was read the article
array:24 [ "pii" => "S157821902100233X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.021" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2608" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:845-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0001731021001034" "issn" => "00017310" "doi" => "10.1016/j.ad.2019.07.024" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2608" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:845-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imágenes en Dermatología</span>" "titulo" => "Síndrome de Noonan con lentiginosis: manifestaciones dermatológicas sutiles y claves" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "845" "paginaFinal" => "846" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Noonan Syndrome With Multiple Lentigines: Subtle Key Skin Clues to the Diagnosis" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1633 "Ancho" => 2175 "Tamanyo" => 491944 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen clínica. Obsérvese lentiginosis, queratosis pilar, cejas poco pobladas, <span class="elsevierStyleItalic">filtrum</span> nasal ancho, nariz bulbosa y pelo ensortijado.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Lozano-Masdemont, J. Rojas-Calva, M.T. Darnaude-Ortiz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Lozano-Masdemont" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Rojas-Calva" ] 2 => array:2 [ "nombre" => "M.T." "apellidos" => "Darnaude-Ortiz" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S157821902100233X" "doi" => "10.1016/j.adengl.2021.07.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821902100233X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021001034?idApp=UINPBA000044" "url" => "/00017310/0000011200000009/v1_202110020514/S0001731021001034/v1_202110020514/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219021002353" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.023" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2653" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2021;112:847-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident’s Forum</span>" "titulo" => "Noninvoluting Congenital Hemangiomas That Exhibit Postnatal Growth" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "847" "paginaFinal" => "848" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemangiomas congénitos no involutivos (NICH) con crecimiento postnatal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Boix-Vilanova, I. Gracia-Darder, A. Martín-Santiago" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Boix-Vilanova" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Gracia-Darder" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Martín-Santiago" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173102100171X" "doi" => "10.1016/j.ad.2019.09.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102100171X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002353?idApp=UINPBA000044" "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002353/v1_202110091021/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219021002080" "issn" => "15782190" "doi" => "10.1016/j.adengl.2021.07.008" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "2616" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:843-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Sudden appearance of a painful bluish nodule on the hand" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "843" "paginaFinal" => "844" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aparición súbita de un nódulo azulado doloroso en la mano" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 601 "Ancho" => 800 "Tamanyo" => 157236 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, ×100.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Batista, A. Brinca, R. Vieira" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Batista" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Brinca" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Vieira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731021001125" "doi" => "10.1016/j.ad.2019.09.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021001125?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002080?idApp=UINPBA000044" "url" => "/15782190/0000011200000009/v1_202110091021/S1578219021002080/v1_202110091021/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "Noonan Syndrome With Multiple Lentigines: Subtle Key Skin Clues to the Diagnosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "845" "paginaFinal" => "846" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "B. Lozano-Masdemont, J. Rojas-Calva, M.T. Darnaude-Ortiz" "autores" => array:3 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "Lozano-Masdemont" "email" => array:1 [ 0 => "belenmasdemont@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Rojas-Calva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M.T." "apellidos" => "Darnaude-Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Móstoles, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Universidad Rey Juan Carlos, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Genética, Hospital Universitario de Móstoles, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Noonan con lentiginosis: manifestaciones dermatológicas sutiles y claves" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1633 "Ancho" => 2175 "Tamanyo" => 491944 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image showing multiple lentigines, keratosis pilaris, sparse eyebrows, a broad nasal philtrum, bulbous nose, and curly hair.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 15-year-old woman was evaluated for generalized redness and roughness of the skin that had been present since childhood. She had congenital pulmonary valve stenosis, incomplete pyeloureteral duplication of the right kidney, and learning difficulties. Physical examination revealed multiple lentigines on the face and neck, about 100 melanocytic nevi, 4 nevus spilus-like spots, a depressed nasal bridge, and a broad philtrum (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Other notable findings included short stature; sparse eyebrows; follicular hyperkeratosis of the face, arms, and thighs; curly hair; and phototype IV. Family members did not present any diseases of interest and shared none of the aforementioned findings. A genetic study found that the patient was heterozygous for the c.1403 C>T (p.Thr486Met) mutation in PTPN11, which is associated with Noonan syndrome with multiple lentigines (formerly known as LEOPARD syndrome).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Bessis et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> prospectively collected data on skin alterations in 34 patients genetically diagnosed with Noonan syndrome with multiple lentigines. In addition to those described in our patient, the following signs can be observed: café noir spots, alopecia, temporary alopecia, ulerythema ophryogenes, palmoplantar hyperkeratosis, skin hypermobility, redundant skin in acral regions, ecchymosis, hyperhidrosis, and lymphedema.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0015" class="elsevierStylePara elsevierViewall">This work has not received any type of funding.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "Reference" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Lozano-Masdemont B, Rojas-Calva J, Darnaude-Ortiz MT. Síndrome de Noonan con lentiginosis: manifestaciones dermatológicas sutiles y claves. Actas Dermosifiliogr. 2021;112:845–846.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1633 "Ancho" => 2175 "Tamanyo" => 491944 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image showing multiple lentigines, keratosis pilaris, sparse eyebrows, a broad nasal philtrum, bulbous nose, and curly hair.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatological manifestations in Noonan syndrome: a prospective multicentric study of 129 patients positive for mutation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Bessis" 1 => "J. Miquel" 2 => "E. Bourrat" 3 => "C. Chiaverini" 4 => "F. Morice-Picard" 5 => "C. Abadie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.17404" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2019" "volumen" => "180" "paginaInicial" => "1438" "paginaFinal" => "1448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30417923" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011200000009/v1_202110091021/S157821902100233X/v1_202110091021/en/main.assets" "Apartado" => array:4 [ "identificador" => "41141" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000009/v1_202110091021/S157821902100233X/v1_202110091021/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821902100233X?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 10 | 13 | 23 |
2024 October | 93 | 56 | 149 |
2024 September | 95 | 44 | 139 |
2024 August | 115 | 53 | 168 |
2024 July | 95 | 42 | 137 |
2024 June | 100 | 31 | 131 |
2024 May | 135 | 39 | 174 |
2024 April | 90 | 30 | 120 |
2024 March | 111 | 32 | 143 |
2024 February | 76 | 42 | 118 |
2024 January | 70 | 39 | 109 |
2023 December | 68 | 16 | 84 |
2023 November | 91 | 35 | 126 |
2023 October | 68 | 22 | 90 |
2023 September | 57 | 30 | 87 |
2023 August | 39 | 15 | 54 |
2023 July | 78 | 33 | 111 |
2023 June | 61 | 28 | 89 |
2023 May | 58 | 27 | 85 |
2023 April | 30 | 13 | 43 |
2023 March | 58 | 29 | 87 |
2023 February | 40 | 23 | 63 |
2023 January | 37 | 28 | 65 |
2022 December | 68 | 43 | 111 |
2022 November | 39 | 24 | 63 |
2022 October | 28 | 11 | 39 |
2022 September | 25 | 35 | 60 |
2022 August | 37 | 37 | 74 |
2022 July | 30 | 34 | 64 |
2022 June | 29 | 27 | 56 |
2022 May | 71 | 42 | 113 |
2022 April | 82 | 33 | 115 |
2022 March | 68 | 69 | 137 |
2022 February | 98 | 34 | 132 |
2022 January | 95 | 53 | 148 |
2021 December | 108 | 39 | 147 |
2021 November | 116 | 62 | 178 |
2021 October | 170 | 89 | 259 |
2021 September | 46 | 52 | 98 |
2021 August | 49 | 35 | 84 |
2021 July | 1 | 0 | 1 |