From the academy
Guidelines of care for the management of cutaneous squamous cell carcinoma

https://doi.org/10.1016/j.jaad.2017.10.007Get rights and content

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include biopsy techniques and histopathologic assessment, tumor staging, surgical and nonsurgical management, follow-up and prevention of recurrence, and management of advanced disease. The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.

Key words

biopsy
curettage
metastasis
phototherapy
radiotherapy
squamous cell carcinoma
staging
surgery
surveillance
topical therapy

Abbreviations used

AAD
American Academy of Dermatology
AJCC
American Joint Committee on Cancer
BCC
basal cell carcinoma
BWH
Brigham and Women's Hospital
C&E
curettage and electrodesiccation
CT
computed tomography
5-FU
5-fluorouracil
MM
malignant melanoma
MMS
Mohs micrographic surgery
NCCN
National Comprehensive Cancer Network
PI
principal investigator
RCT
randomized controlled trial
cSCC
cutaneous Squamous Cell carcinoma
SLNB
sentinel lymph node biopsy
SOTR
solid organ transplant recipient

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Funding sources: None.

The management of conflict of interests for this guideline series complies with the Council of Medical Special Societies' Code of Interactions with Companies. The authors' conflict of interest/disclosure statements appear at the end of this article.

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