Review
Eruptive nevi associated with medications (ENAMs)

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Eruptive melanocytic nevi have been reported in association with severe blistering diseases, renal transplantation, malignancy, AIDS, and medications. Eruptive nevi associated with medications have been reported with increasing frequency. Of particular interest are eruptive nevi associated with medications developing in association with biologic therapies, which we anticipate will continue to become more common as use of these medications continues to increase. We searched the databases PubMed/MEDLINE, Cochrane, and Cumulative Index to Nursing and Allied Health Literature for associated medications using the terms “eruptive nevi,” “melanocytic + medications,” and “nevi + medications” for relevant articles. We report the summary of our findings, which were used in defining what constitutes an eruptive nevi associated with medication and developing a classification system by medication type.

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Discussion

Common acquired melanocytic nevi typically will gradually increase in numbers during the first decades of life reaching a peak of approximately 30 to 40 nevi during the third decade of life.33 Melanocytic nevi are most commonly found on the trunk and extremities with involvement of palms or soles seen in only approximately 3.3% to 9.4% of patients.34, 35 In the existing literature there is not a precise definition for what constitutes eruptive melanocytic nevi. For our purposes, ENAM involves

References (125)

  • J. Wonders et al.

    Spot diagnosis: eruptive melanocytic nevi during azathioprine therapy in Crohn's disease

    J Crohns Colitis

    (2012)
  • S. Piaserico et al.

    Clinical and dermatoscopic fading of post-transplant eruptive melanocytic nevi after suspension of immunosuppressive therapy

    J Am Acad Dermatol

    (2006)
  • L. Hueso et al.

    Nevos plantares múltiples posquimioterapia

    Actas Dermosifiliogr

    (2006)
  • J.M. Martín Hernández et al.

    Nevos acrales eruptivos tras quimioterapia en niños afectados de leucemia linfoblástica aguda

    An Pediatr (Barc)

    (2006)
  • J.L. Michel

    Nævus éruptifs sous octréotide

    Ann Dermatol Venereol

    (2011)
  • M. Bennani-Lahlou et al.

    Eruptive nevi associated with sorafenib treatment

    Ann Dermatol Venereol

    (2008)
  • L. Hueso-Gabriel et al.

    Nevos displásicos eruptivos tras el consumo de melanotan

    Actas Dermo- Sifiliográficas

    (2012)
  • G. Koseoglu et al.

    Dermoscopic changes in melanocytic nevi in patients receiving immunosuppressive and biologic treatments: results of a prospective case-control study

    J Am Acad Dermatol

    (2015)
  • C.H. Smith et al.

    Excess melanocytic nevi in children with renal allografts

    J Am Acad Dermatol

    (1993)
  • L. Boussemart et al.

    Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients

    Ann Oncol

    (2013)
  • E.Y. Chu et al.

    Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study

    J Am Acad Dermatol

    (2012)
  • J. Hutchinson

    Outbreak of a large crop of moles. Remarks as to possible connection with melanosis

    J Cutan Med Dis Skin

    (1868)
  • A.W. Kopf et al.

    Eruptive nevocytic nevi after severe bullous disease

    Arch Dermatol

    (1977)
  • S. Lebeau et al.

    Acquired melanocytic nevus in childhood vulval pemphigoid

    Dermatology

    (2006)
  • J.D. Kirby et al.

    Eruptive melanocytic nevi following severe bullous disease

    Br J Dermatol

    (1978)
  • J. Szepietowski et al.

    Excess benign melanocytic nevi in renal transplant recipients

    Dermatology

    (1997)
  • N. Erfan et al.

    Eruptive nevi following bone marrow transplantation: a reflectance confocal microscopy study

    J Eur Acad Dermatol Venereol

    (2012)
  • T. Bogenrieder et al.

    Eruptive multiple lentigo-maligna-like lesions in a patient undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing colorectal carcinoma: a lesson for the pathogenesis of malignant melanoma?

    Dermatology

    (2002)
  • M. Duvic et al.

    Eruptive dysplastic nevi associated with human immunodeficiency virus infection

    Arch Dermatol

    (1989)
  • I. Betloch et al.

    Eruptive melanocytic nevi in human immunodeficiency virus infection

    Int J Dermatol

    (1991)
  • I. Koelemij et al.

    Eruptive melanocytic nevi as a sign of primary adrenocortical insufficiency

    Clin Exp Dermatol

    (2013)
  • H.H. Ibsen et al.

    Eruptive nevi in Addison's disease

    Arch Dermatol

    (1990)
  • A.A. Navarini et al.

    Trauma as triggering factor for development of melanocytic nevi

    Dermatology

    (2010)
  • P. Donati et al.

    Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?

    J Dermatol Case Rep

    (2014)
  • C. Surinach et al.

    Flexural agminated eruptive nevi in Langerhans cell histiocytosis

    JAMA Dermatol

    (2013)
  • A. Cruz et al.

    Acral PUVA-induced pigmented macules

    Bol Asoc Med P R

    (1990)
  • H.W. Bong et al.

    Disseminated eruptive nevocellular nevi

    J Dermatol

    (1995)
  • R.A. Eady et al.

    Eruptive nevi: report of two cases, with enzyme histochemical, light and electron microscopical findings

    Br J Dermatol

    (1977)
  • R.J. Coskey

    Eruptive nevi

    Arch Dermatol

    (1975)
  • M.Y. Walsh

    Eruptive disseminated blue nevi of the scalp

    J Dermatol

    (1999)
  • M.H. Krause et al.

    Coincidence of multiple, disseminated, tardive-eruptive blue nevi with cutis marmorata teleangiectatica congenita

    Dermatology

    (2000)
  • N. Onsun et al.

    Eruptive widespread Spitz nevi: can pregnancy be a stimulating factor?

    J Am Acad Dermatol

    (1999)
  • J. Capetanakis

    Juvenile melanoma disseminatum

    Br J Dermatol

    (1975)
  • R.M. MacKie et al.

    The number and distribution of benign pigmented moles (melanocytic nevi) in a healthy British population

    Br J Dermatol

    (1985)
  • A. Kukita et al.

    Clinical features and distribution of malignant melanoma and pigmented nevi on the soles of the feet in Japan

    J Invest Dermatol

    (1989)
  • S.I. Cullen

    Incidence of nevi. Report of survey of the palms, soles, and genitalia of 10,000 young men

    Arch Dermatol

    (1962)
  • A. Belloni Fortina et al.

    Dermoscopic features of eruptive melanocytic nevi in an adult patient receiving immunosuppressive therapy for Crohn's disease

    Melanoma Res

    (2005)
  • S.A. Braun et al.

    Eruptive melanozytäre nävi unter behandlung einer myasthenia gravis mit azathioprin

    Hautarzt

    (2012)
  • H.J. Bovenschen et al.

    Induction of eruptive benign melanocytic nevi by immune suppressive agents, including biologicals

    Br J Dermatol

    (2006)
  • J.M. McGregor et al.

    The development of excess numbers of melanocytic nevi in an immunosuppressed identical twin

    Clin Exp Dermatol

    (1991)
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    Funding sources: None.

    Conflicts of interest: None declared.

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