Toward Better Management of Merkel Cell Carcinoma Using a Consensus Staging System, New Diagnostic Codes and a Recently Discovered Virus
Hacia un mejor tratamiento del carcinoma de células de merkel utilizando una estadificación de consenso, nuevos códigos diagnósticos y un virus descubierto recientemente
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Flores, Y. Qian, L.A. Díaz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Flores" ] 1 => array:2 [ "nombre" => "Y." "apellidos" => "Qian" ] 2 => array:2 [ "nombre" => "L.A." "apellidos" => "Díaz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731009733770?idApp=UINPBA000044" "url" => "/00017310/00000100000000S2/v1_201304241226/S0001731009733770/v1_201304241226/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "titulo" => "Toward Better Management of Merkel Cell Carcinoma Using a Consensus Staging System, New Diagnostic Codes and a Recently Discovered Virus" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "54" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.G. Iyer, S. Koba, P. Nghiem" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J.G." "apellidos" => "Iyer" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Koba" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 2 => array:4 [ "nombre" => "P." "apellidos" => "Nghiem" "email" => array:1 [ 0 => "pnghiem@uw.edu" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Dermatology Division. University of Washington. Seattle. Washington. USA" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Dermatology Division. Saga University. Saga. Japan" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance. Seattle. Washington. USA" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Paul Nghiem, MD, PhD. 815 Mercer Street Seattle, WA 98109." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hacia un mejor tratamiento del carcinoma de células de merkel utilizando una estadificación de consenso, nuevos códigos diagnósticos y un virus descubierto recientemente" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82460" "palabras" => array:3 [ 0 => "Merkel cell carcinoma" 1 => "skin cancer" 2 => "neuroendocrine" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82459" "palabras" => array:3 [ 0 => "carcinoma de células de Merkel" 1 => "cáncer cutáneo" 2 => "neuroendocrino" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a higher propensity for recurrence and metastasis than melanoma or squamous cell carcinoma. Despite aggressive behavior and the tripling of its reported incidence in the past 20 years, there is extensive confusion about how MCC should be managed. Here we address two issues that have impeded optimal MCC management: lack of a consensus staging system and lack of unique diagnostic codes for MCC. Five conflicting systems currently used to stage MCC will be replaced by one system in 2010 that will diminish confusion about prognosis and management among physicians and patients. The diagnostic bundling of MCC with numerous less aggressive skin cancers leads to care refusals by insurance and an inability to track MCC care costs. Worldwide adoption in 2009 of specific diagnostic codes for MCC will also improve understanding and management of this often-lethal skin cancer.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El carcinoma de células de Merkel (CCM) es una neoplasia cutánea neuroendocrina con una mayor propensión para desarrollar recurrencias y metástasis que el melanoma o el carcinoma epidermoide. A pesar de su comportamiento agresivo, y el hecho de que su incidencia se haya triplicado en los últimos 20 años, aún existe una gran confusión respecto al tratamiento del CCM. En esta revisión abordaremos dos cuestiones que han dificultado el tratamiento óptimo del CCM: la carencia de un sistema de estadificación consensuado y la falta de códigos diagnósticos exclusivos para el CCM. Los 5 sistemas contradictorios que actualmente se utilizan para estadificar el CCM serán reemplazados solamente por uno en 2010, lo que disminuirá la confusión sobre el pronóstico y el tratamiento entre los médicos y pacientes. La codificación diagnóstica del CCM, junto con numerosas neoplasias cutáneas menos agresivas, ha condicionado la denegación de atención por parte de las compañías aseguradoras y la incapacidad para evaluar los costes de la atención sanitaria por CCM.</p><p class="elsevierStyleSimplePara elsevierViewall">La adopción, que se ha efectuado en 2009, de códigos diagnósticos específicos para el CCM también mejorará la comprensión y el tratamiento de esta neoplasia cutánea frecuentemente letal.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">These authors contributed equally</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 10 | 12 |
