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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Prescripci&#243;n de los primeros tratamientos biol&#243;gicos en pacientes <span class="elsevierStyleItalic">na&#239;ve</span> entre los a&#241;os 2008 y 2018&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La disponibilidad de nuevos f&#225;rmacos biol&#243;gicos y de nuevas mol&#233;culas sigue cambiando el manejo de los pacientes con psoriasis moderada a severa&#46; Un metaan&#225;lisis reciente revis&#243; cu&#225;les fueron las mejores opciones para alcanzar el <span class="elsevierStyleItalic">Psoriasis Area and Severity Index</span> &#40;PASI&#41; 90 y no encontr&#243; diferencias entre el perfil de seguridad de los medicamentos<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a>&#46; Sin embargo&#44; la elecci&#243;n del tratamiento de primera l&#237;nea para la psoriasis moderada a severa en la vida real no se basar&#225; &#250;nicamente en los datos de eficacia o de seguridad&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En Espa&#241;a&#44; los medicamentos biol&#243;gicos y el apremilast son reembolsables por el Servicio Nacional de Salud en pacientes que tengan una respuesta inadecuada o contraindicaciones para la terapia sist&#233;mica cl&#225;sica&#46; Las gu&#237;as espa&#241;olas y europeas no incluyen recomendaciones acerca de cu&#225;les deben ser los tratamientos biol&#243;gicos de primera l&#237;nea<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">2&#44;3</span></a>&#46; Sin embargo&#44; tanto la gu&#237;a cl&#237;nica brit&#225;nica como la francesa&#44; recientemente actualizadas&#44; han propuesto a ustekinumab o a adalimumab como tratamientos de primera l&#237;nea<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los objetivos del presente estudio fueron&#58; 1&#41;<span class="elsevierStyleHsp" style=""></span>describir los cambios en la prescripci&#243;n del primer tratamiento biol&#243;gico o de las nuevas mol&#233;culas peque&#241;as en el tratamiento de la psoriasis y 2&#41;<span class="elsevierStyleHsp" style=""></span>comparar las tasas de abandono del tratamiento y la incidencia de eventos adversos durante 10<span class="elsevierStyleHsp" style=""></span>a&#241;os de seguimiento&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">En el presente estudio se utiliz&#243; el registro Biobadaderm&#58; un registro multic&#233;ntrico prospectivo de cohortes compuesto por pacientes diagnosticados de psoriasis que recibieron tratamiento sist&#233;mico&#46; Este registro tiene la finalidad de detectar eventos adversos relacionados con las terapias sist&#233;micas&#46; El formulario de recopilaci&#243;n de datos y la codificaci&#243;n del registro se han descrito en una publicaci&#243;n previa<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Para describir las tendencias en los patrones de tratamiento a lo largo del tiempo los datos se clasificaron en tres ventanas de tiempo similares&#58; a&#41;<span class="elsevierStyleHsp" style=""></span>2008-2010&#59; b&#41;<span class="elsevierStyleHsp" style=""></span>2011-2014&#44; y c&#41;<span class="elsevierStyleHsp" style=""></span>2015-2018&#46; Para este an&#225;lisis solo se consideraron los casos de pacientes que hab&#237;an recibido monoterapia y que eran <span class="elsevierStyleItalic">na&#239;ve</span> para los tratamientos biol&#243;gicos&#44; ya que estos podr&#237;an reflejar de una mejor forma cu&#225;l fue la opci&#243;n terap&#233;utica de primera l&#237;nea y hacer que los grupos de estudio fuesen comparables&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Los resultados se presentaron en dos cohortes&#58; una de terapia biol&#243;gica o nuevas mol&#233;culas peque&#241;as &#40;apremilast&#41;&#44; y otra de terapias cl&#225;sicas&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas de los pacientes para cada grupo se presentaron de manera descriptiva&#58; en n&#250;meros absolutos y en porcentajes para las variables cualitativas&#44; y como mediana y rango intercuart&#237;lico para las variables asim&#233;tricas&#46; Las diferencias entre los grupos se compararon utilizando la prueba de chi cuadrado o la prueba de Wilcoxon-Mann-Whitney&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se usaron modelos de riesgos competitivos para comparar las funciones de incidencia acumulada de la interrupci&#243;n de los tratamientos &#40;ya sea por ineficacia como por un evento adverso&#44; o por la remisi&#243;n de la enfermedad&#41;&#46; Los otros motivos por los cuales se interrumpi&#243; el tratamiento se consideraron como causas de censura &#40;p&#46;ej&#46;&#44; p&#233;rdida de seguimiento&#44; decisiones del paciente&#44; embarazo planificado o deseado&#44; etc&#46;&#41;&#46; Tambi&#233;n describimos las tasas de incidencia de los eventos adversos por cada 1&#46;000 paciente-a&#241;os de exposici&#243;n con un intervalo de confianza &#40;IC&#41; del 95&#37; por cada periodo de tiempo&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Los datos se analizaron con el software estad&#237;stico Stata&#44; versi&#243;n 14&#46;2 &#40;StataCorp&#46; 2015&#46; College Station&#44; TX&#58; StataCorp LP&#41; y los valores de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 se consideraron como estad&#237;sticamente significativos&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El registro Biobadaderm fue aprobado por el Comit&#233; de &#201;tica del Hospital 12 de Octubre &#40;216&#47;07&#41; y se realiz&#243; en conformidad con la Declaraci&#243;n de Helsinki&#46; Todos los pacientes dieron su consentimiento por escrito para poder participar&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">En