SARS-CoV-2 Vaccines and the Skin | Actas Dermo-Sifiliográficas

array:24 ["pii" => "S1578219021002407" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.028" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2680" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2021;112:828-36" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0001731021002039" "issn" => "00017310" "doi" => "10.1016/j.ad.2021.05.011" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2680" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2021;112:828-36" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "Novedades en Dermatología" "titulo" => "Vacunas frente a SARS-CoV-2 y piel" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "828" "paginaFinal" => "836" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "SARS-CoV-2 Vaccines and the Skin" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 594 "Ancho" => 1333 "Tamanyo" => 113821 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Galván-Casas, A. Català, C. Muñoz-Santos" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Galván-Casas" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Català" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Muñoz-Santos" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<elsevierMultimedia ident="fig0030"></elsevierMultimedia>" ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219021002407" "doi" => "10.1016/j.adengl.2021.07.028" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002407?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002039?idApp=UINPBA000044" "url" => "/00017310/0000011200000009/v1_202110020514/S0001731021002039/v1_202110020514/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219021002377" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.025" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2611" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:837-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Practical Dermoscopy" "titulo" => "Millimetric Papule on the Antihelix Dermoscopically Constituted by Hairpin Vessels in a Radial Pattern" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "837" "paginaFinal" => "838" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápula milimétrica en antehélix constituida dermatoscópicamente por corona de vasos en horquilla" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1110 "Ancho" => 2083 "Tamanyo" => 378613 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "A, Clinical presentation of the lesion on the right antihelix. B, Dermoscopic image of the lesion using contact dermoscopy and 60× magnification (image acquisition was very difficult given the very small size of the lesion). Slightly whiteish central area without structure (*) and radially distributed hairpin vessels (^)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Martin-Gorgojo, F.J. Bru-Gorraiz, E. Pascual-Rodríguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Martin-Gorgojo" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Bru-Gorraiz" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Pascual-Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173102100106X" "doi" => "10.1016/j.ad.2020.02.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102100106X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002377?idApp=UINPBA000044" "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002377/v1_202110091021/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219021002158" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.015" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2679" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2021;112:817-27" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Characterization and Outcomes in Patients Treated With Apremilast in Routine Clinical Practice in Spain: Results From the APPRECIATE Study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "817" "paginaFinal" => "827" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Caracterización y resultados de pacientes tratados con apremilast en la práctica clínica habitual española: resultados del estudio APPRECIATE" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1425 "Ancho" => 2556 "Tamanyo" => 179232 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Main reasons for considering apremilast treatment." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Herranz, L. Trasobares, A. Mateu, E. Martínez, R. Ruiz-Villaverde, O. Baniandrés, J. Mataix Díaz, N. Jiménez-Gómez, M. Serra, D.P. Ruiz Genao, N. Rivera, J. Tercedor-Sánchez, C. Garcia, M. Cordey, E. Herrera-Acosta" "autores" => array:15 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Herranz" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Trasobares" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Mateu" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Martínez" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] 5 => array:2 [ "nombre" => "O." "apellidos" => "Baniandrés" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Mataix Díaz" ] 7 => array:2 [ "nombre" => "N." "apellidos" => "Jiménez-Gómez" ] 8 => array:2 [ "nombre" => "M." "apellidos" => "Serra" ] 9 => array:2 [ "nombre" => "D.P." "apellidos" => "Ruiz Genao" ] 10 => array:2 [ "nombre" => "N." "apellidos" => "Rivera" ] 11 => array:2 [ "nombre" => "J." "apellidos" => "Tercedor-Sánchez" ] 12 => array:2 [ "nombre" => "C." "apellidos" => "Garcia" ] 13 => array:2 [ "nombre" => "M." "apellidos" => "Cordey" ] 14 => array:2 [ "nombre" => "E." "apellidos" => "Herrera-Acosta" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731021002027" "doi" => "10.1016/j.ad.2021.05.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002027?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002158?idApp=UINPBA000044" "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002158/v1_202110091021/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "Novelties in Dermatology" "titulo" => "SARS-CoV-2 Vaccines and the Skin" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "828" "paginaFinal" => "836" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Galván-Casas, A. Català, C. Muñoz-Santos" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Galván-Casas" "email" => array:1 [ 0 => "galvancasascristina@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Català" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Muñoz-Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Sede Plató, Hospital Clínic, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General de Granollers, Granollers, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vacunas frente a SARS-CoV-2 y piel" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 2015 "Ancho" => 2925 "Tamanyo" => 442881 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Decision algorithm. Reactions to COVID-19 vaccines." ] ] ] "textoCompleto" => "IntroductionThe lessons learned from other epidemics (Ebola, SARS-CoV, and MERS-CoV) and the international coordination of the knowledge generated have facilitate the global response to the COVID-19 pandemic. The COVID-NMA international research initiative, which arose from the WHO R&D plan, has facilitated the joint evaluation of a large number of clinical trials and of evidence on prevention, treatment, and vaccines for the disease. This has made it possible to gain knowledge, make decisions, and achieve a vaccine, the essential tool for controlling the pandemic, in record time<a class="elsevierStyleCrossRefs" href="#bib0005">1,2</a>.Although such vaccines were being developed, to date, no effective vaccine had been used in humans against coronaviruses (CoV). Preclinical development was reached with SARS-CoV but was halted due to the disappearance of the virus as a health threat. But the similarity of the gene sequences of SARS-CoV-2 and SARS-CoV<a class="elsevierStyleCrossRef" href="#bib0015">3</a> reduced the time given over to design. Phase I/II clinical trials soon began and, based on the intermediate analysis of the results phase II trials were begun more quickly and with parallel trials. Before the studies were completed, production of several candidate vaccines had already begun. All this made it possible to have the vaccines available to inoculate the population with unimaginable speed<a class="elsevierStyleCrossRef" href="#bib0005">1</a>.The novel technology used and the speed of the process does not mean that the necessary safety controls were ignored. But it was to be expected, as we are seeing, that with clinical use, adverse effects would appear that were not found or were not sufficiently categorized during the preclinical phase. Cutaneous manifestations and their categorization were important for understanding the disease<a class="elsevierStyleCrossRef" href="#bib0020">4</a>, in the same way that those caused by the vaccines may be<a class="elsevierStyleCrossRef" href="#bib0025">5</a>. In many of these dermatologic manifestations associated with COVID-19, no sign was found of the virus or its direct cytopathic action, and they may be linked to the host immune response.The authorization documents of all the available vaccines mentions the presence of dermatologic adverse effects and, after their clinical use, publications of various skin reactions continue to appear. As dermatologists, it is important to understand the characteristics of the different types of vaccine, their interaction with the host, and the range of systemic and dermatologic reactions that we may find.SARS-CoV-2 VaccinesSARS-CoV-2 enters the host cell by binding to the angiotensin converting enzyme 2 (ACE2) by means of its surface spike (S) protein. The release of RNA leads to replication, transcription, and synthesis of viral RNA and the resulting structural proteins (viral RNA, nucleocapsid [N], membrane [M], envelope [E], and S) form the mature virion, which can escape the host cell to infect others.In the host, SARS-CoV-2 induces an innate immune response, with the participation of IFN-I and other proinflammatory cytokines, and an adaptive immune response, in which T CD4+ and CD8+ lymphocytes react against the viral proteins S, M, and N, Nsp, and ORF3a. In the mucosa of the upper respiratory tract, contact with the virus induces the formation of secretory IgA. At the systemic level, IgG specifies against the S protein and the protein of its receptor-binding domain (RBD) is recruited from the serum to the lower respiratory tract. The responses of serum IgM and IgA are less intense<a class="elsevierStyleCrossRefs" href="#bib0005">1,6</a>.The vaccines train the immune system using harmless SARS-CoV-2 antigens to stimulate an immune response without causing disease. Following intramuscular administration, they essentially induce humoral immunity but are not able to improve the local response. Those administered intranasally induce a potentially sterilizing lgA-dependent local immunity but induce less effective systemic immunity. Some vaccines use adjuvants to activate the cell receptors and induce an innate immune response locally and in the regional lymph nodes, or to polarize the type of immune response desired. They improve the immune response but they also increase reactions to the vaccine<a class="elsevierStyleCrossRefs" href="#bib0030">6,7</a>. Both inactivated-virus vaccines and protein-based viruses are formulated with adjuvants.Each vaccine introduces one type of antigen, triggering a specific immune response that, in turn, generates the immune memory that makes it possible to combat SARS-CoV-2 in the event of future exposure. This antigen is processed by the antigen-presenting cells and is presented to the CD8+ and CD4+ T cells. Th1 cytokines also stimulate the CD8+ T cells and Th2 cytokines induce the production of neutralizing antibodies by the B cells.All the vaccines induce some level of inflammation triggered by the activation of the innate immune response<a class="elsevierStyleCrossRef" href="#bib0040">8</a>. The imbalance of these responses may give rise to inflammatory reactions<a class="elsevierStyleCrossRef" href="#bib0030">6</a>, which can manifest in the skin.Anti-protein S antibodies inhibit the SARS-CoV-2–ACE-2 bond and the development of vaccines has thus focused on antigens derived from the S protein. The different forms used by the vaccines to introduce the antigen are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. And the different characteristics of the main vaccines available and under development are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Reactogenicity of the VaccinesReactogenicity or the physical manifestation of the inflammatory response may present as a local reaction at the injection site (pain, heat, reddening, swelling, hardness) and/or with systemic symptoms (fever, myalgia, headache, etc.). The sequence of reactions induced from the moment of contact with the vaccine are shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>.