Aphthous stomatitis (canker sores): A consequence of high oral submucosal viscosity (the role of extracellular matrix and the possible role of lectins)
References (25)
- et al.
Aphthous ulcers — A review of the literature on etiology, pathogenesis, diagnosis, and treatment
J Am Dent Assoc
(1980) - et al.
The primary histologic lesion of seborrheic dermatitis and psoriasis
J Invest Derm
(1966) Inflammation spurts—the role of ground substance viscosity
Medical Hypotheses
(1986)- et al.
An alternative mechanism for gluten toxicity in coeliac disease
Lancet
(1976) Dermatitis herpetiformis and gluten sensitive enteropathy (including celiac disease)—Increased subepithelial extracellular matrix viscosity due to gliadin
Medical Hypotheses
(1990)Chemistry and metabolism of connective tissue glycosaminoglycans (mucopolysacharides)
Int Rev Connect Tis Res
(1964)- et al.
Role of mucosal injury in initiating recurrent aphthous stomatititis
Br Med J
(1981) - et al.
The sterile cutaneous pustular reaction
J Invest Derm
(1967) Applied Oral Physiology
- et al.
Ulcerative Conditions
Dermal glycosaminoglycans characterize the primary irritant dermatitis in psoriasis and healthy individuals
Clin Chim Acta
Chemical trauma, polysaccharides
Cited by (19)
Recurrent aphthous stomatitis
2023, Medicina ClinicaRecurrent Aphthous Stomatitis
2014, Dental Clinics of North AmericaCitation Excerpt :Local trauma is regarded as a causative agent for RAS in susceptible individuals.10,11 Trauma predisposes to RAS by inducing edema and early cellular inflammation associated with an increased viscosity of the oral submucosal extracellular matrix.12 Not all oral trauma leads to RAS, because denture wearers do not have a high prevalence of RAS despite this cohort being 3 times more susceptible to oral mucosal ulceration.13
Recurrent aphthous stomatitis
2005, Dental Clinics of North AmericaCitation Excerpt :Local trauma is regarded as a causative agent for RAS in susceptible individuals [7]. Trauma predisposes to RAS by inducing edema, early cellular inflammation associated with an increased viscosity of the oral submucosal extracellular matrix [8]. Not all oral trauma lead to RAS, because denture wearers are usually three times more susceptible to oral mucosal ulceration, but RAS is not the most prevalent ulceration in this cohort [9].
Adhesive tablet effective for treating canker sores in humans
2004, Journal of Pharmaceutical SciencesCitation Excerpt :The canker sore is most painful during the first 3–4 days. The discomfort gradually diminishes and the sore heals in 10–14 days, usually without scarring.3–5 Before it becomes visible, the canker sore may produce a tingling or burning sensation.
Recurrent aphthous ulcers: A review of diagnosis and treatment
1996, Journal of the American Dental AssociationPellagra - Increased viscosity of extracellular matrix
1993, Medical Hypotheses