total 3&#46;090 pacientes con psoriasis iniciaron un tratamiento entre el a&#241;o 2008 y el 2018&#46; De estos&#44; 2&#46;526 cumplieron con los criterios de inclusi&#243;n &#40;tratamiento en monoterapia y ser <span class="elsevierStyleItalic">na&#239;ve</span> para tratamiento biol&#243;gico&#41;&#58; 1&#46;075 &#40;43&#37;&#41; se encontraban dentro del grupo de medicamentos biol&#243;gicos o de nuevas mol&#233;culas peque&#241;as y 1&#46;451 &#40;57&#37;&#41; en el grupo de medicamentos cl&#225;sicos&#46; De los 2&#46;526 pacientes&#44; el 43&#44;4&#37; &#40;1&#46;096&#41; iniciaron el tratamiento entre los a&#241;os 2008 y 2010 &#40;periodo<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; el 29&#44;4&#37; &#40;743&#41; entre 2011 y 2014 &#40;per&#237;odo<span class="elsevierStyleHsp" style=""></span>2&#41; y el 27&#44;2&#37; &#40;687&#41; entre 2015 y 2018 &#40;per&#237;odo<span class="elsevierStyleHsp" style=""></span>3&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La informaci&#243;n demogr&#225;fica de la poblaci&#243;n encuestada se resume en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; En el grupo de medicamentos cl&#225;sicos se objetivaron las siguientes diferencias entre los tres periodos de tiempo&#58; forma de presentaci&#243;n de la psoriasis &#40;mayor n&#250;mero de pacientes con psoriasis palmoplantar y un menor n&#250;mero de artritis psori&#225;sica y de psoriasis en placas&#41;&#44; menor frecuencia de comorbilidades asociadas &#40;hipertensi&#243;n&#44; diabetes e hipercolesterolemia&#41;&#44; menor edad y tiempo de enfermedad en los periodos posteriores&#46; Por otro lado&#44; el grupo de terapias biol&#243;gicas o de nuevas mol&#233;culas peque&#241;as se caracteriz&#243; por tener un mayor n&#250;mero de pacientes del sexo femenino&#44; una mayor asociaci&#243;n a comorbilidades &#40;hipertensi&#243;n&#44; c&#225;ncer&#44; enfermedad hep&#225;tica cr&#243;nica y enfermedad pulmonar obstructiva cr&#243;nica&#41; y tener pacientes de menor edad&#44; duraci&#243;n de la enfermedad y PASI&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Como era de esperar&#44; con mayor frecuencia los f&#225;rmacos anti-TNF fueron el primer tratamiento biol&#243;gico recetado en pacientes <span class="elsevierStyleItalic">na&#239;ve</span> &#40;80&#37;&#41; durante el per&#237;odo 2008-2010 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Su uso como primer tratamiento disminuy&#243; dr&#225;sticamente durante el segundo y tercer periodos&#44; representando el 60 y el 26&#37; de los tratamientos biol&#243;gicos&#44; respectivamente&#46; Al analizar los medicamentos anti-TNF por separado&#44; etanercept fue el primer biol&#243;gico m&#225;s recetado en el primer per&#237;odo&#59; el segundo medicamento recetado en frecuencia fue adalimumab&#46; A partir del a&#241;o 2011&#44; sin embargo&#44; tanto etanercept como adalimumab se prescribieron a un ritmo similar&#46; La elecci&#243;n de infliximab como primer f&#225;rmaco biol&#243;gico fue excepcional despu&#233;s del a&#241;o 2010&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">El uso de ustekinumab vari&#243; significativamente con el transcurso del tiempo&#46; Aument&#243; de manera significativa en el segundo periodo y disminuy&#243; con la aparici&#243;n de nuevos medicamentos despu&#233;s del a&#241;o 2015&#46; Secukinumab&#44; ixekizumab y apremilast se prescribieron por primera vez en el per&#237;odo 2015-2018 y representaron casi la mitad de los tratamientos &#40;47&#37;&#41;&#59; cada uno se prescribi&#243; en porcentajes m&#225;s altos que los de etanercept y de adalimumab&#44; pero m&#225;s bajos que los de ustekinumab&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Las principales razones por las que se suspendieron los tratamientos fueron los eventos adversos&#44; la falta de eficacia y la remisi&#243;n de la enfermedad&#46; La <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> representa el porcentaje acumulado de pacientes del grupo de terapias biol&#243;gicas y de nuevas mol&#233;culas peque&#241;as que descontinuaron el primer tratamiento y cu&#225;l fue el motivo&#59; la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> muestra estos datos para el grupo de medicamentos cl&#225;sico&#46; En ambos grupos las curvas de incidencia acumulada mostraron que en los &#250;ltimos a&#241;os los participantes ten&#237;an menos probabilidades de interrumpir el tratamiento debido a la falta de eficacia&#44; eventos adversos o eficacia&#46; En cada periodo los umbrales fueron m&#225;s elevados que en el periodo previo&#44; lo que indica que los tratamientos fueron menos propensos a ser interrumpidos por cualquiera de estos motivos&#44; en especial en relaci&#243;n con la remisi&#243;n de la enfermedad&#44; ya que esta variable mostraba curvas incluso m&#225;s separadas&#46; Con respecto a la terapia biol&#243;gica y a apremilast&#44; la interrupci&#243;n debida a la remisi&#243;n de la enfermedad mostr&#243; un aumento dr&#225;stico en el umbral &#40;disminuci&#243;n de la curva&#41; en el &#250;ltimo per&#237;odo &#40;2015-2018&#41;&#44; lo que significa que en menos pacientes esta medicaci&#243;n fue retirada debido a la remisi&#243;n de la enfermedad&#46; Un patr&#243;n similar&#44; aunque menos pronunciado&#44; se vio en la curva en relaci&#243;n con los eventos adversos&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Las tasas de todos los eventos adversos en general disminuyeron con el transcurso de los a&#241;os&#59; sin embargo&#44; las tasas espec&#237;ficas de los eventos adversos graves o fatales se mantuvieron estables a lo largo del tiempo &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Con respecto al tipo de tratamiento&#44; en el grupo de terapias biol&#243;gicas y de apremilast&#44; aparentemente&#44; las nuevas terapias &#40;apremilast e ixekizumab&#41; tuvieron tasas m&#225;s elevadas en comparaci&#243;n con las tasas de las terapias &#171;m&#225;s antiguas&#187; &#40;anti-TNF y ustekinumab&#41;&#46; Estos n&#250;meros son comparables a los evidenciados con los anti-TNF y ustekinumab durante el primer per&#237;odo&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discusi&#243;n</span><p id="par0085" class="elsevierStylePara elsevierViewall">Este es un estudio de tipo poblacional acerca del uso de medicamentos y de la tendencia en las prescripciones del primer tratamiento biol&#243;gico y de apremilast durante un periodo de 10<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Este estudio se realiz&#243; en un entorno de pr&#225;ctica cl&#237;nica real en pacientes con diagn&#243;stico de psoriasis&#46; Si bien&#44; en comparaci&#243;n con adalimumab&#44; hubo una mayor tendencia a recetar etanercept durante el periodo 2008-2010&#44; probablemente debido a la introducci&#243;n de ustekinumab en 2009&#44; el uso tanto de etanercept como de adalimumab disminuy&#243; significativamente&#44; y desde entonces ambos han tenido tasas de prescripci&#243;n similares y estables&#46; En Estados Unidos etanercept en un inicio fue el medicamento biol&#243;gico m&#225;s indicado&#59; sin embargo&#44; tras recibir la aprobaci&#243;n para la artritis psori&#225;sica en 2005 y para la psoriasis en 2008&#44; el uso de adalimumab aument&#243; de manera gradual a partir de 2011<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a>&#46; Seg&#250;n nuestro registro&#44; adalimumab ha tenido una tendencia de prescripci&#243;n diferente&#44; presentando una clara disminuci&#243;n despu&#233;s del a&#241;o 2011&#46; Por otro lado&#44; a partir de 2014 ustekinumab empez&#243; a ser recetado como primer medicamento biol&#243;gico con mayor frecuencia&#46; Recientemente un metaan&#225;lisis sugiri&#243; que ustekinumab es el medicamento biol&#243;gico preferido en el tratamiento de la psoriasis<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a>&#46; Adem&#225;s&#44; las gu&#237;as tanto de la asociaci&#243;n brit&#225;nica como de la francesa recomiendan ustekinumab o adalimumab como tratamientos biol&#243;gicos de primera elecci&#243;n en pacientes con psoriasis<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Los inhibidores de la IL-17 tienen una eficacia muy elevada&#46; Este hecho&#44; sumado a que compiten con productos biol&#243;gicos &#171;m&#225;s antiguos&#187;&#44; est&#225; cambiando las tendencias actuales de prescripci&#243;n&#46; Durante el tercer per&#237;odo &#40;2015-2018&#41; la prescripci&#243;n de secukinumab como el primer f&#225;rmaco biol&#243;gico indicado en pacientes <span class="elsevierStyleItalic">na&#239;ve</span> super&#243; a la de los anti-TNF e igual&#243; a la de ustekinumab&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Apremilast ha demostrado una menor eficacia en comparaci&#243;n con los medicamentos biol&#243;gicos<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;10</span></a>&#59; sin embargo&#44; su uso como terapia de primera elecci&#243;n fue comparable a la de secukinumab durante el per&#237;odo comprendido entre los a&#241;os 2015 y 2018&#46; Probablemente el perfil de seguridad de apremilast<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a>&#44; as&#237; como su menor coste comparado con los productos biol&#243;gicos&#44; haya jugado un papel importante&#46; Sin embargo&#44; algunos expertos no recomiendan su uso en monoterapia&#46; Por ejemplo&#44; las pautas francesas recomiendan el uso de agentes biol&#243;gicos antes de iniciar el tratamiento sist&#233;mico con apremilast&#46; A pesar de que despu&#233;s del a&#241;o 2011 se cont&#243; con medicamentos m&#225;s efectivos&#44; tanto etanercept como adalimumab siguieron siendo los primeros medicamentos recetados en el 6-8&#37; de los pacientes&#46; Esto puede deberse a la presencia de artritis psori&#225;sica y al hecho de que muchos dermat&#243;logos se sienten m&#225;s c&#243;modos usando medicamentos &#171;m&#225;s antiguos&#187;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">En el presente estudio la p&#233;rdida de eficacia fue el principal motivo por el cual se decidi&#243; suspender el tratamiento&#46; Estos datos ya hab&#237;an sido descritos previamente tanto en nuestro registro<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> como en otros estudios m&#225;s amplios<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">13&#44;14</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El an&#225;lisis que realizamos nos permiti&#243; comparar diferentes per&#237;odos de tiempo&#46; Esto mostr&#243; que la tasa de interrupci&#243;n de los tratamientos disminuy&#243; con el paso de los a&#241;os&#44; y que un menor porcentaje de los pacientes tuvieron que dejar el tratamiento biol&#243;gico o apremilast debido a una falta o p&#233;rdida de eficacia o por el desarrollo de efectos adversos&#46; Al parecer los dermat&#243;logos son m&#225;s tolerantes a los eventos adversos de menor gravedad&#44; lo que conlleva menores tasas de notificaci&#243;n e interrupci&#243;n de los tratamientos&#46; Este hecho se debe probablemente tambi&#233;n a un mayor grado de conocimiento acerca del perfil de seguridad de estas mol&#233;culas&#46; En un estudio reciente se pudo demostrar que las tasas de los eventos adversos en general fueron m&#225;s frecuentes durante el primer a&#241;o de tratamiento con todos los