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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Las epiderm&#243;lisis ampollosas hereditarias &#40;EA&#41; son un grupo heterog&#233;neo de genodermatosis caracterizadas por fragilidad cut&#225;nea de tipo mec&#225;nico<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Se realiz&#243; un estudio descriptivo y retrospectivo que incluy&#243; a los pacientes diagnosticados de EA mediante estudio gen&#233;tico en el Hospital Cl&#237;nico Universitario de Valencia&#44; entre 1968 y 2018&#46; No se dispon&#237;a de ning&#250;n registro con los casos valorados sin diagn&#243;stico molecular&#46; En 2018&#44; la poblaci&#243;n adscrita al Departamento de Salud Cl&#237;nico-La Malvarrosa era de 344&#46;019 personas<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Las variables analizadas fueron&#58; edad al diagn&#243;stico&#44; edad actual&#44; antecedentes familiares de EA&#44; manifestaciones cl&#237;nicas&#44; localizaci&#243;n de las lesiones&#44; plano de separaci&#243;n dermo-epid&#233;rmico&#44; estudio histol&#243;gico&#44; gen mutado&#44; mutaci&#243;n&#44; tipo de herencia&#44; cigosidad&#44; tipo de EA&#44; tratamiento y complicaciones &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Respecto a las complicaciones&#44; se evalu&#243; la presencia de caries&#44; erosiones y &#250;lceras orales&#44; reflujo gastroesof&#225;gico&#44; estre&#241;imiento&#44; retraso del crecimiento&#44; anemia&#44; enfermedad renal&#44; sindactalia&#44; carcinoma epidermoide cut&#225;neo &#40;CEC&#41; y depresi&#243;n&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">El n&#250;mero de pacientes fue de ocho&#59; tres se diagnosticaron de EA simple y cinco de EA distr&#243;fica&#46; Los subtipos m&#225;s frecuentes fueron la EA simple localizada y la EA distr&#243;fica generalizada&#46; El 75&#37; eran mujeres&#44; el 62&#44;5&#37; se diagnosticaron al nacimiento y presentaban antecedentes familiares&#46; Los pacientes 1 y 2&#44; y el 7 y 8 eran hermanos&#46; La manifestaci&#243;n cl&#237;nica m&#225;s frecuente fueron las ampollas &#40;87&#44;5&#37;&#41; y se localizaron principalmente en las extremidades&#46; Todos los pacientes recibieron tratamiento t&#243;pico y seis precisaron hidroxicina como tratamiento sintom&#225;tico del prurito&#46; El tratamiento t&#243;pico consisti&#243; en antibi&#243;ticos&#44; curas locales con antis&#233;pticos y ap&#243;sitos primarios &#40;ap&#243;sitos de silicona&#41; y&#47;o con ap&#243;sitos secundarios &#40;ap&#243;sitos algodonosos y&#47;o malla tubular&#41;&#46; A todos los pacientes se les indicaron medidas higi&#233;nicas&#44; que incluyeron&#58; usar ropa de algod&#243;n&#44; realizar duchas sin jab&#243;n&#44; usar loci&#243;n hidratante&#44; secar el cuerpo con toques delicados&#44; drenar el contenido de las ampollas con aguja est&#233;ril sin desepitelizarlas y usar clorhexidina 0&#44;5&#37; como antis&#233;ptico&#46; La paciente con EA distr&#243;fica &#40;EAD&#41; generalizada severa requiri&#243; gabapentina por prurito refractario y soporte nutricional por desnutrici&#243;n&#46; Una paciente con EAD generalizada present&#243; un CEC metast&#225;sico en la pierna derecha que se trat&#243; con amputaci&#243;n&#44; linfadenectom&#237;a inguinal y radioterapia paliativa&#46; La anemia fue la complicaci&#243;n m&#225;s frecuente &#40;50&#37;&#41; y dos pacientes requirieron tratamiento con hierro oral por presentar una cifra de hemoglobina menor a 10<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#46; La evoluci&#243;n cl&#237;nica fue variable&#44; desde la mejor&#237;a de las lesiones hasta el fallecimiento de una paciente por un CEC metast&#225;sico&#46; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Las EA se producen por mutaciones en los genes que codifican las prote&#237;nas estructurales de la uni&#243;n dermoepid&#233;rmica&#46; El nivel de separaci&#243;n histopatol&#243;gico y la mutaci&#243;n gen&#233;tica define el tipo y subtipo de EA&#46; Los tipos de EA son&#58; EA simple &#40;EAS&#41;&#44; EA juntural &#40;EAJ&#41;&#44; EA distr&#243;fica &#40;EAD&#41; y s&#237;ndrome de Kindler<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46; En la EAS la ampolla aparece en el plano epid&#233;rmico&#44; en la EAJ en la l&#225;mina l&#250;cida y en la EAD en la subl&#225;mina densa&#46; La EAJ y la EAD suelen ser m&#225;s graves porque pueden afectar a otros &#243;rganos cubiertos por un epitelio<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La EAS suele presentarse en el periodo neonatal&#46; Las cicatrices&#44; los quistes de milium y la distrofia ungueal son menos frecuentes que en la EAJ y EAD&#46; La EAS localizada es el subtipo m&#225;s frecuente y se presenta con ampollas en las palmas y plantas&#46; La EAS generalizada severa se caracteriza por ampollas generalizadas en el periodo neonatal&#44; distribuci&#243;n herpetiforme de las lesiones en la infancia y desarrollo de una queratodermia palmoplantar<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La caracter&#237;stica m&#225;s