Adalimumab: la molécula y el proceso de obtención

Martínez de Lagrán, Z; Pérez-Barrio, S; Díaz-Pérez, JL

Actas Dermo-Sifiliográficas

ISSN: 0001-7310

The Official publication of the Spanish Academy of Dermatology and Venereology (AEDV). Actas Dermo-Sifiliográficas, founded in 1909, is the oldest monthly medical journals published in Spain. In the year 2006 has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern. All articles are subjected to a rigorous process of revision in pairs, and careful editing for literary and scientific style. Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews. Dermo-Sifiliográficas is an essential publication for anyone who needs to be current on all aspects of Spanish and world dermatology.

Con su JCI 2023, Actas Dermo-Sifiliográficas es Q1 y se posiciona la revista nº 15 de 94 en Dermatología

With JCI 2023, Actas Dermo-Sifiliográficas is Q1 and is ranked number 15 of 94 in Dermatology

Indexed in:

Web of Science, Emerging Sources Citation Index (WoS, Clarivate), PubMed/Medlinee, IME, Embase/Excerpta Medica, Embase, Toxline, Cab Abstracts, Cab Health, Cancerlit NIm, Serline: Biomed, Bibliomed, Pascal, Scopus , IBECS

Adalimumab es un anticuerpo monoclonal totalmente humano y dirigido contra el factor de necrosis tumoral alfa (TNF-α). El TNF-α es una citocina proinflamatoria, implicada en la Etiopatogenia de múltiples entidades, entre ellas la psoriasis. El mecanismo de obtención de adalimumab es complejo y se basa en la denominada técnica de selección mediante presentación en fagos.

Palabras clave:

psoriasis, adalimumab, fagos

Adalimumab is a fully human monoclonal antibody targeted toward tumor necrosis factor alpha (TNF-α). TNF-α is proinflammatory cytokine envolved in the patogenesis of many inflammatory diseases, as the psoriasis. The production process of adalimumab is complex and it is based in the called phague display technology.

Keywords:

psoriasis, adalimumab, phagues

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