Statistics

 array:24 [
  "pii" => "S0001731009733757"
  "issn" => "00017310"
  "doi" => "10.1016/S0001-7310(09)73375-7"
  "estado" => "S300"
  "fechaPublicacion" => "2009-12-01"
  "aid" => "73375"
  "copyright" => "Academia Española de Dermatología y Venereología"
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2009;100 Supl 2:28-31"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1727
    "formatos" => array:3 [
      "EPUB" => 33
      "HTML" => 1077
      "PDF" => 617
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731009733769"
    "issn" => "00017310"
    "doi" => "10.1016/S0001-7310(09)73376-9"
    "estado" => "S300"
    "fechaPublicacion" => "2009-12-01"
    "aid" => "73376"
    "copyright" => "Academia Española de Dermatología y Venereología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100 Supl 2:32-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1915
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 1302
        "PDF" => 576
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Looking Ahead in Dermatology: Skin and Allergy"
      "tienePdf" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "32"
          "paginaFinal" => "39"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Mirando hacia el futuro en dermatología: piel y alergia"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:2 [
        "en" => true
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Ring, B. Belloni, H. Behrendt"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "J."
              "apellidos" => "Ring"
            ]
            1 => array:2 [
              "nombre" => "B."
              "apellidos" => "Belloni"
            ]
            2 => array:2 [
              "nombre" => "H."
              "apellidos" => "Behrendt"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731009733769?idApp=UINPBA000044"
    "url" => "/00017310/00000100000000S2/v1_201304241226/S0001731009733769/v1_201304241226/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731009733745"
    "issn" => "00017310"
    "doi" => "10.1016/S0001-7310(09)73374-5"
    "estado" => "S300"
    "fechaPublicacion" => "2009-12-01"
    "aid" => "73374"
    "copyright" => "Academia Española de Dermatología y Venereología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100 Supl 2:22-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2001
      "formatos" => array:3 [
        "EPUB" => 35
        "HTML" => 1352
        "PDF" => 614
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Managing Comorbidities in Psoriasis"
      "tienePdf" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "22"
          "paginaFinal" => "27"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamiento de enfermedades concomitantes en la psoriasis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:2 [
        "en" => true
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "W.H. Boehncke, S. Boehncke"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "W.H."
              "apellidos" => "Boehncke"
            ]
            1 => array:2 [
              "nombre" => "S."
              "apellidos" => "Boehncke"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731009733745?idApp=UINPBA000044"
    "url" => "/00017310/00000100000000S2/v1_201304241226/S0001731009733745/v1_201304241226/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Future Therapeutic Directions for the Treatment of Psoriasis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "28"
        "paginaFinal" => "31"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R.B. Warren, C.E.M. Griffiths"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "R.B."
            "apellidos" => "Warren"
            "email" => array:1 [
              0 => "Richard.warren@manchester.ac.uk"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "C&#46;E&#46;M&#46;"
            "apellidos" => "Griffiths"
            "email" => array:1 [
              0 => "Christopher&#46;griffiths&#64;manchester&#46;ac&#46;uk"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Dermatological Sciences&#46; Salford Royal Hospital&#46; University of Manchester&#46; Manchester Academic Health Science Centre&#44; Manchester&#44; M6 8HD&#44; UK"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Futuro en el tratamiento de la psoriasis"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec82450"
          "palabras" => array:6 [
            0 => "pharmacogenetics"
            1 => "psoriasis"
            2 => "phenotypes"
            3 => "biologics"
            4 => "personalised medicine"
            5 => "biologic therapy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec82449"
          "palabras" => array:6 [
            0 => "farmacogen&#233;tica"
            1 => "psoriasis"
            2 => "fenotipo"
            3 => "biol&#243;gicos"
            4 => "medicina personalizada"
            5 => "terapia biol&#243;gica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The future management of psoriasis will depend on a number of distinct but ultimately inter-related strands of evidence&#44; these are&#58; &#40;i&#41; the interplay of genes and environment and the characterisation of psoriasis phenotypes&#59; &#40;ii&#41; the role of pharmacogenetics in personalised healthcare&#59; &#40;iii&#41; the translation of basic scientific discovery of relevant immune and angiogenic pathways into targeted biologic and small molecule therapies&#59; and &#40;iv&#41; the recognition that the management of any chronic disease is enhanced by an understanding of psychosocial issues&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">A reductionist approach to development of new therapies will be paramount but serendipity and the prepared mind will contribute&#44; as they have always done&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El manejo de la psoriasis en el futuro depender&#225; de una serie de parcelas diferentes pero esencialmente interrelacionadas de evidencia