Original articleAccuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma
Section snippets
Methods
This was a retrospective study conducted at the Skin Cancer Unit of the Arcispedale Santa Maria Nuova IRCCS in Reggio Emilia, Italy. The ethics committee approval was waived, as the study affected neither the routine diagnostic, nor therapeutic management. Patients recorded in our database were screened for eligibility for inclusion in the study. Inclusion criteria were a definite histopathologic diagnosis of BCC, the availability of clinical and dermoscopic images of the tumor before
General data
In all, 313 patients (mean age 67.1 ± 15.3 years) with a definite histopathologic diagnosis of BCC were included in the study. Our sample included 172 men (mean age 69.7 ± 13.6 years) and 141 women (mean age 63.9 ± 16.6 years). The histopathologic categorization of the included BCCs after the re-evaluation of histopathologic slides was superficial in 77, nodular in 154, micronodular in 19, morpheaform in 8, mixed in 15, infiltrating in 32, and fibroepithelioma of Pinkus in 8 patients.
Discussion
In this study we assessed the accuracy of dermoscopic criteria for differentiating sBCC from other subtypes. Our results suggest that dermoscopy, in addition to its documented value for differentiating BCC from other diseases, is also valid for predicting its superficial nature. In particular, maple leaf–like areas and short fine superficial telangiectasias in the absence of arborizing vessels, blue-gray ovoid nests, and ulceration are predictive of sBCC with a sensitivity of 81.9% and a
References (25)
- et al.
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies
J Am Acad Dermatol
(2004) - et al.
Risk factors for histological types and anatomic sites of cutaneous basal-cell carcinoma: an Italian case-control study
J Invest Dermatol
(2007) - et al.
Differences in age, site distribution, and sex between nodular and superficial basal cell carcinoma indicate different types of tumors
J Invest Dermatol
(1998) - et al.
Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis
J Am Acad Dermatol
(2010) - et al.
Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque-features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis
J Am Acad Dermatol
(2008) - et al.
Dermoscopic–pathologic correlation: an atlas of 15 cases
Clin Dermatol
(2002) - et al.
New concepts for basal cell carcinoma: demographic, clinical, histological risk factors, and biomarkers; a systematic review of evidence regarding risk for tumor development, susceptibility for second primary and recurrence
J Surg Res
(2010) - et al.
Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial
Arch Dermatol
(2004) - et al.
Guidelines for the management of basal cell carcinoma
Br J Dermatol
(2008) Guidelines: the management of basal cell carcinoma
Eur J Dermatol
(2006)
Interventions for basal cell carcinoma of the skin: systematic review
BMJ
Basal-cell carcinoma
N Engl J Med
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2021, Journal of the American Academy of DermatologyCitation Excerpt :In concordance with previous studies evaluating biopsied/treated lesions, dermoscopy was not very helpful in evaluating the presence or absence of residual BCC.19 The only dermoscopic feature with potential relevance was the presence of arborizing vessels, typically seen in nodular BCC5,30; however, only 6 of our patients had disease of the nodular subtype. In addition, other BCC-specific dermoscopic features, such as short, fine telangiectasias and shiny white blotches and strands, lose validity in biopsied lesions because they can also be seen in scars.19
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Supported in part by the Italian Ministry of Health (RF-2010-2316524).
Conflicts of interest: None declared.