Ustekinumab. Neoplasias y otros aspectos de seguridad
Ustekinumab. Neoplasms and Other Safety Aspects
J. Santos-Juanes
, P. Coto, C. Galache
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Servicio de Dermatología II. Hospital Universitario Central de Asturias. Asturias. España
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"apellidos" => "Coto" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Galache" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología II. Hospital Universitario Central de Asturias. Asturias. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ustekinumab. Neoplasms and Other Safety Aspects" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85094" "palabras" => array:2 [ 0 => "Ustekinumab" 1 => "Seguridad" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85095" "palabras" => array:2 [ 0 => "Ustekinumab" 1 => "Safety" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La reciente aparición de nuevos tratamientos biológicos ha permitido un importante avance en el control de la psoriasis. Las interleucinas 12 y 23 desempeñan un papel importante en el control de neoplasias e infecciones. La aparición de nuevas moléculas que bloquean su acción ha reavivado el debate sobre el riesgo de desarrollar neoplasias en los pacientes con psoriasis que reciben este tipo de medicaciones.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En este artículo, realizamos una revisión de los estudios de seguridad a tres y cuatro años disponibles hasta la fecha y una revisión de la literatura.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Con los datos actuales, se puede concluir que los pacientes expuestos a ustekinumab no presentan mayor riesgo de padecer neoplasias que la población general.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The recent introduction of a new class of biologic agents in psoriasis has led to important advances in the management of this disease. IL-12 and IL-23 play a key role in the control of malignancies and infections. The development of novel molecules capable of blocking the action of these cytokines has rekindled the debate on whether biologic agents increase the risk of malignancy in patients with psoriasis.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In this chapter, we review the safety data for patients who have been treated for 3 or 4 years and the literature on the use of ustekinumab.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Based on the available evidence, it can be concluded that patients treated with stekinumab do not have a higher risk of malignancy than the general population.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 6 | 15 |
| 2024 October | 62 | 37 | 99 |
| 2024 September | 60 | 21 | 81 |
| 2024 August | 78 | 57 | 135 |
| 2024 July | 95 | 24 | 119 |
| 2024 June | 59 | 28 | 87 |
| 2024 May | 54 | 34 | 88 |
| 2024 April | 63 | 15 | 78 |
| 2024 March | 37 | 28 | 65 |
| 2024 February | 35 | 28 | 63 |
| 2024 January | 32 | 21 | 53 |
| 2023 December | 24 | 14 | 38 |
| 2023 November | 50 | 26 | 76 |
| 2023 October | 21 | 8 | 29 |
| 2023 September | 48 | 25 | 73 |
| 2023 August | 27 | 15 | 42 |
| 2023 July | 32 | 23 | 55 |
| 2023 June | 21 | 24 | 45 |