como&#58; &#40;i&#41; la interacci&#243;n de los genes y el ambiente con la caracterizaci&#243;n fenot&#237;pica de la psoriasis&#59; &#40;ii&#41; el papel de la farmacogen&#233;tica en el cuidado personalizado de la salud&#59; &#40;iii&#41; la traslaci&#243;n del descubrimiento cient&#237;fico b&#225;sico de los procesos inmunitarios y angiog&#233;nicos a terapias biol&#243;gicas y mol&#233;culas de peque&#241;o tama&#241;o&#59; y &#40;iv&#41; el reconocimiento de que el manejo de cualquier enfermedad cr&#243;nica mejora con la comprensi&#243;n de los aspectos psicosociales&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Aunque un acercamiento reduccionista al desarrollo de nuevas terapias ser&#225; primordial&#44; tambi&#233;n lo es&#44; como siempre lo ha sido&#44; la casualidad y una mente abierta&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "On Cutaneous Diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Willan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1808"
                        "editorial" => "J&#46; Johnson"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis of early and late onset&#58; characterization of two types of psoriasis vulgaris"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Henseler"
                            1 => "E&#46; Christophers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1985"
                        "volumen" => "13"
                        "paginaInicial" => "450"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4056119"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002937800275303"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A classification of psoriasis vulgaris according to phenotype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;E&#46; Griffiths"
                            1 => "E&#46; Christophers"
                            2 => "J&#46;N&#46; Barker"
                            3 => "R&#46;J&#46; Chalmers"
                            4 => "S&#46; Chimenti"
                            5 => "G&#46;G&#46; Krueger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07675.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "156"
                        "paginaInicial" => "258"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223864"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;H&#46; Allen"
                            1 => "H&#46; Ameen"
                            2 => "C&#46; Veal"
                            3 => "J&#46; Evans"
                            4 => "V&#46;S&#46; Ramrakha-Jones"
                            5 => "A&#46;M&#46; Marsland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2004.23511.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "124"
                        "paginaInicial" => "103"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15654960"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct clinical differences between HLA-Cw&#42;0602 positive and negative psoriasis patients&#8211;an analysis of 1019 HLA-C- and HLA-B-typed patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Gudjonsson"
                            1 => "A&#46; Karason"
                            2 => "E&#46;H&#46; Runarsdottir"
                            3 => "A&#46;A&#46; Antonsdottir"
                            4 => "V&#46;B&#46; Hauksson"
                            5 => "H&#46;H&#46; J&#243;nsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46;Inves Dermatol"
                        "fecha" => "2006"
                        "volumen" => "126"
                        "paginaInicial" => "740"
                        "paginaFinal" => "745"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathogenesis and clinical features of psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;E&#46;M&#46; Griffiths"
                            1 => "J&#46;N&#46;W&#46;N&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)61128-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "370"
                        "paginaInicial" => "263"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17658397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Asumalahti"
                            1 => "M&#46; Ameen"
                            2 => "S&#46; Suomela"
                            3 => "E&#46; Hagforsen"
                            4 => "G&#46; Micha&#235;lsson"
                            5 => "J&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.2003.12094.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2003"
                        "volumen" => "120"
                        "paginaInicial" => "627"
                        "paginaFinal" => "632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12648227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenetics and adverse drug reactions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "U&#46;A&#46; Meyer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(00)03167-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "356"
                        "paginaInicial" => "1667"
                        "paginaFinal" => "1671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11089838"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Moderne problem der humangenetik"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Vogel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ergeb Inn Med Kinderheilkd"
                        "fecha" => "1959"
                        "volumen" => "12"
                        "paginaInicial" => "52"
                        "paginaFinal" => "125"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema&#58; a double-blind&#44; randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Meggitt"
                            1 => "J&#46;C&#46; Gray"
                            2 => "N&#46;J&#46; Reynolds"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(06)68340-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2006"
                        "volumen" => "367"
