADERM&#46; Es un estudio impulsado por el Grupo de Psoriasis de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a &#40;AEDV&#41;&#44; cuyo objetivo es analizar la seguridad de los tratamientos sist&#233;micos en psoriasis&#46; La descripci&#243;n del estudio ha sido publicada previamente<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se recogieron las caracter&#237;sticas demogr&#225;ficas y cl&#237;nicas &#8212;incluyendo la forma cl&#237;nica&#44; as&#237; como la gravedad&#44; Psoriasis Area Severity Index &#40;PASI&#41;&#8212; las comorbilidades&#44; los tratamientos previos&#44; el n&#250;mero de tratamientos realizados&#44; los eventos adversos y la evoluci&#243;n de los pacientes incluidos en BIOBADADERM menores de 18 a&#241;os incluidos en el registro hasta noviembre 2020&#46; De forma an&#225;loga&#44; se describieron tambi&#233;n las caracter&#237;sticas de los pacientes con edades comprendidas entre los 19 y 21 a&#241;os&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">BIOBADADERM fue aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n Cl&#237;nica del Hospital Doce de Octubre &#40;216&#47;07&#44; Madrid&#41; y se realiz&#243; en conformidad con la Declaraci&#243;n de Helsinki&#46; Todos los pacientes incluidos dieron su consentimiento por escrito y&#44; en el caso de los menores de edad&#44; lo hicieron sus padres y&#47;o tutores legales&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis descriptivo&#46; Las variables continuas se mostraron como medias con desviaciones est&#225;ndar o medianas y rangos intercuart&#237;licos&#46; Las variables cualitativas se expresaron con porcentajes y valores absolutos&#46; El an&#225;lisis estad&#237;stico se realiz&#243; con Stata&#174; &#40;StataCorp&#46; 2019&#46; Stata Statistical Software&#58; Release 16&#46; College Station&#44; TX&#58; StataCorp LLC&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="par0040" class="elsevierStylePara elsevierViewall">Del total de 3&#46;946 pacientes incluidos en el registro&#44; 9 pacientes eran menores de 18 a&#241;os y 15 de edades entre 19 y 21 a&#241;os&#46; Globalmente&#44; presentaban una edad media al diagn&#243;stico de la enfermedad de 16 &#40;DE&#58; 3&#44;1&#41; a&#241;os y predominio del sexo masculino &#40;71&#37;&#41;&#46; La duraci&#243;n media de enfermedad desde el diagn&#243;stico hasta el inicio del tratamiento era de unos 5&#44;5 &#40;DE&#58; 4&#44;8&#41; a&#241;os y presentaban un PASI medio de 9&#44;4 &#40;DE&#58; 5&#44;7&#41; al inicio del registro&#46; A excepci&#243;n de dos pacientes en el grupo de 19-21 a&#241;os &#40;hipertensi&#243;n arterial e infecci&#243;n por VIH&#41;&#44; el resto de los pacientes no presentaba comorbilidades&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La forma cl&#237;nica de psoriasis y los tratamientos previos realizados por ambos grupos se recogen en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los pacientes incluidos en este estudio recibieron como primer tratamiento dentro del registro&#44; un f&#225;rmaco sist&#233;mico no biol&#243;gico &#40;67&#37;&#41;&#58; 5 recibieron tratamiento con acitretina&#44; 3 con ciclosporina y 8 con metotrexato &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; En el grupo de pacientes que comenzaron con tratamiento biol&#243;gico&#44; ustekinumab fue el m&#225;s frecuente&#44; seguido de adalimumab y guselkumab&#46; En el grupo de pacientes menores de 18 a&#241;os&#44; el tratamiento sist&#233;mico m&#225;s frecuentemente prescrito a lo largo del seguimiento fue acitretina&#44; a diferencia de los pacientes de 19-21 a&#241;os&#44; en los que fue metotrexato&#46; El tiempo global de seguimiento para todos los pacientes fue de 38 personas&#47;a&#241;o&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">De los 46 ciclos de tratamiento administrados&#44; 28 &#40;61&#37;&#41; fueron suspendidos&#44; 14 &#40;28&#37;&#41; de los cuales fueron por p&#233;rdida o falta de eficacia o por EA&#44; perteneciendo cuatro de estos pacientes al grupo de menores de 18 a&#241;os&#46; Los EA que motivaron la suspensi&#243;n fueron diarrea y n&#225;useas asociadas a cefalea&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Del total de los 27 EA registrados&#44; 5 fueron en menores de 18 a&#241;os &#40;ninguno de ellos considerado como grave&#41; y 22 en pacientes de 19-21 a&#241;os&#46; En este grupo&#44; se registraron dos EA infecciosos en pacientes diferentes que no condicionaron la suspensi&#243;n del tratamiento&#58; una otitis media aguda&#44; en un paciente en tratamiento con acitretina y una apendicitis aguda&#44; en otro paciente con risankizumab&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">En este estudio se recogieron los datos de los 24 pacientes menores de 21 a&#241;os con diagn&#243;stico de psoriasis incluidos en el registro BIOBADADERM&#44; los