Looking Ahead in Dermatology: Skin and Allergy
Mirando hacia el futuro en dermatología: piel y alergia
J. Ring
, B. Belloni, H. Behrendt
Corresponding author
johannes.ring@lrz.tum.de
Correspondence: Department of Dermatology and Allergology Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29. 80802 Munich. Germany.
Correspondence: Department of Dermatology and Allergology Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29. 80802 Munich. Germany.
Department of Dermatology and Allergology Biederstein. ZAUM – Zentrum Allergie und Umwelt (Center for Allergy and Environment). Technische Universität München
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"apellidos" => "Ring" "email" => array:1 [ 0 => "johannes.ring@lrz.tum.de" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Belloni" ] 2 => array:2 [ "nombre" => "H." "apellidos" => "Behrendt" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Dermatology and Allergology Biederstein. ZAUM – Zentrum Allergie und Umwelt (Center for Allergy and Environment). Technische Universität München" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Department of Dermatology and Allergology Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29. 80802 Munich. Germany." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mirando hacia el futuro en dermatología: piel y alergia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec82454" "palabras" => array:11 [ 0 => "allergy" 1 => "allergic skin disease" 2 => "urticaria" 3 => "angioedema" 4 => "anaphylaxis" 5 => "purpura" 6 => "vasculitis" 7 => "contact dermatitis" 8 => "atopic eczema" 9 => "drug eruptions" 10 => "granulomatous reactions" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82453" "palabras" => array:11 [ 0 => "alergia" 1 => "enfermedad alérgica cutánea" 2 => "urticaria" 3 => "angioedema" 4 => "anafilaxia" 5 => "púrpura" 6 => "vasculitis" 7 => "dermatitis de contacto" 8 => "eccema atópico" 9 => "toxicodermias" 10 => "reacciones granulomatosas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The prevalence of allergic diseases has increased tremendously over the last decades. Clinically they comprise a spectrum of many different conditions caused by specific immunological hypersensitivity in response to a mostly apathogenic substance. Environmental factors such as lack of immune-stimulating contacts (infection, vaccination) and exposure to allergy-enhancing anthropogenic pollutants from tobacco smoke or traffic exhaust particles are suspected to be involved in the increase of allergies. Recently it has been shown that pollens are not only allergen carriers but also secrete highly active proinflammatory lipid mediators, pollen-associated lipid mediators (PALMs), which have proinflammatory and immuno-modulatory capacity that facilitates allergic sensitization of the skin and mucous membranes.</p><p class="elsevierStyleSimplePara elsevierViewall">The skin is one of the most important organs where allergic reactions manifest. Many different morphological and physiopathological entities can be observed in the skin that represent all kinds of pathogenetic immune reactions from immediate-type allergy, urticaria, angioedema, anaphylaxis, cytotoxic and immune complex reactions such as thrombocytopenic purpura or allergic leukocytoclastic vasculitis, exanthematous drug eruptions, granulomatous skin reactions to tattoos or fillers as well as a wide spectrum of dermatitis and eczema with allergic contact dermatitis being one of the most common occupational diseases in many countries.