                        "paginaInicial" => "839"
                        "paginaFinal" => "846"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16530578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Hider"
                            1 => "W&#46; Thomson"
                            2 => "L&#46;F&#46; Mack"
                            3 => "D&#46;J&#46; Armstrong"
                            4 => "M&#46; Shadforth"
                            5 => "I&#46;N&#46; Bruce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2008"
                        "volumen" => "47"
                        "paginaInicial" => "1156"
                        "paginaFinal" => "1159"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939410000255"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The C677T mutation in the methylene tetrahydrofolate reductase gene&#58; a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;E&#46; van Ede"
                            1 => "R&#46;F&#46; Laan"
                            2 => "H&#46;J&#46; Blom"
                            3 => "T&#46;W&#46; Huizinga"
                            4 => "C&#46;J&#46; Haagsma"
                            5 => "B&#46;A&#46; Giesendorf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "2525"
                        "paginaFinal" => "2530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11710708"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphisms in folate&#44; pyrimidine&#44; and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Campalani"
                            1 => "M&#46; Arenas"
                            2 => "A&#46;M&#46; Marinaki"
                            3 => "C&#46;M&#46; Lewis"
                            4 => "J&#46;N&#46; Barker"
                            5 => "C&#46;H&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.jid.5700808"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2007"
                        "volumen" => "127"
                        "paginaInicial" => "1860"
                        "paginaFinal" => "1867"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17410198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic Variation in Efflux Transporters Influences Outcome to Methotrexate Therapy in Patients with Psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Warren"
                            1 => "R&#46;L&#46; Smith"
                            2 => "E&#46; Campalani"
                            3 => "S&#46; Eyre"
                            4 => "C&#46;H&#46; Smith"
                            5 => "J&#46;N&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2008.16"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2008"
                        "volumen" => "128"
                        "paginaInicial" => "1925"
                        "paginaFinal" => "1929"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18256692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Maxwell JR&#44; Potter C&#44; Hyrich KL&#59; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate&#44; Barton A&#44; Worthington J&#44; Isaacs JD&#44; et al&#46; Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis&#46; Hum Mol Genet&#46; 2008&#59;17&#58;3532-8&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Warren"
                            1 => "R&#46;L&#46; Smith"
                            2 => "E&#46; Campalani"
                            3 => "S&#46; Eyre"
                            4 => "C&#46;H&#46; Smith"
                            5 => "J&#46;N&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2008.08898.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "160"
                        "paginaInicial" => "438"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19016697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efalizumab for patients with moderate to severe plaque psoriasis&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;B&#46; Gordon"
                            1 => "K&#46;A&#46; Papp"
                            2 => "T&#46;K&#46; Hamilton"
                            3 => "P&#46;A&#46; Walicke"
                            4 => "W&#46; Dummer"
                            5 => "N&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.290.23.3073"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2003"
                        "volumen" => "290"
                        "paginaInicial" => "3073"
                        "paginaFinal" => "3080"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14679270"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic association studies to detect adverse drug reactions&#58; abacavir hypersensitivity as an example"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;R&#46; Hughes"
                            1 => "C&#46;H&#46; Brothers"
                            2 => "M&#46; Mosteller"
                            3 => "W&#46;R&#46; Spreen"
                            4 => "D&#46;K&#46; Burns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/14622416.10.2.225"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacogenomics"
                        "fecha" => "2009"
                        "volumen" => "10"
                        "paginaInicial" => "225"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19207023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful translation of pharmacogenetics into the clinic&#58; the abacavir example"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Phillips"
                            1 => "S&#46; Mallal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Diagn Ther"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "paginaInicial" => "1"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19351209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growing pains for metabolomics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46; Daviss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "The Scientist"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "25"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advance in psoriasis treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;V&#46; Sch&#246;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)67542-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2005"