<elsevierMultimedia ident="fig0010"></elsevierMultimedia>The tolerability and immunogenicity profile of the vaccines varies depending on the type of antigen and the adjuvant used. RNA vaccines (potent activator of the innate immune response) induce frequent, though mild, adverse reactions. Other factors that modify these effects are age (more reactogenicity in young people), a high body mass index (perhaps linked to a poor subcutaneous injection technique), pre-existing immunity, the route and site of administration, the injection technique, sex (more reactogenicity in women), some genetic and racial factors, and anxiety.Adverse Effects of the COVID-19 VaccinesThe clinical trials prior to approval of the available vaccines notified adverse effects, including skin reactions, sometimes with few details, which are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a><a class="elsevierStyleCrossRefs" href="#bib0045">9–12</a>.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Cutaneous adverse effects published after the vaccine reached the market are, partly, the same as those described in the clinical trials. These include the following:COVID-Arm (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>)This is the most commonly reported reaction. It involves the appearance of erythematous, edematous plaques of different sizes in the area where the vaccine was administered. These eruptions have been described with other vaccines, such as the combined pneumococcal vaccine<a class="elsevierStyleCrossRef" href="#bib0065">13</a>.<elsevierMultimedia ident="fig0015"></elsevierMultimedia>The first published cases<a class="elsevierStyleCrossRef" href="#bib0040">8</a> appeared between 7 and 10 days after the first dose of the Moderna® vaccine, which was initially attributed to a hypersensitive reaction to the polyethylene glycol contained in the vaccine. In another series, however, the intradermal test with polyethylene glycol-polysorbate was only positive in one patient with a reaction that appeared only after the second dose. This does not support an IgE-mediated reaction to these compounds as a cause<a class="elsevierStyleCrossRef" href="#bib0070">14</a>. Another study supports a delayed or T-cell mediated hypersensitivity reaction as a cause, based on the histopathology that showed the presence of superficial perivascular and perifollicular lymphocytic infiltrates with mastocytes and disperse eosinophils<a class="elsevierStyleCrossRefs" href="#bib0075">15,16</a>. A retrospective study analyzed the cutaneous reactions in a group of health workers vaccinated with the Pfizer® vaccine. A delayed local reaction was observed in 2.1%, after both the first and second dose. As reported in other series, in half of cases, the reaction was repeated after the second dose. Two were biopsied and a superficial and deep perivascular lymphocyte infiltrate was found, with dilated vessels, intraluminal neutrophils, and immune staining negative for the SARS-CoV-2 spike protein 1A9<a class="elsevierStyleCrossRef" href="#bib0085">17</a>.All reported cases resolved with conservative treatment, such as local application of cold, topical corticosteroids, and/or antihistamines. No severe adverse reactions have been reported following the second dose and changing the guidelines is therefore not recommended.Inflammatory Reactions in Areas With Hyaluronic Acid Dermal Filler (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>)The appearance of erythema, edema, and nodules in areas that had previously been subjected to dermal fillers following processes such as viral infections or vaccines is well known<a class="elsevierStyleCrossRef" href="#bib0090">18</a>, and this has also been described in coincidence with SARS-CoV-2 infection and in some isolated cases after vaccination against COVID-19<a class="elsevierStyleCrossRefs" href="#bib0095">19,20</a>. Taking into account the number of vaccines administered globally and the number of people who have dermal fillers, it seems likely that the frequency is very low<a class="elsevierStyleCrossRef" href="#bib0105">21</a>.<elsevierMultimedia ident="fig0020"></elsevierMultimedia>A suggested pathophysiological mechanism is a cascade of events that begins with deficient phagocytosis of the hyaluronic acid, formation of a biofilm around the filler material, activation of T cells, and formation of fibrosis and granulomas. These alterations favor the presence of Th1/CD8+ T cells and the high concentrations of ACE2 in the resident cells. This would lead to abnormal regulation between the production of proinflammatory angiotensin II and anti-inflammatory angiotensin I. The binding of the S protein to ACE2, induced by the vaccine, would tilt the balance toward inflammation. In 5 cases, this hypothesis justified treatment of these reactions by blocking the angiotensin II with an ACE inhibitor, with good results. The authors recommend lisinopril 5 mg/d, doubling the dosage if no improvement is achieved in 72 h and pretreatment before the second dose of the vaccine of patients who presented this complication after the first dose.It is important to bear in mind that, although there are currently few cases, all those reported have evolved favorably regardless of the prescribed treatment, which has been highly diverse. Cases have been reported that were treated with systemic antihistamines, antibiotics, or corticosteroids, intralesional corticosteroids and 5-fluorouracil, and injections of hyaluronidase. A more thorough understanding and broader experience are doubtless necessary before reaching conclusions.Other Cutaneous EruptionsAs with COVID-19, a wide variety of cutaneous manifestations have been reported coinciding with vaccination and with no other apparent cause. Morbilliform eruptions<a class="elsevierStyleCrossRef" href="#bib0075">15</a>, urticarial eruptions<a class="elsevierStyleCrossRef" href="#bib0085">17</a>, maculopapular eruptions<a class="elsevierStyleCrossRef" href="#bib0110">22</a>, lichen planus<a class="elsevierStyleCrossRefs" href="#bib0115">23,24</a>, erythema multiforme<a class="elsevierStyleCrossRef" href="#bib0125">25</a>, and reactivations of herpes zoster<a class="elsevierStyleCrossRef" href="#bib0130">26</a>. These data corroborate the recent publication of 414 reactions following the Moderna® and Pfizer® vaccines reported by different health care professionals through the register of SARS-CoV-2 cutaneous manifestations of the American Academy of Dermatology. No severe reactions were found and half of patients with reactions following the first dose did not present these reactions after the second dose. Different reactions have been added, which were observed both after the first dose and after the second dose, such as erythromelalgia and perniosis<a class="elsevierStyleCrossRef" href="#bib0135">27</a>.Other ManifestationsSelf-limiting enlarged supraclavicular lymph nodes have been reported and have been linked to the injection at an inappropriate site, higher than recommended (2–3 fingers below the acromion)<a class="elsevierStyleCrossRef" href="#bib0140">28</a> and rare anaphylactic reactions with no fatalities<a class="elsevierStyleCrossRef" href="#bib0145">29</a> but in a higher percentage than with the usual vaccines (4.2 cases per million compared to 1 case per million).The CDC has issued recommendations for mRNA vaccines, about when to give a green light, take precautions, or avoid administering them, which are summarized in <a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>. Although most patients who have had anaphylactic reactions have a history of allergies<a class="elsevierStyleCrossRef" href="#bib0150">30</a>, atopic patients with rash and with eczema, while they should be correctly treated at the moment of vaccination, should not delay vaccination, and do not have an increased risk of severe allergic reactions<a class="elsevierStyleCrossRef" href="#bib0155">31</a>.<elsevierMultimedia ident="fig0025"></elsevierMultimedia>COVID-19 Vaccines-Skin StudyAs occurred with the COVID-19 emergency, the mass administration to the population of a newly created vaccine and technology is bringing to light a wide variety of cutaneous manifestations. As dermatologists, it is our mission to be watchful, to analyze, categorize, evaluate the significance and the consequences of each manifestation, and communicate our findings to the pharmacovigilance bodies and to the scientific community.With this goal and with the support of the Spanish Academy of Dermatology, may dermatologists in Spain have proposed recording as many dermatologic adverse effects as possible.At present, most of the cases reported correspond to women and to the Pfizer vaccine®. A similar number of effects has been reported after the first dose and after the second dose. The most frequent manifestations are covid-arm, urticarial eruptions, and reactivation of herpes zoster<a class="elsevierStyleCrossRef" href="#bib166">34</a>. Information: <a href="http://vacunascovidpiel@gmail.com">vacunascovidpiel@gmail.com</a>; <a href="https://aedv.es/reacciones-cutaneas-tras-la-administracion-de-vacunas-frente-a-sars-cov-2/">https://aedv.es/reacciones-cutaneas-tras-la-administracion-de-vacunas-frente-a-sars-cov-2/</a>ConclusionThe vaccines have a proven safety profile. Nevertheless, they do present systemic and local reactions that we should be aware of.The correct categorization of cutaneous reactions to the vaccines will make it possible to provide adequate information to our patients, prevent unnecessary rejection of vaccination, reduce severe adverse effects in predisposed individuals, and gain a deeper understanding of the pathophysiological mechanisms underlying the immune reaction to SARS-CoV-2.FundingThis study has not received funding of any kind.Conflicts of interestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres1585954" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1427055" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1585953" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1427054" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "SARS-CoV-2 Vaccines" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Reactogenicity of the Vaccines" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Adverse Effects of the COVID-19 Vaccines" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "COVID-Arm (Fig. 3)" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Inflammatory Reactions in Areas With Hyaluronic Acid Dermal Filler (Fig. 4)" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Other Cutaneous Eruptions" ] 3 => array:2 [ "identificador" => "sec0040" "titulo" => "Other Manifestations" ] ] ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "COVID-19 Vaccines-Skin Study" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion" ] 10 => array:2 [ "identificador" => "sec0055" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of interest" ] 12 => array:2 [ "identificador" => "xack560501" "titulo" => "Acknowledgments" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-05-11" "fechaAceptado" => "2021-05-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1427055" "palabras" => array:4 [ 0 => "COVID-19" 1 => "SARS-CoV-2 vaccines" 2 => "Skin reactions" 3 => "Vacines" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1427054" "palabras" => array:4 [ 0 => "COVID-19" 1 => "Vacunas contra SARS-CoV-2" 2 => "Vacunas" 3 => "Reacciones cutáneas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Vaccines against the severe acute respiratory coronavirus 2, which are the first to be used in humans against any coronavirus, were developed and produced in record time. Dermatologic adverse effects appeared during clinical trials and have also been described in the population since approval. Just as descriptions and categorization of skin manifestations of the coronavirus disease 2019 proved important for understanding the disease itself, characterizing the effects of vaccines may also further that goal. This paper reviews the properties of the different types of vaccines currently available and under development and describes how they interact with the immune system and the clinical signs they may cause. We focus on dermatologic adverse effects reported to date and recommendations for managing them." