Manejo práctico de ustekinumab en la psoriasis moderada-grave
Practical management of ustekinumab in moderate-severe psoriasis
J. Notario
, X. Bordas
Corresponding author
Servicio de Dermatología. Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat. Barcelona. España
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Rivera, F. Vanaclocha" "autores" => array:2 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Rivera" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Vanaclocha" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101270008X?idApp=UINPBA000044" "url" => "/00017310/00000103000000S2/v1_201304241722/S000173101270008X/v1_201304241722/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Manejo práctico de ustekinumab en la psoriasis moderada-grave" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "52" "paginaFinal" => "58" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Notario, X. Bordas" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Notario" "email" => array:1 [ 0 => "jnotario@bellvitgehospital.cat" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Bordas" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología. Hospital Universitari de Bellvitge. L’Hospitalet de Llobregat. Barcelona. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Practical management of ustekinumab in moderate-severe psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85100" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Ustekinumab" 2 => "Fármacos biológicos" 3 => "Tratamiento combinado" 4 => "Tránsito tratamientos" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85099" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Ustekinumab" 2 => "Biologic agents" 3 => "Combination therapy" 4 => "Treatment switch" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ustekinumab (UST) es hasta la fecha el último fármaco biológico aprobado para el tratamiento de la psoriasis. En su manejo práctico nos son útiles tanto los trabajos con UST como la experiencia previa acumulada con otros agentes. Los estudios previos al tratamiento, así como su monitorización y seguimiento presentan semejanzas entre los diferentes fármacos biológicos. En otros aspectos como el tratamiento combinado o el tránsito entre tratamientos, la todavía corta experiencia con UST nos obliga a tomar decisiones según la práctica seguida con otros agentes biológicos.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este artículo es repasar algunos aspectos relacionados con el manejo práctico de UST incidiendo en características diferenciales del fármaco e intentar aprovechar el conocimiento de que disponemos con otras terapias biológicas para optimizar su uso.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ustekinumab is the latest biologic agent to be approved for the treatment of psoriasis. Experience is therefore limited, but data from studies of ustekinumab can be complemented by experience with other biologic agents. While the guidelines for pretreatment screening and follow-up practices are similar in all of the biologic therapies, no standardized information on combination therapy or treatment switches is yet available for ustekinumab, and dermatologists thus have to base their decisions on experience with other biologic agents.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This chapter discusses several aspects related to the use of ustekinumab in clinical practice. We focus on the distinguishing characteristics of this drug and discuss how our knowledge and experience with other biologic agents can be used to help optimize the use of ustekinumab.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ficha técnica de ustekinumab. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 11 | 13 |
| 2024 October | 23 | 42 | 65 |
