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Letter to the Editor
Pityriasis Rosea in a Confirmed COVID-19 Pediatric Patient
Pitiriasis rosada en un paciente pediátrico con diagnóstico confirmado de COVID-19
I.N.S. Öncüa,
Corresponding author
oncuisin@gmail.com

Corresponding author.
, D. Gülera, G. Gürela, G.Ş. Yalçınb
a Departamento de Dermatología, Facultad de Medicina, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey
b Departamento de Patología, Facultad de Medicina, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Pitiriasis rosada en un paciente pedi&#225;trico con diagn&#243;stico confirmado de COVID-19"
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    ]
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Focal mounds of parakeratosis&#44; mild exocytosis of lymphocytes&#44; mild perivascular mononuclear inflammatory cells and some extravasated erythocytes &#40;Hematoxylin &#38; eosin&#44; &#215;200&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">On December 31&#44; 2019&#44; the World Health Organization identified a novel coronavirus &#40;SARS-CoV-2&#41; in the city of Wuhan in China that spread very quickly and has to date resulted in the deaths of thousands of people by causing COVID-19 disease&#46; Various Coronavirus disease-19 &#40;COVID-19&#41; associated dermatological manifestations have been reported&#46; Among these&#44; Pityriasis rosea &#40;PR&#41; and PR-like rash have been published previously&#46; During the COVID-19 pandemic&#44; the diagnosis of PR has become more common<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;5</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">PR is a self-limited inflammatory skin disease that can be induced viral agents especially HHV-6 &#40;Human herpes virus 6&#41;&#44; HHV-7 &#40;Human herpes virus 7&#41;&#44; autoimmunity&#44; psychogenic factors&#44; vaccines and drugs<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present here a case of PR in a confirmed COVID-19 pediatric patient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A 10-year-old boy presented with a 20-day history of skin rash&#46; It was learned that he had Covid-19 infection about 1 month ago and he did not use any medication&#46; In dermatological examination&#44; there were small plaques with erythema and collary scaly located parallel to the ribs on the body &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Complete blood count&#44; liver and kidney function tests&#44; hepatitis markers&#44; sedimentation and CRP values were in normal ranges&#46; Histopathology of one lesion&#39;s biopsy showed focal parakeratotic peaks&#44; spongiosis&#44; focal spongiotic vesiculation&#44; lymphocyte exocytosis&#44; mildly irregular acanthosis with mild homogenization of collagen in the dermis&#44; mild to moderate perivascular erythocyte infiltration in the superficial vascular plexus&#44; scattered lymphocyte infiltration&#44; sparse lymphocytes was seen &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The diagnosis of PR after Covid -19 infection was established with clinical and histopathologic findings&#46; The patient was treated with betamethasone valerate ointment&#44; 10&#37; urea and cetirizine&#46; Lesions regressed one month later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The association between PR and COVID&#8208;19 infection is not clearly known&#46; In the literature&#44; patients with confirmed COVID-19 developed PR and PR-like rash&#44; some of them while asymptomatic or symptomatic disease&#44; others after COVID-19 infection<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a>&#46; Therefore&#44; in a patient presenting with PR and PR-like rash&#44; it is necessary to keep in mind Covid-19 infection and suggest SARs-CoV-2 testing for necessary patients&#46; PR could be directly dependent to COVID-19 infection&#44; or to viral reactivation &#40;HHV-6&#44; HHV-7&#44; EBV&#41;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;5</span></a>&#46; In addition&#44; the increased psychological stress caused by the pandemic period may have contributed to the trigger<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Due to the limited number of data&#44; it is very difficult to prove a causal relation in these cases&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; dermatologists should be aware that cutaneous symptoms may be linked to COVID-19 infection&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; &#214;nc&#252; INS&#44; G&#252;ler D&#44; G&#252;rel G&#44; Yal&#231;&#305;n G&#350;&#46; Pitiriasis rosada en un paciente pedi&#225;trico con diagn&#243;stico confirmado de COVID-19&#46; Actas Dermosifiliogr&#46; 2021&#59;112&#58;864&#8211;865&#46;</p>"
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                        0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pityriasis rosea-like eruption revealing COVID-19"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Veraldi"
                            1 => "M&#46; Romagnuolo"
                            2 => "V&#46; Benzecry"
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                        ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Australas J Dermatol&#46;"
                        "fecha" => "2020"
                        "volumen" => "10"
                        "paginaInicial" => "1111"
                      ]
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                      "titulo" => "Human herpesvirus-6&#44; -7&#44; and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "A&#46; Rebora"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
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