Journal Information
Vol. 106. Issue 6.
Pages 510 (July - August 2015)
Vol. 106. Issue 6.
Pages 510 (July - August 2015)
Images in Dermatology
DOI: 10.1016/j.adengl.2015.05.006
Full text access
Calciphylaxis and Ecthyma Gangrenosum in Chronic Kidney Disease: Clinical Similarities
Calcifilaxis y ectima gangrenoso en insuficiencia renal crónica: semejanzas clínicas
Visits
...
G. Blasco-Morente
Corresponding author
gonzaloblascomorente@gmail.com

Corresponding author.
, C. Garrido-Colmenero, J.M. Latorre-Fuentes
Unidad de Gestión Clínica Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
Article information
Full Text
Download PDF
Statistics
Figures (1)
Full Text

Two patients on hemodialysis for chronic kidney failure developed fever. The first patient was a 53-year-old woman who was seen for a painful and indurated necrotic plaque that had developed 20 days earlier on the anterior aspect of the right thigh (Fig. 1A). The relevant findings in the laboratory tests were calcemia, 8.6mg/dL, and parathyroid hormone, 569pg/ml. On computed tomography there were areas of calcification in the subcutaneous cellular tissue beneath the lesion, and skin biopsy was compatible with calciphylaxis. Treatment was started with sodium thiosulfate 20mg/48h and meropenem 500mg/12h but the lesions did not improve and the patient died. The second patient was a man aged 56 years who was seen for an indurated, painful plaque on the lateral aspect of the thigh. The plaque had a central blister of serous fluid with a necrotic base (Fig. 1B). Histopathology revealed necrotizing panniculitis and Pseudomonas aeruginosa was cultured from the skin biopsy. The patient was diagnosed with ecthyma gangrenosum and the lesion healed after 10 days of treatment with ciprofloxacin 250mg/12h. Calciphylaxis and ecthyma gangrenosum in patients with chronic kidney failure are rare conditions due, respectively, to secondary hypoparathyroidism and immunosuppression. Both conditions are painful and are usually associated with fever. The clinical manifestations are similar in the initial stages, and recognition is therefore important to avoid a delay in starting treatment.

Figure 1.

A, Indurated erythematous plaque with a central ulcer on the anterior aspect of the right thigh. B, Indurated erythematous plaque on the lateral aspect of the right thigh; there is a central blister of serous fluid with a necrotic base.

(0.13MB).

Please cite this article as: Blasco-Morente G, Garrido-Colmenero C, Latorre-Fuentes JM. Calcifilaxis y ectima gangrenoso en insuficiencia renal crónica: semejanzas clínicas. Actas Dermosifiliogr. 2015;106:510.

Copyright © 2015. Elsevier España, S.L.U. and AEDV
Idiomas
Actas Dermo-Sifiliográficas (English Edition)

Subscribe to our newsletter

Article options
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
  • Additional material
Tools
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.