Original articleThe role of skin trauma in the distribution of morphea lesions: A cross-sectional survey of the Morphea in Adults and Children cohort IV
Section snippets
Patients
The institutional review board–approved MAC cohort contained 329 adults (≥18 years old at enrollment) and children (≤17 years old at enrollment) as of March 2012. Patients were prospectively recruited from within the University of Texas Southwestern Medical Center system and from private practitioners providing patients of varied disease severity, subtypes, and socioeconomic backgrounds. Criteria for inclusion in this study included: eligibility for enrollment in the MAC cohort, age 4 years or
Results
Of the 329 patients in the MAC cohort, a total of 52 (16%) met the inclusion criteria: 21 (6%) isotopic and 31 (9%) isomorphic. Patients (n = 277) were excluded from the study because of the following: age younger than 4 years (n = 9), insufficient data on variables of interest (n = 29), indeterminate subtype (n = 8), and lack of inciting event or isomorphic distribution of lesions (n = 231). The demographics of the patients included in the study are shown in Table I. The mean age of onset for
Discussion
The objective of this cross-sectional study was to determine the frequency of skin trauma-associated lesions in the MAC cohort and the associated demographic and clinical features in these patients. We found that of 329 patients, 52 (16%) had evidence for skin trauma or friction in the clinical distribution of skin lesions at the onset of disease. This was present most frequently in adults with the subtype of generalized morphea (Table II) implicating the possibility of an isotopic/isomorphic
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Research for this manuscript was supported in part by National Institutes of Health (NIH) Grant No. K23AR056303-4. This work was conducted with support from UT-STAR, NIH/National Center for Research Resources (NCRR)/National Center for Advancing Translational Sciences Grant No. UL1RR024982. The content is solely the responsibility of the authors and does not necessarily represent the official views of UT-STAR, University of Texas Southwestern Medical Center at Dallas and its affiliated academic and health care centers, the NCRR, or the NIH.
Conflicts of interest: None declared.
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