ReportOutcomes of melanoma in recipients of solid organ transplant
Section snippets
Methods
The study was approved by the institutional review board at Mayo Clinic. A search of our surgical and medical indices databases of Mayo Clinic, Rochester, Minn, identified patients who had a diagnosis of MM and a solid organ transplantation between 1978 and 2007. Known cases from Mayo Clinic, Scottsdale, Ariz, and Mayo Clinic, Jacksonville, Fla, were also identified. A retrospective chart review was performed, and variables that were abstracted included date of birth, sex, race, Fitzpatrick
Results
In all, 48 MMs were identified in 43 patients. Thirteen MMs occurred in 12 patients before transplantation, and 34 MMs were found in 31 patients after transplantation. Of these 31 patients, one patient also had an MM before transplantation. Among the 43 patients, one patient was identified whose MM resulted from donor transmission.
Discussion
This study presents the most complete data of staging and outcomes currently reported for a case series of MM in transplant recipients. Although it does not statistically confirm or refute a worse prognosis of MM in solid organ transplant recipients, its trends differ from those of previous case reports and case series published in the medical literature, which had raised concern for a worse prognosis.
Specifically, in the group with MM before transplantation, we identified no recurrences,
References (39)
- et al.
Changing patterns of skin melanoma mortality in West Germany from 1968 through 1999
Ann Epidemiol
(2003) - et al.
Trends in melanoma mortality in Australia: 1950-2002 and their implications for melanoma control
Aust N Z J Public Health
(2005) - et al.
Malignant melanoma in renal-transplant recipients
Lancet
(1981) - et al.
Effect of cyclosporin A on DNA repair and cancer incidence in kidney transplant recipients
J Lab Clin Med
(2001) - et al.
Genetic epidemiology of familial melanoma
Dermatol Clin
(1995) - et al.
Welsh Transplantation Research Group. Transmission of donor melanoma to multiple organ transplant recipients
Am J Transplant
(2004) - et al.
Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
J Clin Oncol
(2001) - et al.
Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
Cancer
(1996) - et al.
Complete regression of primary cutaneous malignant melanoma
Arch Surg
(1997) - et al.
Spontaneous regression of human melanoma/nonmelanoma skin cancer: association with infiltrating CD4+ T cells
World J Surg
(1995)
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
Proc Natl Acad Sci U S A
Immunological characteristics correlating with clinical response to immunotherapy in patients with advanced metastatic melanoma
Immunol Cell Biol
Incidence of skin cancer in 5356 patients following organ transplantation
Br J Dermatol
Melanomas in renal transplant recipients
Br J Dermatol
Altered clinical course of malignant melanoma in HIV-positive patients
Arch Dermatol
Evidence for an association between cutaneous malignant melanoma and lymphoid malignancy: a population-based retrospective cohort study in Scotland
Br J Cancer
Improved graft survival after renal transplantation in the United States, 1988 to 1996
N Engl J Med
Occurrence of cancers in immunosuppressed organ transplant recipients
Clin Transpl
Cited by (49)
Melanoma in Solid Organ Transplant Recipients
2021, Actas Dermo-SifiliograficasPreexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: A consensus expert opinion statement
2021, American Journal of TransplantationCancer recurrence after solid organ transplantation: A systematic review and meta-analysis
2017, Transplantation ReviewsCitation Excerpt :Study characteristics, cohort design, exposure, and outcomes are described in Table 1. Among the 57 studies [15,25–81], 33 examined SOTR with any type of PTM, while 24 studies examined SOTR with a type-specific PTM. The study cohorts include kidney (N = 19), heart (N = 11), liver (N = 7), lung (N = 3) and various organ transplants (N = 17).
Recommendations for Solid Organ Transplantation for Transplant Candidates with a Pretransplant Diagnosis of Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma and Melanoma: A Consensus Opinion from the International Transplant Skin Cancer Collaborative (ITSCC)
2016, American Journal of TransplantationClinical spectrum of cutaneous manifestations in renal and renopancreatic recipients in two centers in Uruguay
2014, Transplantation ProceedingsPrognostic Factors for Melanoma
2012, Dermatologic ClinicsCitation Excerpt :Particular concern arises when considering a transplant in patients with a previous history of melanoma (pretransplant melanoma) because of the potential for immunosuppression causing recurrence or progression of the melanoma. In addition, in patients without a history of melanoma undergoing a solid organ transplant, the risk for developing melanoma related to the immunosuppressed state (posttransplant melanoma) has recently become a prominent concern.36–38 Statistically significant data have previously been limited for both scenarios.
Funding sources: None.
Conflicts of interest: None declared.