cuales representaban solo el 0&#44;6&#37; del total de participantes&#46; La edad media al inicio del tratamiento sist&#233;mico cl&#225;sico o biol&#243;gico entre los menores de 18 a&#241;os fue de 14&#44;5 a&#241;os&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Estos datos podr&#237;an ser reflejo de la menor carga de enfermedad en la edad pedi&#225;trica&#44; en la que la mayor&#237;a de los casos se controlar&#237;a con tratamiento t&#243;pico<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;2</span></a> o de infratratamiento&#44; en los que el inicio de un tratamiento sist&#233;mico ser&#237;a retrasado hasta la edad adulta<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;7</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">La mayor&#237;a de la evidencia disponible en el tratamiento de la psoriasis moderada-grave en la edad pedi&#225;trica con tratamientos sist&#233;micos cl&#225;sicos y biol&#243;gicos est&#225; basada en la experiencia descrita en adultos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a>&#46; Aun as&#237;&#44; los datos en seguridad y eficacia de los diferentes biol&#243;gicos en la edad pedi&#225;trica est&#225; aumentando de forma considerable en los &#250;ltimos a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">8&#8211;17</span></a>&#46; A d&#237;a de hoy&#44; existen 5 f&#225;rmacos sist&#233;micos biol&#243;gicos aprobados por la European Medicines Agency &#40;EMA&#41; para el tratamiento de la psoriasis pedi&#225;trica&#58; etanercept&#44; ustekinumab&#44; secukinumab&#44; ixekizumab y adalimumab&#46; Los 4 primeros tienen indicaci&#243;n para el tratamiento de psoriasis moderada-grave en placas en pacientes pedi&#225;tricos mayores de 6 a&#241;os&#44; tras fallo o contraindicaci&#243;n a tratamientos sist&#233;micos cl&#225;sicos y&#47;o fototerapia y&#44; en el caso de adalimumab&#44; en pacientes mayores de 4 a&#241;os y como primera l&#237;nea de tratamiento en psoriasis grave<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Existen varios estudios retrospectivos que analizan las caracter&#237;sticas y el tratamiento de pacientes menores de 18 a&#241;os&#44; con diagn&#243;stico de psoriasis moderada-severa&#46; Charbit et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a> realizaron un estudio retrospectivo multic&#233;ntrico en el que se recogieron 154 pacientes&#46; Presentaban una edad media al diagn&#243;stico de 7&#44;7 a&#241;os y una edad media de inicio de tratamiento sist&#233;mico de 10&#44;3 a&#241;os&#46; Acitretina fue el tratamiento m&#225;s usado &#40;55&#44;2&#37;&#41; y prescrito como primera l&#237;nea de tratamiento &#40;76&#44;6&#37;&#41;&#59; 34 pacientes de la serie precisaron tratamiento biol&#243;gico&#46; De los 261 ciclos de tratamiento&#44; 15 tuvieron que ser suspendidos por EA&#46; Ciclosporina fue el f&#225;rmaco que m&#225;s se asoci&#243; a EA graves&#44; condicionando la suspensi&#243;n del tratamiento &#40;mialgias&#44; trastornos gastrointestinales&#44; hipertricosis&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Otro estudio<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a> recogi&#243; las caracter&#237;sticas de 51 pacientes&#46; Analizan los pacientes que reciben tratamiento sist&#233;mico cl&#225;sico y biol&#243;gico en monoterapia y&#47;o en combinaci&#243;n&#46; Metotrexato es el tratamiento no biol&#243;gico m&#225;s utilizado &#40;27&#44;5&#37;&#41; en monoterapia y combinado con f&#225;rmaco biol&#243;gico&#59; solo un paciente recibi&#243; tratamiento con acitretina&#46; El tratamiento biol&#243;gico m&#225;s usado fue etanercept &#40;23 pacientes&#41;&#44; seguido de adalimumab y ustekinumab&#46; Se reportaron 29 EA del total de 80 ciclos de tratamiento&#46; Los esquemas de tratamiento combinado no presentaron mayor n&#250;mero de EA&#44; aunque el poder estad&#237;stico para detectar diferencias es bajo&#46; El EA m&#225;s frecuente en los pacientes en tratamiento con metotrexato fue la intolerancia gastrointestinal&#59; solo un paciente recib&#237;a el tratamiento de forma subcut&#225;nea&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">En nuestro medio&#44; un estudio<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a> recogi&#243; un grupo de 40 pacientes menores de edad que presentaban una edad media al diagn&#243;stico de psoriasis de 10&#44;2 a&#241;os y de inicio de tratamiento sist&#233;mico de 13&#44;4 a&#241;os&#46; De los 63 ciclos de tratamiento y excluyendo 36 de los mismos &#40;tratamiento con fototerapia&#41;&#44; el tratamiento m&#225;s usado en primera l&#237;nea fue acitretina&#44; pero&#44; globalmente&#44; fue metotrexato&#46; Etanercept y acitretina fueron los tratamientos m&#225;s prolongados&#46; Describen un 11&#37; de EA&#44; ninguno de los cuales condicion&#243; la suspensi&#243;n del