medicamentos<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a>&#46; Sin embargo&#44; la tasa de eventos adversos graves se mantuvo estable durante el tiempo&#44; lo que indica que los pacientes tendr&#225;n que continuar en seguimiento a lo largo del tiempo&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">De manera curiosa&#44; si se compara con los periodos previos&#44; hoy en d&#237;a la remisi&#243;n de la enfermedad ser&#225; m&#225;s dif&#237;cil de lograr&#46; As&#237; mismo&#44; las tasas de interrupci&#243;n de los tratamientos tambi&#233;n han disminuido&#46; Esto puede deberse&#44; en parte&#44; al grado de insatisfacci&#243;n de los pacientes despu&#233;s de tener una reca&#237;da leve de la enfermedad&#46; El cambio en las expectativas de los pacientes buscando conseguir un PASI 90-100 es cada vez m&#225;s frecuente&#44; lo que ha generado en la pr&#225;ctica cl&#237;nica menores tasas de interrupci&#243;n de los tratamientos debido a una remisi&#243;n de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el presente estudio ha identificado el comportamiento y la tendencia en la tasa de prescripci&#243;n de los f&#225;rmacos biol&#243;gicos y de las nuevas mol&#233;culas peque&#241;as &#40;apremilast&#41; utilizados como primera l&#237;nea en la pr&#225;ctica cl&#237;nica en pacientes diagnosticados de psoriasis entre los a&#241;os 2008 y 2018 en Espa&#241;a&#46; Adem&#225;s&#44; nos sugiere que los dermat&#243;logos han modificado sus pautas de prescripci&#243;n&#44; probablemente debido a que se sienten m&#225;s c&#243;modos con el perfil de seguridad de los medicamentos&#59; as&#237; mismo&#44; son m&#225;s exigentes con la eficacia de los tratamientos&#44; por lo que se evidenciaron tasas m&#225;s bajas de interrupci&#243;n de los tratamientos&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financiaci&#243;n</span><p id="par0120" class="elsevierStylePara elsevierViewall">El proyecto BIOBADADERM fue promovido por la Fundaci&#243;n Piel Sana de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a&#44; y recibe apoyo financiero de la Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios y de compa&#241;&#237;as farmac&#233;uticas &#40;Abbott&#47;Abbvie&#44; Pfizer&#44; MSD&#44; Novartis&#44; Lilly&#44; Janssen y Almirall&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Las compa&#241;&#237;as farmac&#233;uticas colaboradoras no participaron en el dise&#241;o y la realizaci&#243;n del estudio&#59; tampoco en la recopilaci&#243;n&#44; gesti&#243;n&#44; an&#225;lisis e interpretaci&#243;n de datos&#44; ni en la preparaci&#243;n&#44; revisi&#243;n o aprobaci&#243;n del manuscrito y decisi&#243;n de enviar el manuscrito para su publicaci&#243;n&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicto de intereses</span><p id="par0130" class="elsevierStylePara elsevierViewall">La Dra&#46; Ruiz-Genao ha sido remunerada por Pfizer&#44; Janssen&#44; Celgene&#44; AbbVie&#44; Novartis y Leo Pharma por servicios de asesoramiento y conferencias&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El Dr&#46; Carretero ha sido remunerado por Janssen&#44; Abbvie&#44; Novartis&#44; Pfizer&#44; MSD y Celgene por servicios de asesoramiento y conferencias&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La Dra&#46; Rivera ha actuado como consultora y&#47;o ponente y&#47;o ha participado en ensayos cl&#237;nicos como IP para AbbVie&#44; Almirall&#44; Celgene&#44; Janssen&#44; Leo Pharma&#44; Lilly&#44; Novartis&#44; MSD y Pfizer-Wyeth&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">El Dr&#46; Ferr&#225;ndiz ha participado como consultor y&#47;o ponente remunerado y&#47;o ha participado en ensayos cl&#237;nicos patrocinados por compa&#241;&#237;as farmac&#233;uticas del &#225;mbito de la psoriasis&#44; incluidas AbbVie&#44; Amgen&#44; Celgene&#44; Janssen-Cilag&#44; LEO Pharma&#44; Lilly&#44; Merck&#44; Sharp &#38; Dohme&#44; Novartis Pfizer y Almirall&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El Dr&#46; Daud&#233;n ha actuado como consultor para Abbott&#44; Amgen&#44; Astellas&#44; Centocor Ortho Biotech Inc&#44; Galderma&#44; Glaxo&#44; Janssen-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD y Celgene&#59; ha recibido honorarios de Abbott&#44; Amgen&#44; Janssen-Cilag&#44; Leo Pharma&#44; Novartis&#44; Pfizer&#44; MSD&#44; Celgene&#59; ha participado en una oficina de conferenciantes para Abbott&#44; Pfizer&#44; MSD y Janssen&#44; y recibi&#243; subvenciones de Pfizer&#44; Abbott&#44; Janssen y MSD&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">El Dr&#46; de la Cueva ha actuado como consultor y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; UCB&#44; Biogen&#44; Celgene&#44; Amgen&#44; Sandoz&#44; Sanofi y Leo-Pharma&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">La Dra&#46; Belinch&#243;n ha actuado como ponente y&#47;o asesora de Janssen Pharmaceuticals&#44; Almirall&#44; Lilly&#44; AbbVie&#44; Novartis&#44; Celgene&#44; Biogen Amgen&#44; Leo-Pharma&#44; Pfizer-Wyeth y MSD&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">El Dr&#46; Herrera-Acosta ha participado como consultor y&#47;o ponente en Leo Pharma&#44; Novartis&#44; Janssen&#44; Lilly&#44; Celgene y AbbVie&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">El Dr&#46; L&#243;pez-Estebaranz ha participado como AB y ha recibido becas educativas de Janssen&#44; Abbvie&#44; MSD&#44; Lilly&#44; Novartis&#44; Leo Pharma y Pfizer&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La Dra&#46; Ferr&#225;n-Farr&#233;s ha participado como ponente y&#47;o asesora de Janssen&#44; Lilly&#44; Novartis&#44; Pfizer&#44; MSD&#44; Abbvie Celgene y Almirall&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">La Dra&#46; Alsina