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Rodríguez-Lomba, B. Lozano-Masdemont" "autores" => array:2 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Rodríguez-Lomba" "email" => array:1 [ 0 => "enriquerlomba@outlook.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Lozano-Masdemont" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Móstoles, Móstoles, Madrid, España" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lisch Nodules: A Key Diagnostic Sign of Neurofibromatosis Type<span class="elsevierStyleHsp" style=""></span>1" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 833 "Ancho" => 1500 "Tamanyo" => 235807 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Los nódulos de Lisch forman parte de los criterios diagnósticos de neurofibromatosis tipo<span class="elsevierStyleHsp" style=""></span>1 cuando se presentan 2 o más de ellos. Se consideran hamartomas melanocíticos del iris que se observan frecuentemente antes de los 6<span class="elsevierStyleHsp" style=""></span>años y aumentan en número y prevalencia con la edad. Habitualmente tienen color marrón claro u oscuro y son más evidentes sobre ojos claros.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Una niña de 9<span class="elsevierStyleHsp" style=""></span>años en seguimiento por sospecha de neurofibromatosis presentaba 6 manchas café con leche superiores a 5<span class="elsevierStyleHsp" style=""></span>mm en tronco y extremidades además de efélides axilares. A la exploración física evidenciamos 3 manchas marrón claro en iris derecho (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>A). Este hallazgo fue confirmado por oftalmología y resultó diagnóstico.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Por otro lado, una anciana de 72<span class="elsevierStyleHsp" style=""></span>años con diagnóstico de neurofibromatosis tipo<span class="elsevierStyleHsp" style=""></span>1 confirmado mediante test genético presentaba múltiples manchas marrón claro sobre ambos iris azules (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>B). A diferencia del caso anterior, la presentación clínica resulta muy evidente.</p><p id="par0020" class="elsevierStylePara elsevierViewall">En los primeros años de vida, la identificación de nódulos de Lisch puede confirmar el diagnóstico en pacientes que todavía no cumplen suficientes criterios clásicos. Consideramos importante que el dermatólogo busque esta manifestación clínica, cuyo hallazgo puede resultar útil ante el diagnóstico diferencial con otros síndromes neurocutáneos en edades tempranas.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 833 "Ancho" => 1500 "Tamanyo" => 235807 ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00017310/0000011200000005/v1_202105061359/S0001731020305263/v1_202105061359/es/main.assets" "Apartado" => array:4 [ "identificador" => "41021" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imágenes en Dermatología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011200000005/v1_202105061359/S0001731020305263/v1_202105061359/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020305263?idApp=UINPBA000044" ]
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