                        "volumen" => "366"
                        "paginaInicial" => "1333"
                        "paginaFinal" => "1335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16226595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis and metabolic disease&#58; epidemiology and pathophysiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;S&#46; Azfar"
                            1 => "J&#46;M&#46; Gelfand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/BOR.0b013e3283031c99"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "20"
                        "paginaInicial" => "416"
                        "paginaFinal" => "422"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18525354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Balancing the benefits and risks of drug treatment a stated preference&#44; discrete choice experiment with patients with psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;M&#46; Seston"
                            1 => "D&#46;M&#46; Ashcroft"
                            2 => "C&#46;E&#46;M&#46; Griffiths"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.143.9.1175"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2007"
                        "volumen" => "143"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17875880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The PKC inhibitor AEB071 may be a therapeutic option for psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Skvara"
                            1 => "M&#46; Dawid"
                            2 => "E&#46; Kleyn"
                            3 => "B&#46; Wolff"
                            4 => "J&#46;G&#46; Meingassner"
                            5 => "H&#46; Knight"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI35636"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2008"
                        "volumen" => "118"
                        "paginaInicial" => "3151"
                        "paginaFinal" => "3159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18688284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overexpression of vascular permeability factor&#47; vascular endothelial growth factor and its receptor in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Detmar"
                            1 => "L&#46;F&#46; Brown"
                            2 => "K&#46;P&#46; Claffey"
                            3 => "K&#46;T&#46; Yeo"
                            4 => "O&#46; Kocher"
                            5 => "R&#46;W&#46; Jackman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1994"
                        "volumen" => "180"
                        "paginaInicial" => "1141"
                        "paginaFinal" => "1146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8064230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Single nucleotide polymorphism of vascular endothelaial growth factor in psoriasis of early onset"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;S&#46; Young"
                            1 => "A&#46;M&#46; Summers"
                            2 => "M&#46; Bhushan"
                            3 => "P&#46;E&#46; Brenchley"
                            4 => "C&#46;E&#46;M&#46; Griffiths"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.0022-202X.2003.22107.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2004"
                        "volumen" => "122"
                        "paginaInicial" => "209"
                        "paginaFinal" => "211"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962110"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411001486"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complete remission of psoriasis following bevacizumab therapy for colon cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Akman"
                            1 => "E&#46; Yilmaz"
                            2 => "H&#46; Mutlu"
                            3 => "M&#46; Ozdogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2008.02991.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2009"
                        "volumen" => "34"
                        "paginaInicial" => "e202"
                        "paginaFinal" => "e204"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19077094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeting cognitive behavioural therapy to patient&#39;s implicit model of psoriasis&#58; results from a patient preference controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;G&#46; Fortune"
                            1 => "H&#46;L&#46; Ricahrds"
                            2 => "C&#46;E&#46;M&#46; Griffiths"
                            3 => "C&#46;J&#46; Main"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1348/014466504772812977"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Clin Psychol"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "65"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15005907"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642008002935"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/00000100000000S2/v1_201304241226/S0001731009733757/v1_201304241226/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/00017310/00000100000000S2/v1_201304241226/S0001731009733757/v1_201304241226/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731009733757?idApp=UINPBA000044"
  "pdfAlternativo" => array:1 [
    0 => array:3 [
      "idioma" => "es"
      "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/00017310/addon/S0001731009733757/S300/es/103v100nSupl.2a13146414pdf001_2.pdf"
      "portada" => "103v100nSupl.2a13146414pdf001_2.png"
    ]
  ]
]