Mycosis fungoides beginning in childhood and adolescence

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Mycosis fungoides is a form of cutaneous T cell lymphoma usually occurring in mid to late adulthood. We report 12 patients with mycosis fungoides whose eruption began before age 20 years, including one patient with histologic documentation at 5 years of age. The onset of mycosis fungoides during the first two decades may be more common than is generally recognized and should be included in the differential diagnosis of chronic dermatoses in children and adolescents.

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  • Cited by (75)

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      In our study, PL-like MF was the most common variant, followed by the classic form in juvenile MF. Of the known total incidence of MF, juvenile MF accounts for 0.5% to 5%.25,26 However, we found 37 patients (16.6%) with juvenile MF.

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      The incidence rate of mycosis fungoides is 0.05% per 100,000 persons per year before the age of 20, and only approximately 0.5-5% of all mycosis fungoides cases are diagnosed before 20 years of age.3,13,15 The true incidence, however, may be higher because MF may be underdiagnosed in younger individuals; often in many patients cutaneous lesions appeared in childhood, but the correct diagnosis was made in adulthood.16–18 Geographic and ethnic variations in the incidence rate have also been observed in children.

    • Clinical presentation, immunopathology, and treatment of juvenile-onset mycosis fungoides: A case series of 34 patients

      2014, Journal of the American Academy of Dermatology
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      Our study revealed similar data, which contrast with the adult MF population where only 5% exhibit a CD8+ phenotype.10 Five of our patients had coexisting conditions with MF as described previously including: lymphomatoid papulosis, folliculotropic MF with mucinosis, granulomatous slack skin, Hodgkin lymphoma, and pityriasis lichenoides et varioliformis acuta.4,6-8,19-27 We also noted vitamin-D insufficiency or deficiency in 85% of tested patients.

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    • Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides

      2009, Journal of the American Academy of Dermatology
      Citation Excerpt :

      There are few articles examining age or sex with relation to prevalence of MF in AAs or Hispanics. Koch et al10 reviewed patients with onset of symptoms before age 20 years and suggested that MF may be underdiagnosed in younger patients. Only 4% to 20% of patients with MF had onset of symptoms before age 20 years.

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