ReportIrritant contact dermatitis induced by a common household irritant: A noninvasive evaluation of ethnic variability in skin response
Section snippets
Participants
The research protocol was approved by our subcommittee on human studies at the institutional review board. Ten participants (5 Caucasian [skin phototype (SPT) II-III] and 5 African American [SPT V-VI]) plus 20 healthy volunteers (10 Caucasian [SPT II-III] and 10 African American [SPT V-VI]) between the ages 18 to 49 years were recruited to participate in this study. Those with a history of significant skin disease or atopy were excluded from the protocol. Written consent was obtained before
Clinical threshold
Fig 1 illustrates the mean clinical threshold in African American versus Caucasian individuals as determined in the preliminary study (n = 10). Average threshold concentrations were 10% in the Caucasian group and 25% in the African American group (P < .0001).
In vivo RCM
Characteristic RCM features of ICD, such as SC disruption, parakeratosis, individual corneocytes, spongiosis, and vesicle formation at the level of the granular and spinous compartment were observed in both groups at sites with similar
Discussion
There is currently no consensus about the relationship between the propensity to develop ICD and ethnicity. Although most published data have reported increased skin susceptibility to irritation in Caucasian skin over African American skin, several studies have presented convincing data demonstrating otherwise.9, 17, 18 The conflicting results are mainly thought to be a result of the difficulty in assessing erythema in deeply pigmented skin.21
Hicks et al41 and others43, 44 have recently used
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2021, Photodiagnosis and Photodynamic TherapyCitation Excerpt :For instance, confocal scanning laser microscopy brings to the dermatologist's eyes detailed skin structure without the need for biopsy. This scale of resolution is very explanatory in skin diseases including contact dermatitis, as shown in Fig. 7 [99,100]. Confocal microscopy is comparable both histology and patch testing, in diagnosing and monitoring allergic contact dermatitis (ACD), due to its high sensitivity and specificity in detection [100].
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2019, Actas Dermo-SifiliograficasCommon spongiotic dermatoses
2017, Seminars in Diagnostic PathologyCitation Excerpt :It causes damage to the skin without prior sensitization, and occurs in all members of the population with variation in individual susceptibility. High-risk occupations include caterers, furniture/industry workers, chemical workers, dry cleaners, metal workers, florists, and warehouse workers.4,62–64 ICD represents a chronic effect of a weak irritant agent to the skin, and the hands are the most common affected areas (80%).
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2013, International Journal of PharmaceuticsCitation Excerpt :However, the order of increase in the TEWL values immediately after patch removal was highest for patch only (56.62 g h−1 m−2), followed by patch containing MN arrays (34.40 g h−1 m−2) and patch containing MN base-plate (24.80 g h−1 m−2), respectively. The clinical photographs collected from each treatment protocol were scored by visual inspection and an Irritant Contact Dermatitis (ICD) score was assigned to each photograph (Astner et al., 2006). Fig. 13 shows some sample clinical photographs taken before and after removal of the patches following 24 h treatments.
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Supported by a National Institutes of Health R01 grant (Dr González) and Johnson & Johnson Consumer and Personal Products Worldwide unrestricted gift (Dr Doukas).
Conflicts of interest: None identified.
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Dr Astner and Dr Burnett contributed equally to this report.