Confocal Reflectance Microscopy in Dermatology: Promise and Reality of Non-Invasive Diagnosis and Monitoring
Microscopía confocal de reflectancia en dermatología: promesa y realidad de diagnóstico y seguimiento no invasivos
S. González
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gonzals6@mskcc.org
Correspondence: Faculty of Dermatology Service. Memorial Sloan-Kettering Cancer Center. New York. 160 E 53rd Street, NY-10022.
Correspondence: Faculty of Dermatology Service. Memorial Sloan-Kettering Cancer Center. New York. 160 E 53rd Street, NY-10022.
Dermatology Service. Memorial Sloan-Kettering Cancer Center. New York. United States of America. Hospital Ramón y Cajal. Universidad de Alcalá de Henares. Madrid. Spain
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"apellidos" => "González" "email" => array:1 [ 0 => "gonzals6@mskcc.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Dermatology Service. Memorial Sloan-Kettering Cancer Center. New York. United States of America. Hospital Ramón y Cajal. Universidad de Alcalá de Henares. Madrid. Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Faculty of Dermatology Service. Memorial Sloan-Kettering Cancer Center. New York. 160 E 53rd Street, NY-10022." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Microscopía confocal de reflectancia en dermatología: promesa y realidad de diagnóstico y seguimiento no invasivos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82468" "palabras" => array:4 [ 0 => "reflectance confocal microscopy" 1 => "non-invasive imaging techniques" 2 => "<span class="elsevierStyleItalic">in vivo</span> microscopy" 3 => "skin cancer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82467" "palabras" => array:4 [ 0 => "microscopía confocal de reflectancia" 1 => "técnica no invasiva" 2 => "microscopía <span class="elsevierStyleItalic">in vivo</span>" 3 => "cáncer cutáneo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">In vivo</span> reflectance confocal microscopy (RCM) constitutes a novel non-invasive imaging method that enables visualization of cells and structures in living skin in real time with resolution close to histological analysis. RCM has been successfully implemented in the assessment of benign and malignant lesions. It also enables monitoring dynamic changes in the skin over time and in response to different stimuli, such as ultraviolet exposure or specific treatments. The non-invasive nature of this technique allows repetitive sampling without biopsy collection, causing no further damage to the areas under investigation. In this article, I provide an overview of RCM, including the latest technological advances as well as novel applications in the characterization of both normal and pathological skin.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La microscopía confocal de reflectancia (MCR) <span class="elsevierStyleItalic">in vivo</span> constituye un novedoso método de imagen no invasivo que permite la visualización de células y estructuras de la piel viva en tiempo real, con una resolución próxima al estudio histológico. La MCR también se ha implementado con éxito para la valoración de lesiones benignas y malignas. Asimismo, permite detectar los cambios dinámicos en la piel con el paso del tiempo y en respuesta a diferentes estímulos, como la exposición a la radiación ultravioleta o a tratamientos específicos. La naturaleza no invasiva de esta técnica permite repetir las muestras sin realizar una biopsia, evitando así causar más daño a las zonas que están siendo estudiadas. En este artículo se aporta una visión de conjunto sobre la MCR, incluyendo los últimos avances tecnológicos, así como las aplicaciones novedosas para la caracterización de la piel sana y enferma.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:57 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopy: what's new?" 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 10 | 17 |
| 2024 October | 38 | 30 | 68 |
| 2024 September | 36 | 30 | 66 |
| 2024 August | 48 | 45 | 93 |