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Las vacunas contra el SARS-CoV-2 son las primeras vacunas que han sido usadas en humanos contra coronavirus y su desarrollo se ha producido en un tiempo récord. En los análisis de seguridad de los ensayos clínicos previos a su aprobación y en la fase postautorización en la población, se han descrito efectos secundarios dermatológicos. La descripción y categorización de las manifestaciones cutáneas de la COVID-19 fueron importantes para el conocimiento de la enfermedad y de la misma forma pueden serlo las generadas por las vacunas. En este artículo hacemos un repaso a las características de los diferentes tipos de vacunas disponibles y en desarrollo, su modo de interacción con el sistema inmune, las consecuentes manifestaciones clínicas que pueden generar, con especial interés en los efectos secundarios dermatológicos hasta el momento descritos, y las actitudes terapéuticas recomendadas ante cada una de estas reacciones." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Galván-Casas C, Català A, Muñoz-Santos C. Vacunas frente a SARS-CoV-2 y piel. Actas Dermosifiliogr. 2021;112:828–836." ] ] "multimedia" => array:7 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2009 "Ancho" => 2925 "Tamanyo" => 621277 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Different ways in which vaccines are used to introduce an antigen." ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1041 "Ancho" => 2341 "Tamanyo" => 328060 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Vaccine immunogenicity sequence." ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1210 "Ancho" => 755 "Tamanyo" => 118820 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "COVID-Arm." ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 587 "Ancho" => 1255 "Tamanyo" => 95318 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Late-onset inflammatory reaction in the area of dermal filler (due to non-COVID vaccine). Courtesy of Dr. José Luis Martínez Amo." ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 2015 "Ancho" => 2925 "Tamanyo" => 442881 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Decision algorithm. Reactions to COVID-19 vaccines." ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of vaccine \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Name/company/country \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Composition \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Special characteristics \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Advantages \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Disadvantages \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Inactivated SARS-CoV-2 viruses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CoronaVac® (Sinovac Biotech®, China) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SARS-CoV-2 cell culture and inactivation of the virus using chemical or physical methods (formaldehyde, heat, or ultraviolet light)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The immune response is aimed at S, M, E, and N proteins. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Safer than attenuated live vaccines; they cannot cause disease and generate fewer reactions.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They generate a weaker immune response. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Covaxin® (Bharat Biotech®, India)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They use adjuvants to potentiate their effect (aluminium hydroxide). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Local reactions to aluminium hydroxide</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intramuscular administration \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Viral vectors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vaxzevria® (Oxford/AstraZeneca®, United Kingdom) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They use another virus, modified to express an antigen of SARS-CoV-2.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AstraZeneca uses a chimpanzee adenovirus designed to express S protein and modified to be unable to replicate in cells.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Conservation at normal refrigerator temperatures, which facilitates logistics and distribution in developing countries.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Risk of loss of efficacy if neutralized by pre-existing immunity. To prevent this, the vaccine uses vectors that are rare in humans or with low immunogenic ability.</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ad26Cov2-S (Janssen®, United States) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sputnik-V® (Gamaleya®, Russia) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intramuscular administration \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Recombinant proteins</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NVX-CoV2373 (Novavax®), United States</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They use artificially created proteins of the virus, such as the receptor-binding domain (RBD) of the S protein.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Obtained through genetic engineering, supported by experience with other authorized vaccines (hepatitis B, HPV, influenza) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Manufacturing is simpler</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They generate a weaker immune response.</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They use adjuvants to potentiate their effect (MATRIX-M). \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intramuscular administration \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RNA vaccines</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BNT162/Comirnaty® (Pfizer®/BioNTech®, Germany, United States) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They contain messenger RNA (mRNA) that teaches the cells to produce the protein that triggers an immune response to infection (it induces ribosomal production of proteins that code for the antigen). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">More frequent adverse reactions (mRNA is a potent immunity activator) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They are not able to produce disease (like attenuated-virus vaccines) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Instability \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">mRNA 1273 (Moderna®, United States)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Self-replicating RNA vaccines contain an RNA-polymerase complex that amplifies the mRNA and produces a larger amount of antigen.</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Particular precaution in people with a history of allergies and anaphylaxis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They are not able to form part of the host genome (like DNA vaccines) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Difficult conservation conditions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intramuscular administration</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They generate a stronger and longer-lasting immune response. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ability to stimulate the innate immune system, with production of INF1 and eventual reduction of efficacy<a class="elsevierStyleCrossRefs" href="#bib0160">32,33</a></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">They stimulate the innate immune system. mRNA and lipid carriers act as an adjuvant. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2716698.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Comparative characteristics of the different types of vaccine." ] ] 6 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Systemic \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Very frequent: headache, fatigue, and joint pain \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less frequent: fever, enlarged lymph nodes, nausea/vomiting, diarrhea, and chills \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">With the Moderna® and Pfizer® vaccines, they are more frequent after the second dose and with the AstraZeneca® vaccine, they are more frequent after the first dose. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Local \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Extremely frequent: pain and sensitivity at the injection site (84.2% of participants after the first dose) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less frequent: erythema and edema<a class="elsevierStyleCrossRef" href="#bib0055">11</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Local inflammation greater than 2.5 cm was considered an adverse effect and greater than 10 cm was considered severe. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Delayed local reactions (a week or more after the injection) 0.8% of participants after the first dose; 0.2% after the second dose. (Moderna®) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Other cutaneous adverse effects \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rosacea and cellulitis (AstraZeneca®) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urticaria (1), maculopapular rash (1), non-anaphylactic hypersensitivity reactions (1.5% of those vaccinated) and edema at sites where dermal filler had been used (3) (Moderna®) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-anaphylactic hypersensitivity reactions in 0.63% (Pfizer®) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urticaria (5) and urticaria with angioedema (1), 7 and 4 days after receiving the vaccine (Janssen®) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2716697.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Adverse effects described in clinical trials." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "SARS-CoV-2 vaccines in development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Krammer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41586-020-2798-3" "Revista" => array:6 [ "tituloSerie" => "Nature." "fecha" => "2020" "volumen" => "586" "paginaInicial" => "516" "paginaFinal" => "527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32967006" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The COVID-NMA project: building an evidence ecosystem for the COVID-19 pandemic" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Boutron" 1 => "A. Chaimani" 2 => "J.J. Meerpohl" 3 => "A. Hróbjartsson" 4 => "D. Devane" 5 => "G. Rada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7326/M20-5261" "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med." "fecha" => "2020" "volumen" => "173" "paginaInicial" => "1015" "paginaFinal" => "1017" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32931326" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics and genomics of SARS-CoV-2: a review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rahimi" 1 => "A. Mirzazadeh" 2 => "S. Tavakolpour" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ygeno.2020.09.059" "Revista" => array:6 [ "tituloSerie" => "Genomics." "fecha" => "2021" "volumen" => "113" "paginaInicial" => "1221" "paginaFinal" => "1232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33007398" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Galván Casas" 1 => "A. Català" 2 => "G. Carretero Hernández" 3 => "P. Rodríguez-Jiménez" 4 => "D. Fernández-Nieto" 5 => "A.G. Rodríguez-Villa Lario" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.19163" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2020" "volumen" => "183" "paginaInicial" => "71" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32348545" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "May 2021: heterogeneity in reported skin manifestations of COVID-19 and vaccines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Kantor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2021.03.022" "Revista" => array:4 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2021" "volumen" => "84" "paginaInicial" => "1251" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review of SARS-CoV-2 vaccine candidates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Dong" 1 => "T. Dai" 2 => "Y. Wei" 3 => "L. Zhang" 4 => "M. Zheng" 5 => "F. Zhou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41392-020-00352-y" "Revista" => array:5 [ "tituloSerie" => "Signal Transduct Target Ther." "fecha" => "2020" "volumen" => "5" "paginaInicial" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33051445" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant protein vaccines, a proven approach against coronavirus pandemics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Pollet" 1 => "W.