Statistics

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      "titulo" => "IL-17 and infections"
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    "titulo" => "Role of IL-17 and IL-22 in autoimmunity and cancer"
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        "titulo" => "Papel de la IL-17 e IL-22 en autoinmunidad y c&#225;ncer"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The dysregulation of inflammatory cytokines can cause a variety of diseases&#44; such as autoimmunity and cancer&#46; Since their identification in 2005&#44; Th17 cells and its signature cytokine IL-17&#44; have been implicated in the pathogenesis of autoimmune diseases such as psoriasis and rheumatoid arthritis &#40;RA&#41;&#44; and inflammatory associated cancers such as colorectal carcinoma &#40;CRC&#41;&#46; Recently&#44; IL-22 a Th17 related cytokine has been shown to be pathogenic in psoriasis and RA&#46; In this review&#44; we will summarize the biological functions of IL-17 and IL-22&#44; their role in autoimmune diseases and briefly review results from clinical trials targeting IL-17 or its receptor for the treatment of autoimmune diseases&#46; Next&#44; we will discuss pre-clinical and clinical data supporting the rationale of targeting other cytokines implicated in the Th17&#47;IL-17 pathway&#44; such as IL-22 and IL-23&#46; Finally&#44; we discuss the role of IL-17&#44; and in particularly IL-22 in tumour immunity and possible therapeutic interventions&#46;</p>"
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      "es" => array:2 [
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El desequilibrio de las citocinas inflamatorias puede causar una serie de enfermedades como son la autoinmunidad y el c&#225;ncer&#46; Desde su tipificaci&#243;n en el a&#241;o 2005&#44; las c&#233;lulas Th17 y su distintiva citocina IL-17 han estado implicadas en la patog&#233;nesis de enfermedades autoinmunes&#44; como son la psoriasis y la artritis reumatoide &#40;AR&#41;&#44; e inflamatorias asociadas al c&#225;ncer&#44; como es el carcinoma colorectal &#40;CCR&#41;&#46; Recientemente&#44; se ha demostrado que la IL-22&#44; citocina relacionada con Th17&#44; es patog&#233;nica en la psoriasis y la AR&#46; En esta revisi&#243;n resumiremos las funciones biol&#243;gicas de la IL-17 y la IL-22&#44; su papel en las enfermedades autoinmunes y revisaremos brevemente los resultados de estudios cl&#237;nicos enfocados en la IL-17 o su receptor para el tratamiento de enfermedades autoinmunes&#46; Al mismo tiempo&#44; analizaremos los datos precl&#237;nicos y cl&#237;nicos que apoyan la raz&#243;n de enfocar otras citocinas implicadas en la v&#237;a Th17&#47;IL-17&#44; como son la IL-22 y la IL-23&#46; Finalmente&#44; analizaremos el papel de la IL-17&#44; y en particular de la IL-22&#44; en la inmunidad tumoral y las posibles intervenciones terap&#233;uticas&#46;</p>"
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