Journal of the American Academy of Dermatology
Unusual aspects of juvenile xanthogranuloma
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Cited by (61)
Juvenile and adult xanthogranuloma: A 30-year single-center experience and review of the disorder and its relationship to other histiocytoses
2022, Annals of Diagnostic PathologyJuvenile Xanthogranuloma: An Entity With a Wide Clinical Spectrum
2020, Actas Dermo-SifiliograficasSkin and superficial soft tissue neoplasms with multinucleated giant cells: Clinical, histologic, phenotypic, and molecular differentiating features
2019, Annals of Diagnostic PathologyCitation Excerpt :JXG expresses factor XIIIa, CD68 (Fig. 6C), CD163, CD14, and fascin. S100 is rarely positive, while CD1a is only expressed in interspersed Langerhans cells [106,124-127]. The differential diagnosis of JXG includes Langerhans cell histiocytosis (positive for S100 and CD1a), papular xanthoma (very uncommon lesion, factor XIIIa negative, most cases located on the trunk in older individuals), dermatofibroma (dense collagenous stroma, storiform growth pattern, overlying pseudo-epitheliomatous hyperplasia), and Spitz nevus (positive for melanocytic markers such as S100, Melan-A, and tyrosinase) [128].
CD68-negative nonlipidized juvenile xanthogranuloma
2017, Dermatologica SinicaCitation Excerpt :The authors suggest that mononuclear cells in JXG might derive from plasmacytoid monocytes. CD68, a widely-used monocyte/macrophage lineage marker, was shown to be positive in all cases of JXG,16 and in 11 of 15 reported cases of NJXG.3,5,7–14 Of the four cases of CD68-negative NJXG, FXIIIa was positive in all four, weakly or focally Ham57- or Mac387-positive in three, and focally lysozyme-positive in one.
Juvenile xanthogranuloma in a 4-year-old child
2017, Archives de PediatrieLocalized eruptive juvenile xanthogranuloma
2014, Annales de Dermatologie et de Venereologie