| 2024 July | 38 | 28 | 66 |
| 2024 June | 39 | 33 | 72 |
| 2024 May | 34 | 40 | 74 |
| 2024 April | 38 | 38 | 76 |
| 2024 March | 30 | 29 | 59 |
| 2024 February | 36 | 35 | 71 |
| 2024 January | 27 | 28 | 55 |
| 2023 December | 25 | 21 | 46 |
| 2023 November | 34 | 24 | 58 |
| 2023 October | 33 | 23 | 56 |
| 2023 September | 57 | 25 | 82 |
| 2023 August | 50 | 24 | 74 |
| 2023 July | 34 | 34 | 68 |
| 2023 June | 27 | 20 | 47 |
| 2023 May | 10 | 9 | 19 |
| 2023 April | 21 | 28 | 49 |
| 2023 March | 22 | 20 | 42 |
| 2023 February | 17 | 27 | 44 |
| 2023 January | 22 | 24 | 46 |
| 2022 December | 32 | 29 | 61 |
| 2022 November | 32 | 28 | 60 |
| 2022 October | 23 | 11 | 34 |
| 2022 September | 17 | 27 | 44 |
| 2022 August | 24 | 30 | 54 |
| 2022 July | 23 | 33 | 56 |
| 2022 June | 13 | 28 | 41 |
| 2022 May | 20 | 42 | 62 |
| 2022 April | 19 | 25 | 44 |
| 2022 March | 36 | 41 | 77 |
| 2022 February | 24 | 19 | 43 |
| 2022 January | 22 | 42 | 64 |
| 2021 December | 21 | 31 | 52 |
| 2021 November | 23 | 49 | 72 |
| 2021 October | 20 | 51 | 71 |
| 2021 September | 23 | 36 | 59 |
| 2021 August | 23 | 32 | 55 |
| 2021 July | 11 | 34 | 45 |
| 2021 June | 13 | 23 | 36 |
| 2021 May | 22 | 37 | 59 |
| 2021 April | 25 | 51 | 76 |
| 2021 March | 27 | 33 | 60 |
| 2021 February | 14 | 23 | 37 |
| 2021 January | 19 | 24 | 43 |
| 2020 December | 16 | 15 | 31 |
| 2020 November | 19 | 9 | 28 |
| 2020 October | 5 | 1 | 6 |
| 2020 September | 12 | 9 | 21 |
| 2020 August | 12 | 18 | 30 |
| 2020 July | 5 | 7 | 12 |
| 2020 June | 20 | 22 | 42 |
| 2020 May | 15 | 14 | 29 |
| 2020 April | 20 | 19 | 39 |
| 2020 March | 19 | 18 | 37 |
| 2020 February | 1 | 0 | 1 |
| 2019 April | 0 | 2 | 2 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 11 | 3 | 14 |
| 2018 January | 10 | 3 | 13 |
| 2017 December | 11 | 6 | 17 |
| 2017 November | 15 | 7 | 22 |
| 2017 October | 14 | 5 | 19 |
| 2017 September | 11 | 7 | 18 |
| 2017 August | 8 | 8 | 16 |
| 2017 July | 15 | 1 | 16 |
| 2017 June | 15 | 10 | 25 |
| 2017 May | 12 | 7 | 19 |
| 2017 April | 15 | 11 | 26 |
| 2017 March | 22 | 4 | 26 |
| 2017 February | 12 | 4 | 16 |
| 2017 January | 8 | 3 | 11 |
| 2016 December | 22 | 3 | 25 |
| 2016 November | 28 | 8 | 36 |
| 2016 October | 32 | 10 | 42 |
| 2016 September | 28 | 7 | 35 |
| 2016 August | 13 | 5 | 18 |
| 2016 July | 15 | 4 | 19 |
| 2016 June | 0 | 12 | 12 |
| 2016 May | 0 | 17 | 17 |
| 2016 March | 0 | 2 | 2 |
| 2016 February | 0 | 8 | 8 |
| 2016 January | 0 | 26 | 26 |
| 2015 December | 3 | 13 | 16 |
| 2015 November | 10 | 12 | 22 |
| 2015 October | 3 | 0 | 3 |
| 2015 September | 2 | 3 | 5 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 31 | 1 | 32 |
| 2015 June | 23 | 11 | 34 |
| 2015 May | 36 | 14 | 50 |
| 2015 April | 41 | 6 | 47 |
| 2015 March | 19 | 3 | 22 |
| 2015 February | 21 | 1 | 22 |
| 2015 January | 19 | 0 | 19 |
| 2014 December | 21 | 0 | 21 |
| 2014 November | 17 | 0 | 17 |
| 2014 October | 20 | 0 | 20 |
| 2014 September | 20 | 0 | 20 |
| 2014 August | 19 | 0 | 19 |
| 2014 July | 25 | 0 | 25 |
| 2014 June | 28 | 0 | 28 |
| 2014 May | 28 | 1 | 29 |
| 2014 April | 28 | 0 | 28 |
| 2014 March | 36 | 13 | 49 |
| 2014 February | 24 | 18 | 42 |
| 2014 January | 27 | 16 | 43 |
| 2013 December | 30 | 15 | 45 |
| 2013 November | 18 | 14 | 32 |
| 2013 October | 23 | 22 | 45 |
| 2013 September | 21 | 15 | 36 |
| 2013 August | 23 | 21 | 44 |
| 2013 July | 39 | 31 | 70 |
| 2013 June | 23 | 15 | 38 |
| 2013 May | 27 | 18 | 45 |
| 2013 April | 31 | 22 | 53 |
| 2013 March | 36 | 15 | 51 |
| 2013 February | 21 | 15 | 36 |
| 2013 January | 14 | 9 | 23 |
| 2012 December | 13 | 14 | 27 |
| 2012 November | 11 | 23 | 34 |
| 2012 October | 7 | 7 | 14 |
| 2012 September | 3 | 12 | 15 |
| 2010 November | 11 | 0 | 11 |
| 2010 October | 10 | 0 | 10 |
| 2010 September | 4 | 0 | 4 |
| 2010 August | 15 | 0 | 15 |
| 2010 July | 14 | 0 | 14 |
| 2010 June | 18 | 0 | 18 |
| 2010 May | 24 | 0 | 24 |
| 2010 April | 22 | 0 | 22 |
| 2010 March | 2 | 0 | 2 |
| 2010 January | 1 | 0 | 1 |
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