The Enigmatic Autoimmune Response in Endemic Pemphigus Foliaceus

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Ring, B. Belloni, H. Behrendt" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Ring" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Belloni" ] 2 => array:2 [ "nombre" => "H." "apellidos" => "Behrendt" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731009733769?idApp=UINPBA000044" "url" => "/00017310/00000100000000S2/v1_201304241226/S0001731009733769/v1_201304241226/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "The Enigmatic Autoimmune Response in Endemic Pemphigus Foliaceus" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "40" "paginaFinal" => "48" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G. Flores, Y. Qian, L.A. Díaz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Flores" ] 1 => array:2 [ "nombre" => "Y." "apellidos" => "Qian" ] 2 => array:4 [ "nombre" => "L.A." "apellidos" => "Díaz" "email" => array:1 [ 0 => "ldiaz@med.unc.edu" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Dermatology. University of North Carolina School of Medicine. Chapel Hill. North Carolina. United States of America" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Department of Dermatology. University of North Carolina. Chapel Hill 3100. Thurston Building, CB#7287 Chapel Hill, NC 27599." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La enigmática respuesta autoinmunitaria en el pénfigo foliáceo endémico" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82458" "palabras" => array:5 [ 0 => "fogo selvagem" 1 => "desmoglein" 2 => "pemphigus foliaceus" 3 => "pemphigus vulgaris" 4 => "ELISA" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82457" "palabras" => array:5 [ 0 => "fogo selvagem" 1 => "desmogleína" 2 => "pénfigo foliáceo" 3 => "pénfigo vulgar" 4 => "ELISA" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Endemic pemphigus foliaceus, known as Fogo Selvagem (FS) in Brazil, is a disease characterized by subcorneal blisters and IgG4 anti-dermoglein 1 (Dsg1) autoantibodies. Epidemiological studies of FS strongly an environmental etiology. A 15-year surveillance of the Limao Verde Amerindian reservation in Brazil has uncovered information on the transition of the autoimmune response from the pre-clinical stage to disease state. This incubation time may evolve over several years. The serological markers of the pre-clinical state of FS are IgM anti-Dsg1, IgE and non-IgG4 autoantibodies against Dsg1. The disease stage of FS is characterized by the rise of pathogenic IgG4 anti-Dsg1 autoantibodies. In this review, the authors reviewed the literature on the relevance of the humoral autoimmune response of FS as well as the possible environmental triggers of anti-Dsg1 autoantibody formation. Based on epidemiological observations, the authors hypothesize that the pathogenic IgG4 response in FS may be triggered by hematophagous insect bites." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El pénfigo foliáceo endémico, conocido como fogo selvagem (FS) en Brasil, es una enfermedad caracterizada por ampollas subcórneas y autoanticuerpos IgG4 frente a la desmogleína 1 (Dsg1).Los estudios epidemiológicos sobre el FS apoyan de manera sólida una etiología ambiental. Un seguimiento durante 15 años de la reserva amerindia de Limao Verde ha revelado información sobre la transición de la respuesta autoinmunitaria desde el estadio preclínico hasta la fase clínica florida. Este periodo de incubación puede desarrollarse a lo largo de varios años. Los marcadores serológicos del estadio preclínico del FS son autoan ticuerpos IgM, IgE y no IgG4 frente a la Dsg1. La fase florida del FS se caracteriza por el aumento de los autoanticuerpos patogénicos IgG4 frente a la Dsg1.En este artículo los autores revisan la literatura sobre la relevancia de la respuesta humoral autoinmunitaria del FS, así como los posibles factores ambientales desencadenantes para la formación de autoanticuerpos frente a la Dgs-1. Los autores sugieren, basándose en los estudios epidemiológicos, que la respuesta patogénica mediada por IgG4 en el FS puede estar provocada por las picaduras de insectos hematófagos." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:96 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. Bystryn" 1 => "J.L. 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La enigmática respuesta autoinmunitaria en el pénfigo foliáceo endémico

G. Flores, Y. Qian, L.A. Díaz

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ldiaz@med.unc.edu

Correspondence: Department of Dermatology. University of North Carolina. Chapel Hill 3100. Thurston Building, CB#7287 Chapel Hill, NC 27599.

