ReportPityriasis lichenoides in childhood: A retrospective review of 124 patients
Section snippets
Patients
Children who were given the diagnosis of PL at our institution between 1993 and 2003 were included for review. The study was approved by our institutional review board. A total of 181 patient charts were retrospectively reviewed. Patients who had a clinical- and/or biopsy-proven diagnosis of PLEVA/PLC were included. In all, 57 patients were excluded from the study as they did not have sufficient clinical or histopathologic features to make a definitive diagnosis of PLC/PLEVA. A total of 124
Results
In all, 124 children with PL met inclusion criteria. The diagnosis was based on clinical appearance alone in 39% of the patients, with typical scaly papules and plaques in PLC (Fig 1) and necrotic, erythematous papules in PLEVA (Fig 2). PLC was diagnosed at onset in 46 patients (37%), PLEVA in 71 patients (57.3%), and clinical features of both disorders were seen simultaneously in the remaining 7 patients (5.7%) (Table I). The median age of onset of PL was 60 months (range: 6-180 months), and
Discussion
PL is a lymphocytic disorder that often occurs during childhood. Presentation before 2 years of age is unusual. Gelmetti et al10 reported a bimodal age distribution with peaks at 5 and 10 years of age, whereas Romani et al11 noted peaks at 5, 10, and 12 years of age. Similarly, we rarely observed PL before the age of 2 years and, in our cohort, age of onset peaked at both 2 to 3 and 5 to 7 years. PLEVA had an earlier age of onset (median: 60 months) than PLC (median: 72 months) (P = .03). In
References (21)
- et al.
Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder
Hum Pathol
(2002) - et al.
Pityriasis lichenoides in children: a long-term follow-up of eighty-nine cases
J Am Acad Dermatol
(1990) - et al.
Pityriasis lichenoides in children: therapeutic response to erythromycin
J Am Acad Dermatol
(1986) - et al.
Pityriasis lichenoides of childhood with atypical CD30-positive cells and clonal T-cell receptor gene rearrangements
J Am Acad Dermatol
(1996) - et al.
Pityriasis lichenoides–an immune complex disease
Br J Dermatol
(1977) - et al.
An immunofluorescence study of pityriasis lichenoides
Br J Dermatol
(1978) - et al.
The clonal nature of pityriasis lichenoides
Arch Dermatol
(2002) Tetracycline for the treatment of pityriasis lichenoides
Br J Dermatol
(1974)- et al.
Toxoplasmosis and pityriasis lichenoides
Br J Dermatol
(1972) - et al.
Cutaneous T-cell lymphoma (parapsoriasis en plaque): an association with pityriasis lichenoides et varioliformis acuta (Mucha-Haberman disease) in young children
Arch Dermatol
(1990)
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