-H. Chen" 2 => "U. Strych" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.addr.2021.01.001" "Revista" => array:6 [ "tituloSerie" => "Adv Drug Deliv Rev." "fecha" => "2021" "volumen" => "170" "paginaInicial" => "71" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33421475" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The how’s and what’s of vaccine reactogenicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Hervé" 1 => "B. Laupèze" 2 => "G. del Giudice" 3 => "A.M. Didierlaurent" 4 => "F. Tavares da Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41541-019-0132-6" "Revista" => array:5 [ "tituloSerie" => "Npj Vaccines." "fecha" => "2019" "volumen" => "4" "paginaInicial" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31583123" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "EMA European Medicines Agency. Vaxzevria (previously COVID-19 Vaccine AstraZeneca). Available from: <a target="_blank" href="https://www.ema.europa.eu/en/medicines/human/EPAR/vaxzevria-previously-covid-19-vaccine-astrazeneca">https://www.ema.europa.eu/en/medicines/human/EPAR/vaxzevria-previously-covid-19-vaccine-astrazeneca</a> [Accessed 01 April 2021]." ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "EMA European Medicines Agency. EMA recommends COVID-19 Vaccine Janssen for authorisation in the EU. Available from: https://www.ema.europa.eu/en/news/ema-recommends-covid-19-vaccine-janssen-authorisation-eu [Accessed 01 April 2021]." ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.P. Polack" 1 => "S.J. Thomas" 2 => "N. Kitchin" 3 => "J. Absalon" 4 => "A. Gurtman" 5 => "S. Lokhart" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa2034577" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2020" "volumen" => "383" "paginaInicial" => "2603" "paginaFinal" => "2615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33301246" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.R. Baden" 1 => "H.M. El Sahly" 2 => "B. Essink" 3 => "K. Kotloff" 4 => "S. Frey" 5 => "R. Novak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa2035389" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2021" "volumen" => "384" "paginaInicial" => "403" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33378609" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Recher" 1 => "J.R. Hirsiger" 2 => "M.B. Bigler" 3 => "M. Iff" 4 => "B. Lemaître" 5 => "K. Scherer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41541-018-0059-3" "Revista" => array:5 [ "tituloSerie" => "Npj Vaccines." "fecha" => "2018" "volumen" => "3" "paginaInicial" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29796310" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polyethylene glycol and polysorbate skin testing in the evaluation of COVID-19 vaccine reactions: early report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.M. Pitlick" 1 => "A.N. Sitek" 2 => "S.A. Kinate" 3 => "A.Y. Joshi" 4 => "M.A. Park" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anai.2021.03.012" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol." "fecha" => "2021" "volumen" => "126" "paginaInicial" => "735" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33775902" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“COVID arm”: a reaction to the moderna vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Wei" 1 => "M. Fishman" 2 => "D. Wattenberg" 3 => "M. Gordon" 4 => "M. Lebwohl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdcr.2021.02.014" "Revista" => array:6 [ "tituloSerie" => "JAAD Case Rep." "fecha" => "2021" "volumen" => "10" "paginaInicial" => "92" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33748377" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.G. Blumenthal" 1 => "E.E. Freeman" 2 => "R.R. Saff" 3 => "L.B. Robinson" 4 => "A.R. Wolfson" 5 => "R.K. Foreman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMc2102131" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med." "fecha" => "2021" "volumen" => "84" "paginaInicial" => "1273" "paginaFinal" => "1277" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin manifestations of the BNT162b2 mRNA COVID-19 vaccine in healthcare workers. “COVID-arm”: a clinical and histological characterization" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Fernandez-Nieto" 1 => "J. Hammerle" 2 => "M. Fernandez-Escribano" 3 => "C.M. Moreno-del-Real" 4 => "P. García-Abellas" 5 => "I. Carretero-Barrio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17250" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retrospective review of delayed adverse events secondary to treatment with a smooth, cohesive 20-mg/mL hyaluronic acid filler in 4500 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Humphrey" 1 => "D.H. Jones" 2 => "J.D. Carruthers" 3 => "A. Carruthers" 4 => "K. Beleznay" 5 => "N. Wesley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2020.01.066" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2020" "volumen" => "83" "paginaInicial" => "86" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32035107" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypersensitivity reaction to hyaluronic acid dermal filler following novel coronavirus infection—a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Rowland-Warmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jocd.14074" "Revista" => array:2 [ "tituloSerie" => "J Cosmet Dermatol." "fecha" => "2021" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.G. Munavalli" 1 => "R. Guthridge" 2 => "S. Knutsen-Larson" 3 => "A. Brodsky" 4 => "E. Matthew" 5 => "M. Landau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00403-021-02190-6" "Revista" => array:4 [ "tituloSerie" => "Arch Dermatol Res." "fecha" => "2021" "paginaInicial" => "1" "paginaFinal" => "15" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II–induced cutaneous inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.G. Munavalli" 1 => "S. Knutsen-Larson" 2 => "M.P. Lupo" 3 => "R.G. Geronemus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jdcr.2021.02.018" "Revista" => array:6 [ "tituloSerie" => "JAAD Case Rep." "fecha" => "2021" "volumen" => "10" "paginaInicial" => "63" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33681439" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent maculopapular rash after the first dose of Pfizer-BioNTech COVID-19 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Ackerman" 1 => "D. Henry" 2 => "A. Finon" 3 => "R. Binois" 4 => "E. Esteve" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17248" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 “second wave” and vaccines: the dermatologists’ perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Burlando" 1 => "R. Russo" 2 => "E. Cozzani" 3 => "A. Parodi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.15547" "Revista" => array:2 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2021" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lichen planus arising after COVID-19 vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Hiltun" 1 => "J. Sarriugarte" 2 => "I. Martínez-de-Espronceda" 3 => "A. Garcés" 4 => "C. Llanos" 5 => "R. Vives" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17221" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prompt onset of erythema multiforme following the first BNT162b2 SARS-CoV-2 vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Gambichler" 1 => "L. Scholl" 2 => "L. Ocker" 3 => "R. Stranzenbach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17225" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Herpes zoster following inactivated COVID-19 vaccine: a coexistence or coincidence?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Bostan" 1 => "B. Yalici-Armagan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jocd.14035" "Revista" => array:2 [ "tituloSerie" => "J Cosmet Dermatol." "fecha" => "2021" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.E. McMahon" 1 => "E. Amerson" 2 => "M. Rosenbach" 3 => "J. Lipoff" 4 => "D. Moustafa" 5 => "A. Tyagi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2021.03.092" "Revista" => array:2 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2021" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique, Spain, January and February 2021" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Fernández-Prada" 1 => "I. Rivero-Calle" 2 => "A. Calvache-González" 3 => "F. Martinón-Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2807/1560-7917.ES.2021.26.10.2100193" "Revista" => array:3 [ "tituloSerie" => "Eurosurveillance." "fecha" => "2021" "volumen" => "26" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US—December 14, 2020–January 18, 2021" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.T. Shimabukuro" 1 => "M. Cole" 2 => "J.R. Su" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2021.1967" "Revista" => array:4 [ "tituloSerie" => "JAMA." "fecha" => "2021" "volumen" => "325" "paginaInicial" => "1101" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient cutaneous manifestations after administration of Pfizer-BioNTech COVID-19 vaccine: an Italian single-centre case series" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Corbeddu" 1 => "A. Diociaiuti" 2 => "M.R. Vinci" 3 => "A. Santoro" 4 => "V. Camisa" 5 => "S. Zaffina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17268" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases—practical recommendations. A position statement of ETFAD with external experts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Ring" 1 => "M. Worm" 2 => "A. Wollenberg" 3 => "J.P. Thyssen" 4 => "T. Jakob" 5 => "L. Klimek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17237" "Revista" => array:2 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of action of mRNA-based vaccines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Iavarone" 1 => "D.T. O’hagan" 2 => "D. Yu" 3 => "N.F. Delahaye" 4 => "J.B. Ulmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/14760584.2017.1355245" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Vaccines." "fecha" => "2017" "volumen" => "16" "paginaInicial" => "871" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28701102" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in mRNA vaccines for infectious diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Zhang" 1 => "G. Maruggi" 2 => "H. Shan" 3 => "J. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fimmu.2019.00594" "Revista" => array:5 [ "tituloSerie" => "Front Immunol." "fecha" => "2019" "volumen" => "10" "paginaInicial" => "594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30972078" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib166" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous reactions after SARS-COV-2 vaccination: A cross-sectional Spanish nationwide study of 405 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Català" 1 => "C. Muñoz-Santos" 2 => "C. Galván-Casas" 3 => "M. Roncero Riesco" 4 => "D. Revilla Nebreda" 5 => "A. Solá-Truyols" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.20639" "Revista" => array:2 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2021" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack560501" "titulo" => "Acknowledgments" "texto" => "The authors would like to thank the Spanish Academy of Dermatology for its support, Álvaro Frías Sánchez for the graphics, and José Luis Martínez Amo for allowing the use of <a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002407/v1_202110091021/en/main.assets" "Apartado" => array:4 [ "identificador" => "6170" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Novelties in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000009/v1_202110091021/S1578219021002407/v1_202110091021/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002407?idApp=UINPBA000044"]

