TY - JOUR T1 - Primary Cutaneous Acral CD8+ T-cell Lymphoma Induced by Persistent Delayed Hypersensitivity to Gold Earrings JO - Actas Dermo-Sifiliográficas T2 - AU - Molinero Caturla,J. AU - Sánchez Sánchez,J. AU - Marcoval Caus,J. AU - Muniesa Montserrat,C. AU - Climent Esteller,J. AU - Servitje Bedate,O. SN - 15782190 M3 - 10.1016/j.adengl.2021.05.006 DO - 10.1016/j.adengl.2021.05.006 UR - https://actasdermo.org/en-primary-cutaneous-acral-cd8-t-cell-articulo-S1578219021001657 AB - Primary cutaneous CD8+ T-cell lymphoma has been included as a provisional entity within the new revised classification of lymphoid neoplasms of the World Health Organization in 20161. It was initially described as indolent CD8+ lymphoid proliferation of the ear2 and a total of 29 cases of such neoplasm have been published in the literature so far. None of them have been linked to delayed contact hypersensitivity reactions. We present a case of acral type primary cutaneous lymphoma T CD8+ involving both earlobes clearly related with the prolonged use of gold earrings, confirmed with epicutaneous tests, histopathology, immunohistochemical and molecular studies. Auricular skin lesions were induced again with a provocation test with identical histopathologycal and the same clonality, confirming both the diagnosis of lymphoma and its induction by the antigenic stimulus of gold. ER -