HypothesisHair follicle dermal sheath cells: unsung participants in wound healing
Section snippets
Supporting evidence
This idea originates in part from the striking developmental and structural parallels between the hair follicle epithelial outer root sheath and the dermal sheath. These segregate from interfollicular epidermis and dermis during early follicle development, and assume characteristic morphological and molecular phenotypes. Anatomically, both are contiguous with their equivalent tissues in skin, the outer root sheath with the epidermis, the dermal sheath with the upper or papillary dermis. The two
Testing of the hypothesis, and its significance for surgery/clinical dermatology
We suggest that the relative lack of large hair follicles over most areas of human skin contributes to inferior dermal repair and scar formation, but what are the clinical and practical implications of our hypothesis? Over the past two decades there have been significant improvements in the treatment of skin loss after burns or other injury and skin has become one of the main targets for tissue engineering projects. Of the two main tissues comprising skin, the epidermis is more readily
References (17)
- et al.
Involvement of follicular stem cells in forming not only the follicle but also the epidermis
Cell
(2000) - et al.
A quantitative study of the differential expression of alpha-smooth muscle actin in cell populations of follicular and non-follicular origin
J Invest Dematol
(1993) - et al.
Standard depth burns in the rat. The importance of the hair growth cycle
Br J Plast Surg
(1967) - et al.
Comparative study of split thickness skin grafts taken from the scalp and thigh in children
Burns
(1994) - et al.
Glil protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin
J Invest Dermatol
(1999) Histological studies of whisker regeneration in the hooded rat
J Embryol Exp Morphol
(2000)- et al.
The role of the myofibroblast in wound healing and fibrocontractive diseases
- et al.
Coordinate expression of NGF and alpha-smooth muscle actin mRNA and protein in cutaneous wound tissue of developing and adult rats
Cell Tissue Res
(2000)
Cited by (209)
Recent omics advances in hair aging biology and hair biomarkers analysis
2023, Ageing Research ReviewsFabrication and evaluation of a bi-layered gelatin based scaffold with arrayed micro-pits for full-thickness skin construct
2023, International Journal of Biological Macromolecules3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution
2022, Journal of Advanced ResearchHair transplantation: Basic overview
2021, Journal of the American Academy of DermatologyAge-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging
2021, Journal of Investigative Dermatology