f&#225;rmaco&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Con respecto al uso de tratamientos biol&#243;gicos&#44; Bronckers et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> realizaron un estudio retrospectivo de 390 pacientes&#44; con una edad media de 11 a&#241;os y 482 ciclos de tratamiento incluidos&#46; El tratamiento biol&#243;gico m&#225;s usado fue etanercept&#44; seguido de adalimumab&#44; ustekinumab e infliximab&#46; De los 270 pacientes que fueron tratados con metotrexato&#44; el 48&#44;1&#37; experiment&#243; alg&#250;n EA&#44; siendo 3 de ellos considerados como graves y condicionando la suspensi&#243;n del tratamiento&#46; Tres pacientes en tratamiento con fumaratos y 2 con adalimumab tuvieron que suspender el tratamiento por EA grave&#46; No se observ&#243; ning&#250;n EA en los 2 pacientes tratados con infliximab&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Ollech et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> recogieron una serie de 10 pacientes con psoriasis grave&#59; etanercept tambi&#233;n fue el tratamiento biol&#243;gico m&#225;s prescrito&#46; La edad media de inicio de tratamiento biol&#243;gico fue de 12&#44;6 a&#241;os&#46; Fue preciso el uso de una segunda l&#237;nea en 6 casos y de una tercera&#44; en 3&#46; En cuanto a los EA&#44; los dos casos que hab&#237;an recibido tratamiento con infliximab tuvieron que ser suspendidos por reacci&#243;n de hipersensibilidad al f&#225;rmaco&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los datos del registro BIOBADADERM muestran que los menores representan un grupo muy peque&#241;o dentro de los pacientes con psoriasis que reciben tratamiento sist&#233;mico y son manejados m&#225;s frecuentemente con tratamientos cl&#225;sicos&#44; sin poder establecer si el motivo es por la menor gravedad o un posible infratratamiento&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Financiaci&#243;n</span><p id="par0110" class="elsevierStylePara elsevierViewall">El proyecto BIOBADADERM est&#225; promovido por la Fundaci&#243;n Piel Sana&#44; Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a&#44; que cuenta con el apoyo econ&#243;mico de la Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios y de empresas farmac&#233;uticas &#40;Abbott&#47;AbbVie&#44; Amgen&#44; Almirall&#44; Janssen&#44; Novartis y UCB&#41;&#46; Las siguientes empresas tambi&#233;n han colaborado en el pasado &#40;Leo Pharma&#44; Lilly&#44; MSD y Pfizer&#41;&#46; Las empresas farmac&#233;uticas colaboradoras no han participado en el dise&#241;o y la realizaci&#243;n del estudio&#59; recopilaci&#243;n&#44; gesti&#243;n&#44; an&#225;lisis e interpretaci&#243;n de datos&#59; preparaci&#243;n&#44; revisi&#243;n o aprobaci&#243;n del manuscrito&#59; decisi&#243;n de enviar el manuscrito para su publicaci&#243;n&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">La Dra&#46; Baniandr&#233;s-Rodr&#237;guez ha actuado como consultora y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Celgene&#44; Leo Pharma y Almirall&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">El Dr&#46; Carretero ha sido reembolsado por Janssen&#44; AbbVie&#44; Novartis&#44; Pfizer&#44; MSD y Celgene por servicios de asesoramiento y conferencias&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">El Dr&#46; Vilar-Alejo particip&#243; como AB de Janssen&#44; Novartis&#44; AbbVie&#44; Almirall y Celgene&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">La Dra&#46; Rivera actu&#243; como consultora y&#47;o ponente y&#47;o particip&#243; en ensayos cl&#237;nicos como IP para AbbVie&#44; Almirall&#44; Celgene&#44; Janssen&#44; Leo Pharma&#44; Lilly&#44; Novartis&#44; MSD y Pfizer-Wyeth&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El Dr&#46; Carrascosa ha participado como ponente y&#47;o asesor de Celgene&#44; Janssen&#44; Lilly&#44; Novartis&#44; Leo Pharma&#44; Pfizer&#44; MSD&#44; AbbVie&#44; Biogen Amgen&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">El Dr&#46; Dauden actu&#243; como consultor para Abbott&#44; Amgen&#44; Astellas&#44; Centocor Ortho Biotech Inc&#44; Galderma&#44; Glaxo&#44; Jansenn-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD y Celgene&#44; recibi&#243; honorarios de Abbott&#44; Amgen&#44; Janssen-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD&#44; Celgene&#44; particip&#243; en <span class="elsevierStyleItalic">speakers bureau</span> para Abbott&#44; Pfizer&#44; MSD y Janssen y recibi&#243; subvenciones de Pfizer&#44; Abbott&#44; Janssen y MSD&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">El Dr&#46; Herrera-Acosta ha desempe&#241;ado como consultor y&#47;o ponente en Leo Pharma&#44; Novartis&#44; Janssen&#44; Lilly&#44; Celgene y AbbVie&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El Dr&#46; Sahuquillo ha desempe&#241;ado como consultor y&#47;o orador pagado y&#47;o participado en ensayos