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which formed slit-like channels and stained positive for human herpesvirus 8&#46; These features are characteristic of Kaposi sarcoma in plaque&#47;nodular stage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After the diagnosis of Kaposi sarcoma&#44; tacrolimus was replaced by everolimus and he was referred to the Oncology department&#44; to proceed with exclusion of extra-cutaneous manifestations&#44; that proved to be negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Gradually the skin plaque on the patient scar disappeared and was replaced by an hyperpigmented brown patch &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Kaposi sarcoma &#40;KS&#41; is an angioproliferative disorder that is associated with infection with human herpes virus 8 &#40;HHV-8&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Iatrogenic&#44; immunosuppressive drug-associated KS is frequent among renal transplant recipients&#44; accounting for &#60; 3-4&#37; of all neoplasms&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The incidence of KS among solid organ transplant recipients is 500 times greater as compared with the general population&#8217;s&#44; suggesting a role for immunosuppression in the development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Iatrogenic Kaposi sarcoma presents mainly with cutaneous manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A presentation of Kaposi sarcoma&#44; de novo&#44; in a scar is extremely rare&#44; and this location can be explained by the Koebner&#8217;s phenomenon&#46; The Koebner phenomenon is the localization of skin disease to a site of trauma in an individual who is susceptible to that disease&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> A key role has been suggested for basic fibroblast growth factor &#40;b-FGF&#41;&#44; a mitogen for endothelial cells and keratinocytes&#46; Trauma&#44; like surgical intervention&#44; to susceptible skin may cause the release of this and other cytokines &#40;interleukin-1&#44; interleukin- 6&#44; tumour necrosis factor-alfa&#44; vascular endothelial growth factor&#44; platelet-derived growth factor&#44; granulocyte&#8211;macrophage colony-stimulating factor&#41; triggering angiogenesis&#46; The increased angiogenesis and the reactivation of the HHV-8 would contribute to the development of Kaposi sarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The advent of inhibitors of the mammalian target of rapamycin &#40;mTOR inhibitors&#41;&#44; such as sirolimus and everolimus&#44; represents an alternative for the antirejection maintenance therapy&#46; Furthermore&#44; they can have a role in the treatment of Kaposi&#8217;s sarcoma&#44; since they also decrease the production of VEGF and inhibit the response of vascular endothelial cells to stimulation by VEGF&#46; 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Case and Research Letters
Kaposi Sarcoma, De Novo, in a Kidney Transplant Surgical Scar
Sarcoma de Kaposi, de novo, en una cicatriz quirúrgica de transplante de riñón
L.F. Santos Silva
Corresponding author
leandrofilipe@hotmail.com

Corresponding author.
, A. Miroux Catarino, C. Sordo Amaro, I. Faro Viana
Departamento de Dermatología, Hospital de Egas Moniz, Centro Hospitalario de Lisboa Occidental, Lisboa, Portugal
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        "titulo" => "Sarcoma de Kaposi&#44; <span class="elsevierStyleItalic">de novo</span>&#44; en una cicatriz quir&#250;rgica de transplante de ri&#241;&#243;n"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histological examination characteristic of Kaposi sarcoma &#40;hematoxylin-eosin stain&#59; x400 magnification&#41; and immunohistochemical staining for HHV8 &#40;x400 magnification&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 56 years old Caucasian man presented to our Dermatology consultation with a slow-growing solitary skin lesion on the abdomen of 3-4 months of evolution&#44; accompanied of slight burning sensation&#46; He had a medical history of hypertension&#44; chronic kidney disease and secondary hyperparathyroidism&#44; that had undergone kidney transplantation 5 months before&#46; He was being treated with tacrolimus&#44; mycophenolate mofetil&#44; prednisolone&#44; nifedipine&#44; carvedilol and cotrimoxazole&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Clinical examination revealed a 20&#8239;cm large purple plaque located at the inferior extremity of the abdominal surgical scar with no other skin or mucosal lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A punch biopsy demonstrated dermal proliferation of spindle shaped cells with mild cytologic atypia&#44; which formed slit-like channels and stained positive for human herpesvirus 8&#46; These features are characteristic of Kaposi sarcoma in plaque&#47;nodular stage &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After the diagnosis of Kaposi sarcoma&#44; tacrolimus was replaced by everolimus and he was referred to the Oncology department&#44; to proceed with exclusion of extra-cutaneous manifestations&#44; that proved to be negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Gradually the skin plaque on the patient scar disappeared and was replaced by an hyperpigmented brown patch &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Kaposi sarcoma &#40;KS&#41; is an angioproliferative disorder that is associated with infection with human herpes virus 8 &#40;HHV-8&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Iatrogenic&#44; immunosuppressive drug-associated KS is frequent among renal transplant recipients&#44; accounting for &#60; 3-4&#37; of all neoplasms&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The incidence of KS among solid organ transplant recipients is 500 times greater as compared with the general population&#8217;s&#44; suggesting a role for immunosuppression in the development of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Iatrogenic Kaposi sarcoma presents mainly with cutaneous manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A presentation of Kaposi sarcoma&#44; de novo&#44; in a scar is extremely rare&#44; and this location can be explained by the Koebner&#8217;s phenomenon&#46; The Koebner phenomenon is the localization of skin disease to a site of trauma in an individual who is susceptible to that disease&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> A key role has been suggested for basic fibroblast growth factor &#40;b-FGF&#41;&#44; a mitogen for endothelial cells and keratinocytes&#46; Trauma&#44; like surgical intervention&#44; to susceptible skin may cause the release of this and other cytokines &#40;interleukin-1&#44; interleukin- 6&#44; tumour necrosis factor-alfa&#44; vascular endothelial growth factor&#44; platelet-derived growth factor&#44; granulocyte&#8211;macrophage colony-stimulating factor&#41; triggering angiogenesis&#46; The increased angiogenesis and the reactivation of the HHV-8 would contribute to the development of Kaposi sarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The advent of inhibitors of the mammalian target of rapamycin &#40;mTOR inhibitors&#41;&#44; such as sirolimus and everolimus&#44; represents an alternative for the antirejection maintenance therapy&#46; Furthermore&#44; they can have a role in the treatment of Kaposi&#8217;s sarcoma&#44; since they also decrease the production of VEGF and inhibit the response of vascular endothelial cells to stimulation by VEGF&#46; Therefore&#44; mTOR inhibitors&#44; not only inhibit the growth of certain vascularized tumors&#44; while maintaining a lower risk of losing the renal graft&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In the present case the patient presented only with a cutaneous lesion due to Kaposi Sarcoma&#44; that resolved with the switch from tacrolimus to everolimus&#46; This fact supports that mTOR inhibitors represent an alternative that allows the preservation of the renal graft&#44; while treating Kaposi sarcoma&#46;</p></span>"
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