Original article
The clinical spectrum of COVID-19–associated cutaneous manifestations: An Italian multicenter study of 200 adult patients

https://doi.org/10.1016/j.jaad.2021.01.023Get rights and content

Background

COVID-19 is associated with a wide range of skin manifestations.

Objective

To describe the clinical characteristics of COVID-19–associated skin manifestations and explore the relationships among the 6 main cutaneous phenotypes and systemic findings.

Methods

Twenty-one Italian Dermatology Units were asked to collect the demographic, clinical, and histopathologic data of 200 patients with COVID-19–associated skin manifestations. The severity of COVID-19 was classified as asymptomatic, mild, moderate, or severe.

Results

A chilblain-like acral pattern was significantly associated with a younger age (P < .0001) and, after adjusting for age, significantly associated with less severe COVID-19 (P = .0009). However, the median duration of chilblain-like lesions was significantly longer than that of the other cutaneous manifestations taken together (P < .0001). Patients with moderate/severe COVID-19 were more represented than those with asymptomatic/mild COVID-19 among the patients with cutaneous manifestations other than chilblain-like lesions, but only the confluent erythematous/maculo-papular/morbilliform phenotype was significantly associated with more severe COVID-19 (P = .015), and this significance disappeared after adjustment for age.

Limitations

Laboratory confirmation of COVID-19 was not possible in all cases.

Conclusions

After adjustment for age, there was no clear-cut spectrum of COVID-19 severity in patients with COVID-19–related skin manifestations, although chilblain-like acral lesions were more frequent in younger patients with asymptomatic/pauci-symptomatic COVID-19.

Key words

coronavirus
COVID-19
infection
skin manifestations
SARS-CoV-2

Abbreviations used

CI
confidence interval
IQR
interquartile range
OR
odds ratio
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2

Cited by (0)

Drs Calzavara-Pinton and Berti contributed equally to this article.

Funding sources: None.

IRB approval status: Reviewed and approved by all participating sites and the IRB of the principal investigator's center (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan: protocol no. 464_2020).

Reprints not available from the authors.

View Abstract