| 2024 September | 23 | 23 | 46 |
| 2024 August | 40 | 54 | 94 |
| 2024 July | 28 | 40 | 68 |
| 2024 June | 29 | 39 | 68 |
| 2024 May | 29 | 32 | 61 |
| 2024 April | 20 | 21 | 41 |
| 2024 March | 27 | 50 | 77 |
| 2024 February | 22 | 31 | 53 |
| 2024 January | 16 | 33 | 49 |
| 2023 December | 14 | 20 | 34 |
| 2023 November | 17 | 34 | 51 |
| 2023 October | 19 | 25 | 44 |
| 2023 September | 16 | 24 | 40 |
| 2023 August | 13 | 12 | 25 |
| 2023 July | 17 | 30 | 47 |
| 2023 June | 8 | 25 | 33 |
| 2023 May | 4 | 11 | 15 |
| 2023 April | 22 | 23 | 45 |
| 2023 March | 12 | 38 | 50 |
| 2023 February | 16 | 20 | 36 |
| 2023 January | 16 | 34 | 50 |
| 2022 December | 23 | 36 | 59 |
| 2022 November | 12 | 22 | 34 |
| 2022 October | 18 | 32 | 50 |
| 2022 September | 14 | 62 | 76 |
| 2022 August | 16 | 52 | 68 |
| 2022 July | 27 | 66 | 93 |
| 2022 June | 10 | 40 | 50 |
| 2022 May | 26 | 53 | 79 |
| 2022 April | 21 | 48 | 69 |
| 2022 March | 18 | 49 | 67 |
| 2022 February | 17 | 38 | 55 |
| 2022 January | 23 | 41 | 64 |
| 2021 December | 16 | 50 | 66 |
| 2021 November | 22 | 48 | 70 |
| 2021 October | 21 | 57 | 78 |
| 2021 September | 15 | 55 | 70 |
| 2021 August | 28 | 37 | 65 |
| 2021 July | 28 | 54 | 82 |
| 2021 June | 15 | 32 | 47 |
| 2021 May | 15 | 44 | 59 |
| 2021 April | 45 | 49 | 94 |
| 2021 March | 27 | 36 | 63 |
| 2021 February | 24 | 38 | 62 |
| 2021 January | 20 | 30 | 50 |
| 2020 December | 16 | 11 | 27 |
| 2020 November | 15 | 21 | 36 |
| 2020 October | 9 | 16 | 25 |
| 2020 September | 7 | 10 | 17 |
| 2020 August | 11 | 29 | 40 |
| 2020 July | 7 | 19 | 26 |
| 2020 June | 16 | 15 | 31 |
| 2020 May | 19 | 35 | 54 |
| 2020 April | 9 | 12 | 21 |
| 2020 March | 9 | 19 | 28 |
| 2019 December | 0 | 3 | 3 |
| 2019 November | 0 | 8 | 8 |
| 2019 October | 0 | 1 | 1 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 5 | 5 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 0 | 13 | 13 |
| 2019 April | 0 | 2 | 2 |
| 2019 March | 0 | 1 | 1 |
| 2019 February | 0 | 5 | 5 |
| 2018 December | 0 | 2 | 2 |
| 2018 November | 0 | 5 | 5 |
| 2018 October | 0 | 1 | 1 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 13 | 3 | 16 |
| 2018 January | 9 | 5 | 14 |
| 2017 December | 23 | 7 | 30 |
| 2017 November | 9 | 4 | 13 |
| 2017 October | 13 | 9 | 22 |
| 2017 September | 5 | 13 | 18 |
| 2017 August | 8 | 13 | 21 |
| 2017 July | 10 | 3 | 13 |
| 2017 June | 19 | 56 | 75 |
| 2017 May | 18 | 17 | 35 |
| 2017 April | 23 | 7 | 30 |
| 2017 March | 19 | 27 | 46 |
| 2017 February | 17 | 5 | 22 |
| 2017 January | 17 | 14 | 31 |
| 2016 December | 23 | 7 | 30 |
| 2016 November | 25 | 5 | 30 |
| 2016 October | 42 | 13 | 55 |
| 2016 September | 35 | 14 | 49 |
| 2016 August | 35 | 26 | 61 |
| 2016 July | 27 | 20 | 47 |
| 2016 June | 0 | 12 | 12 |
| 2016 May | 1 | 20 | 21 |
| 2016 April | 0 | 3 | 3 |
| 2016 March | 0 | 3 | 3 |
| 2016 February | 0 | 3 | 3 |
| 2016 January | 1 | 25 | 26 |
| 2015 December | 2 | 14 | 16 |
| 2015 November | 5 | 21 | 26 |
| 2015 October | 5 | 13 | 18 |
| 2015 September | 2 | 12 | 14 |
| 2015 August | 2 | 8 | 10 |
| 2015 July | 26 | 2 | 28 |
| 2015 June | 25 | 14 | 39 |
| 2015 May | 42 | 22 | 64 |
| 2015 April | 37 | 16 | 53 |
| 2015 March | 35 | 10 | 45 |
| 2015 February | 35 | 13 | 48 |
| 2015 January | 25 | 13 | 38 |
| 2014 December | 19 | 22 | 41 |
| 2014 November | 26 | 16 | 42 |
| 2014 October | 22 | 25 | 47 |
| 2014 September | 0 | 1 | 1 |
| 2014 August | 1 | 0 | 1 |
| 2014 July | 0 | 1 | 1 |
| 2014 February | 1 | 0 | 1 |
| 2014 January | 1 | 2 | 3 |
| 2013 October | 1 | 0 | 1 |
| 2013 September | 0 | 1 | 1 |
| 2013 June | 2 | 4 | 6 |
| 2013 May | 1 | 2 | 3 |
| 2013 April | 1 | 1 | 2 |
| 2013 March | 1 | 1 | 2 |
| 2013 February | 0 | 2 | 2 |
| 2013 January | 0 | 1 | 1 |
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