ha participado dando charlas de expertos para Merck-Schering Plough&#44; Pfizer&#44; Janssen&#44; Novartis y Abbott&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">La Dra&#46; Baniandr&#233;s-Rodr&#237;guez ha actuado como consultora y&#47;o ponente para Janssen-Cilag&#44; AbbVie&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Celgene&#44; Leo Pharma y Almirall&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">El Dr&#46; S&#225;nchez-Carazo ha participado como AB de Janssen&#44; Novartis y Leo Pharma&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">El Dr&#46; Sahuquillo ha participado como consultor y&#47;o ponente remunerado y&#47;o ha participado en ensayos cl&#237;nicos patrocinados por compa&#241;&#237;as farmac&#233;uticas que desarrollan medicamentos para la psoriasis&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; Leo Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">La Dra&#46; Rodr&#237;guez Fern&#225;ndez-Freire ha actuado como consultora y ponente para Janssen-Cilag&#44; AbbVie&#44; MSD&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall&#44; Celgene y Leo Pharma&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">El Dr&#46; Vilar-Alejo ha participado como AB de Janssen&#44; Novartis&#44; AbbVie&#44; Almirall y Celgene&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">La Dra&#46; Garc&#237;a-Donoso ha participado como AB de AbbVie&#44; Almirall y ponente de Janssen&#44; Lilly y Celgene&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">El Dr&#46; Carrascosa ha participado como ponente y&#47;o asesor de Celgene&#44; Janssen&#44; Lilly&#44; Novartis&#44; Leo Pharma&#44; Pfizer&#44; MSD&#44; Abbvie&#44; Biogen Amgen&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">La Dra&#46; Llamas ha actuado como consultora y ponente para Janssen-Cilag&#44; AbbVie&#44; Celgene&#44; Pfizer&#44; Novartis&#44; Lilly&#44; Almirall y Leo-Pharma&#44; y ha participado en ensayos cl&#237;nicos&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">El Dr&#46; Herrera-Ceballos ha participado como consultor y&#47;o conferencista y&#47;o en ensayos cl&#237;nicos como IP y ha sido patrocinado por la industria farmac&#233;utica&#44; incluyendo AbbVie&#44; Janssen-Cilag&#44; Leo Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">El Dr&#46; Botella ha participado como consultor y&#47;o ponente remunerado y&#47;o ha participado en ensayos cl&#237;nicos patrocinados por la industria farmac&#233;utica&#44; incluidas AbbVie&#44; Celgene&#44; Janssen-Cilag&#44; Leo Pharma&#44; Lilly&#44; Novartis y Pfizer&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">El Dr&#46; Garc&#237;a-Doval ha recibido ayudas para congresos de Abbvie&#44; MSD y Pfizer&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Ninguno de los otros autores tiene alg&#250;n conflicto de intereses que declarar&#46;&#91;ll1&#93;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las gu&#237;as sobre el tratamiento de la psoriasis habitualmente no incluyen las recomendaciones acerca de cu&#225;l debe ser la primera l&#237;nea de tratamiento sist&#233;mico o biol&#243;gico&#46; Los objetivos de este estudio fueron describir las tendencias en la prescripci&#243;n del primer f&#225;rmaco biol&#243;gico y comparar la retirada de los f&#225;rmacos y las tasas de efectos adversos a lo largo de los 10 a&#241;os de seguimiento&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se utiliz&#243; el registro Biobadaderm para determinar cu&#225;l fue el primer f&#225;rmaco biol&#243;gico indicado en pacientes con psoriasis <span class="elsevierStyleItalic">na&#239;ve</span> para biol&#243;gicos&#44; as&#237; como cu&#225;l es la tasa de efectos adversos y los motivos de suspensi&#243;n de los f&#225;rmacos&#46; Los resultados obtenidos se compararon en tres periodos distintos de tiempo &#40;2008-2010&#44; 2011-2014&#44; 2015-2018&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los f&#225;rmacos anti-TNF fueron los biol&#243;gicos prescritos con mayor frecuencia entre los a&#241;os 2008 y 2010&#46; Ustekinumab se convirti&#243; en el tratamiento biol&#243;gico m&#225;s indicado a partir de 2014&#46; El motivo principal de suspensi&#243;n de los tratamientos fueron los efectos adversos&#44; la falta de eficacia y la remisi&#243;n de la enfermedad&#46; La probabilidad de suspender los f&#225;rmacos por uno de estos motivos fue cada vez menor si se compara con el periodo de tiempo previo&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El presente estudio identifica cu&#225;les fueron las tendencias en la prescripci&#243;n del primer f&#225;rmaco biol&#243;gico en la pr&#225;ctica cl&#237;nica habitual entre los a&#241;os 2008 y 2018&#46; Sugiere que los dermat&#243;logos estamos cada vez m&#225;s seguros en cuanto al perfil de seguridad y somos cada vez m&#225;s exigentes en cuanto a la eficacia de los f&#225;rmacos&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes y objetivos"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Current psoriasis guidelines do not usually include recommendations about first line classical or biologic treatment&#46; The objectives of this study were&#58; to describe shifts in the prescription of the first biological treatment&#44; and to compare treatment withdrawal and rates of adverse events over ten years&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Biobadaderm registry was analyzed to describe&#58; first biological prescription in bio-na&#239;ve patients&#44; adverse events rate and reasons for drug withdrawal comparing three periods of time &#40;2008-2010&#44; 2011-2014&#44; 2015-2018&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Anti-TNF drugs