cl&#237;nicos patrocinados por compa&#241;&#237;as que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">El Dr&#46; de la Cueva actu&#243; como consultor y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; UCB&#44; Biogen&#44; Celgene&#44; Amgen&#44; Sandoz&#44; Sanofi y Leo-Pharma&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">El Dr&#46; L&#243;pez-Estebaranz particip&#243; como AB y recibi&#243; becas de Janssen&#44; AbbVie&#44; MSD&#44; Lilly&#44; Novartis&#44; Leo Pharma&#44; Pfizer&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">La Dra&#46; Belinch&#243;n actu&#243; como consultora y&#47;o ponente para y&#47;o particip&#243; en ensayos cl&#237;nicos patrocinados por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas Janssen Pharmaceuticals Inc&#44; Almirall SA&#44; Lilly&#44; AbbVie&#44; Novartis&#44; Celgene&#44; Biogen Amgen&#44; Leo-Pharma&#44; UCB&#44; Pfizer-Wyeth y MSD&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La Dra&#46; Ferran-Farr&#233;s ha participado como ponente o asesor de Janssen&#44; Lilly&#44; Novartis&#44; Pfizer&#44; MSD&#44; Abbvie Celgene y Almirall&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La Dra&#46; Rodr&#237;guez Fern&#225;ndez-Freire actu&#243; como consultor y ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; Celgene y Leo-Pharma&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">La Dra&#46; Garc&#237;a-Donoso particip&#243; como AB de AbbVie&#44; Almirall y ponente de Janssen&#44; Lilly y Celgene&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">La Dra&#46; Llamas-Velasco actu&#243; como consultor y ponente y particip&#243; en ensayos cl&#237;nicos para Janssen-Cilag&#44; AbbVie&#44; Celgene&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall y Leo-Pharma&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">La Dra&#46; Herrera-Ceballos se ha desempe&#241;ado como consultora y&#47;o ponente para y&#47;o participado en ensayos cl&#237;nicos como IP y patrocinada por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">El Dr&#46; Botella-Estrada se ha desempe&#241;ado como consultor y&#47;o orador pagado y&#47;o participado en ensayos cl&#237;nicos patrocinados por empresas que fabrican medicamentos utilizados para el tratamiento de la psoriasis&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">La Dra&#46; Ruiz-Genao ha sido reembolsada por Pfizer&#44; Janssen&#44; Celgene&#44; AbbVie&#44; Novartis y LEO Pharma por servicios de asesoramiento y conferencias&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">El Dr&#46; Riera-Monroig recibi&#243; becas de viaje para congresos de AbbVie&#44; Almirall&#44; Janssen&#44; LEO-Pharma y Novartis&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">El Dr&#46; Garc&#237;a-Doval recibi&#243; becas de viaje para congresos de AbbVie&#44; MSD y Pfizer&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Ninguno de los otros autores tiene intereses en conflicto que declarar&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El comienzo de la psoriasis en la edad pedi&#225;trica&#44; aunque generalmente leve&#44; puede requerir tratamiento sist&#233;mico en las formas moderadas o graves de la enfermedad&#46; El objetivo de este trabajo es analizar la frecuencia relativa&#44; las caracter&#237;sticas de los pacientes&#44; el tratamiento empleado y los eventos adversos &#40;EA&#41; observados a partir del registro BIOBADADERM en ni&#241;os y j&#243;venes con psoriasis moderada-grave&#46; Del total de 3&#46;946 pacientes del registro&#44; se incluyen 24 pacientes menores de 21 a&#241;os&#44; con una edad media al inicio del tratamiento en BIOBADADERM de 16&#44;1 a&#241;os y un PASI medio de 9&#44;4&#46; El 67&#37; de los pacientes estaba en tratamiento sist&#233;mico cl&#225;sico al inicio del registro&#46; Catorce pacientes &#40;58&#37;&#41; suspendieron el tratamiento por p&#233;rdida o falta de eficacia o por EA&#46; En conclusi&#243;n&#44; los datos del registro BIOBADADERM muestran que los menores representan un grupo muy peque&#241;o dentro de los pacientes con psoriasis que reciben tratamiento sist&#233;mico y son manejados m&#225;s frecuentemente con tratamientos cl&#225;sicos&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment&#46; The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe psoriasis in the BIOBADADERM registry and to analyze the characteristics of these patients&#44; treatments used&#44; and adverse events&#46; Of the 3946 patients in the registry&#44; 24 were aged 21 years or younger&#46; They had mean age of 16&#46;1 years on starting treatment&#46; When the registry was started&#44; they had a Psoriasis Area and Severity Index of 9&#46;4 and 67&#37; were being treated with a conventional systemic drug&#46; Treatment was discontinued in 14 patients &#40;58&#37;&#41; due to adverse events or a loss or lack of