</p><p class="elsevierStyleSimplePara elsevierViewall">Recent progress in pathophysiology has revealed a role of epidermal barrier function as well as immunodeviation in atopic eczema giving rise to new diagnostic and therapeutic strategies.</p><p class="elsevierStyleSimplePara elsevierViewall">The interdisciplinary character of allergy implies a close cooperation between different disciplines where dermatology plays a major role in the management of allergic diseases, covering diagnostic, therapeutic and preventive aspects.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de las enfermedades alérgicas ha aumentado tremendamente en las últimas décadas. Clínicamente abarcan un espectro de diferentes entidades que están causadas por una hipersensibilidad inmunológica específica como respuesta a una sustancia, en general, no patógena. Se sospecha que el aumento de las alergias se debe a factores ambientales como la falta de contactos que estimulen el sistema inmunitario (infección, vacunas) y la exposición a contaminantes antropogénicos que intensifican las alergias como el humo del tabaco o las partículas de combustión. Recientemente se ha demostrado que los pólenes no son solo portadores de alérgenos, sino que también segregan mediadores lipídicos altamente proinflamatorios, mediadores lipídicos asociados al pólen (siglas en inglés PALM), que facilitan la sensibilización alérgica de la piel y las membrabas mucosas por su capacidad proinflamatoria e inmunomoduladora.</p><p class="elsevierStyleSimplePara elsevierViewall">La piel es uno de los órganos más importantes donde se manifiestan las reacciones alérgicas. En la piel se pueden observar diferentes entidades morfológicas y fisiopatológicas que representan todos los tipos de reacciones inmunitarias patogénicas desde alergia inmediata, urticaria, angioedema, anafilaxia, reacciones citotóxicas y mediadas por inmunocomplejos como la púrpura trombocitopénica o la vasculitis leucocitoclástica, toxicodermias exantemáticas, reacciones cutáneas granulomatosas por tatuajes o rellenos así como un amplio espectro de dermatitis y eccema, siendo la dermatitis alérgica de contacto una de las enfermedades profesionales más frecuentes en muchos países.</p><p class="elsevierStyleSimplePara elsevierViewall">Los recientes avances en la fisiopatología han revelado un rol de la función de la barrera epidérmica así como una desviación inmunitaria en el eccema atópico, lo que da lugar a nuevas estrategias diagnósticas y terapéuticas.</p><p class="elsevierStyleSimplePara elsevierViewall">El carácter interdisciplinar de la alergia implica una estrecha colaboración entre diferentes disciplinas donde la dermatología tiene un papel principal tanto en el diagnóstico, el tratamiento como en la prevención de las enfermedades alérgicas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 10 | 19 |
| 2024 October | 28 | 29 | 57 |
| 2024 September | 31 | 22 | 53 |
| 2024 August | 39 | 50 | 89 |
| 2024 July | 36 | 28 | 64 |
| 2024 June | 32 | 23 | 55 |
| 2024 May | 31 | 30 | 61 |
| 2024 April | 20 | 36 | 56 |
| 2024 March | 34 | 20 | 54 |
| 2024 February | 34 | 36 | 70 |
| 2024 January | 24 | 26 | 50 |
| 2023 December | 28 | 10 | 38 |
| 2023 November | 25 | 18 | 43 |
| 2023 October | 21 | 24 | 45 |
| 2023 September | 22 | 21 | 43 |
| 2023 August | 15 | 14 | 29 |
| 2023 July | 21 | 32 | 53 |
| 2023 June | 15 | 29 | 44 |
| 2023 May | 12 | 8 | 20 |
| 2023 April | 14 | 20 | 34 |
| 2023 March | 21 | 15 | 36 |