| 2024 October | 28 | 35 | 63 |
| 2024 September | 24 | 40 | 64 |
| 2024 August | 44 | 63 | 107 |
| 2024 July | 25 | 28 | 53 |
| 2024 June | 42 | 18 | 60 |
| 2024 May | 19 | 25 | 44 |
| 2024 April | 32 | 17 | 49 |
| 2024 March | 27 | 16 | 43 |
| 2024 February | 27 | 27 | 54 |
| 2024 January | 20 | 25 | 45 |
| 2023 December | 22 | 20 | 42 |
| 2023 November | 18 | 16 | 34 |
| 2023 October | 19 | 15 | 34 |
| 2023 September | 22 | 15 | 37 |
| 2023 August | 17 | 16 | 33 |
| 2023 July | 20 | 30 | 50 |
| 2023 June | 17 | 21 | 38 |
| 2023 May | 4 | 7 | 11 |
| 2023 April | 13 | 19 | 32 |
| 2023 March | 12 | 16 | 28 |
| 2023 February | 17 | 15 | 32 |
| 2023 January | 9 | 21 | 30 |
| 2022 December | 20 | 26 | 46 |
| 2022 November | 25 | 40 | 65 |
| 2022 October | 15 | 18 | 33 |
| 2022 September | 23 | 34 | 57 |
| 2022 August | 18 | 24 | 42 |
| 2022 July | 17 | 35 | 52 |
| 2022 June | 12 | 19 | 31 |
| 2022 May | 14 | 30 | 44 |
| 2022 April | 19 | 30 | 49 |
| 2022 March | 19 | 41 | 60 |
| 2022 February | 13 | 24 | 37 |
| 2022 January | 21 | 44 | 65 |
| 2021 December | 22 | 33 | 55 |
| 2021 November | 31 | 45 | 76 |
| 2021 October | 22 | 50 | 72 |
| 2021 September | 23 | 36 | 59 |
| 2021 August | 17 | 28 | 45 |
| 2021 July | 22 | 31 | 53 |
| 2021 June | 29 | 28 | 57 |
| 2021 May | 16 | 33 | 49 |
| 2021 April | 23 | 36 | 59 |
| 2021 March | 24 | 17 | 41 |
| 2021 February | 24 | 20 | 44 |
| 2021 January | 21 | 17 | 38 |
| 2020 December | 26 | 20 | 46 |
| 2020 November | 14 | 12 | 26 |
| 2020 October | 8 | 6 | 14 |
| 2020 September | 11 | 10 | 21 |
| 2020 August | 22 | 17 | 39 |
| 2020 July | 14 | 6 | 20 |
| 2020 June | 18 | 17 | 35 |
| 2020 May | 30 | 21 | 51 |
| 2020 April | 13 | 21 | 34 |
| 2020 March | 20 | 20 | 40 |
| 2020 February | 2 | 0 | 2 |
| 2019 March | 0 | 1 | 1 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 14 | 4 | 18 |
| 2018 January | 8 | 5 | 13 |
| 2017 December | 13 | 9 | 22 |
| 2017 November | 13 | 1 | 14 |
| 2017 October | 14 | 6 | 20 |
| 2017 September | 10 | 9 | 19 |
| 2017 August | 6 | 8 | 14 |
| 2017 July | 8 | 3 | 11 |
| 2017 June | 17 | 10 | 27 |
| 2017 May | 9 | 6 | 15 |
| 2017 April | 13 | 12 | 25 |
| 2017 March | 13 | 5 | 18 |
| 2017 February | 7 | 5 | 12 |
| 2017 January | 12 | 99 | 111 |
| 2016 December | 12 | 5 | 17 |
| 2016 November | 22 | 7 | 29 |
| 2016 October | 28 | 6 | 34 |
| 2016 September | 13 | 5 | 18 |
| 2016 August | 9 | 5 | 14 |
| 2016 July | 10 | 8 | 18 |
| 2016 June | 0 | 3 | 3 |
| 2016 May | 0 | 6 | 6 |
| 2016 April | 1 | 2 | 3 |
| 2016 March | 0 | 2 | 2 |
| 2016 February | 0 | 5 | 5 |
| 2016 January | 0 | 23 | 23 |
| 2015 December | 1 | 10 | 11 |
| 2015 November | 6 | 17 | 23 |
| 2015 October | 2 | 9 | 11 |
| 2015 September | 1 | 5 | 6 |
| 2015 August | 5 | 4 | 9 |
| 2015 July | 32 | 1 | 33 |
| 2015 June | 17 | 13 | 30 |
| 2015 May | 27 | 17 | 44 |
| 2015 April | 33 | 4 | 37 |
| 2015 March | 20 | 2 | 22 |
| 2015 February | 22 | 1 | 23 |
| 2015 January | 22 | 0 | 22 |
| 2014 December | 21 | 0 | 21 |
| 2014 November | 19 | 0 | 19 |
| 2014 October | 20 | 0 | 20 |
| 2014 September | 22 | 0 | 22 |
| 2014 August | 23 | 0 | 23 |
| 2014 July | 30 | 0 | 30 |
| 2014 June | 24 | 0 | 24 |
| 2014 May | 23 | 0 | 23 |
| 2014 April | 24 | 0 | 24 |
| 2014 March | 35 | 16 | 51 |
| 2014 February | 28 | 17 | 45 |
| 2014 January | 21 | 14 | 35 |
| 2013 December | 32 | 17 | 49 |
| 2013 November | 17 | 14 | 31 |
| 2013 October | 30 | 16 | 46 |
| 2013 September | 16 | 19 | 35 |
| 2013 August | 16 | 21 | 37 |
| 2013 July | 27 | 16 | 43 |
| 2013 June | 15 | 15 | 30 |
| 2013 May | 25 | 18 | 43 |
| 2013 April | 20 | 13 | 33 |
| 2013 March | 31 | 16 | 47 |
| 2013 February | 19 | 10 | 29 |
| 2013 January | 9 | 5 | 14 |
| 2012 December | 9 | 6 | 15 |
| 2012 November | 9 | 11 | 20 |
| 2012 October | 6 | 8 | 14 |
| 2012 September | 3 | 3 | 6 |
| 2010 November | 7 | 0 | 7 |
| 2010 October | 11 | 0 | 11 |
| 2010 September | 6 | 0 | 6 |
| 2010 August | 4 | 0 | 4 |
| 2010 July | 15 | 0 | 15 |
| 2010 June | 6 | 0 | 6 |
| 2010 May | 21 | 0 | 21 |
| 2010 April | 21 | 0 | 21 |
| 2010 March | 2 | 0 | 2 |
| 2010 January | 7 | 0 | 7 |
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