effectiveness&#46; In conclusion&#44; the BIOBADADERM registry shows that young people account for a small proportion of psoriasis patients receiving systemic treatment&#44; and they are more likely to be treated using conventional systemic drugs&#46;</p></span>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero total de pacientes &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Varones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad media &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;DE&#58; 0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;DE&#58; 1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;DE&#58; 2&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad media al inicio del tratamiento &#40;a&#241;os&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;5 &#40;DE&#58; 4&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;5 &#40;DE&#58; 2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;DE&#58; 3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gravedad de la enfermedad al inicio del registro &#40;PASI&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;7 &#40;DE&#58; 6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;3 &#40;DE&#58; 4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;4 &#40;DE&#58; 5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Forma cl&#237;nica de psoriasis &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Psoriasis en placas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Psoriasis en gotas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Eritrodermia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artritis psori&#225;sica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamientos previos realizados &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PUVA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>UVBbe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acitretina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">N&#250;mero de tratamientos previos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab2917523.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de las caracter&#237;sticas epidemiol&#243;gicas&#44; cl&#237;nicas y tratamientos previos realizados por los pacientes incluidos en el estudio</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">COVID-19&#58; coronavirus disease-19&#59; N&#58; n&#250;mero&#59; &#37;&#58; porcentaje&#46;</p>"
          "tablatextoimagen" => array:3 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes &#8804; 18 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes 19-21 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tratamiento al inicio del registro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acitretina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adalimumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guselkumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2917525.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ciclos de tratamiento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acitretina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ciclosporina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fumarato de dimetilo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adalimumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guselkumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risankizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secukinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2917526.png"
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            2 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Motivos de suspensi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N &#40;&#37; sobre total de pacientes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ineficacia o p&#233;rdida de eficacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acontecimiento adverso&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remisi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspensi&#243;n preventiva por COVID-19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Otros&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Tratamientos realizados y efectos adversos notificados durante el registro BIOBADADERM</p>"
        ]
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        "tipo" => "MULTIMEDIAFIGURA"
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          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 739
            "Ancho" => 1333
            "Tamanyo" => 142803
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    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis&#58; Which therapy for which patient Focus on special populations and chronic infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;B&#46; Kaushik"
                            1 => "M&#46;G&#46; Lebwohl"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2018.06.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2019"