were the most prescribed biological drug from 2008 to 2010&#46; Ustekinumab has become the most prescribed first biologic since 2014&#46; The main reasons for drug discontinuation were adverse events&#44; lack of efficacy and remission&#46; In each period any treatment was less likely to be discontinued due to any of these three reasons comparing to the previous period&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The present study identifies trends in prescription of the first biological antipsoriatic drug in clinical practice from 2008 to 2018&#46; It suggests that we have become more comfortable with the safety profile and more exigent with the efficacy of the drugs&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0035"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">El resto de los integrantes del grupo BIOBADADERM se enumeran en el <a class="elsevierStyleCrossRef" href="#sec0035">anexo</a>&#46;</p>"
        "identificador" => "fn0005"
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            "apendice" => "<p id="par0245" class="elsevierStylePara elsevierViewall">Este estudio ha sido realizado en el marco del grupo de trabajo BIOBADADERM Study Group&#46; Los siguientes miembros han participado en la adquisici&#243;n de datos y en la revisi&#243;n del manuscrito&#58;</p> <p id="par0250" class="elsevierStylePara elsevierViewall">Esteban Daud&#233;n&#44; Mar Llamas-Velasco &#40;Hospital Universitario de la Princesa&#41;&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall">Gregorio Carretero&#44; Jaime Vilar-Alejo &#40;Hospital Universitario de Gran Canaria Dr&#46; Negr&#237;n&#41;&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall">Raquel Rivera&#44; Carmen Garc&#237;a-Donoso &#40;Hospital Universitario 12 de Octubre&#41;&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall">Carlos Ferr&#225;ndiz&#44; Jos&#233; Manuel Carrascosa&#44; Ferr&#225;n Ballesc&#225; &#40;Hospital Universitari Germans Trias i Pujol&#41;&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall">Pablo de la Cueva &#40;Hospital Universitario Infanta Leonor&#41;&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall">Isabel Belinch&#243;n &#40;Hospital General Universitario de Alicante&#41;&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall">Fran J&#46; G&#243;mez-Garc&#237;a&#44; Rafael Jim&#233;nez &#40;Hospital Universitario Reina Sof&#237;a&#41;&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall">Enrique Herrera-Ceballos&#44; Enrique Herrera-Acosta &#40;Hospital Universitario Virgen de la Victoria&#41;&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall">Jos&#233; Luis L&#243;pez-Estebaranz&#44; Diana Patricia Ruiz-Genao &#40;Fundaci&#243;n Hospital de Alcorc&#243;n&#41;&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall">Marta Ferr&#225;n Farr&#233;s &#40;Hospital del Mar&#44; Parc de Salut Mar de Barcelona&#41;&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall">Merc&#232; Alsina &#40;Hospital Cl&#237;nic de Barcelona&#41;&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall">Ofelia Baniandr&#233;s&#44; Lula Nieto &#40;Hospital General Universitario Gregorio Mara&#241;&#243;n&#41;&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall">Jos&#233; Luis S&#225;nchez-Carazo &#40;Hospital General Universitario de Valencia&#41;&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall">Antonio Sahuquillo-Torralba&#44; Rafael Botella-Estrada&#44; Conrad Pujol Marco &#40;Hospital Universitario La Fe de Valencia&#41;&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall">Lourdes Rodr&#237;guez Fern&#225;ndez-Freire &#40;Hospital Universitario Virgen del Roc&#237;o de Sevilla&#41;&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall">Almudena Mateu Puchades &#40;Hospital Universitario Dr&#46; Peset&#41;&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall">&#193;ngeles Fl&#243;rez Men&#233;ndez&#44; Laura Salgado&#44; Beatriz Gonz&#225;lez Sixto &#40;Complexo Hospitalario Universitario de Pontevedra&#41;&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall">Noem&#237; Eiris &#40;Complejo Asistencial Universitario de Le&#243;n&#41;&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall">Ignacio Garc&#237;a-Doval&#44; Miguel &#193;ngel Descalzo Gallego&#44; Marina de Vega Mart&#237;nez &#40;Fundaci&#243;n Piel Sana AEDV&#41;&#46;</p>"
            "etiqueta" => "Anexo"
            "identificador" => "sec0035"
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        "etiqueta" => "Figura 1"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Prescripci&#243;n de los primeros tratamientos biol&#243;gicos en pacientes <span class="elsevierStyleItalic">na&#239;ve</span> entre los a&#241;os 2008 y 2018&#46;</p>"
        ]
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        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Curvas de incidencia acumulada de la interrupci&#243;n de los tratamientos desde el a&#241;o 2008 al 2018&#46; Cada l&#237;nea representa la probabilidad acumulada de interrupci&#243;n para cada motivo espec&#237;fico a lo largo del tiempo&#46;</p>"
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        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
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        "detalles" => array:1 [
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            "identificador" => "at1"
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            "rol" => "short"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#59; PASI&#58; <span class="elsevierStyleItalic">Psoriasis Area Severity Index</span>&#59; VIH&#58; virus de la inmunodeficiencia humana&#46;</p>"
