Cancer Cell
Volume 23, Issue 1, 14 January 2013, Pages 23-34
ArticleItraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
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Graphical Abstract
Highlights
► Itraconazole inhibits the activity of GDC-0449-resistant SMOD477G ► Itraconazole and ATO combine to block SMOD477G pathway activity in vitro ► Itraconazole and ATO inhibit SMOWT and SMOD477G tumor growth and prolong survival ► Itraconazole and ATO retain activity in all reported drug-resistant SMO mutants
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These authors contributed equally to this work
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Present address: Division of Hematology-Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX 75390-8593, USA
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Present address: Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94158, USA
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