Statistics

Novelties in Dermatology

SARS-CoV-2 Vaccines and the Skin

Vacunas frente a SARS-CoV-2 y piel

C. Galván-Casasa,

Corresponding author

galvancasascristina@gmail.com

Corresponding author.

, A. Catalàb, C. Muñoz-Santosc

a Servicio de Dermatología, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain

b Servicio de Dermatología, Sede Plató, Hospital Clínic, Barcelona, Spain

c Servicio de Dermatología, Hospital General de Granollers, Granollers, Barcelona, Spain

Read

8737

Times
was read the article

2101

Total PDF

6636

Total HTML

Share statistics

 array:24 [
  "pii" => "S1578219021002407"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2021.07.028"
  "estado" => "S300"
  "fechaPublicacion" => "2021-10-01"
  "aid" => "2680"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "rev"
  "cita" => "Actas Dermosifiliogr. 2021;112:828-36"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0001731021002039"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2021.05.011"
      "estado" => "S300"
      "fechaPublicacion" => "2021-10-01"
      "aid" => "2680"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "rev"
      "cita" => "Actas Dermosifiliogr. 2021;112:828-36"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:14 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Novedades en Dermatolog&#237;a</span>"
        "titulo" => "Vacunas frente a SARS-CoV-2 y piel"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:3 [
          0 => "es"
          1 => "es"
          2 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "828"
            "paginaFinal" => "836"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "SARS-CoV-2 Vaccines and the Skin"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 1
          "multimedia" => array:5 [
            "identificador" => "fig0030"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => false
            "mostrarDisplay" => true
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "fx1.jpeg"
                "Alto" => 594
                "Ancho" => 1333
                "Tamanyo" => 113821
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Galv&#225;n-Casas, A&#46; Catal&#224;, C&#46; Mu&#241;oz-Santos"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Galv&#225;n-Casas"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Catal&#224;"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Mu&#241;oz-Santos"
              ]
            ]
          ]
        ]
        "resumen" => array:1 [
          0 => array:3 [
            "titulo" => "Graphical abstract"
            "clase" => "graphical"
            "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>"
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219021002407"
          "doi" => "10.1016/j.adengl.2021.07.028"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002407?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002039?idApp=UINPBA000044"
      "url" => "/00017310/0000011200000009/v1_202110020514/S0001731021002039/v1_202110020514/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219021002377"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2021.07.025"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "2611"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2021;112:837-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Practical Dermoscopy</span>"
      "titulo" => "Millimetric Papule on the Antihelix Dermoscopically Constituted by Hairpin Vessels in a Radial Pattern"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "837"
          "paginaFinal" => "838"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#225;pula milim&#233;trica en anteh&#233;lix constituida dermatosc&#243;picamente por corona de vasos en horquilla"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1110
              "Ancho" => 2083
              "Tamanyo" => 378613
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Clinical presentation of the lesion on the right antihelix&#46; B&#44; Dermoscopic image of the lesion using contact dermoscopy and 60&#215; magnification &#40;image acquisition was very difficult given the very small size of the lesion&#41;&#46; Slightly whiteish central area without structure &#40;&#42;&#41; and radially distributed hairpin vessels &#40;&#94;&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Martin-Gorgojo, F&#46;J&#46; Bru-Gorraiz, E&#46; Pascual-Rodr&#237;guez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martin-Gorgojo"
            ]
            1 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Bru-Gorraiz"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Pascual-Rodr&#237;guez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173102100106X"
        "doi" => "10.1016/j.ad.2020.02.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102100106X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002377?idApp=UINPBA000044"
    "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002377/v1_202110091021/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219021002158"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2021.07.015"
    "estado" => "S300"
    "fechaPublicacion" => "2021-10-01"
    "aid" => "2679"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2021;112:817-27"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Characterization and Outcomes in Patients Treated With Apremilast in Routine Clinical Practice in Spain&#58; Results From the APPRECIATE Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "817"
          "paginaFinal" => "827"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Caracterizaci&#243;n y resultados de pacientes tratados con apremilast en la pr&#225;ctica cl&#237;nica habitual espa&#241;ola&#58; resultados del estudio APPRECIATE"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1425
              "Ancho" => 2556
              "Tamanyo" => 179232
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Main reasons for considering apremilast treatment&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Herranz, L&#46; Trasobares, A&#46; Mateu, E&#46; Mart&#237;nez, R&#46; Ruiz-Villaverde, O&#46; Baniandr&#233;s, J&#46; Mataix D&#237;az, N&#46; Jim&#233;nez-G&#243;mez, M&#46; Serra, D&#46;P&#46; Ruiz Genao, N&#46; Rivera, J&#46; Tercedor-S&#225;nchez, C&#46; Garcia, M&#46; Cordey, E&#46; Herrera-Acosta"
          "autores" => array:15 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Herranz"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Trasobares"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mateu"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Mart&#237;nez"
            ]
            4 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            5 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "Baniandr&#233;s"
            ]
            6 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Mataix D&#237;az"
            ]
            7 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Jim&#233;nez-G&#243;mez"
            ]
            8 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Serra"
            ]
            9 => array:2 [
              "nombre" => "D&#46;P&#46;"
              "apellidos" => "Ruiz Genao"
            ]
            10 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Rivera"
            ]
            11 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            12 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Garcia"
            ]
            13 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Cordey"
            ]
            14 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Herrera-Acosta"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731021002027"
        "doi" => "10.1016/j.ad.2021.05.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002027?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002158?idApp=UINPBA000044"
    "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002158/v1_202110091021/en/main.assets"
  ]
  "en" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Novelties in Dermatology</span>"
    "titulo" => "SARS-CoV-2 Vaccines and the Skin"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "828"
        "paginaFinal" => "836"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Galv&#225;n-Casas, A&#46; Catal&#224;, C&#46; Mu&#241;oz-Santos"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "Galv&#225;n-Casas"
            "email" => array:1 [
              0 => "galvancasascristina@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Catal&#224;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Mu&#241;oz-Santos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de M&#243;stoles&#44; M&#243;stoles&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Sede Plat&#243;&#44; Hospital Cl&#237;nic&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General de Granollers&#44; Granollers&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Vacunas frente a SARS-CoV-2 y piel"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 2015
            "Ancho" => 2925
            "Tamanyo" => 442881
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Decision algorithm&#46; Reactions to COVID-19 vaccines&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The lessons learned from other epidemics &#40;Ebola&#44; SARS-CoV&#44; and MERS-CoV&#41; and the international coordination of the knowledge generated have facilitate the global response to the COVID-19 pandemic&#46; The COVID-NMA international research initiative&#44; which arose from the WHO R&#38;D plan&#44; has facilitated the joint evaluation of a large number of clinical trials and of evidence on prevention&#44; treatment&#44; and vaccines for the disease&#46; This has made it possible to gain knowledge&#44; make decisions&#44; and achieve a vaccine&#44; the essential tool for controlling the pandemic&#44; in record time<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although such vaccines were being developed&#44; to date&#44; no effective vaccine had been used in humans against coronaviruses &#40;CoV&#41;&#46; Preclinical development was reached with SARS-CoV but was halted due to the disappearance of the virus as a health threat&#46; But the similarity of the gene sequences of SARS-CoV-2 and SARS-CoV<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reduced the time given over to design&#46; Phase <span class="elsevierStyleSmallCaps">I</span>&#47;<span class="elsevierStyleSmallCaps">II</span> clinical trials soon began and&#44; based on the intermediate analysis of the results phase <span class="elsevierStyleSmallCaps">II</span> trials were begun more quickly and with parallel trials&#46; Before the studies were completed&#44; production of several candidate vaccines had already begun&#46; All this made it possible to have the vaccines available to inoculate the population with unimaginable speed<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The novel technology used and the speed of the process does not mean that the necessary safety controls were ignored&#46; But it was to be expected&#44; as we are seeing&#44; that with clinical use&#44; adverse effects would appear that were not found or were not sufficiently categorized during the preclinical phase&#46; Cutaneous manifestations and their categorization were important for understanding the disease<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#44; in the same way that those caused by the vaccines may be<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; In many of these dermatologic manifestations associated with COVID-19&#44; no sign was found of the virus or its direct cytopathic action&#44; and they may be linked to the host immune response&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The authorization documents of all the available vaccines mentions the presence of dermatologic adverse effects and&#44; after their clinical use&#44; publications of various skin reactions continue to appear&#46; As dermatologists&#44; it is important to understand the characteristics of the different types of vaccine&#44; their interaction with the host&#44; and the range of systemic and dermatologic reactions that we may find&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">SARS-CoV-2 Vaccines</span><p id="par0025" class="elsevierStylePara elsevierViewall">SARS-CoV-2 enters the host cell by binding to the angiotensin converting enzyme 2 &#40;ACE2&#41; by means of its surface spike &#40;S&#41; protein&#46; The release of RNA leads to replication&#44; transcription&#44; and synthesis of viral RNA and the resulting structural proteins &#40;viral RNA&#44; nucleocapsid &#91;N&#93;&#44; membrane &#91;M&#93;&#44; envelope &#91;E&#93;&#44; and S&#41; form the mature virion&#44; which can escape the host cell to infect others&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In the host&#44; SARS-CoV-2 induces an innate immune response&#44; with the participation of IFN-I and other proinflammatory cytokines&#44; and an adaptive immune response&#44; in which T CD4&#43; and CD8&#43; lymphocytes react against the viral proteins S&#44; M&#44; and N&#44; Nsp&#44; and ORF3a&#46; In the mucosa of the upper respiratory tract&#44; contact with the virus induces the formation of secretory IgA&#46; At the systemic level&#44; IgG specifies against the S protein and the protein of its receptor-binding domain &#40;RBD&#41; is recruited from the serum to the lower respiratory tract&#46; The responses of serum IgM and IgA are less intense<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;6</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The vaccines train the immune system using harmless SARS-CoV-2 antigens to stimulate an immune response without causing disease&#46; Following intramuscular administration&#44; they essentially induce humoral immunity but are not able to improve the local response&#46; Those administered intranasally induce a potentially sterilizing lgA-dependent local immunity but induce less effective systemic immunity&#46; Some vaccines use adjuvants to activate the cell receptors and induce an innate immune response locally and in the regional lymph nodes&#44; or to polarize the type of immune response desired&#46; They improve the immune response but they also increase reactions to the vaccine<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a>&#46; Both inactivated-virus vaccines and protein-based viruses are formulated with adjuvants&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Each vaccine introduces one type of antigen&#44; triggering a specific immune response that&#44; in turn&#44; generates the immune memory that makes it possible to combat SARS-CoV-2 in the event of future exposure&#46; This antigen is processed by the antigen-presenting cells and is presented to the CD8&#43; and CD4&#43; T cells&#46; Th1 cytokines also stimulate the CD8&#43; T cells and Th2 cytokines induce the production of neutralizing antibodies by the B cells&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All the vaccines induce some level of inflammation triggered by the activation of the innate immune response<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; The imbalance of these responses may give rise to inflammatory reactions<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#44; which can manifest in the skin&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Anti-protein S antibodies inhibit the SARS-CoV-2&#8211;ACE-2 bond and the development of vaccines has thus focused on antigens derived from the S protein&#46; The different forms used by the vaccines to introduce the antigen are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; And the different characteristics of the main vaccines available and under development