Mecanismo de acción de ustekinumab y su relevancia en la patogénesis de la psoriasis. Impacto en el sistema inmune
Mechanism of Action of Ustekinumab and its Relevance in the Pathogenesisof Psoriasis. Impact on the Immune System
J.M. Carrascosa
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Servei de Dermatologia. Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona. Badalona.Barcelona. España
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Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona. Badalona.Barcelona. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mechanism of Action of Ustekinumab and its Relevance in the Pathogenesisof Psoriasis. Impact on the Immune System" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85081" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Th17" 2 => "IL-12/23" 3 => "Psoriasis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85082" "palabras" => array:3 [ 0 => "Ustekinumab: TH17" 1 => "IL-12/23" 2 => "Psoriasis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La psoriasis es un proceso inflamatorio crónico en el que participan de forma conjunta la inmunidad innata y la adquirida. Los queratinocitos serán la primera diana a través de la liberación de péptidos antimicrobianos tales como la catelicidina LL37, que a través de la formación de agregados con el ADN del individuo permite la activación de diversas poblaciones de células dendríticas. En este modelo, algunas poblaciones linfocitarias no descritas previamente en la psoriasis, como las células dendríticas mieloides CD11<span class="elsevierStyleSup">+</span> y los linfocitos Th17, desempeñan un papel fundamental en la patogenia de las lesiones. Asimismo, la vía de las interleucinas 12/23, que permite la diferenciación y proliferación clonal de las subpoblaciones linfocitarias Th1 y Th17, implicadas de forma prioritaria en la génesis de la placa psoriásica, representa un punto clave no sólo como nexo entre la inmunidad innata y la adquirida, sino también como diana terapéutica, demostrada ya en la práctica clínica por ustekinumab.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is a chronic inflammatory disorder mediated by elements of both the innate and the adaptive immune system. The first cells involved in the inflammatory response are keratinocytes. These release antimicrobial peptides, such as cathelicidin LL37, which subsequently form complexes with self DNA, enabling the activation of different dendritic cell populations. It is now considered that lymphocyte subsets that have only recently been implicated in psoriasis, such as CD11<span class="elsevierStyleSup">+</span> dendritic cells and T<span class="elsevierStyleInf">H</span>17 cells, play a key role in the pathogenesis of psoriatic lesions. The interleukin 12/23 pathway enables the differentiation and clonal expansion of T<span class="elsevierStyleInf">H</span>1 and T<span class="elsevierStyleInf">H</span>17 cells, 2 types of helper T cells that have an essential role in the formation of psoriatic plaques. This pathway not only acts as a bridge between the innate and adaptive immune system, but is also an important therapeutic target, as has been demonstrated clinically with ustekinumab.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 11 | 7 | 18 |
| 2024 October | 106 | 26 | 132 |
| 2024 September | 103 | 27 | 130 |
| 2024 August | 87 | 47 | 134 |
| 2024 July | 61 | 26 | 87 |
| 2024 June | 87 | 35 | 122 |
| 2024 May | 56 | 33 | 89 |
| 2024 April | 71 | 26 | 97 |
| 2024 March | 60 | 33 | 93 |
| 2024 February | 50 | 27 | 77 |
| 2024 January | 48 | 31 | 79 |
| 2023 December | 45 | 18 | 63 |
| 2023 November | 69 | 33 | 102 |
| 2023 October | 58 | 17 | 75 |
