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García-Gil, M. Ramírez-Lluch, M.A. Concellón-Doñate" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.F." "apellidos" => "García-Gil" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Ramírez-Lluch" ] 2 => array:2 [ "nombre" => "M.A." "apellidos" => "Concellón-Doñate" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020305536" "doi" => "10.1016/j.ad.2019.07.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020305536?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021001530?idApp=UINPBA000044" "url" => "/15782190/0000011200000006/v1_202106020933/S1578219021001530/v1_202106020933/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Chronic Fibrosing Vasculitis: A Histologic Finding in a Case of Long-Established Erythema Elevatum Diutinum" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "556" "paginaFinal" => "557" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. García-Vázquez, S. Guillen-Climent, F. Rausell Félix, M.D. Ramón Quiles" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "García-Vázquez" "email" => array:1 [ 0 => "alejandrogv92@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Guillen-Climent" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Rausell Félix" ] 3 => array:2 [ "nombre" => "M.D." "apellidos" => "Ramón Quiles" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Valencia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vasculitis fibrosante crónica, manifestación histológica de un eritema elevatum diutinum de larga evolución" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 524 "Ancho" => 1674 "Tamanyo" => 459122 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fibrosis and an increase in dermal collagen, which is arranged concentrically around the blood vessels and in parallel bundles. Hematoxylin-eosin, original magnification × 100 (A) and × 200 (B).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 38-year-old man who was seen for 2 asymptomatic brownish plaques on the left popliteal fossa. He had received no previous treatment for the plaques, which had been present since childhood. On the surface of each of the 2 plaques were excrescent fibrous papules of the same color as the plaques (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy of one of the plaques 6 years earlier had shown histological findings consistent with erythema elevatum diutinum (EED). A new biopsy showed perivascular lymphohistiocytic inflammatory infiltrate and an increase in dermal collagen, which was arranged in concentric bands parallel to the epidermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The clinical and histological findings were compatible with a diagnosis of localized chronic fibrosing vasculitis. The results of laboratory tests, including autoimmunity studies and blood tests, a chest X-ray, and an abdominal ultrasound were all normal. Given the stability of the lesions and the absence of clinical signs, a wait-and-see approach was adopted and periodic follow-up was scheduled.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In 1997, Carlson and LeBoit described a series of 8 patients who had solitary lesions with histological hallmarks suggestive of the late stages of EED and facial granuloma (FG), but incompatible clinical signs.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They called this condition localized chronic fibrosing vasculitis. Since then, there have been multiple descriptions of patients with lesions histologically compatible with EED and FG, but clinical signs that do not fit with the classic presentation. EED and FG are 2 entities classified within the group of chronic fibrosing vasculitis, and share some common clinical and pathological characteristics. EED traditionally presents as erythematous–violaceous papules, plaques, or nodules distributed bilaterally or symmetrically on the extensor surfaces of the extremities (especially the interphalangeal joints, elbows, knees, and ankles),<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> while classic FG presents as one or more brown erythematous papules or plaques located on the face,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> although extrafacial involvement has been described, as well as cases without facial lesions.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> These 2 conditions share similar histological findings: the acute phase is characterized by leukocytoclastic vasculitis with numerous neutrophils, and the chronic phase by cicatricial changes and fibrosis with a concentric or storiform perivascular distribution.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Histological data that guide the diagnosis include a predominantly neutrophilic infiltrate and more marked fibrosis in EED, and the presence of eosinophils and an intact subepidermal Grenz zone in FG.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,5,6</span></a> However, in many cases overlapping histological findings prevent differentiation between the 2 entities,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> and therefore diagnosis is usually based on the clinical presentation.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The literature describes many atypical cases that do not correspond to any of the classic presentations, due to either the location or distribution of the lesions. Some authors refer to these forms as atypical EED, and others as FG with extrafacial involvement. Furthermore, there are published descriptions of atypical EED with facial involvement,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and of extrafacial FG without lesions on the face.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> There are no clear criteria regarding the use of one term or the other. In most cases the choice appears to be arbitrary, which has led to some confusion.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are discrepancies, most authors agree that EED, FG, and their atypical presentations lie on the same spectrum and that chronic fibrosing vasculitis is a common and characteristic histological finding in advanced disease stages characterized by an increase in dermal collagen bundles, which are arranged parallel to the epidermis and concentrically around the vessels. We agree with this view, and wish to emphasize the diagnostic value of this histological pattern in atypical cases, such as that presented here, in which clinical signs alone may be insufficient to guide the diagnosis.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García-Vázquez A, Guillen-Climent S, Rausell Félix F, Ramón Quiles MD. Vasculitis fibrosante crónica, manifestación histológica de un eritema elevatum diutinum de larga evolución. Actas Dermosifiliogr. 2021;112:556–557.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 726 "Ancho" => 1674 "Tamanyo" => 170992 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Brownish plaques with superficial papules located on the left popliteal fossa. B, After biopsy the plaques acquired a more erythematous appearance, but remained stable.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 524 "Ancho" => 1674 "Tamanyo" => 459122 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fibrosis and an increase in dermal collagen, which is arranged concentrically around the blood vessels and in parallel bundles. Hematoxylin-eosin, original magnification × 100 (A) and × 200 (B).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localized chronic fibrosing vasculitis of the skin: an inflammatory reaction that occurs in settings other than erythema elevatum diutinum and granuloma faciale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Carlson" 1 => "P.E. 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2024 November | 3 | 3 | 6 |
2024 October | 70 | 44 | 114 |
2024 September | 68 | 28 | 96 |
2024 August | 92 | 58 | 150 |
2024 July | 70 | 26 | 96 |
2024 June | 73 | 20 | 93 |
2024 May | 68 | 33 | 101 |
2024 April | 67 | 23 | 90 |
2024 March | 78 | 37 | 115 |
2024 February | 88 | 35 | 123 |
2024 January | 47 | 27 | 74 |
2023 December | 40 | 21 | 61 |
2023 November | 70 | 23 | 93 |
2023 October | 73 | 29 | 102 |
2023 September | 70 | 29 | 99 |
2023 August | 48 | 16 | 64 |
2023 July | 66 | 31 | 97 |
2023 June | 60 | 20 | 80 |
2023 May | 65 | 28 | 93 |
2023 April | 44 | 18 | 62 |
2023 March | 50 | 46 | 96 |
2023 February | 60 | 21 | 81 |
2023 January | 54 | 22 | 76 |
2022 December | 49 | 30 | 79 |
2022 November | 37 | 23 | 60 |
2022 October | 33 | 13 | 46 |
2022 September | 32 | 44 | 76 |
2022 August | 30 | 22 | 52 |
2022 July | 31 | 38 | 69 |
2022 June | 28 | 32 | 60 |
2022 May | 47 | 40 | 87 |
2022 April | 65 | 42 | 107 |
2022 March | 67 | 68 | 135 |
2022 February | 58 | 33 | 91 |
2022 January | 75 | 37 | 112 |
2021 December | 45 | 35 | 80 |
2021 November | 62 | 50 | 112 |
2021 October | 54 | 56 | 110 |
2021 September | 41 | 43 | 84 |
2021 August | 45 | 35 | 80 |
2021 July | 52 | 20 | 72 |
2021 June | 62 | 41 | 103 |
2021 May | 55 | 39 | 94 |
2021 April | 106 | 68 | 174 |
2021 March | 154 | 90 | 244 |