are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Reactogenicity of the Vaccines</span><p id="par0055" class="elsevierStylePara elsevierViewall">Reactogenicity or the physical manifestation of the inflammatory response may present as a local reaction at the injection site &#40;pain&#44; heat&#44; reddening&#44; swelling&#44; hardness&#41; and&#47;or with systemic symptoms &#40;fever&#44; myalgia&#44; headache&#44; etc&#46;&#41;&#46; The sequence of reactions induced from the moment of contact with the vaccine are shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The tolerability and immunogenicity profile of the vaccines varies depending on the type of antigen and the adjuvant used&#46; RNA vaccines &#40;potent activator of the innate immune response&#41; induce frequent&#44; though mild&#44; adverse reactions&#46; Other factors that modify these effects are age &#40;more reactogenicity in young people&#41;&#44; a high body mass index &#40;perhaps linked to a poor subcutaneous injection technique&#41;&#44; pre-existing immunity&#44; the route and site of administration&#44; the injection technique&#44; sex &#40;more reactogenicity in women&#41;&#44; some genetic and racial factors&#44; and anxiety&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Adverse Effects of the COVID-19 Vaccines</span><p id="par0065" class="elsevierStylePara elsevierViewall">The clinical trials prior to approval of the available vaccines notified adverse effects&#44; including skin reactions&#44; sometimes with few details&#44; which are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a><a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Cutaneous adverse effects published after the vaccine reached the market are&#44; partly&#44; the same as those described in the clinical trials&#46; These include the following&#58;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">COVID-Arm &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall">This is the most commonly reported reaction&#46; It involves the appearance of erythematous&#44; edematous plaques of different sizes in the area where the vaccine was administered&#46; These eruptions have been described with other vaccines&#44; such as the combined pneumococcal vaccine<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The first published cases<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> appeared between 7 and 10 days after the first dose of the Moderna&#174; vaccine&#44; which was initially attributed to a hypersensitive reaction to the polyethylene glycol contained in the vaccine&#46; In another series&#44; however&#44; the intradermal test with polyethylene glycol-polysorbate was only positive in one patient with a reaction that appeared only after the second dose&#46; This does not support an IgE-mediated reaction to these compounds as a cause<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46; Another study supports a delayed or T-cell mediated hypersensitivity reaction as a cause&#44; based on the histopathology that showed the presence of superficial perivascular and perifollicular lymphocytic infiltrates with mastocytes and disperse eosinophils<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; A retrospective study analyzed the cutaneous reactions in a group of health workers vaccinated with the Pfizer&#174; vaccine&#46; A delayed local reaction was observed in 2&#46;1&#37;&#44; after both the first and second dose&#46; As reported in other series&#44; in half of cases&#44; the reaction was repeated after the second dose&#46; Two were biopsied and a superficial and deep perivascular lymphocyte infiltrate was found&#44; with dilated vessels&#44; intraluminal neutrophils&#44; and immune staining negative for the SARS-CoV-2 spike protein 1A9<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">All reported cases resolved with conservative treatment&#44; such as local application of cold&#44; topical corticosteroids&#44; and&#47;or antihistamines&#46; No severe adverse reactions have been reported following the second dose and changing the guidelines is therefore not recommended&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Inflammatory Reactions in Areas With Hyaluronic Acid Dermal Filler &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;</span><p id="par0090" class="elsevierStylePara elsevierViewall">The appearance of erythema&#44; edema&#44; and nodules in areas that had previously been subjected to dermal fillers following processes such as viral infections or vaccines is well known<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#44; and this has also been described in coincidence with SARS-CoV-2 infection and in some isolated cases after vaccination against COVID-19<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a>&#46; Taking into account the number of vaccines administered globally and the number of people who have dermal fillers&#44; it seems likely that the frequency is very low<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">A suggested pathophysiological mechanism is a cascade of events that begins with deficient phagocytosis of the hyaluronic acid&#44; formation of a biofilm around the filler material&#44; activation of T cells&#44; and formation of fibrosis and granulomas&#46; These alterations favor the presence of Th1&#47;CD8&#43; T cells and the high concentrations of ACE2 in the resident cells&#46; This would lead to abnormal regulation between the production of proinflammatory angiotensin <span class="elsevierStyleSmallCaps">II</span> and anti-inflammatory angiotensin <span class="elsevierStyleSmallCaps">I</span>&#46; The binding of the S protein to ACE2&#44; induced by the vaccine&#44; would tilt the balance toward inflammation&#46; In 5 cases&#44; this hypothesis justified treatment of these reactions by blocking the angiotensin <span class="elsevierStyleSmallCaps">II</span> with an ACE inhibitor&#44; with good results&#46; The authors recommend lisinopril 5&#160;mg&#47;d&#44; doubling the dosage if no improvement is achieved in 72&#160;h and pretreatment before the second dose of the vaccine of patients who presented this complication after the first dose&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">It is important to bear in mind that&#44; although there are currently few cases&#44; all those reported have evolved favorably regardless of the prescribed treatment&#44; which has been highly diverse&#46; Cases have been reported that were treated with systemic antihistamines&#44; antibiotics&#44; or corticosteroids&#44; intralesional corticosteroids and 5-fluorouracil&#44; and injections of hyaluronidase&#46; A more thorough understanding and broader experience are doubtless necessary before reaching conclusions&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Other Cutaneous Eruptions</span><p id="par0105" class="elsevierStylePara elsevierViewall">As with COVID-19&#44; a wide variety of cutaneous manifestations have been reported coinciding with vaccination and with no other apparent cause&#46; Morbilliform eruptions<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#44; urticarial eruptions<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#44; maculopapular eruptions<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#44; lichen planus<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a>&#44; erythema multiforme<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#44; and reactivations of herpes zoster<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&#46; These data corroborate the recent publication of 414 reactions following the Moderna&#174; and Pfizer&#174; vaccines reported by different health care professionals through the register of SARS-CoV-2 cutaneous manifestations of the American Academy of Dermatology&#46; No severe reactions were found and half of patients with reactions following the first dose did not present these reactions after the second dose&#46; Different reactions have been added&#44; which were observed both after the first dose and after the second dose&#44; such as erythromelalgia and perniosis<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Other Manifestations</span><p id="par0110" class="elsevierStylePara elsevierViewall">Self-limiting enlarged supraclavicular lymph nodes have been reported and have been linked to the injection at an inappropriate site&#44; higher than recommended &#40;2&#8211;3 fingers below the acromion&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> and rare anaphylactic reactions with no fatalities<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> but in a higher percentage than with the usual vaccines &#40;4&#46;2 cases per million compared to 1 case per million&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The CDC has issued recommendations for mRNA vaccines&#44; about when to give a green light&#44; take precautions&#44; or avoid administering them&#44; which are summarized in <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#46; Although most patients who have had anaphylactic reactions have a history of allergies<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&#44; atopic patients with rash and with eczema&#44; while they should be correctly treated at the moment of vaccination&#44; should not delay vaccination&#44; and do not have an increased risk of severe allergic reactions<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a>&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">COVID-19 Vaccines-Skin Study</span><p id="par0120" class="elsevierStylePara elsevierViewall">As occurred with the COVID-19 emergency&#44; the mass administration to the population of a newly created vaccine and technology is bringing to light a wide variety of cutaneous manifestations&#46; As dermatologists&#44; it is our mission to be watchful&#44; to analyze&#44; categorize&#44; evaluate the significance and the consequences of each manifestation&#44; and communicate our findings to the pharmacovigilance bodies and to the scientific community&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">With this goal and with the support of the Spanish Academy of Dermatology&#44; may dermatologists in Spain have proposed recording as many dermatologic adverse effects as possible&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">At present&#44; most of the cases reported correspond to women and to the Pfizer vaccine&#174;&#46; A similar number of effects has been reported after the first dose and after the second dose&#46; The most frequent manifestations are covid-arm&#44; urticarial eruptions&#44; and reactivation of herpes zoster<a class="elsevierStyleCrossRef" href="#bib166"><span class="elsevierStyleSup">34</span></a>&#46; Information&#58; <a href="http://vacunascovidpiel@gmail.com">vacunascovidpiel&#64;gmail&#46;com</a>&#59; <a href="https://aedv.es/reacciones-cutaneas-tras-la-administracion-de-vacunas-frente-a-sars-cov-2/">https&#58;&#47;&#47;aedv&#46;es&#47;reacciones-cutaneas-tras-la-administracion-de-vacunas-frente-a-sars-cov-2&#47;</a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0135" class="elsevierStylePara elsevierViewall">The vaccines have a proven safety profile&#46; Nevertheless&#44; they do present systemic and local reactions that we should be aware of&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The correct categorization of cutaneous reactions to the vaccines will make it possible to provide adequate information to our patients&#44; prevent unnecessary rejection of vaccination&#44; reduce severe adverse effects in predisposed individuals&#44; and gain a deeper understanding of the pathophysiological mechanisms underlying the immune reaction to SARS-CoV-2&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This study has not received funding of any kind&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:14 [
        0 => array:3 [
          "identificador" => "xres1585954"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1427055"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1585953"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1427054"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "SARS-CoV-2 Vaccines"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Reactogenicity of the Vaccines"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Adverse Effects of the COVID-19 Vaccines"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "COVID-Arm &#40;Fig&#46; 3&#41;"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Inflammatory Reactions in Areas With Hyaluronic Acid Dermal Filler &#40;Fig&#46; 4&#41;"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Other Cutaneous Eruptions"
            ]
            3 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Other Manifestations"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "COVID-19 Vaccines-Skin Study"
        ]
        9 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conclusion"
        ]
        10 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Funding"
        ]
        11 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflicts of interest"
        ]
        12 => array:2 [
          "identificador" => "xack560501"
          "titulo" => "Acknowledgments"
        ]
        13 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-05-11"
    "fechaAceptado" => "2021-05-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1427055"
          "palabras" => array:4 [
            0 => "COVID-19"
            1 => "SARS-CoV-2 vaccines"
            2 => "Skin reactions"
            3 => "Vacines"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1427054"
          "palabras" => array:4 [
            0 => "COVID-19"
            1 => "Vacunas contra SARS-CoV-2"
            2 => "Vacunas"
            3 => "Reacciones cut&#225;neas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Vaccines against the severe acute respiratory coronavirus 2&#44; which are the first to be used in humans against any coronavirus&#44; were developed and produced in record time&#46; Dermatologic adverse effects appeared during clinical trials and have also been described in the population since approval&#46; Just as descriptions and categorization of skin manifestations of the coronavirus disease 2019 proved important for understanding the disease itself&#44; characterizing the effects of vaccines may also further that goal&#46; This paper reviews the properties of the different types of vaccines currently available and under development and describes how they interact with the immune system and the clinical signs they may cause&#46; We focus on dermatologic adverse effects reported to date and recommendations for managing them&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Las vacunas contra el SARS-CoV-2 son las primeras vacunas que han sido usadas en humanos contra coronavirus y su desarrollo se ha producido en un tiempo r&#233;cord&#46; En los an&#225;lisis de seguridad de los ensayos cl&#237;nicos previos a su aprobaci&#243;n y en la fase postautorizaci&#243;n en la poblaci&#243;n&#44; se han descrito efectos secundarios dermatol&#243;gicos&#46; La descripci&#243;n y categorizaci&#243;n de las manifestaciones cut&#225;neas de la COVID-19 fueron importantes para el conocimiento de la enfermedad y de la misma forma pueden serlo las generadas por las vacunas&#46; En este art&#237;culo hacemos un repaso a las caracter&#237;sticas de los diferentes tipos de vacunas disponibles y en desarrollo&#44; su modo de interacci&#243;n con el sistema inmune&#44; las consecuentes manifestaciones cl&#237;nicas que pueden generar&#44; con especial inter&#233;s en los efectos secundarios dermatol&#243;gicos hasta el momento descritos&#44; y las actitudes terap&#233;uticas recomendadas ante cada una de estas reacciones&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Galv&#225;n-Casas C&#44; Catal&#224; A&#44; Mu&#241;oz-Santos C&#46; Vacunas frente a SARS-CoV-2 y piel&#46; Actas Dermosifiliogr&#46; 2021&#59;112&#58;828&#8211;836&#46;</p>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2009