constante de la EAJ es la hipoplasia del esmalte&#44; y en las formas graves&#44; la aparici&#243;n de un tejido de granulaci&#243;n exuberante en las regiones periorificiales y los pliegues<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46; Las EAD autos&#243;mico recesivas son las m&#225;s graves causando una enfermedad ampollosa&#44; erosiva y mutilante con compromiso cut&#225;neo-mucoso y de los &#243;rganos internos&#46; El CEC es m&#225;s frecuente y agresivo en los pacientes con EAD&#44; consider&#225;ndose como la principal causa de muerte en la EA<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4&#8211;7</span></a>&#46; En contraste con la experiencia de Feinstein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#44; en esta serie destaca el predominio de las formas de EAD autos&#243;mica dominante frente a las formas recesivas&#46; Adem&#225;s&#44; es interesante remarcar el desarrollo de CEC en las dos mujeres adultas con EAD generalizada&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En el proceso diagn&#243;stico se debe realizar una biopsia cut&#225;nea de una lesi&#243;n inducida por fricci&#243;n para realizar un mapeo antig&#233;nico histol&#243;gico que establecer&#225; el plano de separaci&#243;n dermo-epid&#233;rmica y orientar&#225; el tipo de EA y el estudio gen&#233;tico<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; El diagn&#243;stico molecular es fundamental&#44; ya que aporta informaci&#243;n esencial para el pron&#243;stico y para un manejo adecuado de los pacientes&#44; y proporciona un consejo gen&#233;tico a los padres e individuos afectados<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El tratamiento es sintom&#225;tico y multidisciplinar&#44; encontr&#225;ndose en desarrollo terapias proteicas&#44; celulares y g&#233;nicas para la EAD<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4&#44;9</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la prevalencia de EA en nuestro departamento de salud es similar a la descrita en estudios previos<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46; La mayor&#237;a de los pacientes eran mujeres y se diagnosticaron al nacimiento&#46; Las manifestaciones cl&#237;nicas fueron heterog&#233;neas&#44; siendo las ampollas&#44; la onicodistrofia y el prurito las m&#225;s frecuentes&#46; La complicaci&#243;n m&#225;s frecuente fue la anemia&#44; lo cual puede estar relacionado con la mayor frecuencia de EAD en nuestra serie&#46; El tratamiento&#44; principalmente&#44; fue sintom&#225;tico&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financiaci&#243;n</span><p id="par0077" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicto de intereses</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paciente 1&#58; Ni&#241;o de 10 a&#241;os con EASl&#59; 1<span class="elsevierStyleHsp" style=""></span>A&#41; Ampolla en la palma de la mano&#59; 1<span class="elsevierStyleHsp" style=""></span>B&#41; Onicodistrofia&#59; 1<span class="elsevierStyleHsp" style=""></span>C&#41; Cicatrizaci&#243;n con quistes de milium en zonas sometidas a traumatismos&#46; Paciente 3&#58; Reci&#233;n nacida con EASgs&#59; 1<span class="elsevierStyleHsp" style=""></span>D&#41; Ampollas y erosiones cut&#225;neas generalizadas&#59; Control en la infancia&#59; 1<span class="elsevierStyleHsp" style=""></span>E&#44; 1<span class="elsevierStyleHsp" style=""></span>H&#41; Ampollas de distribuci&#243;n herpetiforme en la regi&#243;n lumbar&#44; gl&#250;tea y muslos junto con signos de cicatrizaci&#243;n atr&#243;fica&#59; Control en la adolescencia&#59; 1<span class="elsevierStyleHsp" style=""></span>F&#41; Onicodistrofia&#59; 1<span class="elsevierStyleHsp" style=""></span>G&#44; 1<span class="elsevierStyleHsp" style=""></span>I&#41; Queratodermia palmoplantar&#59; 1<span class="elsevierStyleHsp" style=""></span>J&#41; Pseudoliendres o vainas peripilares&#46; Paciente 4&#58; Ni&#241;a de 7 a&#241;os con EADp&#59; 1<span class="elsevierStyleHsp" style=""></span>K&#44; 1<span class="elsevierStyleHsp" style=""></span>L&#44; 1<span class="elsevierStyleHsp" style=""></span>M&#41; Papulon&#243;dulos pruriginosos localizados en las superficies de extensi&#243;n de las extremidades&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas cl&#237;nico-epidemiol&#243;gicas de los pacientes diagnosticados de EA</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t" scope="col">Paciente 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Manifestaciones cl&#237;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQPPPelo raloPseudoliendresOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Papulon&#243;dulos tipo prurigo nodularQuistes de miliumPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumPelo raloOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de milium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumAusencia de u&#241;asPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasP&#233;rdida de dientesAusencia de u&#241;asContracturas en flexi&#243;nPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localizaci&#243;n de las lesiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoGl&#250;teosExtremidadesAcralMucosa oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraTroncoGl&#250;teosExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraTroncoGl&#250;teoExtremidadesAcralMucosa oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Histolog&#237;a<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47;ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47; ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47;ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No realizado&#94;&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No realizado&#94;&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gen mutado&#47;mutaci&#243;n&#47;Edad del diagn&#243;stico molecular<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47;p&#46;Gly12rg&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47;p&#46;Gly12rg&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47; p&#46;Glu477Lys&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; p&#46;Arg1814&#95;Gly1815delinsLeuHis&#47;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47;p&#46;Gly1377Aspfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>22&#47;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herencia&#47;Cigosidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AD Heterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AD Heterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ARHomocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de EA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASgs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADgs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamiento recibido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAntihistam&#237;nicosAp&#243;sitos de siliconaMalla tubularMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntibi&#243;tico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAntibi&#243;tico sist&#233;micoAntihistam&#237;nicosAp&#243;sitos de siliconaMalla tubularNutrici&#243;nHierro oralMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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Carta científico-clínica
Epidermólisis ampollosa hereditaria: serie de casos
Hereditary Epidermolysis Bullosa: A Case Series
S. Guillen-Climenta,
Corresponding author
santigc85@gmail.com

Autor para correspondencia.
, L. Fernández Garcíab, A. García-Vázqueza, J.M. Martína,c
a Servicio de Dermatología, Hospital Clínico Universitario, Valencia, España
b Facultad de Medicina, Universidad de Valencia, Valencia, España
c Departamento de Medicina, Facultad de Medicina, Universidad de Valencia, Valencia, España
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edad al diagn&#243;stico&#44; edad actual&#44; antecedentes familiares de EA&#44; manifestaciones cl&#237;nicas&#44; localizaci&#243;n de las lesiones&#44; plano de separaci&#243;n dermo-epid&#233;rmico&#44; estudio histol&#243;gico&#44; gen mutado&#44; mutaci&#243;n&#44; tipo de herencia&#44; cigosidad&#44; tipo de EA&#44; tratamiento y complicaciones &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Respecto a las complicaciones&#44; se evalu&#243; la presencia de caries&#44; erosiones y &#250;lceras orales&#44; reflujo gastroesof&#225;gico&#44; estre&#241;imiento&#44; retraso del crecimiento&#44; anemia&#44; enfermedad renal&#44; sindactalia&#44; carcinoma epidermoide cut&#225;neo &#40;CEC&#41; y depresi&#243;n&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">El n&#250;mero de pacientes fue de ocho&#59; tres se diagnosticaron de EA simple y cinco de EA distr&#243;fica&#46; Los subtipos m&#225;s frecuentes fueron la EA simple localizada y la EA distr&#243;fica generalizada&#46; 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como antis&#233;ptico&#46; La paciente con EA distr&#243;fica &#40;EAD&#41; generalizada severa requiri&#243; gabapentina por prurito refractario y soporte nutricional por desnutrici&#243;n&#46; Una paciente con EAD generalizada present&#243; un CEC metast&#225;sico en la pierna derecha que se trat&#243; con amputaci&#243;n&#44; linfadenectom&#237;a inguinal y radioterapia paliativa&#46; La anemia fue la complicaci&#243;n m&#225;s frecuente &#40;50&#37;&#41; y dos pacientes requirieron tratamiento con hierro oral por presentar una cifra de hemoglobina menor a 10<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#46; La evoluci&#243;n cl&#237;nica fue variable&#44; desde la mejor&#237;a de las lesiones hasta el fallecimiento de una paciente por un CEC metast&#225;sico&#46; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Las EA se producen por mutaciones en los genes que codifican las prote&#237;nas estructurales de la uni&#243;n dermoepid&#233;rmica&#46; El nivel de separaci&#243;n histopatol&#243;gico y la mutaci&#243;n gen&#233;tica define el tipo y subtipo de EA&#46; Los tipos de EA son&#58; EA simple &#40;EAS&#41;&#44; EA juntural &#40;EAJ&#41;&#44; EA distr&#243;fica &#40;EAD&#41; y s&#237;ndrome de Kindler<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46; En la EAS la ampolla aparece en el plano epid&#233;rmico&#44; en