| 2023 September | 53 | 32 | 85 |
| 2023 August | 43 | 23 | 66 |
| 2023 July | 58 | 72 | 130 |
| 2023 June | 34 | 57 | 91 |
| 2023 May | 7 | 15 | 22 |
| 2023 April | 41 | 23 | 64 |
| 2023 March | 40 | 27 | 67 |
| 2023 February | 42 | 21 | 63 |
| 2023 January | 53 | 35 | 88 |
| 2022 December | 46 | 23 | 69 |
| 2022 November | 39 | 31 | 70 |
| 2022 October | 55 | 35 | 90 |
| 2022 September | 36 | 42 | 78 |
| 2022 August | 49 | 41 | 90 |
| 2022 July | 33 | 42 | 75 |
| 2022 June | 34 | 34 | 68 |
| 2022 May | 37 | 38 | 75 |
| 2022 April | 32 | 35 | 67 |
| 2022 March | 36 | 50 | 86 |
| 2022 February | 25 | 25 | 50 |
| 2022 January | 44 | 40 | 84 |
| 2021 December | 62 | 47 | 109 |
| 2021 November | 62 | 43 | 105 |
| 2021 October | 77 | 58 | 135 |
| 2021 September | 68 | 38 | 106 |
| 2021 August | 49 | 34 | 83 |
| 2021 July | 37 | 42 | 79 |
| 2021 June | 37 | 33 | 70 |
| 2021 May | 27 | 57 | 84 |
| 2021 April | 96 | 66 | 162 |
| 2021 March | 57 | 29 | 86 |
| 2021 February | 29 | 34 | 63 |
| 2021 January | 30 | 23 | 53 |
| 2020 December | 45 | 25 | 70 |
| 2020 November | 20 | 15 | 35 |
| 2020 October | 27 | 20 | 47 |
| 2020 September | 26 | 14 | 40 |
| 2020 August | 32 | 18 | 50 |
| 2020 July | 29 | 13 | 42 |
| 2020 June | 29 | 26 | 55 |
| 2020 May | 28 | 42 | 70 |
| 2020 April | 27 | 14 | 41 |
| 2020 March | 24 | 23 | 47 |
| 2020 February | 1 | 5 | 6 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 1 | 1 |
| 2019 November | 0 | 5 | 5 |
| 2019 October | 0 | 9 | 9 |
| 2019 September | 0 | 10 | 10 |
| 2019 August | 0 | 6 | 6 |
| 2019 July | 0 | 25 | 25 |
| 2019 June | 0 | 46 | 46 |
| 2019 May | 1 | 148 | 149 |
| 2019 April | 0 | 46 | 46 |
| 2019 March | 0 | 9 | 9 |
| 2019 February | 0 | 10 | 10 |
| 2019 January | 0 | 7 | 7 |
| 2018 December | 1 | 10 | 11 |
| 2018 November | 1 | 29 | 30 |
| 2018 October | 0 | 1 | 1 |
| 2018 September | 0 | 8 | 8 |
| 2018 August | 0 | 30 | 30 |
| 2018 July | 0 | 13 | 13 |
| 2018 June | 0 | 6 | 6 |
| 2018 May | 0 | 7 | 7 |
| 2018 April | 0 | 4 | 4 |
| 2018 March | 2 | 13 | 15 |
| 2018 February | 22 | 11 | 33 |
| 2018 January | 20 | 8 | 28 |
| 2017 December | 28 | 14 | 42 |
| 2017 November | 30 | 12 | 42 |
| 2017 October | 48 | 11 | 59 |
| 2017 September | 41 | 17 | 58 |
| 2017 August | 33 | 19 | 52 |
| 2017 July | 32 | 6 | 38 |
| 2017 June | 33 | 35 | 68 |
| 2017 May | 32 | 14 | 46 |
| 2017 April | 36 | 37 | 73 |
| 2017 March | 38 | 23 | 61 |
| 2017 February | 39 | 18 | 57 |
| 2017 January | 29 | 21 | 50 |
| 2016 December | 36 | 15 | 51 |
| 2016 November | 45 | 19 | 64 |
| 2016 October | 66 | 35 | 101 |
| 2016 September | 85 | 52 | 137 |
| 2016 August | 51 | 24 | 75 |
| 2016 July | 30 | 20 | 50 |
| 2016 June | 4 | 16 | 20 |
| 2016 May | 0 | 16 | 16 |
| 2016 April | 0 | 1 | 1 |
| 2016 March | 5 | 3 | 8 |
| 2016 February | 0 | 5 | 5 |
| 2016 January | 0 | 17 | 17 |
| 2015 December | 3 | 19 | 22 |
| 2015 November | 3 | 28 | 31 |
| 2015 October | 1 | 18 | 19 |
| 2015 September | 3 | 12 | 15 |
| 2015 August | 2 | 8 | 10 |
| 2015 July | 20 | 2 | 22 |
| 2015 June | 28 | 12 | 40 |
| 2015 May | 49 | 29 | 78 |
| 2015 April | 38 | 12 | 50 |
| 2015 March | 44 | 15 | 59 |
| 2015 February | 36 | 15 | 51 |
| 2015 January | 31 | 17 | 48 |
| 2014 December | 26 | 12 | 38 |
| 2014 November | 31 | 18 | 49 |
| 2014 October | 36 | 23 | 59 |
| 2014 September | 0 | 1 | 1 |
| 2014 August | 2 | 0 | 2 |
| 2014 July | 1 | 0 | 1 |
| 2014 May | 2 | 0 | 2 |
| 2014 April | 1 | 0 | 1 |
| 2014 February | 0 | 1 | 1 |
| 2014 January | 0 | 1 | 1 |
| 2013 October | 1 | 0 | 1 |
| 2013 September | 1 | 2 | 3 |
| 2013 June | 1 | 2 | 3 |
| 2013 May | 1 | 1 | 2 |
| 2013 March | 1 | 1 | 2 |
| 2013 February | 0 | 1 | 1 |
| 2013 January | 0 | 1 | 1 |
Show all