            "Ancho" => 2925
            "Tamanyo" => 621277
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Different ways in which vaccines are used to introduce an antigen&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1041
            "Ancho" => 2341
            "Tamanyo" => 328060
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Vaccine immunogenicity sequence&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1210
            "Ancho" => 755
            "Tamanyo" => 118820
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">COVID-Arm&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 587
            "Ancho" => 1255
            "Tamanyo" => 95318
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Late-onset inflammatory reaction in the area of dermal filler &#40;due to non-COVID vaccine&#41;&#46; Courtesy of Dr&#46; Jos&#233; Luis Mart&#237;nez Amo&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 2015
            "Ancho" => 2925
            "Tamanyo" => 442881
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Decision algorithm&#46; Reactions to COVID-19 vaccines&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0030"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of vaccine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Name&#47;company&#47;country&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Composition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Special characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Advantages&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Disadvantages&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inactivated SARS-CoV-2 viruses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CoronaVac&#174; &#40;Sinovac Biotech&#174;&#44; China&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SARS-CoV-2 cell culture and inactivation of the virus using chemical or physical methods &#40;formaldehyde&#44; heat&#44; or ultraviolet light&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">The immune response is aimed at S&#44; M&#44; E&#44; and N proteins&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Safer than attenuated live vaccines&#59; they cannot cause disease and generate fewer reactions&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They generate a weaker immune response&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Covaxin&#174; &#40;Bharat Biotech&#174;&#44; India&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They use adjuvants to potentiate their effect &#40;aluminium hydroxide&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Local reactions to aluminium hydroxide</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intramuscular administration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Viral vectors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaxzevria&#174; &#40;Oxford&#47;AstraZeneca&#174;&#44; United Kingdom&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They use another virus&#44; modified to express an antigen of SARS-CoV-2&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AstraZeneca uses a chimpanzee adenovirus designed to express S protein and modified to be unable to replicate in cells&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Conservation at normal refrigerator temperatures&#44; which facilitates logistics and distribution in developing countries&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Risk of loss of efficacy if neutralized by pre-existing immunity&#46; To prevent this&#44; the vaccine uses vectors that are rare in humans or with low immunogenic ability&#46;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ad26Cov2-S &#40;Janssen&#174;&#44; United States&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sputnik-V&#174; &#40;Gamaleya&#174;&#44; Russia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intramuscular administration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recombinant proteins</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NVX-CoV2373 &#40;Novavax&#174;&#41;&#44; United States</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They use artificially created proteins of the virus&#44; such as the receptor-binding domain &#40;RBD&#41; of the S protein&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obtained through genetic engineering&#44; supported by experience with other authorized vaccines &#40;hepatitis B&#44; HPV&#44; influenza&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Manufacturing is simpler</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They generate a weaker immune response&#46;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They use adjuvants to potentiate their effect &#40;MATRIX-M&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intramuscular administration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RNA vaccines</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BNT162&#47;Comirnaty&#174; &#40;Pfizer&#174;&#47;BioNTech&#174;&#44; Germany&#44; United States&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They contain messenger RNA &#40;mRNA&#41; that teaches the cells to produce the protein that triggers an immune response to infection &#40;it induces ribosomal production of proteins that code for the antigen&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">More frequent adverse reactions &#40;mRNA is a potent immunity activator&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They are not able to produce disease &#40;like attenuated-virus vaccines&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Instability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRNA 1273 &#40;Moderna&#174;&#44; United States&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Self-replicating RNA vaccines contain an RNA-polymerase complex that amplifies the mRNA and produces a larger amount of antigen&#46;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Particular precaution in people with a history of allergies and anaphylaxis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They are not able to form part of the host genome &#40;like DNA vaccines&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difficult conservation conditions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intramuscular administration</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They generate a stronger and longer-lasting immune response&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ability to stimulate the innate immune system&#44; with production of INF1 and eventual reduction of efficacy<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32&#44;33</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">They stimulate the innate immune system&#46; mRNA and lipid carriers act as an adjuvant&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2716698.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Comparative characteristics of the different types of vaccine&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0035"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Systemic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Very frequent&#58; headache&#44; fatigue&#44; and joint pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less frequent&#58; fever&#44; enlarged lymph nodes&#44; nausea&#47;vomiting&#44; diarrhea&#44; and chills&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>With the Moderna&#174; and Pfizer&#174; vaccines&#44; they are more frequent after the second dose and with the AstraZeneca&#174; vaccine&#44; they are more frequent after the first dose&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Local</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Extremely frequent&#58; pain and sensitivity at the injection site &#40;84&#46;2&#37; of participants after the first dose&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less frequent&#58; erythema and edema<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Local inflammation greater than 2&#46;5&#160;cm was considered an adverse effect and greater than 10&#160;cm was considered severe&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Delayed local reactions &#40;a week or more after the injection&#41; 0&#46;8&#37; of participants after the first dose&#59; 0&#46;2&#37; after the second dose&#46; &#40;Moderna&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Other cutaneous adverse effects</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Rosacea and cellulitis &#40;AstraZeneca&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Urticaria &#40;1&#41;&#44; maculopapular rash &#40;1&#41;&#44; non-anaphylactic hypersensitivity reactions &#40;1&#46;5&#37; of those vaccinated&#41; and edema at sites where dermal filler had been used &#40;3&#41; &#40;Moderna&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Non-anaphylactic hypersensitivity reactions in 0&#46;63&#37; &#40;Pfizer&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Urticaria &#40;5&#41; and urticaria with angioedema &#40;1&#41;&#44; 7 and 4 days after receiving the vaccine &#40;Janssen&#174;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2716697.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Adverse effects described in clinical trials&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:34 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SARS-CoV-2 vaccines in development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Krammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41586-020-2798-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature&#46;"
                        "fecha" => "2020"
                        "volumen" => "586"
                        "paginaInicial" => "516"
                        "paginaFinal" => "527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32967006"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The COVID-NMA project&#58; building an evidence ecosystem for the COVID-19 pandemic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Boutron"
                            1 => "A&#46; Chaimani"
                            2 => "J&#46;J&#46; Meerpohl"
                            3 => "A&#46; Hr&#243;bjartsson"
                            4 => "D&#46; Devane"
                            5 => "G&#46; Rada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/M20-5261"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med&#46;"
                        "fecha" => "2020"
                        "volumen" => "173"
                        "paginaInicial" => "1015"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32931326"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetics and genomics of SARS-CoV-2&#58; a review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Rahimi"
                            1 => "A&#46; Mirzazadeh"
                            2 => "S&#46; Tavakolpour"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ygeno.2020.09.059"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genomics&#46;"
                        "fecha" => "2021"
                        "volumen" => "113"
                        "paginaInicial" => "1221"
                        "paginaFinal" => "1232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33007398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of the cutaneous manifestations of <span class="elsevierStyleSmallCaps">COVID</span>-19&#58; a rapid prospective nationwide consensus study in Spain with 375 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Galv&#225;n Casas"
                            1 => "A&#46; Catal&#224;"
                            2 => "G&#46; Carretero Hern&#225;ndez"
                            3 => "P&#46; Rodr&#237;guez-Jim&#233;nez"
                            4 => "D&#46; Fern&#225;ndez-Nieto"
                            5 => "A&#46;G&#46; Rodr&#237;guez-Villa Lario"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.19163"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2020"
                        "volumen" => "183"
                        "paginaInicial" => "71"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32348545"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "May 2021&#58; heterogeneity in reported skin manifestations of COVID-19 and vaccines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Kantor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2021.03.022"
                      "Revista" => array:4 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "1251"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of SARS-CoV-2 vaccine candidates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Dong"
                            1 => "T&#46; Dai"
                            2 => "Y&#46; Wei"
                            3 => "L&#46; Zhang"
                            4 => "M&#46; Zheng"
                            5 => "F&#46; Zhou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41392-020-00352-y"
                      "Revista" => array:5 [
                        "tituloSerie" => "Signal Transduct Target Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "5"
                        "paginaInicial" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33051445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant protein vaccines&#44; a proven approach against coronavirus pandemics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Pollet"
                            1 => "W&#46;-H&#46; Chen"
                            2 => "U&#46; Strych"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.addr.2021.01.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Drug Deliv Rev&#46;"
                        "fecha" => "2021"
                        "volumen" => "170"
                        "paginaInicial" => "71"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33421475"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The how&#8217;s and what&#8217;s of vaccine reactogenicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Herv&#233;"
                            1 => "B&#46; Laup&#232;ze"
                            2 => "G&#46; del Giudice"
                            3 => "A&#46;M&#46; Didierlaurent"
                            4 => "F&#46; Tavares da Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41541-019-0132-6"
                      "Revista" => array:5 [
                        "tituloSerie" => "Npj Vaccines&#46;"
                        "fecha" => "2019"
                        "volumen" => "4"
                        "paginaInicial" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31583123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "EMA European Medicines Agency&#46; Vaxzevria &#40;previously COVID-19 Vaccine AstraZeneca&#41;&#46; Available from&#58; <a target="_blank" href="https://www.ema.europa.eu/en/medicines/human/EPAR/vaxzevria-previously-covid-19-vaccine-astrazeneca">https&#58;&#47;&#47;www&#46;ema&#46;europa&#46;eu&#47;en&#47;medicines&#47;human&#47;EPAR&#47;vaxzevria-previously-covid-19-vaccine-astrazeneca</a> &#91;Accessed 01 April 2021&#93;&#46;"
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "EMA European Medicines Agency&#46; EMA recommends COVID-19 Vaccine Janssen for authorisation in the EU&#46; Available from&#58; https&#58;&#47;&#47;www&#46;ema&#46;europa&#46;eu&#47;en&#47;news&#47;ema-recommends-covid-19-vaccine-janssen-authorisation-eu &#91;Accessed 01 April 2021&#93;&#46;"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;P&#46; Polack"