Department of Dermatology. University of North Carolina School of Medicine. Chapel Hill. North Carolina. United States of America

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          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82458"
          "palabras" => array:5 [
            0 => "fogo selvagem"
            1 => "desmoglein"
            2 => "pemphigus foliaceus"
            3 => "pemphigus vulgaris"
            4 => "ELISA"
          ]
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          "palabras" => array:5 [
            0 => "<span class="elsevierStyleItalic">fogo selvagem</span>"
            1 => "desmogle&#237;na"
            2 => "p&#233;nfigo foli&#225;ceo"
            3 => "p&#233;nfigo vulgar"
            4 => "ELISA"
          ]
        ]
      ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Endemic pemphigus foliaceus&#44; known as Fogo Selvagem &#40;FS&#41; in Brazil&#44; is a disease characterized by subcorneal blisters and IgG4 anti-dermoglein 1 &#40;Dsg1&#41; autoantibodies&#46; Epidemiological studies of FS strongly an environmental etiology&#46; A 15-year surveillance of the Limao Verde Amerindian reservation in Brazil has uncovered information on the transition of the autoimmune response from the pre-clinical stage to disease state&#46; This incubation time may evolve over several years&#46; The serological markers of the pre-clinical state of FS are IgM anti-Dsg1&#44; IgE and non-IgG4 autoantibodies against Dsg1&#46; The disease stage of FS is characterized by the rise of pathogenic IgG4 anti-Dsg1 autoantibodies&#46; In this review&#44; the authors reviewed the literature on the relevance of the humoral autoimmune response of FS as well as the possible environmental triggers of anti-Dsg1 autoantibody formation&#46; Based on epidemiological observations&#44; the authors hypothesize that the pathogenic IgG4 response in FS may be triggered by hematophagous insect bites&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El p&#233;nfigo foli&#225;ceo end&#233;mico&#44; conocido como <span class="elsevierStyleItalic">fogo selvagem</span> &#40;FS&#41; en Brasil&#44; es una enfermedad caracterizada por ampollas subc&#243;rneas y autoanticuerpos IgG4 frente a la desmogle&#237;na 1 &#40;Dsg1&#41;&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Los estudios epidemiol&#243;gicos sobre el FS apoyan de manera s&#243;lida una etiolog&#237;a ambiental&#46; Un seguimiento durante 15 a&#241;os de la reserva amerindia de Limao Verde ha revelado informaci&#243;n sobre la transici&#243;n de la respuesta autoinmunitaria desde el estadio precl&#237;nico hasta la fase cl&#237;nica florida&#46; Este periodo de incubaci&#243;n puede desarrollarse a lo largo de varios a&#241;os&#46; Los marcadores serol&#243;gicos del estadio precl&#237;nico del FS son autoan ticuerpos IgM&#44; IgE y no IgG4 frente a la Dsg1&#46; La fase florida del FS se caracteriza por el aumento de los autoanticuerpos patog&#233;nicos IgG4 frente a la Dsg1&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">En este art&#237;culo los autores revisan la literatura sobre la relevancia de la respuesta humoral autoinmunitaria del FS&#44; as&#237; como los posibles factores ambientales desencadenantes para la formaci&#243;n de autoanticuerpos frente a la Dgs-1&#46; Los autores sugieren&#44; bas&#225;ndose en los estudios epidemiol&#243;gicos&#44; que la respuesta patog&#233;nica mediada por IgG4 en el FS puede estar provocada por las picaduras de insectos hemat&#243;fagos&#46;</p>"
      ]
    ]
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Article information

