TY - JOUR T1 - Cutibacterium acnes tetracycline resistance profile in patients with acne vulgaris, in a Colombian dermatologic center JO - Actas Dermo-Sifiliográficas T2 - AU - Castellanos Lorduy,H.J. AU - Pérez Cely,H.C. AU - Casadiego Rincón,E.J. AU - Henao Riveros,S.C. AU - Colorado,C.L. SN - 15782190 M3 - 10.1016/j.adengl.2021.09.003 DO - 10.1016/j.adengl.2021.09.003 UR - https://actasdermo.org/en-cutibacterium-acnes-tetracycline-resistance-profile-articulo-S1578219021002444 AB - IntroductionAcne is a chronic inflammatory disease, in which different events intervene in its pathogenesis, one of which is Cutibacterium acnes (C. acnes). Resistance of this bacteria to different antimicrobials used in treatment has been described in different regions of the world. The purpose of the study is to estimate the resistance of C. acnes to cyclins in patients with moderate and severe acne over 18 years of age. Materials and methodsAn analytical cross-sectional study was carried out. Samples were taken from inflammatory lesions with a comedone extractor. The content of the samples was incubated in an anaerobic atmosphere to grow C. acnes. Finally, the susceptibility of C. acnes to tetracycline, minocycline and doxycycline was determined. ResultsSamples were taken from 147 patients, of which 129 showed growth of C. acnes, finding that 5.43% of the strains were resistant to tetracycline, 5.43% to doxycycline, 0.78% to minocycline and cross resistance between doxycycline and tetracycline in all the cases. An association was found between resistance and being 25 years of age or older. No association was found with the prior use of antibiotics, a history of misuse of oral or topical antibiotics, and other demographic and clinical characteristics evaluated. ConclusionsThe resistance found of C. acnes to cyclines was lower than that reported in other studies. Although no relationship was found with the previous use of antibiotics, it is a factor described in previous studies, which is why the proper use of antibiotics is imperative to avoid the appearance of resistance. ER -