                            1 => "S&#46;J&#46; Thomas"
                            2 => "N&#46; Kitchin"
                            3 => "J&#46; Absalon"
                            4 => "A&#46; Gurtman"
                            5 => "S&#46; Lokhart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa2034577"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2020"
                        "volumen" => "383"
                        "paginaInicial" => "2603"
                        "paginaFinal" => "2615"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33301246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;R&#46; Baden"
                            1 => "H&#46;M&#46; El Sahly"
                            2 => "B&#46; Essink"
                            3 => "K&#46; Kotloff"
                            4 => "S&#46; Frey"
                            5 => "R&#46; Novak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa2035389"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2021"
                        "volumen" => "384"
                        "paginaInicial" => "403"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33378609"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Recher"
                            1 => "J&#46;R&#46; Hirsiger"
                            2 => "M&#46;B&#46; Bigler"
                            3 => "M&#46; Iff"
                            4 => "B&#46; Lema&#238;tre"
                            5 => "K&#46; Scherer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41541-018-0059-3"
                      "Revista" => array:5 [
                        "tituloSerie" => "Npj Vaccines&#46;"
                        "fecha" => "2018"
                        "volumen" => "3"
                        "paginaInicial" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29796310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polyethylene glycol and polysorbate skin testing in the evaluation of COVID-19 vaccine reactions&#58; early report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;M&#46; Pitlick"
                            1 => "A&#46;N&#46; Sitek"
                            2 => "S&#46;A&#46; Kinate"
                            3 => "A&#46;Y&#46; Joshi"
                            4 => "M&#46;A&#46; Park"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.anai.2021.03.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Allergy Asthma Immunol&#46;"
                        "fecha" => "2021"
                        "volumen" => "126"
                        "paginaInicial" => "735"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33775902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;COVID arm&#8221;&#58; a reaction to the moderna vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Wei"
                            1 => "M&#46; Fishman"
                            2 => "D&#46; Wattenberg"
                            3 => "M&#46; Gordon"
                            4 => "M&#46; Lebwohl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2021.02.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAAD Case Rep&#46;"
                        "fecha" => "2021"
                        "volumen" => "10"
                        "paginaInicial" => "92"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33748377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;G&#46; Blumenthal"
                            1 => "E&#46;E&#46; Freeman"
                            2 => "R&#46;R&#46; Saff"
                            3 => "L&#46;B&#46; Robinson"
                            4 => "A&#46;R&#46; Wolfson"
                            5 => "R&#46;K&#46; Foreman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMc2102131"
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "1273"
                        "paginaFinal" => "1277"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin manifestations of the BNT162b2 mRNA COVID-19 vaccine in healthcare workers&#46; &#8220;COVID-arm&#8221;&#58; a clinical and histological characterization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Fernandez-Nieto"
                            1 => "J&#46; Hammerle"
                            2 => "M&#46; Fernandez-Escribano"
                            3 => "C&#46;M&#46; Moreno-del-Real"
                            4 => "P&#46; Garc&#237;a-Abellas"
                            5 => "I&#46; Carretero-Barrio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17250"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retrospective review of delayed adverse events secondary to treatment with a smooth&#44; cohesive 20-mg&#47;mL hyaluronic acid filler in 4500 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Humphrey"
                            1 => "D&#46;H&#46; Jones"
                            2 => "J&#46;D&#46; Carruthers"
                            3 => "A&#46; Carruthers"
                            4 => "K&#46; Beleznay"
                            5 => "N&#46; Wesley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.01.066"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2020"
                        "volumen" => "83"
                        "paginaInicial" => "86"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32035107"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypersensitivity reaction to hyaluronic acid dermal filler following novel coronavirus infection&#8212;a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Rowland-Warmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jocd.14074"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Cosmet Dermatol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COVID-19&#47;SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers&#58; a challenging clinical conundrum in diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;G&#46; Munavalli"
                            1 => "R&#46; Guthridge"
                            2 => "S&#46; Knutsen-Larson"
                            3 => "A&#46; Brodsky"
                            4 => "E&#46; Matthew"
                            5 => "M&#46; Landau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00403-021-02190-6"
                      "Revista" => array:4 [
                        "tituloSerie" => "Arch Dermatol Res&#46;"
                        "fecha" => "2021"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II&#8211;induced cutaneous inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;G&#46; Munavalli"
                            1 => "S&#46; Knutsen-Larson"
                            2 => "M&#46;P&#46; Lupo"
                            3 => "R&#46;G&#46; Geronemus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2021.02.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAAD Case Rep&#46;"
                        "fecha" => "2021"
                        "volumen" => "10"
                        "paginaInicial" => "63"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33681439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent maculopapular rash after the first dose of Pfizer-BioNTech COVID-19 vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ackerman"
                            1 => "D&#46; Henry"
                            2 => "A&#46; Finon"
                            3 => "R&#46; Binois"
                            4 => "E&#46; Esteve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17248"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COVID-19 &#8220;second wave&#8221; and vaccines&#58; the dermatologists&#8217; perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Burlando"
                            1 => "R&#46; Russo"
                            2 => "E&#46; Cozzani"
                            3 => "A&#46; Parodi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.15547"
                      "Revista" => array:2 [
                        "tituloSerie" => "Int J Dermatol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lichen planus arising after COVID-19 vaccination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Hiltun"
                            1 => "J&#46; Sarriugarte"
                            2 => "I&#46; Mart&#237;nez-de-Espronceda"
                            3 => "A&#46; Garc&#233;s"
                            4 => "C&#46; Llanos"
                            5 => "R&#46; Vives"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17221"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prompt onset of erythema multiforme following the first BNT162b2 SARS-CoV-2 vaccination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Gambichler"
                            1 => "L&#46; Scholl"
                            2 => "L&#46; Ocker"
                            3 => "R&#46; Stranzenbach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17225"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Herpes zoster following inactivated COVID-19 vaccine&#58; a coexistence or coincidence&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Bostan"
                            1 => "B&#46; Yalici-Armagan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jocd.14035"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Cosmet Dermatol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination&#58; a registry-based study of 414 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;E&#46; McMahon"
                            1 => "E&#46; Amerson"
                            2 => "M&#46; Rosenbach"
                            3 => "J&#46; Lipoff"
                            4 => "D&#46; Moustafa"
                            5 => "A&#46; Tyagi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2021.03.092"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique&#44; Spain&#44; January and February 2021"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Fern&#225;ndez-Prada"
                            1 => "I&#46; Rivero-Calle"
                            2 => "A&#46; Calvache-Gonz&#225;lez"
                            3 => "F&#46; Martin&#243;n-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2807/1560-7917.ES.2021.26.10.2100193"
                      "Revista" => array:3 [
                        "tituloSerie" => "Eurosurveillance&#46;"
                        "fecha" => "2021"
                        "volumen" => "26"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US&#8212;December 14&#44; 2020&#8211;January 18&#44; 2021"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;T&#46; Shimabukuro"
                            1 => "M&#46; Cole"
                            2 => "J&#46;R&#46; Su"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2021.1967"
                      "Revista" => array:4 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "2021"
                        "volumen" => "325"
                        "paginaInicial" => "1101"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient cutaneous manifestations after administration of Pfizer-BioNTech COVID-19 vaccine&#58; an Italian single-centre case series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Corbeddu"
                            1 => "A&#46; Diociaiuti"
                            2 => "M&#46;R&#46; Vinci"
                            3 => "A&#46; Santoro"
                            4 => "V&#46; Camisa"
                            5 => "S&#46; Zaffina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17268"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases&#8212;practical recommendations&#46; A position statement of ETFAD with external experts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Ring"
                            1 => "M&#46; Worm"
                            2 => "A&#46; Wollenberg"
                            3 => "J&#46;P&#46; Thyssen"
                            4 => "T&#46; Jakob"
                            5 => "L&#46; Klimek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.17237"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of action of mRNA-based vaccines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Iavarone"
                            1 => "D&#46;T&#46; O&#8217;hagan"
                            2 => "D&#46; Yu"
                            3 => "N&#46;F&#46; Delahaye"
                            4 => "J&#46;B&#46; Ulmer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/14760584.2017.1355245"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Vaccines&#46;"
                        "fecha" => "2017"
                        "volumen" => "16"
                        "paginaInicial" => "871"
                        "paginaFinal" => "881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28701102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in mRNA vaccines for infectious diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Zhang"
                            1 => "G&#46; Maruggi"
                            2 => "H&#46; Shan"
                            3 => "J&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2019.00594"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol&#46;"
                        "fecha" => "2019"
                        "volumen" => "10"
                        "paginaInicial" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30972078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib166"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous reactions after SARS-COV-2 vaccination&#58; A cross-sectional Spanish nationwide study of 405 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Catal&#224;"
                            1 => "C&#46; Mu&#241;oz-Santos"
                            2 => "C&#46; Galv&#225;n-Casas"
                            3 => "M&#46; Roncero Riesco"
                            4 => "D&#46; Revilla Nebreda"
                            5 => "A&#46; Sol&#225;-Truyols"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.20639"
                      "Revista" => array:2 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack560501"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0155" class="elsevierStylePara elsevierViewall">The authors would like to thank the Spanish Academy of Dermatology for its support&#44; &#193;lvaro Fr&#237;as S&#225;nchez for the graphics&#44; and Jos&#233; Luis Mart&#237;nez Amo for allowing the use of <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002407/v1_202110091021/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6170"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Novelties in Dermatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000009/v1_202110091021/S1578219021002407/v1_202110091021/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002407?idApp=UINPBA000044"
]

Article information

ISSN: 15782190
Original language: English

DOI:10.1016/j.adengl.2021.07.028

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	17	7	24
2024 October	114	56	170
2024 September	117	36	153
2024 August	156	66	222
2024 July	104	44	148
2024 June	102	40	142
2024 May	93	49	142
2024 April	109	52	161
2024 March	89	28	117
2024 February	142	39	181
2024 January	96	47	143
2023 December	60	21	81
2023 November	106	44	150
2023 October	92	29	121
2023 September	66	23	89
2023 August	70	15	85
2023 July	87	33	120
2023 June	95	20	115
2023 May	104	35	139
2023 April	81	36	117
2023 March	92	50	142
2023 February	70	32	102
2023 January	91	32	123
2022 December	113	48	161
2022 November	88	48	136
2022 October	54	26	80
2022 September	52	52	104
2022 August	76	46	122
2022 July	53	45	98
2022 June	43	32	75
2022 May	155	59	214
2022 April	217	47	264
2022 March	239	94	333
2022 February	220	60	280
2022 January	388	85	473
2021 December	407	110	517
2021 November	452	102	554
2021 October	1730	159	1889
2021 September	179	243	422
2021 August	17	11	28

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter