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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fibrosis and an increase in dermal collagen&#44; which is arranged concentrically around the blood vessels and in parallel bundles&#46; Hematoxylin-eosin&#44; original magnification &#215; 100 &#40;A&#41; and &#215; 200 &#40;B&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 38-year-old man who was seen for 2 asymptomatic brownish plaques on the left popliteal fossa&#46; He had received no previous treatment for the plaques&#44; which had been present since childhood&#46; On the surface of each of the 2 plaques were excrescent fibrous papules of the same color as the plaques &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy of one of the plaques 6 years earlier had shown histological findings consistent with erythema elevatum diutinum &#40;EED&#41;&#46; A new biopsy showed perivascular lymphohistiocytic inflammatory infiltrate and an increase in dermal collagen&#44; which was arranged in concentric bands parallel to the epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The clinical and histological findings were compatible with a diagnosis of localized chronic fibrosing vasculitis&#46; The results of laboratory tests&#44; including autoimmunity studies and blood tests&#44; a chest X-ray&#44; and an abdominal ultrasound were all normal&#46; Given the stability of the lesions and the absence of clinical signs&#44; a wait-and-see approach was adopted and periodic follow-up was scheduled&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In 1997&#44; Carlson and LeBoit described a series of 8 patients who had solitary lesions with histological hallmarks suggestive of the late stages of EED and facial granuloma &#40;FG&#41;&#44; but incompatible clinical signs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They called this condition localized chronic fibrosing vasculitis&#46; Since then&#44; there have been multiple descriptions of patients with lesions histologically compatible with EED and FG&#44; but clinical signs that do not fit with the classic presentation&#46; EED and FG are 2 entities classified within the group of chronic fibrosing vasculitis&#44; and share some common clinical and pathological characteristics&#46; EED traditionally presents as erythematous&#8211;violaceous papules&#44; plaques&#44; or nodules distributed bilaterally or symmetrically on the extensor surfaces of the extremities &#40;especially the interphalangeal joints&#44; elbows&#44; knees&#44; and ankles&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> while classic FG presents as one or more brown erythematous papules or plaques located on the face&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> although extrafacial involvement has been described&#44; as well as cases without facial lesions&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> These 2 conditions share similar histological findings&#58; the acute phase is characterized by leukocytoclastic vasculitis with numerous neutrophils&#44; and the chronic phase by cicatricial changes and fibrosis with a concentric or storiform perivascular distribution&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Histological data that guide the diagnosis include a predominantly neutrophilic infiltrate and more marked fibrosis in EED&#44; and the presence of eosinophils and an intact subepidermal Grenz zone in FG&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5&#44;6</span></a> However&#44; in many cases overlapping histological findings prevent differentiation between the 2 entities&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> and therefore diagnosis is usually based on the clinical presentation&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The literature describes many atypical cases that do not correspond to any of the classic presentations&#44; due to either the location or distribution of the lesions&#46; Some authors refer to these forms as atypical EED&#44; and others as FG with extrafacial involvement&#46; Furthermore&#44; there are published descriptions of atypical EED with facial involvement&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and of extrafacial FG without lesions on the face&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> There are no clear criteria regarding the use of one term or the other&#46; In most cases the choice appears to be arbitrary&#44; which has led to some confusion&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are discrepancies&#44; most authors agree that EED&#44; FG&#44; and their atypical presentations lie on the same spectrum and that chronic fibrosing vasculitis is a common and characteristic histological finding in advanced disease stages characterized by an increase in dermal collagen bundles&#44; which are arranged parallel to the epidermis and concentrically around the vessels&#46; We agree with this view&#44; and wish to emphasize the diagnostic value of this histological pattern in atypical cases&#44; such as that presented here&#44; in which clinical signs alone may be insufficient to guide the diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Chronic Fibrosing Vasculitis: A Histologic Finding in a Case of Long-Established Erythema Elevatum Diutinum
Vasculitis fibrosante crónica, manifestación histológica de un eritema elevatum diutinum de larga evolución
A. García-Vázquez
Corresponding author
alejandrogv92@gmail.com

Corresponding author.
, S. Guillen-Climent, F. Rausell Félix, M.D. Ramón Quiles
Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Valencia, Spain
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The results of laboratory tests&#44; including autoimmunity studies and blood tests&#44; a chest X-ray&#44; and an abdominal ultrasound were all normal&#46; Given the stability of the lesions and the absence of clinical signs&#44; a wait-and-see approach was adopted and periodic follow-up was scheduled&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In 1997&#44; Carlson and LeBoit described a series of 8 patients who had solitary lesions with histological hallmarks suggestive of the late stages of EED and facial granuloma &#40;FG&#41;&#44; but incompatible clinical signs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They called this condition localized chronic fibrosing vasculitis&#46; Since then&#44; there have been multiple descriptions of patients with lesions histologically compatible with EED and FG&#44; but clinical signs that do not fit with the classic presentation&#46; EED and FG are 2 entities classified within the group of chronic fibrosing vasculitis&#44; and share some common clinical and pathological characteristics&#46; EED traditionally presents as erythematous&#8211;violaceous papules&#44; plaques&#44; or nodules distributed bilaterally or symmetrically on the extensor surfaces of the extremities &#40;especially the interphalangeal joints&#44; elbows&#44; knees&#44; and ankles&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> while classic FG presents as one or more brown erythematous papules or plaques located on the face&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> although extrafacial involvement has been described&#44; as well as cases without facial lesions&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> These 2 conditions share similar histological findings&#58; the acute phase is characterized by leukocytoclastic vasculitis with numerous neutrophils&#44; and the chronic phase by cicatricial changes and fibrosis with a concentric or storiform perivascular distribution&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Histological data that guide the diagnosis include a predominantly neutrophilic infiltrate and more marked fibrosis in EED&#44; and the presence of eosinophils and an intact subepidermal Grenz zone in FG&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5&#44;6</span></a> However&#44; in many cases overlapping histological findings prevent differentiation between the 2 entities&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> and therefore diagnosis is usually based on the clinical presentation&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The literature describes many atypical cases that do not correspond to any of the classic presentations&#44; due to either the location or distribution of the lesions&#46; Some authors refer to these forms as atypical EED&#44; and others as FG with extrafacial involvement&#46; Furthermore&#44; there are published descriptions of atypical EED with facial involvement&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and of extrafacial FG without lesions on the face&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> There are no clear criteria regarding the use of one term or the other&#46; In most cases the choice appears to be arbitrary&#44; which has led to some confusion&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are discrepancies&#44; most authors agree that EED&#44; FG&#44; and their atypical presentations lie on the same spectrum and that chronic fibrosing vasculitis is a common and characteristic histological finding in advanced disease stages characterized by an increase in dermal collagen bundles&#44; which are arranged parallel to the epidermis and concentrically around the vessels&#46; We agree with this view&#44; and wish to emphasize the diagnostic value of this histological pattern in atypical cases&#44; such as that presented here&#44; in which clinical signs alone may be insufficient to guide the diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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