la EAJ en la l&#225;mina l&#250;cida y en la EAD en la subl&#225;mina densa&#46; La EAJ y la EAD suelen ser m&#225;s graves porque pueden afectar a otros &#243;rganos cubiertos por un epitelio<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La EAS suele presentarse en el periodo neonatal&#46; Las cicatrices&#44; los quistes de milium y la distrofia ungueal son menos frecuentes que en la EAJ y EAD&#46; La EAS localizada es el subtipo m&#225;s frecuente y se presenta con ampollas en las palmas y plantas&#46; La EAS generalizada severa se caracteriza por ampollas generalizadas en el periodo neonatal&#44; distribuci&#243;n herpetiforme de las lesiones en la infancia y desarrollo de una queratodermia palmoplantar<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La caracter&#237;stica m&#225;s constante de la EAJ es la hipoplasia del esmalte&#44; y en las formas graves&#44; la aparici&#243;n de un tejido de granulaci&#243;n exuberante en las regiones periorificiales y los pliegues<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a>&#46; Las EAD autos&#243;mico recesivas son las m&#225;s graves causando una enfermedad ampollosa&#44; erosiva y mutilante con compromiso cut&#225;neo-mucoso y de los &#243;rganos internos&#46; El CEC es m&#225;s frecuente y agresivo en los pacientes con EAD&#44; consider&#225;ndose como la principal causa de muerte en la EA<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4&#8211;7</span></a>&#46; En contraste con la experiencia de Feinstein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#44; en esta serie destaca el predominio de las formas de EAD autos&#243;mica dominante frente a las formas recesivas&#46; Adem&#225;s&#44; es interesante remarcar el desarrollo de CEC en las dos mujeres adultas con EAD generalizada&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En el proceso diagn&#243;stico se debe realizar una biopsia cut&#225;nea de una lesi&#243;n inducida por fricci&#243;n para realizar un mapeo antig&#233;nico histol&#243;gico que establecer&#225; el plano de separaci&#243;n dermo-epid&#233;rmica y orientar&#225; el tipo de EA y el estudio gen&#233;tico<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; El diagn&#243;stico molecular es fundamental&#44; ya que aporta informaci&#243;n esencial para el pron&#243;stico y para un manejo adecuado de los pacientes&#44; y proporciona un consejo gen&#233;tico a los padres e individuos afectados<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El tratamiento es sintom&#225;tico y multidisciplinar&#44; encontr&#225;ndose en desarrollo terapias proteicas&#44; celulares y g&#233;nicas para la EAD<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;4&#44;9</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la prevalencia de EA en nuestro departamento de salud es similar a la descrita en estudios previos<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#46; La mayor&#237;a de los pacientes eran mujeres y se diagnosticaron al nacimiento&#46; Las manifestaciones cl&#237;nicas fueron heterog&#233;neas&#44; siendo las ampollas&#44; la onicodistrofia y el prurito las m&#225;s frecuentes&#46; La complicaci&#243;n m&#225;s frecuente fue la anemia&#44; lo cual puede estar relacionado con la mayor frecuencia de EAD en nuestra serie&#46; El tratamiento&#44; principalmente&#44; fue sintom&#225;tico&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financiaci&#243;n</span><p id="par0077" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicto de intereses</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paciente 1&#58; Ni&#241;o de 10 a&#241;os con EASl&#59; 1<span class="elsevierStyleHsp" style=""></span>A&#41; Ampolla en la palma de la mano&#59; 1<span class="elsevierStyleHsp" style=""></span>B&#41; Onicodistrofia&#59; 1<span class="elsevierStyleHsp" style=""></span>C&#41; Cicatrizaci&#243;n con quistes de milium en zonas sometidas a traumatismos&#46; Paciente 3&#58; Reci&#233;n nacida con EASgs&#59; 1<span class="elsevierStyleHsp" style=""></span>D&#41; Ampollas y erosiones cut&#225;neas generalizadas&#59; Control en la infancia&#59; 1<span class="elsevierStyleHsp" style=""></span>E&#44; 1<span class="elsevierStyleHsp" style=""></span>H&#41; Ampollas de distribuci&#243;n herpetiforme en la regi&#243;n lumbar&#44; gl&#250;tea y muslos junto con signos de cicatrizaci&#243;n atr&#243;fica&#59; Control en la adolescencia&#59; 1<span class="elsevierStyleHsp" style=""></span>F&#41; Onicodistrofia&#59; 1<span class="elsevierStyleHsp" style=""></span>G&#44; 1<span class="elsevierStyleHsp" style=""></span>I&#41; Queratodermia palmoplantar&#59; 1<span class="elsevierStyleHsp" style=""></span>J&#41; Pseudoliendres o vainas peripilares&#46; Paciente 4&#58; Ni&#241;a de 7 a&#241;os con EADp&#59; 1<span class="elsevierStyleHsp" style=""></span>K&#44; 1<span class="elsevierStyleHsp" style=""></span>L&#44; 1<span class="elsevierStyleHsp" style=""></span>M&#41; Papulon&#243;dulos pruriginosos localizados en las superficies de extensi&#243;n de las extremidades&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caracter&#237;sticas