TY - JOUR T1 - Is p-Phenylenediamine Still a Prevalent Contact Allergen in Spain? JO - Actas Dermo-Sifiliográficas T2 - AU - Sánchez-Pérez,J. AU - Descalzo-Gallego,M.A. AU - Silvestre,J.F. AU - Fernández-Redondo,V. AU - García-Gavín,J. AU - Ruiz-Gonzalez,I. AU - Mercader,P. AU - Armario-Hita,J.C. AU - Garcia-Doval,I. AU - Giménez-Arnau,A. SN - 15782190 M3 - 10.1016/j.adengl.2019.04.017 DO - 10.1016/j.adengl.2019.04.017 UR - https://actasdermo.org/es-is-p-phenylenediamine-still-prevalent-contact-articulo-S1578219019303531 AB - ObjectivesTo analyze trends in the prevalence of contact sensitization to p-phenylenediamine between 2004 and 2014, taking into consideration that the concentration of this product in cosmetics was regulated in 2009. To explore risk factors for contact allergy to p-phenylenediamine. Materials and methodsRetrospective observational study of patients suspected of having contact dermatitis from allergy to p-phenylenediamine during the years between 2004 and 2015 in 8 tertiary level hospitals. The patients underwent patch testing (TRUE-test) with the standard series of the Spanish Research Group on Contact Dermatitis and Skin Allergies. This series included p-phenylenediamine 1%. We followed international recommendations for the statistical analysis of data related to contact allergies. ResultsThree hundred eighty-six out of 9341 patients (4.1%) had positive reactions to p-phenylenediamine. The prevalence tended to decrease in the early years (2004–2007) and then leveled off at around 4%. Risk factors for developing contact dermatitis from p-phenylenediamine were sex, age over 40 years, multiple sensitivities, and profession, notably workers in hair salons and those who handle rubber and plastics. ConclusionsThe prevalence of p-phenylenediamine allergy remains high among patients with contact eczema. Risk factors for p-phenylenediamine contact allergy are consistent with previous reports. ER -