| 2023 May | 15 | 9 | 24 |
| 2023 April | 19 | 15 | 34 |
| 2023 March | 27 | 22 | 49 |
| 2023 February | 25 | 12 | 37 |
| 2023 January | 26 | 21 | 47 |
| 2022 December | 23 | 24 | 47 |
| 2022 November | 27 | 33 | 60 |
| 2022 October | 28 | 36 | 64 |
| 2022 September | 25 | 30 | 55 |
| 2022 August | 23 | 26 | 49 |
| 2022 July | 22 | 33 | 55 |
| 2022 June | 21 | 22 | 43 |
| 2022 May | 34 | 33 | 67 |
| 2022 April | 29 | 30 | 59 |
| 2022 March | 29 | 48 | 77 |
| 2022 February | 22 | 19 | 41 |
| 2022 January | 26 | 31 | 57 |
| 2021 December | 30 | 37 | 67 |
| 2021 November | 33 | 36 | 69 |
| 2021 October | 32 | 42 | 74 |
| 2021 September | 34 | 43 | 77 |
| 2021 August | 26 | 36 | 62 |
| 2021 July | 24 | 27 | 51 |
| 2021 June | 19 | 20 | 39 |
| 2021 May | 19 | 32 | 51 |
| 2021 April | 39 | 66 | 105 |
| 2021 March | 40 | 39 | 79 |
| 2021 February | 28 | 32 | 60 |
| 2021 January | 31 | 21 | 52 |
| 2020 December | 14 | 18 | 32 |
| 2020 November | 14 | 15 | 29 |
| 2020 October | 18 | 3 | 21 |
| 2020 September | 21 | 6 | 27 |
| 2020 August | 24 | 14 | 38 |
| 2020 July | 13 | 10 | 23 |
| 2020 June | 19 | 14 | 33 |
| 2020 May | 36 | 30 | 66 |
| 2020 April | 25 | 20 | 45 |
| 2020 March | 11 | 13 | 24 |
| 2020 February | 0 | 3 | 3 |
| 2020 January | 0 | 1 | 1 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 0 | 16 | 16 |
| 2019 October | 0 | 7 | 7 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 8 | 8 |
| 2019 June | 0 | 1 | 1 |
| 2019 May | 0 | 14 | 14 |
| 2019 April | 0 | 7 | 7 |
| 2019 February | 0 | 2 | 2 |
| 2018 December | 0 | 3 | 3 |
| 2018 November | 0 | 2 | 2 |
| 2018 October | 0 | 2 | 2 |
| 2018 February | 12 | 5 | 17 |
| 2018 January | 3 | 4 | 7 |
| 2017 December | 14 | 7 | 21 |
| 2017 November | 10 | 5 | 15 |
| 2017 October | 8 | 2 | 10 |
| 2017 September | 6 | 5 | 11 |
| 2017 August | 7 | 3 | 10 |
| 2017 July | 6 | 2 | 8 |
| 2017 June | 11 | 11 | 22 |
| 2017 May | 18 | 3 | 21 |
| 2017 April | 18 | 7 | 25 |
| 2017 March | 21 | 2 | 23 |
| 2017 February | 12 | 6 | 18 |
| 2017 January | 13 | 3 | 16 |
| 2016 December | 16 | 4 | 20 |
| 2016 November | 23 | 6 | 29 |
| 2016 October | 26 | 12 | 38 |
| 2016 September | 24 | 12 | 36 |
| 2016 August | 26 | 9 | 35 |
| 2016 July | 28 | 7 | 35 |
| 2016 June | 1 | 7 | 8 |
| 2016 May | 0 | 13 | 13 |
| 2016 April | 0 | 2 | 2 |
| 2016 March | 0 | 3 | 3 |
| 2016 February | 0 | 4 | 4 |
| 2016 January | 0 | 14 | 14 |
| 2015 December | 2 | 13 | 15 |
| 2015 November | 3 | 16 | 19 |
| 2015 October | 0 | 9 | 9 |
| 2015 September | 2 | 11 | 13 |
| 2015 August | 9 | 4 | 13 |
| 2015 July | 10 | 2 | 12 |
| 2015 June | 19 | 7 | 26 |
| 2015 May | 34 | 14 | 48 |
| 2015 April | 27 | 13 | 40 |
| 2015 March | 20 | 11 | 31 |
| 2015 February | 23 | 13 | 36 |
| 2015 January | 18 | 15 | 33 |
| 2014 December | 12 | 12 | 24 |
| 2014 November | 18 | 16 | 34 |
| 2014 October | 27 | 22 | 49 |
| 2014 September | 0 | 2 | 2 |
| 2014 May | 2 | 0 | 2 |
| 2014 April | 1 | 0 | 1 |
| 2014 January | 0 | 1 | 1 |
| 2013 December | 2 | 0 | 2 |
| 2013 September | 1 | 1 | 2 |
| 2013 June | 1 | 1 | 2 |
| 2013 May | 1 | 1 | 2 |
| 2013 April | 1 | 1 | 2 |
| 2013 February | 0 | 1 | 1 |
| 2013 January | 0 | 1 | 1 |
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