Original articleAndrogenetic alopecia as an early marker of benign prostatic hyperplasia
Section snippets
Study subjects and design
This case-control study included 87 Caucasian participants aged 35 to 65 years: 45 with AGA consecutively examined in the outpatient clinic of San Cecilio University Hospital, Granada, Spain, and 42 without AGA. Control subjects were recruited among workers at the hospital (guards, security guards, health care workers). Study inclusion criteria for the patient group were: early-onset (age <35 years) type III, IV, or V AGA on the Ebling scale; age between 35 and 65 years; and written informed
Results
All 87 participants completed the study: 45 in the early-onset AGA group and 42 in the control group. The groups did not significantly differ in age (AGA, 52.7 years vs control, 49.8 years, P = .128) or body mass index (27.71 vs 27.08 kg/m2, P = .062). The mean age at AGA onset was 27.6 years; 36.5% of the AGA group was Ebling type III, 31.1% type IV, and 33.3% type V. The AGA group more frequently reported a family history of alopecia (88% vs 12%, P < .0001; OR 59.2, 95% CI 15.85-221.11) and
Discussion
In this study, patients with early-onset AGA were found to have a larger prostate as measured by transrectal ultrasound, lower urinary flow value, and higher IPSS in comparison with individuals without AGA. AGA proved to be an independent risk factor for a prostate volume greater than 30 mL, urinary flow less than 15 mL/s, and BPH. None of the patients or control subjects reported a history of obstructive urinary symptoms or any consultations for this problem. No differences were detected
References (49)
- et al.
Male androgenetic alopecia and cardiovascular risk factors: a case-control study
Actas Dermosifiliogr
(2010) - et al.
Association of benign prostatic hyperplasia with male pattern baldness
Urology
(1998) - et al.
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride
J Am Acad Dermatol
(2006) - et al.
Sex hormone-binding globulin and risk of hyperglycemia in patients with androgenetic alopecia
J Am Acad Dermatol
(2011) Inflammation and benign prostatic hyperplasia
Urol Clin North Am
(2008)- et al.
Molecular and cellular pathogenesis of benign prostatic hyperplasia
J Urol
(2004) - et al.
The preventive effect of vitamin D3 on radiation-induced hair toxicity in a rat model
Life Sci
(2006) - et al.
Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study
J Am Acad Dermatol
(2010) - et al.
Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: a retrospective analysis
Eur Urol
(2003) - et al.
Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among black men
Urology
(2002)
Patients with a large prostate show a higher prevalence of androgenetic alopecia
J Urol
Hypertension and aldosterone levels in women with early-onset androgenetic alopecia
Br J Dermatol
Elevated aldosterone levels in patients with androgenetic alopecia
Br J Dermatol
Dihydrotestosterone metabolism in prostate hypertrophy: the formation of content of dihydrotestosterone in the hypertrophic prostate of man
J Clin Invest
Tissue content of dihydrotestosterone in human prostatic hyperplasia is not supranormal
J Clin Invest
The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness
J Clin Endocrinol Metab
The metabolism of testosterone by human scalp skin
J Endocrinol
A critical evaluation of simple methods for the estimation of free testosterone in serum
J Clin Endocrinol Metab
Patients with a large prostate show a higher prevalence of androgenetic alopecia
Arch Dermatol Res
Correlation of prostate volume with international prostate symptom score and quality of life in men with benign prostatic hyperplasia
Nepal Med Coll J
Baldness, benign prostate hyperplasia, prostate cancer and androgen levels
Aging Male
Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors
Br J Dermatol
Physical and demographic features of men before developing cancer of the prostate
J Natl Cancer Inst
Early onset baldness and prostate cancer risk
Cancer Epidemiol Biomarkers Prev
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Conflicts of interest: None declared.