                        "volumen" => "80"
                        "paginaInicial" => "43"
                        "paginaFinal" => "53"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30017706"
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              "identificador" => "bib0110"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint American Academy of Dermatology &#8211; National Psoriasis Foundation guidelines of care for the manegement and treatment of psoriasis in pediatric patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Menter"
                            1 => "K&#46;M&#46; Cordoro"
                            2 => "D&#46;M&#46; Davis"
                            3 => "D&#46; Kroshinsky"
                            4 => "A&#46;M&#46; Paller"
                            5 => "A&#46;W&#46; Armsrong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.049"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "161"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31703821"
                            "web" => "Medline"
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              "identificador" => "bib0115"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint AAD-NPF Guidelines for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;A&#46; Elmets"
                            1 => "N&#46;J&#46; Korman"
                            2 => "E&#46;F&#46; Prater"
                            3 => "E&#46;B&#46; Wong"
                            4 => "R&#46;N&#46; Rupani"
                            5 => "D&#46; Kivelevitch"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.07.087"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "432"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32738429"
                            "web" => "Medline"
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            3 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biologic treatment of recalcitrant pediatric psoriasis&#58; A case series from a terciary medical center"
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                            1 => "I&#46; Garc&#237;a-Doval"
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                            3 => "E&#46; Daud&#233;n"
                            4 => "J&#46; S&#225;nchez-Carazo"
                            5 => "C&#46; Ferr&#225;ndiz"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2010.10.016"
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                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                        "volumen" => "102"
                        "paginaInicial" => "132"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21377137"
                            "web" => "Medline"
                          ]
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                ]
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                      "titulo" => "Cambios en las tendencias de la prescripci&#243;n y causas de la interrupci&#243;n en los tratamientos biol&#243;gicos indicados en la psoriasis durante los primeros 10 a&#241;os Datos obtenidos del registro espa&#241;ol Biobadaderm"
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                        "link" => array:1 [
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                      "titulo" => "Translating the 2019 AAD-NPF guidelines of care for the management of psoriasis in pediatric patients"
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                            3 => "J&#46;J&#46; Wu"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33465190"
                            "web" => "Medline"
                          ]
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                ]
              ]
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                      "titulo" => "Safety of systemic agents for the treatment of pediatric psoriasis"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "I&#46; Bronckers"
                            1 => "M&#46;M&#46;B&#46; Seyger"
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                            3 => "I&#46; Lara-Corrales"
                            4 => "M&#46;M&#46; Tollefson"
                            5 => "W&#46;L&#46; Tom"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2017.3029"
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                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2017"
                        "volumen" => "153"
                        "paginaInicial" => "1147"
                        "paginaFinal" => "1157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28903160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "9"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and safety of cyclosporine in pediatric plaque psoriasis&#58; A multicentric retrospective analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Di Lernia"
