Journal Information
Vol. 98. Issue 8.
Pages 553-555 (October 2007)
Vol. 98. Issue 8.
Pages 553-555 (October 2007)
Case report
Full text access
Kaposi Sarcoma Associated With Systemic Corticosteroid Therapy
Sarcoma de Kaposi Asociado a Corticoterapia Sistémica
Visits
6839
B. González-Sixto
Corresponding author
bgonsix@aedv.es

Correspondence: Servicio de Dermatología, Complejo Hospitalario de Pontevedra, Loureiro Crespo 2, 36001 Pontevedra, Spain.
, A. Conde, E. Mayo, R. Pardavila, C. de la Torre, M. Cruces
This item has received
Article information
Abstract

Kaposi sarcoma (KS) was first described in 1872 by Moritz Kaposi. Its epidemiology is suggestive of an infectious disease and in 1994 Chang and coworkers identified DNA sequences corresponding to a previously unidentified herpes virus—human herpes virus 8 (HHV-8)—in AIDS-associated KS biopsies. It is now believed that the presence of HHV-8 is a necessary condition but not sufficient on its own to cause KS. Other factors such as immunosuppression should also be considered and it is known that immunosuppressive therapy increases the risk of KS. We describe a patient who developed KS after prolonged prednisone therapy for temporal arteritis.

Key words:
Kaposi sarcoma
temporal arteritis
glucocorticoids
immunosuppression
Resumen

El sarcoma de Kaposi (SK) fue descrito por Moritz Kaposi en 1872. Las características epidemiológicas del SK apuntan a una probable causa infecciosa. Se han identificado fragmentos de ADN que corresponden a un virus herpes no identificado previamente, el virus herpes humano tipo 8, en biopsias de SK asociado a sida. Se considera un factor necesario pero no suficiente, siendo conveniente tener en cuenta otros factores como la inmunosupresión. Los tratamientos inmunosupresores se asocian con un mayor riesgo de desarrollar SK. Describimos el caso de un paciente que desarrolló SK tras recibir tratamiento prolongado con prednisona con motivo de la arteritis de la temporal que padecía.

Palabras clave:
sarcoma de Kaposi
arteritis temporal
glucocorticoides
inmunosupresión
Full text is only aviable in PDF
References
[1.]
P. Bencini, G. Montagnino, A. Tarantino, E. Alessi, C. Ponticelli, R. Caputo.
Kaposi's sarcoma in kidney transplant recipients.
Arch Dermatol, 129 (1993), pp. 248-250
[2.]
F. Leung, A.G. Fam, D. Osoba.
Kaposi's sarcoma complicating corticosteroid therapy for temporal arteritis.
Am J Med, 71 (1981), pp. 320-322
[3.]
F.M. Buonaguro, M.L. Tormesello, L. Buonaguro, R.A. Satriano, E. Ruocco, G. Castello, et al.
Kaposi's sarcoma: aetiopathogenesis, histology and clinical features.
J Eur Acad Dermatol Venereol, 17 (2003), pp. 138-154
[4.]
Y. Chang, E. Cesarman, M.S. Pessin, F. Lee, J. Culpepper, D.M. Knowles, et al.
Identification of new herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
Science, 266 (1994), pp. 1865-1869
[5.]
P. Geraminejad, O. Memar, I. Aronson, P. Rady, U. Hengge, S.K. Tyring.
Kaposi's sarcoma and others manifestations of human herpesvirus 8.
J Am Acad Dermatol, 47 (2002), pp. 641-655
[6.]
P. Rady, E. Hodak, A. Yen, O. Memar, A. Trattner, M. Feinmesser, et al.
Detection of human herpesvirus-8DNA in Kaposi's sarcomas from iatrogenically immunosuppressed patients.
J Am Acad Dermatol, 38 (1998), pp. 429-437
[7.]
A. Trattner, E. Hodak, M. David, M. Sandbank.
The appearance of Kaposi sarcoma during corticosteroid therapy.
Cancer, 72 (1993), pp. 1779-1783
[8.]
J. Cai, T. Zheng, M. Lotz, Y. Zhang, R. Masood, P. Gill.
Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-_.
Blood, 89 (1997), pp. 1491-1500
[9.]
D.S. Hudnall, P.L. Rady, S.K. Tyring, J.C. Fish.
Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro.
Transplantation, 67 (1999), pp. 648-652
[10.]
V. Di Giacomo, D. Nigro, G. Trocchi, F. Meloni, P. Verallo, M. Bottazzi, et al.
Kaposi's sarcoma following corticosteroid therapy for temporal arteritis.
Angiology, 38 (1987), pp. 56-61
[11.]
R. Calentano, F. Di Pasquale, M. Gregorj, M. D’Uva, S. De Santis.
Horton arteritis and Kaposi's sarcoma: description of a case.
Medicina (Firenze), 9 (1989), pp. 400-401
[12.]
C. Soria, C.M. González-Herrada, D. García-Almagro, R. Díaz, M.A. Piris, J.L. Orradre.
Kaposi's sarcoma in a patient with temporal arteritis treated with corticosteroid.
J Am Acad Dermatol, 24 (1991), pp. 1027-1028
[13.]
J.J. Pérez-Pascual, J. Pérez-Mur, J.M. Casanova, R. Egido.
Kaposi's sarcoma following treatment of giant cell arteritis with corticoids.
Med Clin (Barc), 99 (1992), pp. 793
Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?