ReportNarrowband ultraviolet B phototherapy to clear and maintain clearance in patients with mycosis fungoides
Section snippets
Settings and location
This study is a retrospective review of our experience with all patients with MF treated with narrowband UVB phototherapy at the Phototherapy Unit of Hacettepe University Faculty of Medicine, Department of Dermatology, between May 2000 and June 2003 and who were followed up until April 2004.
Assessment before therapy
All patients had histologically confirmed MF, and histologic diagnoses were made in accordance with published criteria.9 The stage of the disease was classified on the basis of the TNM classification of the
Results
Pretreatment demographic and clinical data of the study group are demonstrated in Table I, and pretreatment laboratory results are presented in Table II.
Of 14 patients treated with narrowband UVB, 11 (78.6%) had CR, 1 patient (7.1%) had PR, and 2 patients (14.3%) had NR. CR was achieved in 2 of 4 patients with stage IA MF, 5 of 6 patients with MF stage IB, and 4 of 4 of those with stage IIA MF. The mean number of treatment sessions until CR was 25.4 ± 9.0. One patient who had hypopigmented MF
Discussion
Narrowband UVB therapy has been proven to be superior to broadband UVB and to be as effective as psoralen plus UVA (PUVA) in the treatment of psoriasis. Recent reports questioning its efficacy in the management of MF at disease stages IA and IB are encouraging. Hofer et al1 reported that 5 of 6 patients in disease stages IA and IB completely cleared with narrowband UVB; however, relapse occurred in all patients within a mean of 6 months. In another study 6 of 8 patients cleared completely and
References (11)
- et al.
Narrowband UVB phototherapy for early-stage mycosis fungoides
J Am Acad Dermatol
(2002) - et al.
Narrowband UVB and psoralen-UVA in the treatment of early-stage mycosis fungoides: a retrospective study
J Am Acad Dermatol
(2003) - et al.
Narrowband (311-nm) UV-B therapy for small plaque parapsoriasis and early-stage mycosis fungoides
Arch Dermatol
(1999) - et al.
Narrowband TL-01 phototherapy for patch-stage mycosis fungoides
Arch Dermatol
(2000) - et al.
Long-term outcome of 525 patients with mycosis fungoides and Sézary syndrome
Arch Dermatol
(2003)
Cited by (0)
Funding sources: None.
Conflicts of interest: None identified.