ISSN: 00017310
Original language: English

DOI:10.1016/S0001-7310(09)73377-0

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Year/Month	Html	Pdf	Total

2024 November	5	9	14
2024 October	29	39	68
2024 September	38	21	59
2024 August	57	58	115
2024 July	35	26	61
2024 June	38	21	59
2024 May	23	25	48
2024 April	29	18	47
2024 March	24	21	45
2024 February	23	33	56
2024 January	23	32	55
2023 December	26	19	45
2023 November	24	29	53
2023 October	25	35	60
2023 September	22	26	48
2023 August	20	18	38
2023 July	18	28	46
2023 June	15	20	35
2023 May	8	9	17
2023 April	16	16	32
2023 March	15	15	30
2023 February	18	20	38
2023 January	13	25	38
2022 December	20	34	54
2022 November	25	43	68
2022 October	24	12	36
2022 September	42	32	74
2022 August	50	25	75
2022 July	78	33	111
2022 June	11	14	25
2022 May	25	27	52
2022 April	26	36	62
2022 March	24	47	71
2022 February	18	25	43
2022 January	24	36	60
2021 December	18	26	44
2021 November	28	40	68
2021 October	21	44	65
2021 September	25	40	65
2021 August	11	23	34
2021 July	11	29	40
2021 June	14	21	35
2021 May	21	38	59
2021 April	21	36	57
2021 March	30	25	55
2021 February	20	19	39
2021 January	16	13	29
2020 December	15	11	26
2020 November	13	17	30
2020 October	10	5	15
2020 September	8	6	14
2020 August	20	26	46
2020 July	13	4	17
2020 June	23	21	44
2020 May	24	25	49
2020 April	29	13	42
2020 March	19	18	37
2020 February	3	0	3
2019 March	8	2	10
2018 March	1	0	1
2018 February	11	5	16
2018 January	14	3	17
2017 December	14	6	20
2017 November	9	4	13
2017 October	11	9	20
2017 September	13	8	21
2017 August	11	6	17
2017 July	10	3	13
2017 June	19	7	26
2017 May	24	13	37
2017 April	21	8	29
2017 March	10	8	18
2017 February	7	3	10
2017 January	17	6	23
2016 December	16	3	19
2016 November	36	5	41
2016 October	28	19	47
2016 September	20	7	27
2016 August	11	7	18
2016 July	16	12	28
2016 June	0	5	5
2016 May	0	12	12
2016 April	0	2	2
2016 March	0	18	18
2016 February	0	3	3
2016 January	0	20	20
2015 December	4	18	22
2015 November	5	10	15
2015 October	1	8	9
2015 September	3	6	9
2015 August	3	4	7
2015 July	15	1	16
2015 June	27	12	39
2015 May	27	18	45
2015 April	35	11	46
2015 March	22	4	26
2015 February	16	2	18
2015 January	21	0	21
2014 December	20	0	20
2014 November	17	0	17
2014 October	22	0	22
2014 September	25	0	25
2014 August	22	0	22
2014 July	33	0	33
2014 June	25	0	25
2014 May	39	0	39
2014 April	31	0	31
2014 March	43	18	61
2014 February	30	26	56
2014 January	18	27	45
2013 December	43	23	66
2013 November	27	22	49
2013 October	27	16	43
2013 September	22	15	37
2013 August	31	27	58
2013 July	29	26	55
2013 June	20	23	43
2013 May	34	30	64
2013 April	26	18	44
2013 March	26	23	49
2013 February	26	11	37
2013 January	11	5	16
2012 December	10	13	23
2012 November	10	9	19
2012 October	6	8	14
2012 September	3	6	9
2012 August	1	0	1
2010 November	9	0	9
2010 October	17	0	17
2010 September	17	0	17
2010 August	22	0	22
2010 July	15	0	15
2010 June	13	0	13
2010 May	15	0	15
2010 April	17	0	17
2010 March	6	0	6
2010 January	3	0	3

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