                            1 => "L&#46; Stingeni"
                            2 => "V&#46; Boccaletti"
                            3 => "P&#46;G&#46; Calzavara Pinton"
                            4 => "C&#46; Guarneri"
                            5 => "A&#46; Belloni Fortina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatol Treat"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "395"
                        "paginaFinal" => "398"
                      ]
                    ]
                  ]
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              "identificador" => "bib0150"
              "etiqueta" => "10"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacokinetics and safety of apremilast in pediatric patients with moderate to severe plaque psoriasis&#58; Results form a phase 2 open-label study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "Y&#46; Hong"
                            2 => "E&#46;M&#46; Becker"
                            3 => "R&#46; de Lucas"
                            4 => "M&#46; Paris"
                            5 => "W&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "389"
                        "paginaFinal" => "397"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31408686"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term safety and efficacy of etanercept in children and adolescents with plaque psoriasis"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "E&#46;C&#46; Siegfried"
                            2 => "D&#46;M&#46; Pariser"
                            3 => "K&#46;C&#46; Rice"
                            4 => "M&#46; Trivedi"
                            5 => "J&#46; Iles"
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.09.056"
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                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2016"
                        "volumen" => "74"
                        "paginaInicial" => "280"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26775775"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "12"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis&#58; A randomised&#44; double-blind&#44; phase 3 trial"
                      "autores" => array:1 [
                        0 => array:2 [
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                            1 => "D&#46; Tha&#231;i"
                            2 => "D&#46; Marcoux"
                            3 => "L&#46; Weibel"
                            4 => "S&#46; Philipp"
                            5 => "P&#46;D&#46; Ghislain"
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                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28478975"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Ustekinumab for the treatment of moderate to severe plaque psoriasis in paediatric patients &#40;&#8805; 6 to &#8804; 12 years of age&#41;&#58; Efficacy&#44; safety&#44; pharmakokinetic and biomarker results from the open-label CADMUS Jr study"
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                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
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                        "paginaFinal" => "947"
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                      "titulo" => "Systemic treatment of recalcitrant pediatric psoriasis&#58; a case series and literature review"
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                      "titulo" => "Systemic treatments in childhood psoriasis&#58; A French multicentre study on 154 children"
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                      "titulo" => "Treatment of moderate to severe pediatric psoriasis&#58; A retrospective case series"
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                      "titulo" => "Tratamiento sist&#233;mico de la psoriasis moderada-grave en edad pedi&#225;trica en Galicia&#58; estudio descriptivo"
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Article information
ISSN: 00017310
Original language: Spanish
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2023 June 99 40 139
2023 May 87 43 130
2023 April 81 39 120
2023 March 95 42 137
2023 February 62 42 104
2023 January 83 59 142
2022 December 98 52 150
2022 November 81 59 140
2022 October 114 59 173
2022 September 72 70 142
2022 August 66 66 132
2022 July 62 50 112
2022 June 100 69 169
2022 May 138 72 210
2022 April 76 47 123
2022 March 74 47 121
2022 February 56 28 84
2022 January 83 41 124
2021 December 29 56 85
2021 November 55 52 107
2021 October 71 68 139
2021 September 12 18 30
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?