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1</a>&#41;&#44; muslos&#44; antebrazos y hombro izquierdo&#46; Las lesiones eran pruriginosas y dolorosas a la palpaci&#243;n&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Se tom&#243; una biopsia cut&#225;nea de una de las lesiones de la pierna derecha&#46; La epidermis no mostraba alteraciones&#46; En dermis superficial y profunda se dispon&#237;a un infiltrado inflamatorio perivascular &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; que alcanzaba el tejido subcut&#225;neo con un patr&#243;n predominantemente lobulillar &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>A&#41;&#46; Este infiltrado estaba compuesto por linfocitos&#44; histiocitos y numerosos eosin&#243;filos &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>B&#41;&#44; con fen&#243;menos de leucocitoclasia&#46; No se observaban figuras en llamarada&#44; y la afectaci&#243;n subcut&#225;nea era superficial sin fibrosis&#46; Hab&#237;a extravasaci&#243;n hem&#225;tica sin vasculitis&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Con estos hallazgos se diagnostic&#243; de paniculitis eosinof&#237;lica secundaria a infecci&#243;n por coronavirus COVID-19&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La paciente fue ingresada para observaci&#243;n&#44; y se inici&#243; tratamiento con ceftriaxona&#44; enoxaparina e hidroxicloroquina&#46; Adem&#225;s&#44; se paut&#243; betametasona en crema en las lesiones cut&#225;neas&#46; La paciente mejor&#243; significativamente en pocos d&#237;as&#44; permitiendo su alta hospitalaria y aislamiento domiciliario&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La paniculitis eosinof&#237;lica es una forma muy poco frecuente de paniculitis&#46; Afecta con m&#225;s frecuencia a mujeres que a varones &#40;3&#58;1&#41;&#44; y tiene 2 picos de incidencia&#44; en la tercera y en la sexta d&#233;cadas de la vida<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; Se trata de un proceso reactivo a diferentes est&#237;mulos&#44; generalmente enfermedades sist&#233;micas&#44; entre las que se encuentran el eritema nudoso&#44; la vasculitis leucocitocl&#225;stica&#44; la dermatitis at&#243;pica&#44; los linfomas&#44; las picaduras de insectos<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#44; la enfermedad de Kimura<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> o el s&#237;ndrome de Wells<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#46; Tambi&#233;n se ha vinculado a ciertos f&#225;rmacos como inmunoterapia con veneno de abeja&#44; penicilina<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> o reacciones en el punto de inyecci&#243;n de heparina<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Tiene mayor inter&#233;s para nuestro caso la implicaci&#243;n de ciertas infecciones&#44; como el VIH&#44; la gnathostomiasis&#44; el estreptococo y la toxocariasis<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se ha planteado como posible mecanismo patog&#233;nico una producci&#243;n excesiva de citoquinas&#44; en concreto IL-4 e IL-5&#44; en respuesta a esos variados est&#237;mulos&#44; provocando una respuesta inmune an&#243;mala<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Conforme la pandemia por coronavirus COVID-19 fue progresando&#44; los dermat&#243;logos empezamos a describir diferentes manifestaciones cut&#225;neas de la infecci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;9&#44;10</span></a>&#46; Las m&#225;s habituales son los exantemas morbiliformes&#44; vesiculosos&#44; urticariales y petequiales&#44; 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Paniculitis eosinofílica secundaria a infección por COVID-19
Eosinophilic Panniculitis Associated With COVID-19
V.M. Leis-Dosila,
Corresponding author
vmanuel.leis@salud.madrid.org

Autor para correspondencia.
, A. Sáez Vicentea, M.M. Lorido-Cortésb
a Sección de Dermatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España
b Servicio de Anatomía Patológica, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España
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1</a>&#41;&#44; muslos&#44; antebrazos y hombro izquierdo&#46; Las lesiones eran pruriginosas y dolorosas a la palpaci&#243;n&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Se tom&#243; una biopsia cut&#225;nea de una de las lesiones de la pierna derecha&#46; La epidermis no mostraba alteraciones&#46; En dermis superficial y profunda se dispon&#237;a un infiltrado inflamatorio perivascular &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; que alcanzaba el tejido subcut&#225;neo con un patr&#243;n predominantemente lobulillar &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>A&#41;&#46; Este infiltrado estaba compuesto por linfocitos&#44; histiocitos y numerosos eosin&#243;filos &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>B&#41;&#44; con fen&#243;menos de leucocitoclasia&#46; No se observaban figuras en llamarada&#44; y la afectaci&#243;n subcut&#225;nea era superficial sin fibrosis&#46; 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y tiene 2 picos de incidencia&#44; en la tercera y en la sexta d&#233;cadas de la vida<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#46; Se trata de un proceso reactivo a diferentes est&#237;mulos&#44; generalmente enfermedades sist&#233;micas&#44; entre las que se encuentran el eritema nudoso&#44; la vasculitis leucocitocl&#225;stica&#44; la dermatitis at&#243;pica&#44; los linfomas&#44; las picaduras de insectos<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#44; la enfermedad de Kimura<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> o el s&#237;ndrome de Wells<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&#46; Tambi&#233;n se ha vinculado a ciertos f&#225;rmacos como inmunoterapia con veneno de abeja&#44; penicilina<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> o reacciones en el punto de inyecci&#243;n de heparina<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Tiene mayor inter&#233;s para nuestro caso la implicaci&#243;n de ciertas infecciones&#44; 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ISSN: 00017310
Original language: Spanish
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