Journal of the American Academy of Dermatology
Case reportOccurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine
Section snippets
Case report
A 77-year-old woman presented at our department of dermatology with a 3-week history of erythematosquamous plaques on her face, lower aspect of her arms, and back of her hands. A diagnosis of advanced gastric cancer had been made in March 2005 and 3 cycles of chemotherapy with leucovorin, 5-FU, and etoposide had been administered. After the first cycle the patient had noticed cervical erythema, which resolved within the next 2 weeks. Cervical and facial erythematous rash again re-evolved during
Discussion
SCLE is a clinically and immunologically distinct subset of lupus erythematosus characterized by erythematous, nonscarring, papulosquamous or annular lesions in a photosensitive distribution (eg, arms, upper aspect of chest, and back).5 Among others, diuretics, antihypertensives (eg, calcium channel blockers, angiotensin-converting enzyme inhibitors, and beta blockers), acid blockers, nonsteroidal anti-inflammatory drugs, and recently terbinafine have been implicated in precipitating SCLE.5, 6
References (14)
- et al.
Capecitabine: a review
Clin Ther
(2005) Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings
Autoimmun Rev
(2005)Drug-induced lupus erythematosus
Clin Dermatol
(1998)Evolving chemotherapy for advanced gastric cancer
Oncologist
(2005)- et al.
Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation
Br J Cancer
(2004) - et al.
Inflammation of actinic keratoses during capecitabine therapy
Arch Dermatol
(2004) - et al.
Terbinafine-induced subacute cutaneous lupus erythematosus
Acta Derm Venereol
(2004)
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2017, Presse MedicaleAromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review
2016, Journal of Advanced ResearchCitation Excerpt :To date, there have been a number of reports of SCLE attributed to the use of antiestrogen therapy [3–7]. In addition, some chemotherapeutic agents have already been reported to induce SCLE, including cyclophosphamide, doxorubicin, paclitaxel, bevacizumab, fluorouracil or capecitabine with most prevalent the use of taxanes [8–12]. However, the accurate mechanism of SLE phenomena and various autoimmune disorders caused by antiestrogen therapy remains to be elucidated.
Capecitabine-induced subacute cutaneous lupus: A case report
2014, Annales de Dermatologie et de VenereologiePhotosensitive lichenoid drug eruption to capecitabine
2014, Journal of the American Academy of Dermatology
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Conflicts of interest: None declared.