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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contact urticaria consists of the appearance of pruritic hives immediately after contact between the skin and an eliciting agent&#46; It resolves after a few minutes or hours&#44; once exposure has ceased&#46; This condition may involve an immunoglobulin &#40;Ig&#41; E&#8211;mediated hypersensitivity mechanism &#40;immunologic origin&#41;&#44; although it may also be due to direct stimulation of subcutaneous inflammatory cells or blood vessels by histamine-releasing or vasoactive substances in foods &#40;nonimmunologic origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Allergy to honey is rare&#44; with an estimated incidence in the general population of less than 0&#46;001&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The most common symptom is oral pruritus&#44; whereas contact urticaria is an extremely rare symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 25-year-old woman with seasonal pollinosis as the only item of interest in her personal history consulted for onset of hives immediately after handling honey from beehives on her farm in Leon&#44; Spain&#46; The farm had a large number of oak and chestnut trees&#46; The hives appeared only at the contact areas and disappeared spontaneously after 10&#8239;minutes&#46; The patient reported that consuming a small amount of honey did not produce symptoms&#46; She also reported having experienced bee stings with an exclusively local reaction and no concomitant systemic symptoms&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the suspicion of allergy to honey&#44; a series of additional tests were performed&#44; as follows&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Prick test with pollens &#40;grasses&#44; olive&#44; plane tree&#44; Arizona cypress&#44; and weeds such as mugwort&#44; amaranth&#44; <span class="elsevierStyleItalic">Chenopodium</span>&#44; <span class="elsevierStyleItalic">Salsola</span>&#44; pellitory&#44; and plantain&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Prick-prick testing with propolis &#40;resinous mix present in beehives&#41;&#44; honey from Leon provided by the patient&#44; another honey from Burgos&#44; and a commercial honey with the trade name &#8220;Luna de Miel&#8221; &#40;Honeymoon&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Prick test with profilin&#44; pollen from birch and oak &#40;as a representative of PR-10&#41;&#44; lipid transfer protein from peach&#44; mustard&#44; and sesame &#40;as representatives of storage proteins&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Laboratory analysis &#40;ImmunoCap&#44; Thermo Fisher&#41;&#58; total IgE&#44; specific IgE to honey&#44; bee venom &#40;<span class="elsevierStyleItalic">Apis</span> species&#41;&#44; as well as to the different pollens available &#40;including some compounds&#41;&#44; namely&#44; <span class="elsevierStyleItalic">Ambrosia elatior</span>&#44; mugwort&#44; <span class="elsevierStyleItalic">Parietaria judaica</span>&#44; <span class="elsevierStyleItalic">Salsola kali</span>&#44; chestnut&#44; rBet v 1 &#40;birch PR-10&#41;&#44; rBet v 2 &#40;profilin&#41;&#44; rPhl p 1 and 2 &#40;timothy grass&#41;&#44; and rOle e 1 &#40;olive&#41;&#46;</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">Relevant sensitization was demonstrated to honey with a positive prick test result for the honey from Leon &#40;15&#8239;mm&#44; positive results were also recorded for the other 2 honeys&#41; and increased specific IgE to honey &#40;5&#46;93&#8239;kU&#47;L&#41; and bee venom &#40;1&#46;77&#8239;kU&#47;L&#41;&#46; The results of the remaining tests&#44; including the skin tests and specific IgE to pollens&#44; were all negative&#44; except for plantain&#44; although this had no clinical relevance owing to its low probability of involvement&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Primary sensitization in honey-allergic patients may be via honey itself&#44; the components of bee venom &#40;and other bee components&#41;&#44; and airborne pollens in the honey&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> which is the most frequent cause and is associated mainly with sensitization to pollen from the compound family &#40;most commonly mugwort&#41; and may vary according to location and season&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a> IgE to bee venom is detected in 30&#37; of honey-allergic patients&#44; and IgE to hymenoptera is detected in 20&#37; of the general population&#44; although the association between allergy to honey and allergy to bee venom is debatable&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the present case&#44; the patient was sensitized to bee venom with no clinical relevance&#44; since she had only experienced a local reaction to bee stings&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Therefore&#44; the patient was diagnosed with contact urticaria induced by honey that was probably associated with an unidentified protein of the honey itself&#46; Given the patient&#8217;s refusal to undergo oral challenge&#44; she was recommended to avoid consuming honey&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In such cases&#44; it is important to perform a complete allergy work-up in order to identify the cause and eventually provide the patient with specific&#44; tailored recommendations on avoidance&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Hives After Handling Honey
Urticaria de contacto por miel
L. González-Bravoa,
Corresponding author
lgonzalezb@fhalcorcon.es

Corresponding author.