cl&#237;nico-epidemiol&#243;gicas de los pacientes diagnosticados de EA</th></tr><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col">Paciente 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Paciente 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Edad del diagn&#243;stico cl&#237;nico &#47;Edad actual<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Reci&#233;n nacido&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Reci&#233;n nacido&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Reci&#233;n nacido&#47;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolar&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Lactante&#47;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reci&#233;n nacido&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preescolar&#47;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Reci&#233;n nacido&#47;&#201;xitus a los 37 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Manifestaciones cl&#237;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQPPPelo raloPseudoliendresOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Papulon&#243;dulos tipo prurigo nodularQuistes de miliumPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumPelo raloOnicodistrofiaPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de milium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasQuistes de miliumAusencia de u&#241;asPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AmpollasP&#233;rdida de dientesAusencia de u&#241;asContracturas en flexi&#243;nPrurito&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Localizaci&#243;n de las lesiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoGl&#250;teosExtremidadesAcralMucosa oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraTroncoGl&#250;teosExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CaraTroncoGl&#250;teoExtremidadesAcralMucosa oral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TroncoExtremidadesAcral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Histolog&#237;a<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47;ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47; ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraepid&#233;rmico&#47;ME&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subl&#225;mina densa&#47; Mapeo antig&#233;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No realizado&#94;&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No realizado&#94;&#94;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gen mutado&#47;mutaci&#243;n&#47;Edad del diagn&#243;stico molecular<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47;p&#46;Gly12rg&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47;p&#46;Gly12rg&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">KRT5</span>&#47; p&#46;Glu477Lys&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; p&#46;Arg1814&#95;Gly1815delinsLeuHis&#47;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47;p&#46;Gly1377Aspfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>22&#47;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COL7A1</span>&#47; Gly2177Trpfs<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>113&#47;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herencia&#47;Cigosidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AD Heterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AD Heterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ARHomocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ADHeterocigosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de EA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASgs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADgs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EADg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamiento recibido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAntihistam&#237;nicosAp&#243;sitos de siliconaMalla tubularMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antis&#233;ptico t&#243;picoAntibi&#243;tico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAntibi&#243;tico sist&#233;micoAntihistam&#237;nicosAp&#243;sitos de siliconaMalla tubularNutrici&#243;nHierro oralMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAntihistam&#237;nicosMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antibi&#243;tico t&#243;picoAp&#243;sitos de siliconaMalla tubularHierro oralAmputaci&#243;nLinfadenectom&#237;aRadioterapiaMedidas higi&#233;nicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Complicaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Erosiones orales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AnemiaSobreinfecci&#243;nEstre&#241;imientoDesnutrici&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Erosiones orales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">AnemiaCEC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">AnemiaDepresi&#243;nCECMet&#225;stasis&#201;xitus&nbsp;\t\t\t\t\t\t\n
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ISSN: 00017310
Original language: Spanish
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