| 2023 February | 15 | 18 | 33 |
| 2023 January | 21 | 30 | 51 |
| 2022 December | 18 | 26 | 44 |
| 2022 November | 24 | 38 | 62 |
| 2022 October | 13 | 15 | 28 |
| 2022 September | 17 | 37 | 54 |
| 2022 August | 23 | 25 | 48 |
| 2022 July | 18 | 33 | 51 |
| 2022 June | 18 | 18 | 36 |
| 2022 May | 14 | 37 | 51 |
| 2022 April | 25 | 46 | 71 |
| 2022 March | 24 | 50 | 74 |
| 2022 February | 20 | 37 | 57 |
| 2022 January | 20 | 40 | 60 |
| 2021 December | 16 | 37 | 53 |
| 2021 November | 29 | 53 | 82 |
| 2021 October | 19 | 45 | 64 |
| 2021 September | 16 | 49 | 65 |
| 2021 August | 26 | 38 | 64 |
| 2021 July | 11 | 30 | 41 |
| 2021 June | 16 | 38 | 54 |
| 2021 May | 19 | 27 | 46 |
| 2021 April | 25 | 74 | 99 |
| 2021 March | 27 | 25 | 52 |
| 2021 February | 12 | 32 | 44 |
| 2021 January | 19 | 15 | 34 |
| 2020 December | 16 | 19 | 35 |
| 2020 November | 10 | 18 | 28 |
| 2020 October | 11 | 2 | 13 |
| 2020 September | 9 | 7 | 16 |
| 2020 August | 12 | 31 | 43 |
| 2020 July | 14 | 13 | 27 |
| 2020 June | 27 | 19 | 46 |
| 2020 May | 24 | 24 | 48 |
| 2020 April | 12 | 16 | 28 |
| 2020 March | 25 | 15 | 40 |
| 2020 February | 2 | 0 | 2 |
| 2019 May | 1 | 0 | 1 |
| 2018 March | 2 | 0 | 2 |
| 2018 February | 8 | 3 | 11 |
| 2018 January | 7 | 4 | 11 |
| 2017 December | 14 | 10 | 24 |
| 2017 November | 19 | 4 | 23 |
| 2017 October | 16 | 6 | 22 |
| 2017 September | 14 | 6 | 20 |
| 2017 August | 13 | 9 | 22 |
| 2017 July | 6 | 0 | 6 |
| 2017 June | 19 | 8 | 27 |
| 2017 May | 14 | 6 | 20 |
| 2017 April | 14 | 7 | 21 |
| 2017 March | 14 | 6 | 20 |
| 2017 February | 7 | 6 | 13 |
| 2017 January | 11 | 2 | 13 |
| 2016 December | 27 | 1 | 28 |
| 2016 November | 36 | 17 | 53 |
| 2016 October | 39 | 13 | 52 |
| 2016 September | 28 | 4 | 32 |
| 2016 August | 14 | 5 | 19 |
| 2016 July | 6 | 8 | 14 |
| 2016 June | 0 | 11 | 11 |
| 2016 May | 0 | 15 | 15 |
| 2016 April | 1 | 1 | 2 |
| 2016 March | 0 | 2 | 2 |
| 2016 February | 0 | 7 | 7 |
| 2016 January | 0 | 29 | 29 |
| 2015 December | 1 | 9 | 10 |
| 2015 November | 7 | 11 | 18 |
| 2015 October | 4 | 0 | 4 |
| 2015 September | 2 | 5 | 7 |
| 2015 August | 3 | 5 | 8 |
| 2015 July | 24 | 1 | 25 |
| 2015 June | 23 | 13 | 36 |
| 2015 May | 24 | 16 | 40 |
| 2015 April | 39 | 9 | 48 |
| 2015 March | 35 | 2 | 37 |
| 2015 February | 19 | 1 | 20 |
| 2015 January | 17 | 0 | 17 |
| 2014 December | 27 | 0 | 27 |
| 2014 November | 20 | 0 | 20 |
| 2014 October | 20 | 0 | 20 |
| 2014 September | 25 | 0 | 25 |
| 2014 August | 24 | 0 | 24 |
| 2014 July | 33 | 0 | 33 |
| 2014 June | 28 | 0 | 28 |
| 2014 May | 34 | 0 | 34 |
| 2014 April | 27 | 0 | 27 |
| 2014 March | 28 | 16 | 44 |
| 2014 February | 9 | 18 | 27 |
| 2014 January | 27 | 19 | 46 |
| 2013 December | 39 | 21 | 60 |
| 2013 November | 20 | 17 | 37 |
| 2013 October | 21 | 19 | 40 |
| 2013 September | 20 | 23 | 43 |
| 2013 August | 20 | 24 | 44 |
| 2013 July | 31 | 27 | 58 |
| 2013 June | 21 | 16 | 37 |
| 2013 May | 22 | 23 | 45 |
| 2013 April | 21 | 20 | 41 |
| 2013 March | 29 | 21 | 50 |
| 2013 February | 19 | 16 | 35 |
| 2013 January | 9 | 4 | 13 |
| 2012 December | 11 | 8 | 19 |
| 2012 November | 13 | 11 | 24 |
| 2012 October | 7 | 5 | 12 |
| 2012 September | 4 | 6 | 10 |
| 2010 November | 9 | 0 | 9 |
| 2010 October | 12 | 0 | 12 |
| 2010 September | 17 | 0 | 17 |
| 2010 August | 5 | 0 | 5 |
| 2010 July | 5 | 0 | 5 |
| 2010 June | 30 | 0 | 30 |
| 2010 May | 20 | 0 | 20 |
| 2010 April | 36 | 0 | 36 |
| 2010 March | 17 | 0 | 17 |
| 2010 January | 14 | 0 | 14 |
Show all