, A. González Morenoa, C. Fuente Sarrób, E. Gómez de la Fuenteb
a Unidad de Alergia, Hospital Universitario Fundación Alcorcón, Madrid, Spain
b Unidad de Dermatología, Hospital Universitario Fundación Alcorcón, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contact urticaria consists of the appearance of pruritic hives immediately after contact between the skin and an eliciting agent&#46; It resolves after a few minutes or hours&#44; once exposure has ceased&#46; This condition may involve an immunoglobulin &#40;Ig&#41; E&#8211;mediated hypersensitivity mechanism &#40;immunologic origin&#41;&#44; although it may also be due to direct stimulation of subcutaneous inflammatory cells or blood vessels by histamine-releasing or vasoactive substances in foods &#40;nonimmunologic origin&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Allergy to honey is rare&#44; with an estimated incidence in the general population of less than 0&#46;001&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The most common symptom is oral pruritus&#44; whereas contact urticaria is an extremely rare symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 25-year-old woman with seasonal pollinosis as the only item of interest in her personal history consulted for onset of hives immediately after handling honey from beehives on her farm in Leon&#44; Spain&#46; The farm had a large number of oak and chestnut trees&#46; The hives appeared only at the contact areas and disappeared spontaneously after 10&#8239;minutes&#46; The patient reported that consuming a small amount of honey did not produce symptoms&#46; She also reported having experienced bee stings with an exclusively local reaction and no concomitant systemic symptoms&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the suspicion of allergy to honey&#44; a series of additional tests were performed&#44; as follows&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Prick test with pollens &#40;grasses&#44; olive&#44; plane tree&#44; Arizona cypress&#44; and weeds such as mugwort&#44; amaranth&#44; <span class="elsevierStyleItalic">Chenopodium</span>&#44; <span class="elsevierStyleItalic">Salsola</span>&#44; pellitory&#44; and plantain&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Prick-prick testing with propolis &#40;resinous mix present in beehives&#41;&#44; honey from Leon provided by the patient&#44; another honey from Burgos&#44; and a commercial honey with the trade name &#8220;Luna de Miel&#8221; &#40;Honeymoon&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Prick test with profilin&#44; pollen from birch and oak &#40;as a representative of PR-10&#41;&#44; lipid transfer protein from peach&#44; mustard&#44; and sesame &#40;as representatives of storage proteins&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Laboratory analysis &#40;ImmunoCap&#44; Thermo Fisher&#41;&#58; total IgE&#44; specific IgE to honey&#44; bee venom &#40;<span class="elsevierStyleItalic">Apis</span> species&#41;&#44; as well as to the different pollens available &#40;including some compounds&#41;&#44; namely&#44; <span class="elsevierStyleItalic">Ambrosia elatior</span>&#44; mugwort&#44; <span class="elsevierStyleItalic">Parietaria judaica</span>&#44; <span class="elsevierStyleItalic">Salsola kali</span>&#44; chestnut&#44; rBet v 1 &#40;birch PR-10&#41;&#44; rBet v 2 &#40;profilin&#41;&#44; rPhl p 1 and 2 &#40;timothy grass&#41;&#44; and rOle e 1 &#40;olive&#41;&#46;</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">Relevant sensitization was demonstrated to honey with a positive prick test result for the honey from Leon &#40;15&#8239;mm&#44; positive results were also recorded for the other 2 honeys&#41; and increased specific IgE to honey &#40;5&#46;93&#8239;kU&#47;L&#41; and bee venom &#40;1&#46;77&#8239;kU&#47;L&#41;&#46; The results of the remaining tests&#44; including the skin tests and specific IgE to pollens&#44; were all negative&#44; except for plantain&#44; although this had no clinical relevance owing to its low probability of involvement&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Primary sensitization in honey-allergic patients may be via honey itself&#44; the components of bee venom &#40;and other bee components&#41;&#44; and airborne pollens in the honey&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> which is the most frequent cause and is associated mainly with sensitization to pollen from the compound family &#40;most commonly mugwort&#41; and may vary according to location and season&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;5</span></a> IgE to bee venom is detected in 30&#37; of honey-allergic patients&#44; and IgE to hymenoptera is detected in 20&#37; of the general population&#44; although the association between allergy to honey and allergy to bee venom is debatable&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the present case&#44; the patient was sensitized to bee venom with no clinical relevance&#44; since she had only experienced a local reaction to bee stings&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Therefore&#44; the patient was diagnosed with contact urticaria induced by honey that was probably associated with an unidentified protein of the honey itself&#46; Given the patient&#8217;s refusal to undergo oral challenge&#44; she was recommended to avoid consuming honey&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In such cases&#44; it is important to perform a complete allergy work-up in order to identify the cause and eventually provide the patient with specific&#44; tailored recommendations on avoidance&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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ISSN: 15782190
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