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Terapias cl&#225;sicas</th><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2008-2010&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2011-2014&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015-2018&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2008-2010&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2011-2014&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015-2018&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Total&#44; n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">515&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">553&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">383&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">581&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">190&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">304&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&#44; media &#40;p25-p75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">54&#44;3 &#40;44&#44;5-68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">50&#44;7 &#40;40&#44;4-62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">49&#44;3 &#40;38&#44;3-58&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">53&#44;3 &#40;44&#44;1-64&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">48 &#40;39&#44;9-59&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">51&#44;7 &#40;40&#44;3-60&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0001<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Duraci&#243;n de la enfermedad&#44; media &#40;p25-p75&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#44;1 &#40;4&#44;9-22&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9&#44;4 &#40;3&#44;4-19&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;3 &#40;2&#44;5-20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0005<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;9 &#40;9&#44;3-27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;6 &#40;6&#44;7-22&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;9 &#40;6&#44;5-26&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0111<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mujer&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">227 &#40;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">232 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;7006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">140 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0303<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis en placas&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">468 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">490 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">327 &#40;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0110<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">562 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">184 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">271 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis en gotas&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9482&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6738&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis eritrod&#233;rmica&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0632&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9682&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis pustulosa generalizada&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0208<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis pustulosa palmoplantar&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0000<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psoriasis pustulosa anular&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;4588&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8801&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acrodermatitis continua de Hallopeau&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;2445&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0407<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Artritis psori&#225;sica&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0001<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0250<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Enfermedad isqu&#233;mica cardiaca&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;9859&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Insuficiencia cardiaca&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;4379&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Hipertensi&#243;n&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0056<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;0448<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Diabetes&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Hipercolesterolemia&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">C&#225;ncer&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Terapias biol&#243;gicas</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Terapias cl&#225;sicas</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2008-2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2011-2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015-2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2008-2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2011-2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015-2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Todos los eventos adversos&#44; n &#40;paciente-a&#241;o&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">920 &#40;1&#46;468&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">280 &#40;581&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157 &#40;352&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">734 &#40;705&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">686 &#40;787&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172 &#40;360&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Eventos adversos serios&#44; n &#40;paciente-a&#241;o&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79 &#40;1&#46;468&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;581&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;352&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58 &#40;705&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;787&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;360&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Eventos adversos no serios&#44; n &#40;paciente-a&#241;o&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">833 &#40;1&#46;468&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">254 &#40;581&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146 &#40;352&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">664 &#40;705&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">633 &#40;787&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151 &#40;360&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Eventos adversos fatales&#44; n &#40;paciente-a&#241;o&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;1&#46;468&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;581&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;352&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;705&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;787&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;360&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tasa de incidencia &#40;por 1&#46;000 habitantes-a&#241;o&#41; &#40;IC 95&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Todos los eventos adversos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;588-669&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">482 &#40;429-542&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">446 &#40;381-522&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1041 &#40;969-1&#46;120&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">872 &#40;809-939&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">478 &#40;412-555&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Eventos adversos serios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;43-67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;30-66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;13-49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82 &#40;64-106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;47-82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;36-86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Eventos adversos no serios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">568 &#40;530-607&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">437 &#40;387-494&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">415 &#40;353-488&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">942 &#40;873-1&#46;017&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">804 &#40;744-869&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">420 &#40;358-492&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Eventos adversos fatales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1-23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;10-30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2-14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0-20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Todos los eventos adversos por tratamiento&#44; tasa &#40;por 1&#46;000 personas-a&#241;o&#41; &#40;IC 95&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Etanercept&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">625 &#40;563-694&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">549 &#40;431-699&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">270 &#40;157-465&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infliximab&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adalimumab&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">655 &#40;590-728&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">616 &#40;506-750&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">420 &#40;288-613&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ustekinumab&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">557 &#40;453-686&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Secukinumab&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Apremilast&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ixekizumab&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acitretina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">920 &#40;809-1&#46;046&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">871 &#40;749-1&#46;013&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">343 &#40;250-469&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ciclosporina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;732 &#40;1&#46;482-2&#46;025&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&#46;858 &#40;1&#46;575-2&#46;191&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">823 &#40;564-1&#46;200&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Metotrexato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">952 &#40;857-1&#46;058&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">727 &#40;657-804&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">497 &#40;411-601&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2437196.png"
              ]
            ]
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